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sentences

Id Subject Object Predicate Lexical cue
T1 0-85 Sentence denotes Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105.
T2 86-246 Sentence denotes Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation.
T3 247-461 Sentence denotes In most cases, the transcriptional factor NF-kappa B is a heterodimer consisting of two subunits, p50 and p65, which are encoded by two distinct genes of the Rel family. p50 is translated as a precursor of 105 kDa.
T4 462-604 Sentence denotes The C-terminal domain of the precursor is rapidly degraded, forming the mature p50 subunit consisted of the N-terminal region of the molecule.
T5 605-653 Sentence denotes The mechanism of generation of p50 is not known.
T6 654-881 Sentence denotes It has been suggested that the ubiquitin-proteasome system is involved in the process; however, the specific enzymes involved and the mechanism of limited proteolysis, in which half of the molecule is spared, have been obscure.
T7 882-923 Sentence denotes Palombella and colleagues (Palombella, V.
T8 924-937 Sentence denotes J., Rando, O.
T9 938-954 Sentence denotes J., Goldberg, A.
T10 955-1139 Sentence denotes L., and Maniatis, T. (1994) Cell 78, 773-785) have shown that ubiquitin is required for the processing in a cell-free system of a truncated, artificially constructed, 60-kDa precursor.
T11 1140-1235 Sentence denotes They have also shown that proteasome inhibitors block the processing both in vitro and in vivo.
T12 1236-1849 Sentence denotes In this study, we demonstrate reconstitution of a cell-free processing system and demonstrate directly that: (a) the ubiquitin-proteasome system is involved in processing of the intact p105 precursor, (b) conjugation of ubiquitin to the precursor is an essential intermediate step in the processing, (c) the recently discovered novel species of the ubiquitin-carrier protein, E2-F1, that is involved in the conjugation and degradation of p53, is also required for the limited processing of the p105 precursor, and (d) a novel, approximately 320-kDa species of ubiquitin-protein ligase, is involved in the process.
T13 1850-1963 Sentence denotes This novel enzyme is distinct from E6-AP, the p53-conjugating ligase, and from E3 alpha, the "N-end rule" ligase.
T1 0-85 Sentence denotes Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105.
T2 86-246 Sentence denotes Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation.
T3 247-461 Sentence denotes In most cases, the transcriptional factor NF-kappa B is a heterodimer consisting of two subunits, p50 and p65, which are encoded by two distinct genes of the Rel family. p50 is translated as a precursor of 105 kDa.
T4 462-604 Sentence denotes The C-terminal domain of the precursor is rapidly degraded, forming the mature p50 subunit consisted of the N-terminal region of the molecule.
T5 605-653 Sentence denotes The mechanism of generation of p50 is not known.
T6 654-881 Sentence denotes It has been suggested that the ubiquitin-proteasome system is involved in the process; however, the specific enzymes involved and the mechanism of limited proteolysis, in which half of the molecule is spared, have been obscure.
T7 882-923 Sentence denotes Palombella and colleagues (Palombella, V.
T8 924-937 Sentence denotes J., Rando, O.
T9 938-954 Sentence denotes J., Goldberg, A.
T10 955-1139 Sentence denotes L., and Maniatis, T. (1994) Cell 78, 773-785) have shown that ubiquitin is required for the processing in a cell-free system of a truncated, artificially constructed, 60-kDa precursor.
T11 1140-1235 Sentence denotes They have also shown that proteasome inhibitors block the processing both in vitro and in vivo.
T12 1236-1849 Sentence denotes In this study, we demonstrate reconstitution of a cell-free processing system and demonstrate directly that: (a) the ubiquitin-proteasome system is involved in processing of the intact p105 precursor, (b) conjugation of ubiquitin to the precursor is an essential intermediate step in the processing, (c) the recently discovered novel species of the ubiquitin-carrier protein, E2-F1, that is involved in the conjugation and degradation of p53, is also required for the limited processing of the p105 precursor, and (d) a novel, approximately 320-kDa species of ubiquitin-protein ligase, is involved in the process.
T13 1850-1963 Sentence denotes This novel enzyme is distinct from E6-AP, the p53-conjugating ligase, and from E3 alpha, the "N-end rule" ligase.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 33-43 protein denotes NF-kappa B
T2 44-79 protein denotes transcriptional activator precursor
T3 80-84 protein denotes p105
T4 149-174 protein denotes ubiquitin-carrier protein
T5 176-178 protein denotes E2
T6 192-216 protein denotes ubiquitin-protein ligase
T7 218-220 protein denotes E3
T8 266-288 protein denotes transcriptional factor
T9 289-299 protein denotes NF-kappa B
T10 305-316 protein denotes heterodimer
T11 345-348 protein denotes p50
T12 353-356 protein denotes p65
T13 405-415 DNA denotes Rel family
T14 417-420 protein denotes p50
T15 453-460 protein denotes 105 kDa
T16 466-483 protein denotes C-terminal domain
T17 534-552 protein denotes mature p50 subunit
T18 570-587 protein denotes N-terminal region
T19 636-639 protein denotes p50
T20 685-694 protein denotes ubiquitin
T21 694-705 protein denotes -proteasome
T22 763-770 protein denotes enzymes
T23 1017-1026 protein denotes ubiquitin
T24 1122-1138 protein denotes 60-kDa precursor
T25 1166-1176 protein denotes proteasome
T26 1353-1362 protein denotes ubiquitin
T27 1362-1373 protein denotes -proteasome
T28 1421-1425 protein denotes p105
T29 1456-1465 protein denotes ubiquitin
T30 1585-1610 protein denotes ubiquitin-carrier protein
T31 1612-1617 protein denotes E2-F1
T32 1674-1677 protein denotes p53
T33 1730-1744 protein denotes p105 precursor
T34 1777-1792 protein denotes 320-kDa species
T35 1796-1820 protein denotes ubiquitin-protein ligase
T36 1885-1890 protein denotes E6-AP
T37 1896-1918 protein denotes p53-conjugating ligase
T38 1929-1937 protein denotes E3 alpha
T39 1943-1962 protein denotes "N-end rule" ligase

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 33-84 NP denotes NF-kappa B transcriptional activator precursor p105
C2 86-122 NP denotes Reconstitution of a cell-free system
C3 145-174 NP denotes the ubiquitin-carrier protein
C4 176-178 NP denotes E2
C5 184-216 NP denotes a novel ubiquitin-protein ligase
C6 218-220 NP denotes E3
C7 331-343 NP denotes two subunits
C8 345-356 NP denotes p50 and p65
C9 358-363 NP denotes which
C10 417-420 NP denotes p50
C11 438-460 NP denotes a precursor of 105 kDa
C12 487-500 NP denotes the precursor
C13 636-639 NP denotes p50
C14 801-820 NP denotes limited proteolysis
C15 825-830 NP denotes which
C16 882-907 NP denotes Palombella and colleagues
C17 1017-1026 NP denotes ubiquitin
C18 1140-1144 NP denotes They
C19 1266-1313 NP denotes reconstitution of a cell-free processing system
C20 1410-1435 NP denotes the intact p105 precursor
C21 1456-1465 NP denotes ubiquitin
C22 1469-1482 NP denotes the precursor
C23 1581-1610 NP denotes the ubiquitin-carrier protein
C24 1612-1617 NP denotes E2-F1
C25 1619-1623 NP denotes that
C26 1726-1744 NP denotes the p105 precursor
C27 1754-1820 NP denotes a novel, approximately 320-kDa species of ubiquitin-protein ligase
C28 1850-1867 NP denotes This novel enzyme
C29 1885-1890 NP denotes E6-AP
C30 1892-1918 NP denotes the p53-conjugating ligase
C31 1929-1937 NP denotes E3 alpha
C32 1939-1962 NP denotes the "N-end rule" ligase
R1 C4 C3 coref-appos E2,the ubiquitin-carrier protein
R2 C6 C5 coref-appos E3,a novel ubiquitin-protein ligase
R3 C8 C7 coref-appos p50 and p65,two subunits
R4 C9 C7 coref-relat which,two subunits
R5 C11 C1 coref-ident a precursor of 105 kDa,NF-kappa B transcriptional activator precursor p105
R6 C12 C11 coref-ident the precursor,a precursor of 105 kDa
R7 C13 C10 coref-ident p50,p50
R8 C15 C14 coref-relat which,limited proteolysis
R9 C18 C16 coref-pron They,Palombella and colleagues
R10 C19 C2 coref-ident reconstitution of a cell-free processing system,Reconstitution of a cell-free system
R11 C21 C17 coref-ident ubiquitin,ubiquitin
R12 C22 C20 coref-ident the precursor,the intact p105 precursor
R13 C24 C23 coref-appos E2-F1,the ubiquitin-carrier protein
R14 C25 C23 coref-relat that,the ubiquitin-carrier protein
R15 C26 C22 coref-ident the p105 precursor,the precursor
R16 C28 C27 coref-ident This novel enzyme,"a novel, approximately 320-kDa species of ubiquitin-protein ligase"
R17 C30 C29 coref-appos the p53-conjugating ligase,E6-AP
R18 C32 C31 coref-appos "the ""N-end rule"" ligase",E3 alpha

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-85 Sentence denotes Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105.
S2 86-246 Sentence denotes Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation.
S3 247-416 Sentence denotes In most cases, the transcriptional factor NF-kappa B is a heterodimer consisting of two subunits, p50 and p65, which are encoded by two distinct genes of the Rel family.
S4 417-461 Sentence denotes p50 is translated as a precursor of 105 kDa.
S5 462-604 Sentence denotes The C-terminal domain of the precursor is rapidly degraded, forming the mature p50 subunit consisted of the N-terminal region of the molecule.
S6 605-653 Sentence denotes The mechanism of generation of p50 is not known.
S7 654-881 Sentence denotes It has been suggested that the ubiquitin-proteasome system is involved in the process; however, the specific enzymes involved and the mechanism of limited proteolysis, in which half of the molecule is spared, have been obscure.
S8 882-1139 Sentence denotes Palombella and colleagues (Palombella, V. J., Rando, O. J., Goldberg, A. L., and Maniatis, T. (1994) Cell 78, 773-785) have shown that ubiquitin is required for the processing in a cell-free system of a truncated, artificially constructed, 60-kDa precursor.
S9 1140-1235 Sentence denotes They have also shown that proteasome inhibitors block the processing both in vitro and in vivo.
S10 1236-1849 Sentence denotes In this study, we demonstrate reconstitution of a cell-free processing system and demonstrate directly that: (a) the ubiquitin-proteasome system is involved in processing of the intact p105 precursor, (b) conjugation of ubiquitin to the precursor is an essential intermediate step in the processing, (c) the recently discovered novel species of the ubiquitin-carrier protein, E2-F1, that is involved in the conjugation and degradation of p53, is also required for the limited processing of the p105 precursor, and (d) a novel, approximately 320-kDa species of ubiquitin-protein ligase, is involved in the process.
S11 1850-1963 Sentence denotes This novel enzyme is distinct from E6-AP, the p53-conjugating ligase, and from E3 alpha, the "N-end rule" ligase.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 33-43 protein_molecule denotes NF-kappa B
T2 44-79 protein_family_or_group denotes transcriptional activator precursor
T3 80-84 protein_molecule denotes p105
T4 106-122 other_name denotes cell-free system
T5 149-174 protein_family_or_group denotes ubiquitin-carrier protein
T6 176-178 protein_molecule denotes E2
T7 192-216 protein_family_or_group denotes ubiquitin-protein ligase
T8 218-220 protein_molecule denotes E3
T9 266-288 protein_family_or_group denotes transcriptional factor
T10 289-299 protein_molecule denotes NF-kappa B
T11 305-316 protein_complex denotes heterodimer
T12 345-348 protein_molecule denotes p50
T13 353-356 protein_molecule denotes p65
T14 405-415 DNA_family_or_group denotes Rel family
T15 417-420 protein_molecule denotes p50
T16 453-460 protein_molecule denotes 105 kDa
T17 466-483 protein_domain_or_region denotes C-terminal domain
T18 534-552 protein_subunit denotes mature p50 subunit
T19 570-587 protein_domain_or_region denotes N-terminal region
T20 636-639 protein_molecule denotes p50
T21 685-694 protein_molecule denotes ubiquitin
T22 694-705 protein_complex denotes -proteasome
T23 763-770 protein_family_or_group denotes enzymes
T24 809-820 other_name denotes proteolysis
T25 1017-1026 protein_molecule denotes ubiquitin
T26 1063-1079 other_name denotes cell-free system
T27 1122-1138 protein_molecule denotes 60-kDa precursor
T28 1166-1176 protein_complex denotes proteasome
T29 1286-1313 other_name denotes cell-free processing system
T30 1353-1362 protein_molecule denotes ubiquitin
T31 1362-1373 protein_complex denotes -proteasome
T32 1421-1425 protein_molecule denotes p105
T33 1456-1465 protein_molecule denotes ubiquitin
T34 1585-1594 protein_molecule denotes ubiquitin
T35 1612-1617 protein_molecule denotes E2-F1
T36 1674-1677 protein_subunit denotes p53
T37 1730-1744 protein_molecule denotes p105 precursor
T38 1777-1792 protein_molecule denotes 320-kDa species
T39 1796-1805 protein_molecule denotes ubiquitin
T40 1885-1890 protein_molecule denotes E6-AP
T41 1896-1899 protein_subunit denotes p53
T42 1929-1931 protein_molecule denotes E3
T43 1943-1962 protein_molecule denotes "N-end rule" ligase