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PubMed:7668252 JSONTXT

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LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 11-16 OrganismTaxon denotes human NCBItxid:9606
T2 219-224 OrganismTaxon denotes human NCBItxid:9606
T3 919-924 OrganismTaxon denotes human NCBItxid:9606

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-128 Sentence denotes Cloning of human very-long-chain acyl-coenzyme A dehydrogenase and molecular characterization of its deficiency in two patients.
T2 129-319 Sentence denotes Two overlapping cDNA clones (1,991 bp and 736 bp, respectively) encoding the precursor of human mitochondrial very-long-chain acyl-coenzyme A dehydrogenase (VLCAD) were cloned and sequenced.
T3 320-526 Sentence denotes The cDNA inserts of these clones together encompass a region of 2,177 bases, encoding the entire protein of 655 amino acids, including a 40-amino acid leader peptide and a 615-amino acid mature polypeptide.
T4 527-626 Sentence denotes PCR-amplified VLCAD cDNAs were sequenced in cultured fibroblasts from two VLCAD-deficient patients.
T5 627-721 Sentence denotes In both patients, a 105-bp deletion encompassing bases 1078-1182 in VLCAD cDNA was identified.
T6 722-807 Sentence denotes The deletion seems to occur due to exon skipping during processing of VLCAD pre-mRNA.
T7 808-879 Sentence denotes This is the first demonstration of a mutation causing VLCAD deficiency.
T8 880-1162 Sentence denotes Quantitative cDNA expression of normal human VLCAD was performed in the patients' fibroblasts, using vaccinia viral system, which demonstrated that the deficiency of the normal VLCAD protein causes impaired long-chain fatty acid beta-oxidation activity in the patients' fibroblasts.
T9 1163-1467 Sentence denotes In patient fibroblasts, raising VLCAD activity to approximately 20% of normal control fibroblast activity raised palmitic acid beta-oxidation flux to the level found in control fibroblasts, which may offer important information for the rational design of future somatic gene therapy for VLCAD deficiency.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
113 11-16 OrganismTaxon denotes human NCBITaxon:9606
114 17-62 GeneOrGeneProduct denotes very-long-chain acyl-coenzyme A dehydrogenase NCBIGene:37
115 119-127 OrganismTaxon denotes patients NCBITaxon:9606
116 219-224 OrganismTaxon denotes human NCBITaxon:9606
117 239-284 GeneOrGeneProduct denotes very-long-chain acyl-coenzyme A dehydrogenase NCBIGene:37
118 286-291 GeneOrGeneProduct denotes VLCAD NCBIGene:37
119 541-546 GeneOrGeneProduct denotes VLCAD NCBIGene:37
120 601-616 DiseaseOrPhenotypicFeature denotes VLCAD-deficient MESH:C536353
121 617-625 OrganismTaxon denotes patients NCBITaxon:9606
122 635-643 OrganismTaxon denotes patients NCBITaxon:9606
123 647-691 SequenceVariant denotes 105-bp deletion encompassing bases 1078-1182 c|DEL|1078-1182|
124 695-700 GeneOrGeneProduct denotes VLCAD NCBIGene:37
125 792-797 GeneOrGeneProduct denotes VLCAD NCBIGene:37
126 862-878 DiseaseOrPhenotypicFeature denotes VLCAD deficiency MESH:C536353
127 919-924 OrganismTaxon denotes human NCBITaxon:9606
128 925-930 GeneOrGeneProduct denotes VLCAD NCBIGene:37
129 952-960 OrganismTaxon denotes patients NCBITaxon:9606
130 1032-1070 DiseaseOrPhenotypicFeature denotes deficiency of the normal VLCAD protein MESH:C536353
131 1087-1108 ChemicalEntity denotes long-chain fatty acid MESH:D005227
132 1140-1148 OrganismTaxon denotes patients NCBITaxon:9606
133 1166-1173 OrganismTaxon denotes patient NCBITaxon:9606
134 1195-1200 GeneOrGeneProduct denotes VLCAD NCBIGene:37
135 1276-1289 ChemicalEntity denotes palmitic acid MESH:D019308
136 1450-1466 DiseaseOrPhenotypicFeature denotes VLCAD deficiency MESH:C536353

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 981-989 DiseaseOrPhenotypicFeature denotes vaccinia 0002595

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 647-662 SequenceVariant denotes 105-bp deletion

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-7 GeneOrGeneProduct denotes Cloning
T2 27-32 GeneOrGeneProduct denotes chain
T3 33-62 GeneOrGeneProduct denotes acyl-coenzyme A dehydrogenase
T4 145-149 GeneOrGeneProduct denotes cDNA
T5 150-156 GeneOrGeneProduct denotes clones
T6 206-215 GeneOrGeneProduct denotes precursor
T7 225-238 GeneOrGeneProduct denotes mitochondrial
T8 249-254 GeneOrGeneProduct denotes chain
T9 255-284 GeneOrGeneProduct denotes acyl-coenzyme A dehydrogenase
T10 286-291 GeneOrGeneProduct denotes VLCAD
T11 298-304 GeneOrGeneProduct denotes cloned
T12 324-328 GeneOrGeneProduct denotes cDNA
T13 346-352 GeneOrGeneProduct denotes clones
T14 390-395 GeneOrGeneProduct denotes bases
T15 410-416 GeneOrGeneProduct denotes entire
T16 417-424 GeneOrGeneProduct denotes protein
T17 432-443 GeneOrGeneProduct denotes amino acids
T18 460-470 GeneOrGeneProduct denotes amino acid
T19 471-485 GeneOrGeneProduct denotes leader peptide
T20 496-506 GeneOrGeneProduct denotes amino acid
T21 514-525 GeneOrGeneProduct denotes polypeptide
T22 541-546 GeneOrGeneProduct denotes VLCAD
T23 601-606 GeneOrGeneProduct denotes VLCAD
T24 676-681 GeneOrGeneProduct denotes bases
T25 695-700 GeneOrGeneProduct denotes VLCAD
T26 701-705 GeneOrGeneProduct denotes cDNA
T27 762-770 GeneOrGeneProduct denotes skipping
T28 778-788 GeneOrGeneProduct denotes processing
T29 792-797 GeneOrGeneProduct denotes VLCAD
T30 802-806 GeneOrGeneProduct denotes mRNA
T31 845-853 GeneOrGeneProduct denotes mutation
T32 862-867 GeneOrGeneProduct denotes VLCAD
T33 893-897 GeneOrGeneProduct denotes cDNA
T34 925-930 GeneOrGeneProduct denotes VLCAD
T35 1057-1062 GeneOrGeneProduct denotes VLCAD
T36 1063-1070 GeneOrGeneProduct denotes protein
T37 1087-1108 GeneOrGeneProduct denotes long-chain fatty acid
T38 1109-1113 GeneOrGeneProduct denotes beta
T39 1124-1132 GeneOrGeneProduct denotes activity
T40 1187-1194 GeneOrGeneProduct denotes raising
T41 1195-1200 GeneOrGeneProduct denotes VLCAD
T42 1201-1209 GeneOrGeneProduct denotes activity
T43 1213-1226 GeneOrGeneProduct denotes approximately
T44 1260-1268 GeneOrGeneProduct denotes activity
T45 1269-1275 GeneOrGeneProduct denotes raised
T46 1285-1289 GeneOrGeneProduct denotes acid
T47 1290-1294 GeneOrGeneProduct denotes beta
T48 1450-1455 GeneOrGeneProduct denotes VLCAD

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 27-32 GeneOrGeneProduct denotes chain
T2 33-62 GeneOrGeneProduct denotes acyl-coenzyme A dehydrogenase
T3 145-149 GeneOrGeneProduct denotes cDNA
T4 206-215 GeneOrGeneProduct denotes precursor
T5 225-238 GeneOrGeneProduct denotes mitochondrial
T6 249-254 GeneOrGeneProduct denotes chain
T7 255-284 GeneOrGeneProduct denotes acyl-coenzyme A dehydrogenase
T8 286-291 GeneOrGeneProduct denotes VLCAD
T9 324-328 GeneOrGeneProduct denotes cDNA
T10 417-424 GeneOrGeneProduct denotes protein
T11 432-443 GeneOrGeneProduct denotes amino acids
T12 460-470 GeneOrGeneProduct denotes amino acid
T13 471-485 GeneOrGeneProduct denotes leader peptide
T14 496-506 GeneOrGeneProduct denotes amino acid
T15 514-525 GeneOrGeneProduct denotes polypeptide
T16 541-546 GeneOrGeneProduct denotes VLCAD
T17 601-606 GeneOrGeneProduct denotes VLCAD
T18 695-700 GeneOrGeneProduct denotes VLCAD
T19 701-705 GeneOrGeneProduct denotes cDNA
T20 778-788 GeneOrGeneProduct denotes processing
T21 792-797 GeneOrGeneProduct denotes VLCAD
T22 802-806 GeneOrGeneProduct denotes mRNA
T23 862-867 GeneOrGeneProduct denotes VLCAD
T24 893-897 GeneOrGeneProduct denotes cDNA
T25 925-930 GeneOrGeneProduct denotes VLCAD
T26 1057-1062 GeneOrGeneProduct denotes VLCAD
T27 1063-1070 GeneOrGeneProduct denotes protein
T28 1087-1108 GeneOrGeneProduct denotes long-chain fatty acid
T29 1109-1113 GeneOrGeneProduct denotes beta
T30 1195-1200 GeneOrGeneProduct denotes VLCAD
T31 1269-1275 GeneOrGeneProduct denotes raised
T32 1285-1289 GeneOrGeneProduct denotes acid
T33 1290-1294 GeneOrGeneProduct denotes beta
T34 1450-1455 GeneOrGeneProduct denotes VLCAD

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 601-616 DiseaseOrPhenotypicFeature denotes VLCAD-deficient C536353
T2 862-878 DiseaseOrPhenotypicFeature denotes VLCAD deficiency C536353
T3 981-989 DiseaseOrPhenotypicFeature denotes vaccinia D014615
T4 1450-1466 DiseaseOrPhenotypicFeature denotes VLCAD deficiency C536353

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 33-62 GeneOrGeneProduct denotes acyl-coenzyme A dehydrogenase
T2 255-284 GeneOrGeneProduct denotes acyl-coenzyme A dehydrogenase
T3 471-485 GeneOrGeneProduct denotes leader peptide
T4 514-525 GeneOrGeneProduct denotes polypeptide
T5 1087-1108 GeneOrGeneProduct denotes long-chain fatty acid

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 286-291 DiseaseOrPhenotypicFeature denotes VLCAD 0008723
T2 541-546 DiseaseOrPhenotypicFeature denotes VLCAD 0008723
T3 601-606 DiseaseOrPhenotypicFeature denotes VLCAD 0008723
T4 695-700 DiseaseOrPhenotypicFeature denotes VLCAD 0008723
T5 792-797 DiseaseOrPhenotypicFeature denotes VLCAD 0008723
T6 862-878 DiseaseOrPhenotypicFeature denotes VLCAD deficiency 0008723
T7 925-930 DiseaseOrPhenotypicFeature denotes VLCAD 0008723
T8 981-989 DiseaseOrPhenotypicFeature denotes vaccinia 0002595
T9 1057-1062 DiseaseOrPhenotypicFeature denotes VLCAD 0008723
T10 1195-1200 DiseaseOrPhenotypicFeature denotes VLCAD 0008723
T11 1450-1466 DiseaseOrPhenotypicFeature denotes VLCAD deficiency 0008723

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 862-878 DiseaseOrPhenotypicFeature denotes VLCAD deficiency C536353
T2 981-989 DiseaseOrPhenotypicFeature denotes vaccinia D014615
T3 1032-1070 DiseaseOrPhenotypicFeature denotes deficiency of the normal VLCAD protein DISEASE
T4 1450-1466 DiseaseOrPhenotypicFeature denotes VLCAD deficiency C536353

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 601-616 DiseaseOrPhenotypicFeature denotes VLCAD-deficient EisukeAdded
T2 862-878 DiseaseOrPhenotypicFeature denotes VLCAD deficiency C536353
T3 1032-1070 DiseaseOrPhenotypicFeature denotes deficiency of the normal VLCAD protein DISEASE
T4 1450-1466 DiseaseOrPhenotypicFeature denotes VLCAD deficiency C536353

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 38-46 ChemicalEntity denotes coenzyme D003067
T2 49-62 ChemicalEntity denotes dehydrogenase D010088
T3 260-268 ChemicalEntity denotes coenzyme D003067
T4 271-284 ChemicalEntity denotes dehydrogenase D010088
T5 514-525 ChemicalEntity denotes polypeptide http://purl.obolibrary.org/obo/CHEBI_15841
T6 1087-1108 ChemicalEntity denotes long-chain fatty acid http://purl.obolibrary.org/obo/CHEBI_15904
T7 1276-1289 ChemicalEntity denotes palmitic acid D019308|http://purl.obolibrary.org/obo/CHEBI_15756

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 11-16 OrganismTaxon denotes human
T2 119-127 OrganismTaxon denotes patients
T3 219-224 OrganismTaxon denotes human
T4 617-625 OrganismTaxon denotes patients
T5 635-643 OrganismTaxon denotes patients
T6 919-924 OrganismTaxon denotes human
T7 952-960 OrganismTaxon denotes patients
T8 1140-1148 OrganismTaxon denotes patients
T9 1166-1173 OrganismTaxon denotes patient

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T7 1276-1289 ChemicalEntity denotes palmitic acid http://purl.obolibrary.org/obo/CHEBI_15756|D019308
T6 1087-1108 ChemicalEntity denotes long-chain fatty acid http://purl.obolibrary.org/obo/CHEBI_15904
T5 514-525 ChemicalEntity denotes polypeptide http://purl.obolibrary.org/obo/CHEBI_15841
T4 271-284 ChemicalEntity denotes dehydrogenase D010088
T3 260-268 ChemicalEntity denotes coenzyme D003067
T2 49-62 ChemicalEntity denotes dehydrogenase D010088
T1 38-46 ChemicalEntity denotes coenzyme D003067
T13707 1087-1108 GeneOrGeneProduct denotes long-chain fatty acid
T82332 514-525 GeneOrGeneProduct denotes polypeptide
T64703 471-485 GeneOrGeneProduct denotes leader peptide
T81866 255-284 GeneOrGeneProduct denotes acyl-coenzyme A dehydrogenase
T75204 33-62 GeneOrGeneProduct denotes acyl-coenzyme A dehydrogenase
T28298 1450-1466 DiseaseOrPhenotypicFeature denotes VLCAD deficiency C536353
T19553 1032-1070 DiseaseOrPhenotypicFeature denotes deficiency of the normal VLCAD protein DISEASE
T50975 862-878 DiseaseOrPhenotypicFeature denotes VLCAD deficiency C536353
T37304 601-616 DiseaseOrPhenotypicFeature denotes VLCAD-deficient EisukeAdded
T9 1166-1173 OrganismTaxon denotes patient
T8 1140-1148 OrganismTaxon denotes patients
T63684 952-960 OrganismTaxon denotes patients
T15942 919-924 OrganismTaxon denotes human
T27913 635-643 OrganismTaxon denotes patients
T47271 617-625 OrganismTaxon denotes patients
T83026 219-224 OrganismTaxon denotes human
T27202 119-127 OrganismTaxon denotes patients
T54857 11-16 OrganismTaxon denotes human
T12876 647-662 SequenceVariant denotes 105-bp deletion

NCBIDiseaseCorpus

Id Subject Object Predicate Lexical cue
T1 601-616 Modifier:C536353 denotes VLCAD-deficient
T2 862-878 SpecificDisease:C536353 denotes VLCAD deficiency
T3 1032-1070 SpecificDisease:C536353 denotes deficiency of the normal VLCAD protein
T4 1450-1466 SpecificDisease:C536353 denotes VLCAD deficiency

NCBI-Disease-Train

Id Subject Object Predicate Lexical cue database_id
T2995 601-616 Modifier denotes VLCAD-deficient C536353
T2996 862-878 SpecificDisease denotes VLCAD deficiency C536353
T2997 1032-1070 SpecificDisease denotes deficiency of the normal VLCAD protein C536353
T2998 1450-1466 SpecificDisease denotes VLCAD deficiency C536353

NCBI-Disease-Corpus-All

Id Subject Object Predicate Lexical cue database_id
T2995 601-616 Modifier denotes VLCAD-deficient C536353
T2996 862-878 SpecificDisease denotes VLCAD deficiency C536353
T2997 1032-1070 SpecificDisease denotes deficiency of the normal VLCAD protein C536353
T2998 1450-1466 SpecificDisease denotes VLCAD deficiency C536353

NCBI-Disease-Corpus-2stage-All

Id Subject Object Predicate Lexical cue
T1 601-606 Modifier denotes VLCAD
T2 862-878 SpecificDisease denotes VLCAD deficiency
T3 1450-1466 SpecificDisease denotes VLCAD deficiency

NCBI-Disease-Corpus-rezarta-All

Id Subject Object Predicate Lexical cue
T1 601-606 DiseaseClass denotes VLCAD
T2 862-878 DiseaseClass denotes VLCAD deficiency
T3 1450-1466 DiseaseClass denotes VLCAD deficiency

NCBI-Disease-Corpus-4oGuideline-All

Id Subject Object Predicate Lexical cue
T1 101-111 SpecificDisease denotes deficiency
T2 601-616 SpecificDisease denotes VLCAD-deficient
T3 862-878 SpecificDisease denotes VLCAD deficiency
T4 1032-1070 SpecificDisease denotes deficiency of the normal VLCAD protein
T5 1450-1466 SpecificDisease denotes VLCAD deficiency

NCBI-Disease-Corpus-Simple-All

Id Subject Object Predicate Lexical cue
T1 101-111 SpecificDisease denotes deficiency
T2 601-616 SpecificDisease denotes VLCAD-deficient
T3 862-878 SpecificDisease denotes VLCAD deficiency
T4 1450-1466 SpecificDisease denotes VLCAD deficiency