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PubMed:7670114 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 196-201 gene:6688 denotes Spi-1
T1 277-293 disease:C0023440 denotes erythroleukemias
R1 T0 T1 associated_with Spi-1,erythroleukemias

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 4-38 protein denotes hematopoietic transcription factor
T2 39-43 protein denotes PU.1
T3 64-97 cell_line denotes human multiple myeloma cell lines
T4 99-103 protein denotes PU.1
T5 109-143 protein denotes hematopoietic transcription factor
T6 161-171 protein denotes Ets-family
T7 196-210 DNA denotes Spi-1 oncogene
T8 295-299 protein denotes PU.1
T9 346-377 cell_type denotes multiple hematopoietic lineages
T10 401-413 cell_type denotes mature cells
T11 457-511 cell_type denotes B-cell-and monocyte/macrophage-differentiation lineage
T12 536-542 DNA denotes Pu box
T13 557-595 DNA denotes tissue-specific regulatory DNA element
T14 644-657 cell_type denotes cell lineages
T15 707-711 protein denotes PU.1
T16 761-773 cell_line denotes B-cell lines
T17 824-840 cell_line denotes early precursors
T18 844-871 cell_line denotes differentiated plasma cells
T19 873-882 RNA denotes PU.1 mRNA
T20 898-902 protein denotes PU.1
T21 1035-1045 cell_line denotes cell lines
T22 1059-1091 cell_line denotes pro-B, pre-B, and mature B cells
T23 1112-1118 DNA denotes Pu box
T24 1200-1210 cell_line denotes cell lines
T25 1240-1267 cell_line denotes multiple myeloma cell lines
T26 1282-1322 cell_type denotes differentiated, plasma cell-like B cells
T27 1324-1328 protein denotes PU.1
T28 1372-1378 DNA denotes Pu box
T29 1455-1480 cell_line denotes lymphoblastoid cell lines
T30 1616-1649 cell_line denotes human multiple myeloma cell lines
T31 1682-1689 cell_type denotes B cells
T32 1709-1713 protein denotes PU.1
T33 1794-1798 protein denotes PU.1
T34 1826-1849 cell_line denotes plasmacytoma cell lines
T35 1897-1901 protein denotes PU.1
T36 1929-1962 cell_line denotes human multiple myeloma cell lines
T37 2072-2105 cell_type denotes terminally differentiated B cells

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
7670114-2#23#28#gene6688 196-201 gene6688 denotes Spi-1
7670114-2#104#120#diseaseC0023440 277-293 diseaseC0023440 denotes erythroleukemias
23#28#gene6688104#120#diseaseC0023440 7670114-2#23#28#gene6688 7670114-2#104#120#diseaseC0023440 associated_with Spi-1,erythroleukemias

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-43 NP denotes The hematopoietic transcription factor PU.1
C2 99-103 NP denotes PU.1
C3 173-175 NP denotes It
C4 192-210 NP denotes the Spi-1 oncogene
C5 212-217 NP denotes which
C6 295-299 NP denotes PU.1
C7 383-386 NP denotes its
C8 453-511 NP denotes the B-cell-and monocyte/macrophage-differentiation lineage
C9 513-515 NP denotes It
C10 522-542 NP denotes the so-called Pu box
C12 638-657 NP denotes these cell lineages
C11 544-657 NP denotes an important tissue-specific regulatory DNA element present in a number of genes expressed in these cell lineages
C13 707-711 NP denotes PU.1
C14 750-817 NP denotes a panel of B-cell lines representing different stages of maturation
C15 873-893 NP denotes PU.1 mRNA expression
C16 898-923 NP denotes PU.1 DNA binding activity
C17 1194-1210 NP denotes these cell lines
C18 1228-1267 NP denotes a number of multiple myeloma cell lines
C19 1324-1349 NP denotes PU.1 DNA binding activity
C20 1351-1366 NP denotes mRNA expression
C21 1455-1480 NP denotes lymphoblastoid cell lines
C22 1482-1487 NP denotes which
C23 1612-1649 NP denotes the human multiple myeloma cell lines
C24 1767-1784 NP denotes the murine system
C25 1788-1793 NP denotes which
C26 1794-1798 NP denotes PU.1
C27 1929-1962 NP denotes human multiple myeloma cell lines
C28 2008-2019 NP denotes these cells
R1 C2 C1 coref-ident PU.1,The hematopoietic transcription factor PU.1
R2 C3 C2 coref-pron It,PU.1
R3 C5 C4 coref-relat which,the Spi-1 oncogene
R4 C6 C2 coref-ident PU.1,PU.1
R5 C7 C6 coref-pron its,PU.1
R6 C9 C6 coref-pron It,PU.1
R7 C12 C8 coref-ident these cell lineages,the B-cell-and monocyte/macrophage-differentiation lineage
R8 C11 C10 coref-appos an important tissue-specific regulatory DNA element present in a number of genes expressed in these cell lineages,the so-called Pu box
R9 C13 C6 coref-ident PU.1,PU.1
R10 C17 C14 coref-ident these cell lines,a panel of B-cell lines representing different stages of maturation
R11 C19 C16 coref-ident PU.1 DNA binding activity,PU.1 DNA binding activity
R12 C20 C15 coref-ident mRNA expression,PU.1 mRNA expression
R13 C22 C21 coref-relat which,lymphoblastoid cell lines
R14 C23 C18 coref-ident the human multiple myeloma cell lines,a number of multiple myeloma cell lines
R15 C25 C24 coref-relat which,the murine system
R16 C26 C13 coref-ident PU.1,PU.1
R17 C27 C23 coref-ident human multiple myeloma cell lines,the human multiple myeloma cell lines
R18 C28 C27 coref-ident these cells,human multiple myeloma cell lines

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-98 Sentence denotes The hematopoietic transcription factor PU.1 is downregulated in human multiple myeloma cell lines.
S2 99-172 Sentence denotes PU.1 is a hematopoietic transcription factor belonging to the Ets-family.
S3 173-294 Sentence denotes It is identical to the Spi-1 oncogene, which is implicated in spleen focus-forming virus-induced murine erythroleukemias.
S4 295-512 Sentence denotes PU.1 seems to be required for early development of multiple hematopoietic lineages, but its expression in mature cells is preferentially observed in cells of the B-cell-and monocyte/macrophage-differentiation lineage.
S5 513-658 Sentence denotes It binds the so-called Pu box, an important tissue-specific regulatory DNA element present in a number of genes expressed in these cell lineages.
S6 659-872 Sentence denotes We have analyzed the expression and activity of PU.1 during human B-cell development using a panel of B-cell lines representing different stages of maturation, from early precursors to differentiated plasma cells.
S7 873-1092 Sentence denotes PU.1 mRNA expression and PU.1 DNA binding activity, as measured by Northern blot analysis and electrophoretic mobility shift assay, respectively, were evident in cell lines representing pro-B, pre-B, and mature B cells.
S8 1093-1211 Sentence denotes We could also show Pu box-dependent transactivation of a reporter gene in transient transfections in these cell lines.
S9 1212-1451 Sentence denotes In contrast, in a number of multiple myeloma cell lines, representing differentiated, plasma cell-like B cells, PU.1 DNA binding activity, mRNA expression, and Pu box-dependent transactivation were absent or detectable at a very low level.
S10 1452-1595 Sentence denotes In lymphoblastoid cell lines, which exemplify an intermediate stage of B-cell differentiation, a reduced expression and activity were observed.
S11 1596-1850 Sentence denotes The findings in the human multiple myeloma cell lines represent the first examples of B cells with downregulated PU.1 expression and apparently contradict observations in the murine system in which PU.1 is expressed and active in plasmacytoma cell lines.
S12 1851-2106 Sentence denotes At present, it is unclear whether the lack of PU.1 expression and activity in human multiple myeloma cell lines represents a malignancy-associated defect in these cells or exemplifies a normal developmental regulation in terminally differentiated B cells.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 4-38 protein_family_or_group denotes hematopoietic transcription factor
T2 39-43 protein_molecule denotes PU.1
T3 64-97 cell_line denotes human multiple myeloma cell lines
T4 99-103 protein_molecule denotes PU.1
T5 109-143 protein_family_or_group denotes hematopoietic transcription factor
T6 161-171 protein_family_or_group denotes Ets-family
T7 196-210 DNA_domain_or_region denotes Spi-1 oncogene
T8 235-241 body_part denotes spleen
T9 295-299 protein_molecule denotes PU.1
T10 346-377 cell_type denotes multiple hematopoietic lineages
T11 401-413 cell_type denotes mature cells
T12 457-488 cell_type denotes B-cell-and monocyte/macrophage-
T13 488-503 other_name denotes differentiation
T14 536-542 DNA_domain_or_region denotes Pu box
T15 557-595 DNA_family_or_group denotes tissue-specific regulatory DNA element
T16 644-657 cell_type denotes cell lineages
T17 707-711 protein_molecule denotes PU.1
T18 719-743 other_name denotes human B-cell development
T19 761-773 cell_line denotes B-cell lines
T20 824-840 cell_line denotes early precursors
T21 844-871 cell_line denotes differentiated plasma cells
T22 873-877 protein_molecule denotes PU.1
T23 898-902 protein_molecule denotes PU.1
T24 940-962 other_name denotes Northern blot analysis
T25 967-1003 other_name denotes electrophoretic mobility shift assay
T26 1035-1045 cell_line denotes cell lines
T27 1112-1118 DNA_domain_or_region denotes Pu box
T28 1200-1210 cell_line denotes cell lines
T29 1240-1267 cell_line denotes multiple myeloma cell lines
T30 1282-1322 cell_type denotes differentiated, plasma cell-like B cells
T31 1324-1328 protein_molecule denotes PU.1
T32 1351-1366 other_name denotes mRNA expression
T33 1372-1378 DNA_domain_or_region denotes Pu box
T34 1455-1480 cell_line denotes lymphoblastoid cell lines
T35 1523-1529 other_name denotes B-cell
T36 1530-1545 other_name denotes differentiation
T37 1557-1567 other_name denotes expression
T38 1616-1621 cell_line denotes human
T39 1622-1649 cell_line denotes multiple myeloma cell lines
T40 1682-1689 cell_type denotes B cells
T41 1695-1708 other_name denotes downregulated
T42 1709-1713 protein_molecule denotes PU.1
T43 1771-1784 other_name denotes murine system
T44 1794-1798 protein_molecule denotes PU.1
T45 1826-1849 cell_line denotes plasmacytoma cell lines
T46 1897-1901 protein_molecule denotes PU.1
T47 1929-1934 cell_line denotes human
T48 1935-1962 cell_line denotes multiple myeloma cell lines
T49 2072-2097 cell_type denotes terminally differentiated
T50 2098-2105 cell_type denotes B cells