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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 218-224 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T2 389-402 Cell denotes T lymphocytes http://purl.obolibrary.org/obo/CL:0000084
T3 537-543 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T4 993-1000 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084

sentences

Id Subject Object Predicate Lexical cue
T1 0-123 Sentence denotes A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1.
T2 124-261 Sentence denotes Activation of the interleukin 2 (IL-2) gene after antigen recognition is a critical event for T cell proliferation and effector function.
T3 262-403 Sentence denotes Prior studies have identified several transcription factors that contribute to the activity of the IL-2 promoter in stimulated T lymphocytes.
T4 404-558 Sentence denotes Here we describe a novel regulatory element within the IL-2 promoter located immediately upstream of the nuclear factor of activated T cell (NFAT) domain.
T5 559-808 Sentence denotes This region (termed the zinc finger protein binding region (ZIP)) serves as binding site for two differently regulated zinc finger proteins: the constitutively expressed transcription factor Sp1 and the inducible early growth response protein EGR-1.
T6 809-982 Sentence denotes In unstimulated cells which do not secrete IL-2, only Sp1 binds to this region, while in stimulated IL-2 secreting cells the inducible EGR-1 protein recognizes this element.
T7 983-1159 Sentence denotes In Jurkat T cells, the ZIP site serves as an activator for IL-2 gene expression, and a combination of ZIP and NFAT binding sites is required for maximal IL-2 promoter activity.
T8 1160-1241 Sentence denotes These results suggest a critical role of the ZIP site for IL-2 promoter activity.
T1 0-123 Sentence denotes A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1.
T2 124-261 Sentence denotes Activation of the interleukin 2 (IL-2) gene after antigen recognition is a critical event for T cell proliferation and effector function.
T3 262-403 Sentence denotes Prior studies have identified several transcription factors that contribute to the activity of the IL-2 promoter in stimulated T lymphocytes.
T4 404-558 Sentence denotes Here we describe a novel regulatory element within the IL-2 promoter located immediately upstream of the nuclear factor of activated T cell (NFAT) domain.
T5 559-808 Sentence denotes This region (termed the zinc finger protein binding region (ZIP)) serves as binding site for two differently regulated zinc finger proteins: the constitutively expressed transcription factor Sp1 and the inducible early growth response protein EGR-1.
T6 809-982 Sentence denotes In unstimulated cells which do not secrete IL-2, only Sp1 binds to this region, while in stimulated IL-2 secreting cells the inducible EGR-1 protein recognizes this element.
T7 983-1159 Sentence denotes In Jurkat T cells, the ZIP site serves as an activator for IL-2 gene expression, and a combination of ZIP and NFAT binding sites is required for maximal IL-2 promoter activity.
T8 1160-1241 Sentence denotes These results suggest a critical role of the ZIP site for IL-2 promoter activity.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 2-20 DNA denotes regulatory element
T2 28-61 DNA denotes human interleukin 2 gene promoter
T3 67-79 DNA denotes binding site
T4 88-108 protein denotes zinc finger proteins
T5 109-112 protein denotes Sp1
T6 117-122 protein denotes EGR-1
T7 142-167 DNA denotes interleukin 2 (IL-2) gene
T8 300-321 protein denotes transcription factors
T9 361-374 DNA denotes IL-2 promoter
T10 378-402 cell_type denotes stimulated T lymphocytes
T11 429-447 DNA denotes regulatory element
T12 459-472 DNA denotes IL-2 promoter
T13 509-557 DNA denotes nuclear factor of activated T cell (NFAT) domain
T14 583-617 DNA denotes zinc finger protein binding region
T15 619-622 DNA denotes ZIP
T16 678-698 protein denotes zinc finger proteins
T17 704-749 protein denotes constitutively expressed transcription factor
T18 750-753 protein denotes Sp1
T19 762-801 protein denotes inducible early growth response protein
T20 802-807 protein denotes EGR-1
T21 812-830 cell_type denotes unstimulated cells
T22 852-856 protein denotes IL-2
T23 863-866 protein denotes Sp1
T24 898-929 cell_line denotes stimulated IL-2 secreting cells
T25 934-957 protein denotes inducible EGR-1 protein
T26 986-1000 cell_line denotes Jurkat T cells
T27 1006-1014 DNA denotes ZIP site
T28 1042-1046 protein denotes IL-2
T29 1085-1088 DNA denotes ZIP
T30 1093-1111 DNA denotes NFAT binding sites
T31 1136-1149 DNA denotes IL-2 promoter
T32 1205-1213 DNA denotes ZIP site
T33 1218-1231 DNA denotes IL-2 promoter

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 24-61 NP denotes the human interleukin 2 gene promoter
C1 0-61 NP denotes A regulatory element in the human interleukin 2 gene promoter
C4 84-122 NP denotes the zinc finger proteins Sp1 and EGR-1
C3 65-122 NP denotes a binding site for the zinc finger proteins Sp1 and EGR-1
C5 292-321 NP denotes several transcription factors
C6 322-326 NP denotes that
C7 357-374 NP denotes the IL-2 promoter
C9 455-472 NP denotes the IL-2 promoter
C8 421-557 NP denotes a novel regulatory element within the IL-2 promoter located immediately upstream of the nuclear factor of activated T cell (NFAT) domain
C10 559-624 NP denotes This region (termed the zinc finger protein binding region (ZIP))
C12 652-698 NP denotes two differently regulated zinc finger proteins
C11 635-698 NP denotes binding site for two differently regulated zinc finger proteins
C13 700-807 NP denotes the constitutively expressed transcription factor Sp1 and the inducible early growth response protein EGR-1
C14 812-830 NP denotes unstimulated cells
C15 831-836 NP denotes which
C16 876-887 NP denotes this region
C17 969-981 NP denotes this element
C18 1002-1014 NP denotes the ZIP site
C19 1201-1213 NP denotes the ZIP site
R1 C6 C5 coref-relat that,several transcription factors
R2 C7 C2 coref-ident the IL-2 promoter,the human interleukin 2 gene promoter
R3 C9 C7 coref-ident the IL-2 promoter,the IL-2 promoter
R4 C8 C1 coref-ident a novel regulatory element within the IL-2 promoter located immediately upstream of the nuclear factor of activated T cell (NFAT) domain,A regulatory element in the human interleukin 2 gene promoter
R5 C10 C8 coref-ident This region (termed the zinc finger protein binding region (ZIP)),a novel regulatory element within the IL-2 promoter located immediately upstream of the nuclear factor of activated T cell (NFAT) domain
R6 C12 C4 coref-ident two differently regulated zinc finger proteins,the zinc finger proteins Sp1 and EGR-1
R7 C11 C3 coref-ident binding site for two differently regulated zinc finger proteins,a binding site for the zinc finger proteins Sp1 and EGR-1
R8 C13 C12 coref-ident the constitutively expressed transcription factor Sp1 and the inducible early growth response protein EGR-1,two differently regulated zinc finger proteins
R9 C15 C14 coref-relat which,unstimulated cells
R10 C16 C10 coref-ident this region,This region (termed the zinc finger protein binding region (ZIP))
R11 C17 C16 coref-ident this element,this region
R12 C18 C17 coref-ident the ZIP site,this element
R13 C19 C18 coref-ident the ZIP site,the ZIP site

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-123 Sentence denotes A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1.
S2 124-261 Sentence denotes Activation of the interleukin 2 (IL-2) gene after antigen recognition is a critical event for T cell proliferation and effector function.
S3 262-403 Sentence denotes Prior studies have identified several transcription factors that contribute to the activity of the IL-2 promoter in stimulated T lymphocytes.
S4 404-558 Sentence denotes Here we describe a novel regulatory element within the IL-2 promoter located immediately upstream of the nuclear factor of activated T cell (NFAT) domain.
S5 559-808 Sentence denotes This region (termed the zinc finger protein binding region (ZIP)) serves as binding site for two differently regulated zinc finger proteins: the constitutively expressed transcription factor Sp1 and the inducible early growth response protein EGR-1.
S6 809-982 Sentence denotes In unstimulated cells which do not secrete IL-2, only Sp1 binds to this region, while in stimulated IL-2 secreting cells the inducible EGR-1 protein recognizes this element.
S7 983-1159 Sentence denotes In Jurkat T cells, the ZIP site serves as an activator for IL-2 gene expression, and a combination of ZIP and NFAT binding sites is required for maximal IL-2 promoter activity.
S8 1160-1241 Sentence denotes These results suggest a critical role of the ZIP site for IL-2 promoter activity.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 2-20 DNA_family_or_group denotes regulatory element
T2 28-61 DNA_domain_or_region denotes human interleukin 2 gene promoter
T3 67-79 DNA_domain_or_region denotes binding site
T4 88-108 protein_family_or_group denotes zinc finger proteins
T5 109-112 protein_molecule denotes Sp1
T6 117-122 protein_molecule denotes EGR-1
T7 142-155 protein_molecule denotes interleukin 2
T8 157-161 protein_molecule denotes IL-2
T9 174-193 other_name denotes antigen recognition
T10 218-238 other_name denotes T cell proliferation
T11 300-321 protein_family_or_group denotes transcription factors
T12 361-365 protein_molecule denotes IL-2
T13 378-402 cell_type denotes stimulated T lymphocytes
T14 429-447 DNA_family_or_group denotes regulatory element
T15 459-472 DNA_domain_or_region denotes IL-2 promoter
T16 509-543 protein_family_or_group denotes nuclear factor of activated T cell
T17 545-549 protein_family_or_group denotes NFAT
T18 583-617 DNA_domain_or_region denotes zinc finger protein binding region
T19 619-622 DNA_domain_or_region denotes ZIP
T20 678-698 protein_family_or_group denotes zinc finger proteins
T21 704-749 protein_family_or_group denotes constitutively expressed transcription factor
T22 750-753 protein_molecule denotes Sp1
T23 762-801 protein_family_or_group denotes inducible early growth response protein
T24 802-807 protein_molecule denotes EGR-1
T25 812-830 cell_type denotes unstimulated cells
T26 852-856 protein_molecule denotes IL-2
T27 863-866 protein_molecule denotes Sp1
T28 898-908 cell_line denotes stimulated
T29 909-913 protein_molecule denotes IL-2
T30 934-943 protein_molecule denotes inducible
T31 944-949 protein_molecule denotes EGR-1
T32 986-1000 cell_line denotes Jurkat T cells
T33 1006-1009 DNA_domain_or_region denotes ZIP
T34 1042-1046 protein_molecule denotes IL-2
T35 1085-1088 DNA_domain_or_region denotes ZIP
T36 1093-1097 protein_family_or_group denotes NFAT
T37 1136-1140 protein_molecule denotes IL-2
T38 1205-1213 DNA_domain_or_region denotes ZIP site
T39 1218-1222 protein_molecule denotes IL-2

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 28-33 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 93-99 Body_part denotes finger http://purl.obolibrary.org/obo/UBERON_0002389
T2 218-224 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T3 389-402 Body_part denotes T lymphocytes http://purl.obolibrary.org/obo/CL_0000084
T4 537-543 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T5 588-594 Body_part denotes finger http://purl.obolibrary.org/obo/UBERON_0002389
T6 683-689 Body_part denotes finger http://purl.obolibrary.org/obo/UBERON_0002389