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PubMed:7684503 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 556-565 gene:3553 denotes IL-1 beta
T1 471-483 disease:C0041296 denotes tuberculosis
R1 T0 T1 associated_with IL-1 beta,tuberculosis

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 18-53 DNA denotes interleukin-1 beta (IL-1 beta) gene
T2 57-81 protein denotes mycobacterial components
T3 124-149 DNA denotes nuclear factor-IL6 motifs
T4 185-194 protein denotes IL-1 beta
T5 229-238 protein denotes TNF-alpha
T6 256-278 cell_type denotes mononuclear phagocytes
T7 556-570 DNA denotes IL-1 beta gene
T8 585-600 cell_type denotes human monocytes
T9 702-711 protein denotes TNF-alpha
T10 711-730 DNA denotes -inducible promoter
T11 798-812 DNA denotes IL-1 beta gene
T12 838-871 protein denotes chloramphenicol acetyltransferase
T13 986-1026 DNA denotes nuclear factor-IL6 (NF-IL6) binding site
T14 1080-1094 DNA denotes NF-IL-6 motifs
T15 1144-1153 protein denotes TNF-alpha
T16 1266-1281 protein denotes nuclear protein
T17 1290-1337 cell_line denotes LAM-, LPS-, or TNF-alpha-stimulated THP-1 cells
T18 1385-1397 DNA denotes NF-IL6 sites
T19 1419-1428 protein denotes IL-1 beta
T20 1470-1479 protein denotes TNF-alpha

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
7684503-2#124#133#gene3553 556-565 gene3553 denotes IL-1 beta
7684503-2#39#51#diseaseC0041296 471-483 diseaseC0041296 denotes tuberculosis
124#133#gene355339#51#diseaseC0041296 7684503-2#124#133#gene3553 7684503-2#39#51#diseaseC0041296 associated_with IL-1 beta,tuberculosis

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 14-53 NP denotes the interleukin-1 beta (IL-1 beta) gene
C2 120-149 NP denotes two nuclear factor-IL6 motifs
C3 151-195 NP denotes The cytokines interleukin-1 beta (IL-1 beta)
C4 200-239 NP denotes tumor necrosis factor alpha (TNF-alpha)
C5 504-527 NP denotes lipoarabinomannan (LAM)
C6 665-669 NP denotes LAM-
C7 671-696 NP denotes lipopolysaccharide (LPS)-
C8 702-712 NP denotes TNF-alpha-
C10 794-812 NP denotes the IL-1 beta gene
C9 743-812 NP denotes a -131/+15 (positions -131 to +15) DNA fragment of the IL-1 beta gene
C11 886-903 NP denotes this DNA fragment
C12 916-1026 NP denotes two novel 9-bp motifs (-90/-82 and -40/-32) with high homology to the nuclear factor-IL6 (NF-IL6) binding site
C13 1072-1094 NP denotes the two NF-IL-6 motifs
C14 1131-1134 NP denotes LAM
C15 1136-1139 NP denotes LPS
C16 1144-1153 NP denotes TNF-alpha
C17 1163-1167 NP denotes they
C18 1290-1294 NP denotes LAM-
C19 1296-1300 NP denotes LPS-
C20 1305-1315 NP denotes TNF-alpha-
C21 1341-1358 NP denotes the NF-IL6 motifs
C22 1419-1428 NP denotes IL-1 beta
C23 1456-1459 NP denotes LAM
C24 1461-1464 NP denotes LPS
C25 1470-1479 NP denotes TNF-alpha
R1 C3 C1 coref-ident The cytokines interleukin-1 beta (IL-1 beta),the interleukin-1 beta (IL-1 beta) gene
R2 C6 C5 coref-ident LAM-,lipoarabinomannan (LAM)
R3 C8 C4 coref-ident TNF-alpha-,tumor necrosis factor alpha (TNF-alpha)
R4 C10 C1 coref-ident the IL-1 beta gene,the interleukin-1 beta (IL-1 beta) gene
R5 C11 C9 coref-ident this DNA fragment,a -131/+15 (positions -131 to +15) DNA fragment of the IL-1 beta gene
R6 C12 C2 coref-ident two novel 9-bp motifs (-90/-82 and -40/-32) with high homology to the nuclear factor-IL6 (NF-IL6) binding site,two nuclear factor-IL6 motifs
R7 C13 C12 coref-ident the two NF-IL-6 motifs,two novel 9-bp motifs (-90/-82 and -40/-32) with high homology to the nuclear factor-IL6 (NF-IL6) binding site
R8 C14 C5 coref-ident LAM,lipoarabinomannan (LAM)
R9 C15 C7 coref-ident LPS,lipopolysaccharide (LPS)-
R10 C16 C4 coref-ident TNF-alpha,tumor necrosis factor alpha (TNF-alpha)
R11 C17 C13 coref-pron they,the two NF-IL-6 motifs
R12 C18 C14 coref-ident LAM-,LAM
R13 C19 C15 coref-ident LPS-,LPS
R14 C20 C16 coref-ident TNF-alpha-,TNF-alpha
R15 C21 C13 coref-ident the NF-IL6 motifs,the two NF-IL-6 motifs
R16 C22 C3 coref-ident IL-1 beta,The cytokines interleukin-1 beta (IL-1 beta)
R17 C23 C18 coref-ident LAM,LAM-
R18 C24 C19 coref-ident LPS,LPS-
R19 C25 C20 coref-ident TNF-alpha,TNF-alpha-

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-150 Sentence denotes Regulation of the interleukin-1 beta (IL-1 beta) gene by mycobacterial components and lipopolysaccharide is mediated by two nuclear factor-IL6 motifs.
S2 151-431 Sentence denotes The cytokines interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha) are released by mononuclear phagocytes in vitro after stimulation with mycobacteria and are considered to mediate pathophysiologic events, including granuloma formation and systemic symptoms.
S3 432-647 Sentence denotes We demonstrated that the Mycobacterium tuberculosis cell wall component lipoarabinomannan (LAM) is a very potent inducer of IL-1 beta gene expression in human monocytes and investigated the mechanism of this effect.
S4 648-878 Sentence denotes We localized the LAM-, lipopolysaccharide (LPS)-, and TNF-alpha-inducible promoter activity to a -131/+15 (positions -131 to +15) DNA fragment of the IL-1 beta gene by deletion analysis and chloramphenicol acetyltransferase assay.
S5 879-1027 Sentence denotes Within this DNA fragment, there were two novel 9-bp motifs (-90/-82 and -40/-32) with high homology to the nuclear factor-IL6 (NF-IL6) binding site.
S6 1028-1211 Sentence denotes Site-directed mutagenesis demonstrated that the two NF-IL-6 motifs could be independently activated by LAM, LPS, or TNF-alpha and that they acted in an orientation-independent manner.
S7 1212-1359 Sentence denotes DNA mobility shift assay revealed specific binding of nuclear protein(s) from LAM-, LPS-, or TNF-alpha-stimulated THP-1 cells to the NF-IL6 motifs.
S8 1360-1480 Sentence denotes We conclude that the two NF-IL6 sites mediate induction of IL-1 beta in response to the stimuli LAM, LPS, and TNF-alpha.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 18-38 DNA_domain_or_region denotes interleukin-1 beta (
T2 38-47 protein_molecule denotes IL-1 beta
T3 57-81 protein_family_or_group denotes mycobacterial components
T4 86-104 lipid denotes lipopolysaccharide
T5 124-149 DNA_domain_or_region denotes nuclear factor-IL6 motifs
T6 185-194 protein_molecule denotes IL-1 beta
T7 229-238 protein_molecule denotes TNF-alpha
T8 256-278 cell_type denotes mononuclear phagocytes
T9 311-323 mono_cell denotes mycobacteria
T10 389-408 other_name denotes granuloma formation
T11 457-483 mono_cell denotes Mycobacterium tuberculosis
T12 504-521 lipid denotes lipoarabinomannan
T13 523-526 lipid denotes LAM
T14 556-570 DNA_domain_or_region denotes IL-1 beta gene
T15 585-600 cell_type denotes human monocytes
T16 665-668 lipid denotes LAM
T17 671-689 lipid denotes lipopolysaccharide
T18 691-694 lipid denotes LPS
T19 702-711 protein_molecule denotes TNF-alpha
T20 711-730 DNA_domain_or_region denotes -inducible promoter
T21 798-812 DNA_domain_or_region denotes IL-1 beta gene
T22 816-833 other_name denotes deletion analysis
T23 838-871 protein_molecule denotes chloramphenicol acetyltransferase
T24 926-937 DNA_substructure denotes 9-bp motifs
T25 986-1004 protein_molecule denotes nuclear factor-IL6
T26 1006-1012 protein_molecule denotes NF-IL6
T27 1080-1094 DNA_domain_or_region denotes NF-IL-6 motifs
T28 1131-1134 lipid denotes LAM
T29 1136-1139 lipid denotes LPS
T30 1144-1153 protein_molecule denotes TNF-alpha
T31 1212-1236 other_name denotes DNA mobility shift assay
T32 1266-1281 protein_domain_or_region denotes nuclear protein
T33 1345-1358 DNA_substructure denotes NF-IL6 motifs
T34 1385-1397 DNA_domain_or_region denotes NF-IL6 sites
T35 1419-1428 protein_molecule denotes IL-1 beta
T36 1456-1459 lipid denotes LAM
T37 1461-1464 lipid denotes LPS
T38 1470-1479 protein_molecule denotes TNF-alpha