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PubMed:7683692 JSONTXT

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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
7683692_0 696-760 ProteinMutation denotes isoleucine (ATT) for valine (GTT) substitution at amino acid 729 rs1353048513
7683692_1 1309-1361 ProteinMutation denotes isoleucine for valine substitution at amino acid 729 rs1353048513

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 18-41 protein denotes glucocorticoid receptor
T2 248-272 protein denotes glucocorticoid receptors
T3 274-277 protein denotes hGR
T4 362-395 protein denotes hGR glucocorticoid-binding domain
T5 477-499 cell_type denotes mononuclear leukocytes
T6 533-542 DNA denotes hGR cDNAs
T7 559-567 DNA denotes hGR cDNA
T8 771-784 protein denotes wild-type hGR
T9 789-800 protein denotes hGR-Ile 729
T10 819-830 cell_line denotes COS-1 cells
T11 994-1007 protein denotes wild-type hGR
T12 1012-1023 protein denotes hGR-Ile 729
T13 1042-1052 cell_line denotes CV-1 cells
T14 1086-1132 DNA denotes mouse mammary tumor virus long terminal repeat
T15 1146-1191 DNA denotes chloramphenicol acetyl transferase (CAT) gene
T16 1197-1208 protein denotes hGR-Ile 729
T17 1291-1294 protein denotes CAT
T18 1390-1393 protein denotes hGR

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 14-41 NP denotes the glucocorticoid receptor
C2 45-72 NP denotes primary cortisol resistance
C3 74-109 NP denotes The precise molecular abnormalities
C4 110-114 NP denotes that
C6 203-230 NP denotes primary cortisol resistance
C5 188-230 NP denotes a subject with primary cortisol resistance
C7 248-278 NP denotes glucocorticoid receptors (hGR)
C8 362-365 NP denotes hGR
C9 457-476 NP denotes the index subject's
C10 520-542 NP denotes first strand hGR cDNAs
C11 548-567 NP denotes the entire hGR cDNA
C12 643-678 NP denotes a homozygous A for G point mutation
C13 679-683 NP denotes that
C15 789-800 NP denotes hGR-Ile 729
C14 767-800 NP denotes the wild-type hGR and hGR-Ile 729
C17 1012-1023 NP denotes hGR-Ile 729
C16 990-1023 NP denotes the wild-type hGR and hGR-Ile 729
C18 1142-1191 NP denotes the chloramphenicol acetyl transferase (CAT) gene
C19 1193-1208 NP denotes the hGR-Ile 729
C20 1291-1294 NP denotes CAT
C21 1386-1393 NP denotes the hGR
C22 1421-1448 NP denotes primary cortisol resistance
C23 1452-1464 NP denotes this subject
R1 C4 C3 coref-relat that,The precise molecular abnormalities
R2 C6 C2 coref-ident primary cortisol resistance,primary cortisol resistance
R3 C7 C1 coref-ident glucocorticoid receptors (hGR),the glucocorticoid receptor
R4 C8 C7 coref-ident hGR,glucocorticoid receptors (hGR)
R5 C9 C5 coref-ident the index subject's,a subject with primary cortisol resistance
R6 C11 C10 coref-whole-part the entire hGR cDNA,first strand hGR cDNAs
R7 C13 C12 coref-relat that,a homozygous A for G point mutation
R8 C17 C15 coref-ident hGR-Ile 729,hGR-Ile 729
R9 C16 C14 coref-ident the wild-type hGR and hGR-Ile 729,the wild-type hGR and hGR-Ile 729
R10 C19 C17 coref-ident the hGR-Ile 729,hGR-Ile 729
R11 C20 C18 coref-ident CAT,the chloramphenicol acetyl transferase (CAT) gene
R12 C21 C8 coref-ident the hGR,hGR
R13 C22 C6 coref-ident primary cortisol resistance,primary cortisol resistance
R14 C23 C5 coref-ident this subject,a subject with primary cortisol resistance

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-73 Sentence denotes A mutation of the glucocorticoid receptor in primary cortisol resistance.
S2 74-184 Sentence denotes The precise molecular abnormalities that cause primary cortisol resistance have not been completely described.
S3 185-323 Sentence denotes In a subject with primary cortisol resistance we have observed glucocorticoid receptors (hGR) with a decreased affinity for dexamethasone.
S4 324-432 Sentence denotes We hypothesize that a mutation of the hGR glucocorticoid-binding domain is the cause of cortisol resistance.
S5 433-608 Sentence denotes Total RNA isolated from the index subject's mononuclear leukocytes was used to produce first strand hGR cDNAs, and the entire hGR cDNA was amplified in segments and sequenced.
S6 609-761 Sentence denotes At nucleotide 2,317 we identified a homozygous A for G point mutation that predicts an isoleucine (ATT) for valine (GTT) substitution at amino acid 729.
S7 762-984 Sentence denotes When the wild-type hGR and hGR-Ile 729 were expressed in COS-1 cells and assayed for [3H]-Dexamethasone binding, the dissociation constants were 0.799 +/- 0.068 and 1.54 +/- 0.06 nM (mean +/- SEM) (P < 0.01), respectively.
S8 985-1304 Sentence denotes When the wild-type hGR and hGR-Ile 729 were expressed in CV-1 cells that were cotransfected with the mouse mammary tumor virus long terminal repeat fused to the chloramphenicol acetyl transferase (CAT) gene, the hGR-Ile 729 conferred a fourfold decrease in apparent potency on dexamethasone stimulation of CAT activity.
S9 1305-1465 Sentence denotes The isoleucine for valine substitution at amino acid 729 impairs the function of the hGR and is the likely cause of primary cortisol resistance in this subject.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 18-41 protein_family_or_group denotes glucocorticoid receptor
T2 45-72 other_name denotes primary cortisol resistance
T3 121-148 other_name denotes primary cortisol resistance
T4 203-230 other_name denotes primary cortisol resistance
T5 248-272 protein_family_or_group denotes glucocorticoid receptors
T6 274-277 protein_family_or_group denotes hGR
T7 309-322 lipid denotes dexamethasone
T8 362-365 protein_family_or_group denotes hGR
T9 412-420 lipid denotes cortisol
T10 477-499 cell_type denotes mononuclear leukocytes
T11 533-536 protein_family_or_group denotes hGR
T12 559-562 protein_family_or_group denotes hGR
T13 612-628 nucleotide denotes nucleotide 2,317
T14 645-657 other_name denotes homozygous A
T15 662-678 other_name denotes G point mutation
T16 696-706 amino_acid_monomer denotes isoleucine
T17 708-711 polynucleotide denotes ATT
T18 717-723 amino_acid_monomer denotes valine
T19 725-728 polynucleotide denotes GTT
T20 746-760 amino_acid_monomer denotes amino acid 729
T21 771-780 protein_molecule denotes wild-type
T22 781-784 protein_family_or_group denotes hGR
T23 789-792 protein_family_or_group denotes hGR
T24 819-830 cell_line denotes COS-1 cells
T25 847-865 lipid denotes [3H]-Dexamethasone
T26 994-1003 protein_molecule denotes wild-type
T27 1004-1007 protein_family_or_group denotes hGR
T28 1012-1015 protein_family_or_group denotes hGR
T29 1042-1052 cell_line denotes CV-1 cells
T30 1086-1111 virus denotes mouse mammary tumor virus
T31 1146-1180 protein_molecule denotes chloramphenicol acetyl transferase
T32 1182-1185 protein_molecule denotes CAT
T33 1197-1200 protein_family_or_group denotes hGR
T34 1262-1275 lipid denotes dexamethasone
T35 1291-1294 protein_molecule denotes CAT
T36 1309-1319 amino_acid_monomer denotes isoleucine
T37 1324-1330 amino_acid_monomer denotes valine
T38 1390-1393 protein_family_or_group denotes hGR
T39 1421-1428 other_name denotes primary
T40 1429-1437 lipid denotes cortisol