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sentences

Id Subject Object Predicate Lexical cue
T1 0-142 Sentence denotes Microtubules mediate cellular 25-hydroxyvitamin D3 trafficking and the genomic response to 1,25-dihydroxyvitamin D3 in normal human monocytes.
T2 143-264 Sentence denotes The genomic actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are mediated by the intracellular vitamin D receptor (VDR).
T3 265-489 Sentence denotes Although immunocytochemistry has shown that disruption of microtubular assembly prevents nuclear access of the sterol-VDR complex, the role of microtubules in the response to 1,25(OH)2D3 has not been studied in viable cells.
T4 490-554 Sentence denotes Our studies examined this interaction in normal human monocytes.
T5 555-660 Sentence denotes Monocytes convert 25(OH)D3 to 1,25(OH)2D3 and to 24-hydroxylated metabolites more polar than 1,25(OH)2D3.
T6 661-902 Sentence denotes Microtubule disruption totally abolished the ability of exogenous 1,25(OH)2D3 to suppress its own synthesis and to induce 24-hydroxylase mRNA and activity, without affecting either total 1,25(OH)2D3 uptake or maximal 1,25(OH)2D3-VDR binding.
T7 903-1002 Sentence denotes Thus, intact microtubules are essential for 1,25(OH)2D3-dependent modulation of gene transcription.
T8 1003-1209 Sentence denotes Interestingly, microtubule disruption also decreased monocyte 1,25(OH)2D3 synthesis, not by decreasing the Vmax of monocyte mitochondrial 1 alpha-hydroxylase but through an increase in the Km for 25(OH)2D3.
T9 1210-1241 Sentence denotes We examined 25(OH)D3 transport.
T10 1242-1373 Sentence denotes Microtubule disruption did not affect total cellular 25(OH)D3 uptake but reduced its intracellular trafficking to the mitochondria.
T11 1374-1502 Sentence denotes Thus, microtubules participate in intracellular 25(OH)D3 transport, and their integrity determines normal 1,25(OH)2D3 synthesis.
T1 0-142 Sentence denotes Microtubules mediate cellular 25-hydroxyvitamin D3 trafficking and the genomic response to 1,25-dihydroxyvitamin D3 in normal human monocytes.
T2 143-264 Sentence denotes The genomic actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are mediated by the intracellular vitamin D receptor (VDR).
T3 265-489 Sentence denotes Although immunocytochemistry has shown that disruption of microtubular assembly prevents nuclear access of the sterol-VDR complex, the role of microtubules in the response to 1,25(OH)2D3 has not been studied in viable cells.
T4 490-554 Sentence denotes Our studies examined this interaction in normal human monocytes.
T5 555-660 Sentence denotes Monocytes convert 25(OH)D3 to 1,25(OH)2D3 and to 24-hydroxylated metabolites more polar than 1,25(OH)2D3.
T6 661-902 Sentence denotes Microtubule disruption totally abolished the ability of exogenous 1,25(OH)2D3 to suppress its own synthesis and to induce 24-hydroxylase mRNA and activity, without affecting either total 1,25(OH)2D3 uptake or maximal 1,25(OH)2D3-VDR binding.
T7 903-1002 Sentence denotes Thus, intact microtubules are essential for 1,25(OH)2D3-dependent modulation of gene transcription.
T8 1003-1209 Sentence denotes Interestingly, microtubule disruption also decreased monocyte 1,25(OH)2D3 synthesis, not by decreasing the Vmax of monocyte mitochondrial 1 alpha-hydroxylase but through an increase in the Km for 25(OH)2D3.
T9 1210-1241 Sentence denotes We examined 25(OH)D3 transport.
T10 1242-1373 Sentence denotes Microtubule disruption did not affect total cellular 25(OH)D3 uptake but reduced its intracellular trafficking to the mitochondria.
T11 1374-1502 Sentence denotes Thus, microtubules participate in intracellular 25(OH)D3 transport, and their integrity determines normal 1,25(OH)2D3 synthesis.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-12 protein denotes Microtubules
T2 126-141 cell_type denotes human monocytes
T3 239-257 protein denotes vitamin D receptor
T4 259-262 protein denotes VDR
T5 376-394 protein denotes sterol-VDR complex
T6 408-420 protein denotes microtubules
T7 476-488 cell_type denotes viable cells
T8 538-553 cell_type denotes human monocytes
T9 783-802 RNA denotes 24-hydroxylase mRNA
T10 889-893 protein denotes -VDR
T11 916-928 protein denotes microtubules
T12 1018-1029 protein denotes microtubule
T13 1056-1064 cell_type denotes monocyte
T14 1118-1160 protein denotes monocyte mitochondrial 1 alpha-hydroxylase
T15 1380-1392 protein denotes microtubules

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-12 NP denotes Microtubules
C2 21-62 NP denotes cellular 25-hydroxyvitamin D3 trafficking
C3 91-115 NP denotes 1,25-dihydroxyvitamin D3
C4 119-141 NP denotes normal human monocytes
C5 166-204 NP denotes 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)
C6 408-420 NP denotes microtubules
C7 440-451 NP denotes 1,25(OH)2D3
C8 531-553 NP denotes normal human monocytes
C9 555-564 NP denotes Monocytes
C10 573-581 NP denotes 25(OH)D3
C11 585-596 NP denotes 1,25(OH)2D3
C12 648-659 NP denotes 1,25(OH)2D3
C13 661-683 NP denotes Microtubule disruption
C14 717-738 NP denotes exogenous 1,25(OH)2D3
C15 751-754 NP denotes its
C16 1018-1040 NP denotes microtubule disruption
C17 1242-1264 NP denotes Microtubule disruption
C19 1323-1326 NP denotes its
C18 1323-1352 NP denotes its intracellular trafficking
C20 1380-1392 NP denotes microtubules
C21 1446-1451 NP denotes their
R1 C5 C3 coref-ident "1,25-dihydroxyvitamin D3 (1,25(OH)2D3)","1,25-dihydroxyvitamin D3"
R2 C6 C1 coref-ident microtubules,Microtubules
R3 C7 C5 coref-ident "1,25(OH)2D3","1,25-dihydroxyvitamin D3 (1,25(OH)2D3)"
R4 C8 C4 coref-ident normal human monocytes,normal human monocytes
R5 C9 C8 coref-ident Monocytes,normal human monocytes
R6 C11 C7 coref-ident "1,25(OH)2D3","1,25(OH)2D3"
R7 C12 C11 coref-ident "1,25(OH)2D3","1,25(OH)2D3"
R8 C15 C14 coref-pron its,"exogenous 1,25(OH)2D3"
R9 C16 C13 coref-ident microtubule disruption,Microtubule disruption
R10 C17 C16 coref-ident Microtubule disruption,microtubule disruption
R11 C19 C10 coref-pron its,25(OH)D3
R12 C18 C2 coref-ident its intracellular trafficking,cellular 25-hydroxyvitamin D3 trafficking
R13 C20 C6 coref-ident microtubules,microtubules
R14 C21 C20 coref-pron their,microtubules

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-142 Sentence denotes Microtubules mediate cellular 25-hydroxyvitamin D3 trafficking and the genomic response to 1,25-dihydroxyvitamin D3 in normal human monocytes.
S2 143-264 Sentence denotes The genomic actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are mediated by the intracellular vitamin D receptor (VDR).
S3 265-489 Sentence denotes Although immunocytochemistry has shown that disruption of microtubular assembly prevents nuclear access of the sterol-VDR complex, the role of microtubules in the response to 1,25(OH)2D3 has not been studied in viable cells.
S4 490-554 Sentence denotes Our studies examined this interaction in normal human monocytes.
S5 555-660 Sentence denotes Monocytes convert 25(OH)D3 to 1,25(OH)2D3 and to 24-hydroxylated metabolites more polar than 1,25(OH)2D3.
S6 661-902 Sentence denotes Microtubule disruption totally abolished the ability of exogenous 1,25(OH)2D3 to suppress its own synthesis and to induce 24-hydroxylase mRNA and activity, without affecting either total 1,25(OH)2D3 uptake or maximal 1,25(OH)2D3-VDR binding.
S7 903-1002 Sentence denotes Thus, intact microtubules are essential for 1,25(OH)2D3-dependent modulation of gene transcription.
S8 1003-1209 Sentence denotes Interestingly, microtubule disruption also decreased monocyte 1,25(OH)2D3 synthesis, not by decreasing the Vmax of monocyte mitochondrial 1 alpha-hydroxylase but through an increase in the Km for 25(OH)2D3.
S9 1210-1241 Sentence denotes We examined 25(OH)D3 transport.
S10 1242-1373 Sentence denotes Microtubule disruption did not affect total cellular 25(OH)D3 uptake but reduced its intracellular trafficking to the mitochondria.
S11 1374-1502 Sentence denotes Thus, microtubules participate in intracellular 25(OH)D3 transport, and their integrity determines normal 1,25(OH)2D3 synthesis.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-12 protein_complex denotes Microtubules
T2 21-29 other_name denotes cellular
T3 30-50 lipid denotes 25-hydroxyvitamin D3
T4 91-115 lipid denotes 1,25-dihydroxyvitamin D3
T5 126-141 cell_type denotes human monocytes
T6 166-190 lipid denotes 1,25-dihydroxyvitamin D3
T7 239-257 protein_family_or_group denotes vitamin D receptor
T8 259-262 protein_family_or_group denotes VDR
T9 274-293 other_name denotes immunocytochemistry
T10 323-344 other_name denotes microtubular assembly
T11 376-383 protein_complex denotes sterol-
T12 383-386 protein_family_or_group denotes VDR
T13 408-420 protein_complex denotes microtubules
T14 440-451 lipid denotes 1,25(OH)2D3
T15 476-488 cell_type denotes viable cells
T16 538-553 cell_type denotes human monocytes
T17 573-581 lipid denotes 25(OH)D3
T18 585-596 lipid denotes 1,25(OH)2D3
T19 648-659 lipid denotes 1,25(OH)2D3
T20 727-738 lipid denotes 1,25(OH)2D3
T21 783-802 RNA_molecule denotes 24-hydroxylase mRNA
T22 842-847 other_name denotes total
T23 848-859 lipid denotes 1,25(OH)2D3
T24 870-877 other_name denotes maximal
T25 878-889 lipid denotes 1,25(OH)2D3
T26 889-893 protein_family_or_group denotes -VDR
T27 916-928 protein_complex denotes microtubules
T28 947-958 lipid denotes 1,25(OH)2D3
T29 983-1001 other_name denotes gene transcription
T30 1018-1029 protein_complex denotes microtubule
T31 1056-1064 cell_type denotes monocyte
T32 1065-1076 lipid denotes 1,25(OH)2D3
T33 1110-1114 other_name denotes Vmax
T34 1118-1126 cell_type denotes monocyte
T35 1192-1194 other_name denotes Km
T36 1199-1208 lipid denotes 25(OH)2D3
T37 1222-1230 lipid denotes 25(OH)D3
T38 1286-1294 other_name denotes cellular
T39 1295-1303 lipid denotes 25(OH)D3
T40 1327-1352 other_name denotes intracellular trafficking
T41 1360-1372 cell_component denotes mitochondria
T42 1380-1392 protein_complex denotes microtubules
T43 1422-1440 other_name denotes 25(OH)D3 transport
T44 1480-1491 lipid denotes 1,25(OH)2D3

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 126-131 OrganismTaxon denotes human 9606
T2 538-543 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 0-12 Body_part denotes Microtubules http://purl.obolibrary.org/obo/GO_0005874
T2 132-141 Body_part denotes monocytes http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T4 225-238 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T5 408-420 Body_part denotes microtubules http://purl.obolibrary.org/obo/GO_0005874
T6 544-553 Body_part denotes monocytes http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T8 661-672 Body_part denotes Microtubule http://purl.obolibrary.org/obo/GO_0005874
T9 916-928 Body_part denotes microtubules http://purl.obolibrary.org/obo/GO_0005874
T10 1018-1029 Body_part denotes microtubule http://purl.obolibrary.org/obo/GO_0005874
T11 1056-1064 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T13 1118-1126 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T15 1242-1253 Body_part denotes Microtubule http://purl.obolibrary.org/obo/GO_0005874
T16 1327-1340 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T17 1380-1392 Body_part denotes microtubules http://purl.obolibrary.org/obo/GO_0005874
T18 1408-1421 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 132-141 Cell denotes monocytes http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T3 544-553 Cell denotes monocytes http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T5 555-564 Cell denotes Monocytes http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T7 1056-1064 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T9 1118-1126 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054