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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 37-41 protein denotes IL-2
T2 70-74 protein denotes IL-2
T3 84-90 cell_type denotes T cell
T4 177-207 protein denotes NFAT-1 transcriptional complex
T5 215-228 DNA denotes IL-2 promoter
T6 246-250 protein denotes IL-2
T7 332-357 DNA denotes NFAT-1 regulatory element
T8 370-389 DNA denotes lac-Z reporter gene
T9 421-425 protein denotes NFAT
T10 437-455 protein denotes beta-galactosidase
T11 559-582 RNA denotes beta-galactosidase mRNA
T12 613-617 protein denotes NFAT
T13 670-679 cell_line denotes cell line
T14 714-740 DNA denotes NFAT-1 regulatory elements
T15 755-777 DNA denotes reporter gene for sCD8
T16 854-887 cell_line denotes NFAT-1-linked lac-Z transfectants
T17 896-913 cell_type denotes human lymphocytes
T18 1017-1021 protein denotes IL-2
T19 1043-1047 protein denotes IL-2
T20 1131-1163 protein denotes calcium-independent anti-CD28 Ab
T21 1180-1184 protein denotes IL-2
T22 1238-1268 protein denotes NFAT-1 transcriptional complex
T23 1416-1420 protein denotes NFAT

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 272-283 NP denotes a cell line
C2 284-288 NP denotes that
C3 466-489 NP denotes WIN 61058 and WIN 53071
C4 509-526 NP denotes microM inhibitors
C5 528-543 NP denotes These compounds
C6 661-679 NP denotes a second cell line
C7 681-686 NP denotes which
C8 793-807 NP denotes both compounds
C9 915-929 NP denotes Both compounds
C10 1211-1225 NP denotes Both compounds
C11 1234-1268 NP denotes the NFAT-1 transcriptional complex
C12 1278-1281 NP denotes its
C13 1369-1445 NP denotes two structurally distinct, novel inhibitors of NFAT-1-mediated transcription
R1 C2 C1 coref-relat that,a cell line
R2 C4 C3 coref-ident microM inhibitors,WIN 61058 and WIN 53071
R3 C5 C3 coref-ident These compounds,WIN 61058 and WIN 53071
R4 C7 C6 coref-relat which,a second cell line
R5 C8 C5 coref-ident both compounds,These compounds
R6 C9 C8 coref-ident Both compounds,both compounds
R7 C10 C9 coref-ident Both compounds,Both compounds
R8 C12 C11 coref-pron its,the NFAT-1 transcriptional complex
R9 C13 C3 coref-ident "two structurally distinct, novel inhibitors of NFAT-1-mediated transcription",WIN 61058 and WIN 53071

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-69 Sentence denotes Functional characterization of novel IL-2 transcriptional inhibitors.
S2 70-159 Sentence denotes IL-2-mediated T cell proliferation is a critical early event in the inflammatory process.
S3 160-265 Sentence denotes Formation of the NFAT-1 transcriptional complex on the IL-2 promoter is essential for IL-2 transcription.
S4 266-465 Sentence denotes Using a cell line that is stably transfected with a trimer of the NFAT-1 regulatory element linked to a lac-Z reporter gene, we screened for inhibitors of NFAT-1-mediated beta-galactosidase activity.
S5 466-527 Sentence denotes WIN 61058 and WIN 53071 were identified as microM inhibitors.
S6 528-590 Sentence denotes These compounds also inhibited beta-galactosidase mRNA levels.
S7 591-778 Sentence denotes Similar inhibition of NFAT-1-mediated gene expression was observed in a second cell line, which is stably transfected with NFAT-1 regulatory elements linked to the reporter gene for sCD8.
S8 779-914 Sentence denotes At 10 microM, both compounds inhibited IL-2 mRNA and protein levels in the NFAT-1-linked lac-Z transfectants, and in human lymphocytes.
S9 915-1022 Sentence denotes Both compounds inhibited the mixed lymphocyte reaction, and this inhibition was reversed by exogenous IL-2.
S10 1023-1118 Sentence denotes WIN 53071 inhibited IL-2 production induced in the calcium-dependent PMA and ionomycin pathway.
S11 1119-1210 Sentence denotes Conversely, calcium-independent anti-CD28 Ab and PMA-induced IL-2 production was resistant.
S12 1211-1308 Sentence denotes Both compounds altered the NFAT-1 transcriptional complex, causing its retarded mobility on gels.
S13 1309-1446 Sentence denotes By these functional criteria, we believe we have identified two structurally distinct, novel inhibitors of NFAT-1-mediated transcription.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 37-41 protein_molecule denotes IL-2
T2 70-74 protein_molecule denotes IL-2
T3 84-90 cell_type denotes T cell
T4 138-158 other_name denotes inflammatory process
T5 177-181 protein_family_or_group denotes NFAT
T6 215-219 protein_molecule denotes IL-2
T7 246-250 protein_molecule denotes IL-2
T8 332-336 protein_family_or_group denotes NFAT
T9 370-389 DNA_domain_or_region denotes lac-Z reporter gene
T10 421-425 protein_family_or_group denotes NFAT
T11 437-455 protein_molecule denotes beta-galactosidase
T12 466-475 other_organic_compound denotes WIN 61058
T13 480-489 other_organic_compound denotes WIN 53071
T14 509-526 other_name denotes microM inhibitors
T15 559-577 protein_molecule denotes beta-galactosidase
T16 613-617 protein_family_or_group denotes NFAT
T17 670-679 cell_line denotes cell line
T18 714-718 protein_family_or_group denotes NFAT
T19 755-777 DNA_domain_or_region denotes reporter gene for sCD8
T20 854-858 protein_family_or_group denotes NFAT
T21 896-913 cell_type denotes human lymphocytes
T22 944-969 other_name denotes mixed lymphocyte reaction
T23 1017-1021 protein_molecule denotes IL-2
T24 1023-1032 other_organic_compound denotes WIN 53071
T25 1043-1047 protein_molecule denotes IL-2
T26 1074-1117 other_name denotes calcium-dependent PMA and ionomycin pathway
T27 1131-1163 protein_molecule denotes calcium-independent anti-CD28 Ab
T28 1168-1179 other_name denotes PMA-induced
T29 1180-1184 protein_molecule denotes IL-2
T30 1238-1242 protein_family_or_group denotes NFAT
T31 1303-1307 other_organic_compound denotes gels
T32 1396-1412 other_name denotes novel inhibitors
T33 1416-1420 protein_family_or_group denotes NFAT