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sentences

Id Subject Object Predicate Lexical cue
T1 0-187 Sentence denotes Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-alpha-responsive elements.
T2 188-323 Sentence denotes The human activation antigen CD69 is a member of the C-type animal lectin superfamily that functions as a signal-transmitting receptor.
T3 324-566 Sentence denotes Although the expression of CD69 can be induced in vitro on cells of most hematopoietic lineages with a wide variety of stimuli, in vivo it is mainly expressed by T-lymphocytes located in the inflammatory infiltrates of several human diseases.
T4 567-771 Sentence denotes To elucidate the mechanisms that regulate the constitutive and inducible expression of CD69 by leukocytes, we isolated the promoter region of the CD69 gene and carried out its functional characterization.
T5 772-1109 Sentence denotes Sequence analysis of the 5'-flanking region of the CD69 gene revealed the presence of a potential TATA element 30 base pairs upstream of the major transcription initiation site and several putative binding sequences for inducible transcription factors (NF-kappa B, Egr-1, AP-1), which might mediate the inducible expression of this gene.
T6 1110-1399 Sentence denotes Transient expression of CD69 promoter-based reporter gene constructs in K562 cells indicated that the proximal promoter region spanning positions -78 to +16 contained the cis-acting sequences necessary for basal and phorbol 12-myristate 13-acetate-inducible transcription of the CD69 gene.
T7 1400-1574 Sentence denotes Removal of the upstream sequences located between positions -78 and -38 resulted in decreased promoter strength and abolished the response to phorbol 12-myristate 13-acetate.
T8 1575-1913 Sentence denotes We also found that tumor necrosis factor-alpha (TNF-alpha) is capable of inducing the surface expression of the CD69 molecule as well as the promoter activity of fusion plasmids that contain 5'-flanking sequences of the CD69 gene, suggesting that this cytokine may regulate in vivo the expression of CD69.(ABSTRACT TRUNCATED AT 250 WORDS)
T1 0-187 Sentence denotes Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-alpha-responsive elements.
T2 188-323 Sentence denotes The human activation antigen CD69 is a member of the C-type animal lectin superfamily that functions as a signal-transmitting receptor.
T3 324-566 Sentence denotes Although the expression of CD69 can be induced in vitro on cells of most hematopoietic lineages with a wide variety of stimuli, in vivo it is mainly expressed by T-lymphocytes located in the inflammatory infiltrates of several human diseases.
T4 567-771 Sentence denotes To elucidate the mechanisms that regulate the constitutive and inducible expression of CD69 by leukocytes, we isolated the promoter region of the CD69 gene and carried out its functional characterization.
T5 772-1109 Sentence denotes Sequence analysis of the 5'-flanking region of the CD69 gene revealed the presence of a potential TATA element 30 base pairs upstream of the major transcription initiation site and several putative binding sequences for inducible transcription factors (NF-kappa B, Egr-1, AP-1), which might mediate the inducible expression of this gene.
T6 1110-1399 Sentence denotes Transient expression of CD69 promoter-based reporter gene constructs in K562 cells indicated that the proximal promoter region spanning positions -78 to +16 contained the cis-acting sequences necessary for basal and phorbol 12-myristate 13-acetate-inducible transcription of the CD69 gene.
T7 1400-1574 Sentence denotes Removal of the upstream sequences located between positions -78 and -38 resulted in decreased promoter strength and abolished the response to phorbol 12-myristate 13-acetate.
T8 1575-1913 Sentence denotes We also found that tumor necrosis factor-alpha (TNF-alpha) is capable of inducing the surface expression of the CD69 molecule as well as the promoter activity of fusion plasmids that contain 5'-flanking sequences of the CD69 gene, suggesting that this cytokine may regulate in vivo the expression of CD69.(ABSTRACT TRUNCATED AT 250 WORDS)

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1212-1220 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 52-90 protein denotes human C-type lectin leukocyte receptor
T2 91-99 protein denotes AIM/CD69
T3 139-186 DNA denotes tumor necrosis factor-alpha-responsive elements
T4 192-216 protein denotes human activation antigen
T5 217-221 protein denotes CD69
T6 241-273 protein denotes C-type animal lectin superfamily
T7 294-322 protein denotes signal-transmitting receptor
T8 351-355 protein denotes CD69
T9 486-499 cell_type denotes T-lymphocytes
T10 654-658 protein denotes CD69
T11 662-672 cell_type denotes leukocytes
T12 690-705 DNA denotes promoter region
T13 713-717 protein denotes CD69
T14 797-815 DNA denotes 5'-flanking region
T15 823-832 DNA denotes CD69 gene
T16 870-882 DNA denotes TATA element
T17 883-905 DNA denotes 30 base pairs upstream
T18 919-948 DNA denotes transcription initiation site
T19 1002-1023 protein denotes transcription factors
T20 1025-1035 protein denotes NF-kappa B
T21 1037-1042 protein denotes Egr-1
T22 1044-1048 protein denotes AP-1
T23 1134-1178 DNA denotes CD69 promoter-based reporter gene constructs
T24 1182-1192 cell_line denotes K562 cells
T25 1212-1236 DNA denotes proximal promoter region
T26 1281-1301 DNA denotes cis-acting sequences
T27 1389-1398 DNA denotes CD69 gene
T28 1594-1621 protein denotes tumor necrosis factor-alpha
T29 1623-1632 protein denotes TNF-alpha
T30 1687-1691 protein denotes CD69
T31 1795-1799 protein denotes CD69
T32 1875-1879 protein denotes CD69

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 30-99 NP denotes the gene encoding the human C-type lectin leukocyte receptor AIM/CD69
C2 135-138 NP denotes its
C3 188-221 NP denotes The human activation antigen CD69
C4 225-273 NP denotes a member of the C-type animal lectin superfamily
C5 274-278 NP denotes that
C6 351-355 NP denotes CD69
C7 460-462 NP denotes it
C8 580-594 NP denotes the mechanisms
C9 595-599 NP denotes that
C10 654-658 NP denotes CD69
C11 709-722 NP denotes the CD69 gene
C12 739-742 NP denotes its
C13 819-832 NP denotes the CD69 gene
C14 858-1049 NP denotes a potential TATA element 30 base pairs upstream of the major transcription initiation site and several putative binding sequences for inducible transcription factors (NF-kappa B, Egr-1, AP-1)
C15 1051-1056 NP denotes which
C16 1099-1108 NP denotes this gene
C17 1385-1398 NP denotes the CD69 gene
C18 1594-1633 NP denotes tumor necrosis factor-alpha (TNF-alpha)
C19 1737-1752 NP denotes fusion plasmids
C20 1753-1757 NP denotes that
C21 1791-1804 NP denotes the CD69 gene
C22 1822-1835 NP denotes this cytokine
C23 1875-1879 NP denotes CD69
R1 C2 C1 coref-pron its,the gene encoding the human C-type lectin leukocyte receptor AIM/CD69
R2 C5 C4 coref-relat that,a member of the C-type animal lectin superfamily
R3 C6 C3 coref-ident CD69,The human activation antigen CD69
R4 C7 C6 coref-pron it,CD69
R5 C9 C8 coref-relat that,the mechanisms
R6 C10 C6 coref-ident CD69,CD69
R7 C11 C1 coref-ident the CD69 gene,the gene encoding the human C-type lectin leukocyte receptor AIM/CD69
R8 C12 C11 coref-pron its,the CD69 gene
R9 C13 C11 coref-ident the CD69 gene,the CD69 gene
R10 C15 C14 coref-relat which,"a potential TATA element 30 base pairs upstream of the major transcription initiation site and several putative binding sequences for inducible transcription factors (NF-kappa B, Egr-1, AP-1)"
R11 C16 C13 coref-ident this gene,the CD69 gene
R12 C17 C16 coref-ident the CD69 gene,this gene
R13 C20 C19 coref-relat that,fusion plasmids
R14 C21 C17 coref-ident the CD69 gene,the CD69 gene
R15 C22 C18 coref-ident this cytokine,tumor necrosis factor-alpha (TNF-alpha)
R16 C23 C10 coref-ident CD69,CD69

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-187 Sentence denotes Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-alpha-responsive elements.
S2 188-323 Sentence denotes The human activation antigen CD69 is a member of the C-type animal lectin superfamily that functions as a signal-transmitting receptor.
S3 324-566 Sentence denotes Although the expression of CD69 can be induced in vitro on cells of most hematopoietic lineages with a wide variety of stimuli, in vivo it is mainly expressed by T-lymphocytes located in the inflammatory infiltrates of several human diseases.
S4 567-771 Sentence denotes To elucidate the mechanisms that regulate the constitutive and inducible expression of CD69 by leukocytes, we isolated the promoter region of the CD69 gene and carried out its functional characterization.
S5 772-1109 Sentence denotes Sequence analysis of the 5'-flanking region of the CD69 gene revealed the presence of a potential TATA element 30 base pairs upstream of the major transcription initiation site and several putative binding sequences for inducible transcription factors (NF-kappa B, Egr-1, AP-1), which might mediate the inducible expression of this gene.
S6 1110-1399 Sentence denotes Transient expression of CD69 promoter-based reporter gene constructs in K562 cells indicated that the proximal promoter region spanning positions -78 to +16 contained the cis-acting sequences necessary for basal and phorbol 12-myristate 13-acetate-inducible transcription of the CD69 gene.
S7 1400-1574 Sentence denotes Removal of the upstream sequences located between positions -78 and -38 resulted in decreased promoter strength and abolished the response to phorbol 12-myristate 13-acetate.
S8 1575-1880 Sentence denotes We also found that tumor necrosis factor-alpha (TNF-alpha) is capable of inducing the surface expression of the CD69 molecule as well as the promoter activity of fusion plasmids that contain 5'-flanking sequences of the CD69 gene, suggesting that this cytokine may regulate in vivo the expression of CD69.
S9 1880-1913 Sentence denotes (ABSTRACT TRUNCATED AT 250 WORDS)

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-26 other_name denotes Transcriptional regulation
T2 52-90 protein_family_or_group denotes human C-type lectin leukocyte receptor
T3 91-99 protein_molecule denotes AIM/CD69
T4 139-166 protein_molecule denotes tumor necrosis factor-alpha
T5 178-186 DNA_domain_or_region denotes elements
T6 192-216 protein_molecule denotes human activation antigen
T7 217-221 protein_molecule denotes CD69
T8 241-273 protein_domain_or_region denotes C-type animal lectin superfamily
T9 294-322 protein_family_or_group denotes signal-transmitting receptor
T10 337-347 other_name denotes expression
T11 351-355 protein_molecule denotes CD69
T12 486-488 cell_type denotes T-
T13 488-499 cell_type denotes lymphocytes
T14 515-539 other_name denotes inflammatory infiltrates
T15 551-565 other_name denotes human diseases
T16 654-658 protein_molecule denotes CD69
T17 662-672 cell_type denotes leukocytes
T18 690-705 DNA_domain_or_region denotes promoter region
T19 713-717 protein_molecule denotes CD69
T20 743-770 other_name denotes functional characterization
T21 797-815 DNA_domain_or_region denotes 5'-flanking region
T22 823-827 protein_molecule denotes CD69
T23 870-882 DNA_domain_or_region denotes TATA element
T24 883-905 DNA_domain_or_region denotes 30 base pairs upstream
T25 919-948 DNA_domain_or_region denotes transcription initiation site
T26 1002-1023 protein_family_or_group denotes transcription factors
T27 1025-1035 protein_molecule denotes NF-kappa B
T28 1037-1042 protein_molecule denotes Egr-1
T29 1044-1048 protein_molecule denotes AP-1
T30 1110-1130 other_name denotes Transient expression
T31 1134-1138 protein_molecule denotes CD69
T32 1182-1192 cell_line denotes K562 cells
T33 1212-1220 DNA_domain_or_region denotes proximal
T34 1221-1236 DNA_domain_or_region denotes promoter region
T35 1281-1301 DNA_domain_or_region denotes cis-acting sequences
T36 1326-1357 other_organic_compound denotes phorbol 12-myristate 13-acetate
T37 1389-1393 protein_molecule denotes CD69
T38 1594-1621 protein_molecule denotes tumor necrosis factor-alpha
T39 1623-1632 protein_molecule denotes TNF-alpha
T40 1687-1691 protein_molecule denotes CD69
T41 1795-1799 protein_molecule denotes CD69
T42 1875-1879 protein_molecule denotes CD69

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 139-144 Phenotype denotes tumor HP:0002664
T2 1594-1599 Phenotype denotes tumor HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 139-144 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 1594-1599 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-187 Sentence denotes Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-alpha-responsive elements.
T2 188-323 Sentence denotes The human activation antigen CD69 is a member of the C-type animal lectin superfamily that functions as a signal-transmitting receptor.
T3 324-566 Sentence denotes Although the expression of CD69 can be induced in vitro on cells of most hematopoietic lineages with a wide variety of stimuli, in vivo it is mainly expressed by T-lymphocytes located in the inflammatory infiltrates of several human diseases.
T4 567-771 Sentence denotes To elucidate the mechanisms that regulate the constitutive and inducible expression of CD69 by leukocytes, we isolated the promoter region of the CD69 gene and carried out its functional characterization.
T5 772-1109 Sentence denotes Sequence analysis of the 5'-flanking region of the CD69 gene revealed the presence of a potential TATA element 30 base pairs upstream of the major transcription initiation site and several putative binding sequences for inducible transcription factors (NF-kappa B, Egr-1, AP-1), which might mediate the inducible expression of this gene.
T6 1110-1399 Sentence denotes Transient expression of CD69 promoter-based reporter gene constructs in K562 cells indicated that the proximal promoter region spanning positions -78 to +16 contained the cis-acting sequences necessary for basal and phorbol 12-myristate 13-acetate-inducible transcription of the CD69 gene.
T7 1400-1574 Sentence denotes Removal of the upstream sequences located between positions -78 and -38 resulted in decreased promoter strength and abolished the response to phorbol 12-myristate 13-acetate.
T8 1575-1913 Sentence denotes We also found that tumor necrosis factor-alpha (TNF-alpha) is capable of inducing the surface expression of the CD69 molecule as well as the promoter activity of fusion plasmids that contain 5'-flanking sequences of the CD69 gene, suggesting that this cytokine may regulate in vivo the expression of CD69.(ABSTRACT TRUNCATED AT 250 WORDS)

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 52-57 OrganismTaxon denotes human 9606
T2 192-197 OrganismTaxon denotes human 9606
T3 551-556 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 72-81 Body_part denotes leukocyte http://purl.obolibrary.org/obo/CL_0000738
T2 486-499 Body_part denotes T-lymphocytes http://purl.obolibrary.org/obo/CL_0000084
T3 662-672 Body_part denotes leukocytes http://purl.obolibrary.org/obo/CL_0000738

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1212-1220 Body_part denotes proximal http://purl.obolibrary.org/obo/MAT_0000491

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 72-81 Cell denotes leukocyte http://purl.obolibrary.org/obo/CL:0000738
T2 486-499 Cell denotes T-lymphocytes http://purl.obolibrary.org/obo/CL:0000084
T3 662-672 Cell denotes leukocytes http://purl.obolibrary.org/obo/CL:0000738
T4 1316-1321 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324