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PubMed:7678994 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 74-79 gene:6886 denotes Tal-1
T1 135-165 disease:C1961099 denotes T acute lymphoblastic leukemia
R1 T0 T1 associated_with Tal-1,T acute lymphoblastic leukemia

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 14-19 protein denotes tal-1
T2 24-45 protein denotes GATA-binding proteins
T3 74-79 protein denotes Tal-1
T4 167-177 DNA denotes Tal-1 gene
T5 197-217 protein denotes transcription factor
T6 225-254 protein denotes basic helix-loop-helix domain
T7 301-320 cell_type denotes hematopoietic cells
T8 353-358 protein denotes tal-1
T9 373-407 cell_type denotes purified human hematopoietic cells
T10 437-469 protein denotes reverse transcriptase polymerase
T11 530-535 protein denotes tal-1
T12 604-627 cell_type denotes basophilic granulocytes
T13 672-689 DNA denotes tal-1 1A promoter
T14 720-738 DNA denotes GATA-binding sites
T15 788-799 DNA denotes GATA-1 gene
T16 857-918 cell_type denotes erythroid, megakaryocytic, and mastocytic/basophilic lineages
T17 931-937 protein denotes GATA-1
T18 967-986 cell_type denotes hematopoietic cells
T19 1002-1024 DNA denotes GATA-1 and tal-1 genes
T20 1184-1212 cell_type denotes immature hematopoietic cells
T21 1214-1236 DNA denotes tal-1 and GATA-1 genes
T22 1256-1283 cell_type denotes committed progenitors cells
T23 1285-1299 cell_line denotes CD34+/CD38(2+)
T24 1346-1361 cell_type denotes primitive cells
T25 1363-1377 cell_line denotes CD34(2+)/CD38-
T26 1393-1399 protein denotes GATA-2
T27 1430-1476 cell_type denotes most primitive and committed progenitors cells
T28 1486-1492 protein denotes GATA-3
T29 1581-1587 protein denotes GATA-1
T30 1619-1624 protein denotes tal-1
T31 1659-1711 cell_type denotes erythroid, megakaryocytic, and basosophilic lineages

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
7678994-1#0#5#gene6886 74-79 gene6886 denotes Tal-1
7678994-1#61#91#diseaseC1961099 135-165 diseaseC1961099 denotes T acute lymphoblastic leukemia
0#5#gene688661#91#diseaseC1961099 7678994-1#0#5#gene6886 7678994-1#61#91#diseaseC1961099 associated_with Tal-1,T acute lymphoblastic leukemia

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 14-19 NP denotes tal-1
C2 74-79 NP denotes Tal-1
C4 167-172 NP denotes Tal-1
C3 167-177 NP denotes Tal-1 gene
C5 301-320 NP denotes hematopoietic cells
C6 353-358 NP denotes tal-1
C7 373-407 NP denotes purified human hematopoietic cells
C8 411-493 NP denotes in situ hybridization and reverse transcriptase polymerase chain reaction analysis
C9 495-507 NP denotes Both methods
C11 530-535 NP denotes tal-1
C10 526-540 NP denotes the tal-1 gene
C12 557-627 NP denotes megakaryocytes and erythroblasts as well as in basophilic granulocytes
C14 672-677 NP denotes tal-1
C13 668-689 NP denotes the tal-1 1A promoter
C15 691-696 NP denotes which
C16 760-774 NP denotes these lineages
C17 788-794 NP denotes GATA-1
C18 853-918 NP denotes the erythroid, megakaryocytic, and mastocytic/basophilic lineages
C19 931-937 NP denotes GATA-1
C20 952-986 NP denotes these purified hematopoietic cells
C22 1002-1008 NP denotes GATA-1
C23 1013-1018 NP denotes tal-1
C21 1002-1024 NP denotes GATA-1 and tal-1 genes
C24 1044-1064 NP denotes these three lineages
C25 1096-1106 NP denotes both genes
C26 1184-1212 NP denotes immature hematopoietic cells
C28 1214-1219 NP denotes tal-1
C29 1224-1230 NP denotes GATA-1
C27 1214-1236 NP denotes tal-1 and GATA-1 genes
C30 1310-1314 NP denotes they
C31 1581-1587 NP denotes GATA-1
C32 1619-1624 NP denotes tal-1
C33 1655-1711 NP denotes the erythroid, megakaryocytic, and basosophilic lineages
R1 C2 C1 coref-ident Tal-1,tal-1
R2 C4 C2 coref-ident Tal-1,Tal-1
R3 C6 C4 coref-ident tal-1,Tal-1
R4 C7 C5 coref-other purified human hematopoietic cells,hematopoietic cells
R5 C9 C8 coref-ident Both methods,in situ hybridization and reverse transcriptase polymerase chain reaction analysis
R6 C11 C6 coref-ident tal-1,tal-1
R7 C10 C3 coref-ident the tal-1 gene,Tal-1 gene
R8 C14 C11 coref-ident tal-1,tal-1
R9 C15 C13 coref-relat which,the tal-1 1A promoter
R10 C16 C12 coref-other these lineages,megakaryocytes and erythroblasts as well as in basophilic granulocytes
R11 C18 C16 coref-other "the erythroid, megakaryocytic, and mastocytic/basophilic lineages",these lineages
R12 C19 C17 coref-ident GATA-1,GATA-1
R13 C20 C7 coref-ident these purified hematopoietic cells,purified human hematopoietic cells
R14 C22 C19 coref-ident GATA-1,GATA-1
R15 C23 C14 coref-ident tal-1,tal-1
R16 C24 C18 coref-ident these three lineages,"the erythroid, megakaryocytic, and mastocytic/basophilic lineages"
R17 C25 C21 coref-ident both genes,GATA-1 and tal-1 genes
R18 C26 C5 coref-other immature hematopoietic cells,hematopoietic cells
R19 C28 C23 coref-ident tal-1,tal-1
R20 C29 C22 coref-ident GATA-1,GATA-1
R21 C27 C25 coref-ident tal-1 and GATA-1 genes,both genes
R22 C30 C27 coref-pron they,tal-1 and GATA-1 genes
R23 C31 C29 coref-ident GATA-1,GATA-1
R24 C32 C28 coref-ident tal-1,tal-1
R25 C33 C24 coref-ident "the erythroid, megakaryocytic, and basosophilic lineages",these three lineages

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-73 Sentence denotes Expression of tal-1 and GATA-binding proteins during human hematopoiesis.
S2 74-166 Sentence denotes Tal-1 rearrangements are associated with nearly 30% of human T acute lymphoblastic leukemia.
S3 167-321 Sentence denotes Tal-1 gene encodes a putative transcription factor with a basic helix-loop-helix domain and is known to be predominantly expressed in hematopoietic cells.
S4 322-494 Sentence denotes We investigated the pattern of tal-1 expression in purified human hematopoietic cells by in situ hybridization and reverse transcriptase polymerase chain reaction analysis.
S5 495-628 Sentence denotes Both methods demonstrated that the tal-1 gene is expressed in megakaryocytes and erythroblasts as well as in basophilic granulocytes.
S6 629-775 Sentence denotes In addition, our results indicate that the tal-1 1A promoter, which contains two consensus GATA-binding sites, is active mainly in these lineages.
S7 776-987 Sentence denotes Because the GATA-1 gene is known to transactivate several genes specific for the erythroid, megakaryocytic, and mastocytic/basophilic lineages, we studied GATA-1 expression in these purified hematopoietic cells.
S8 988-1065 Sentence denotes We found that GATA-1 and tal-1 genes are coexpressed in these three lineages.
S9 1066-1180 Sentence denotes Remarkably, the expression of both genes is downmodulated during erythroid and megakaryocytic terminal maturation.
S10 1181-1379 Sentence denotes In immature hematopoietic cells, tal-1 and GATA-1 genes are coexpressed in committed progenitors cells (CD34+/CD38(2+)), whereas they are not detectable in the most primitive cells (CD34(2+)/CD38-).
S11 1380-1535 Sentence denotes In contrast, GATA-2 is strongly expressed in both most primitive and committed progenitors cells, whereas GATA-3 is mostly detected in most primitive ones.
S12 1536-1712 Sentence denotes Altogether our results strongly suggest that GATA-1 modulates the transcription of tal-1 during the differentiation of the erythroid, megakaryocytic, and basosophilic lineages.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-19 protein_molecule denotes tal-1
T2 24-45 protein_family_or_group denotes GATA-binding proteins
T3 53-72 other_name denotes human hematopoiesis
T4 74-79 protein_molecule denotes Tal-1
T5 129-165 other_name denotes human T acute lymphoblastic leukemia
T6 167-177 DNA_domain_or_region denotes Tal-1 gene
T7 197-217 protein_family_or_group denotes transcription factor
T8 225-254 protein_domain_or_region denotes basic helix-loop-helix domain
T9 301-320 cell_type denotes hematopoietic cells
T10 353-358 protein_molecule denotes tal-1
T11 373-387 cell_type denotes purified human
T12 388-407 cell_type denotes hematopoietic cells
T13 414-432 other_name denotes situ hybridization
T14 437-469 protein_molecule denotes reverse transcriptase polymerase
T15 530-535 protein_molecule denotes tal-1
T16 604-627 cell_type denotes basophilic granulocytes
T17 672-689 DNA_domain_or_region denotes tal-1 1A promoter
T18 720-738 DNA_domain_or_region denotes GATA-binding sites
T19 788-799 DNA_domain_or_region denotes GATA-1 gene
T20 931-937 protein_molecule denotes GATA-1
T21 967-986 cell_type denotes hematopoietic cells
T22 1184-1192 cell_type denotes immature
T23 1193-1212 cell_type denotes hematopoietic cells
T24 1256-1283 cell_type denotes committed progenitors cells
T25 1285-1299 cell_line denotes CD34+/CD38(2+)
T26 1346-1361 cell_type denotes primitive cells
T27 1363-1377 cell_line denotes CD34(2+)/CD38-
T28 1393-1399 protein_molecule denotes GATA-2
T29 1486-1492 protein_molecule denotes GATA-3
T30 1581-1587 protein_molecule denotes GATA-1
T31 1619-1624 protein_molecule denotes tal-1