PubMed:7664335 JSONTXT

{"project":"AIMed","denotations":[{"id":"T1","span":{"begin":83,"end":94},"obj":"protein"},{"id":"T2","span":{"begin":370,"end":373},"obj":"protein"},{"id":"T3","span":{"begin":440,"end":444},"obj":"protein"},{"id":"T4","span":{"begin":499,"end":502},"obj":"protein"},{"id":"T5","span":{"begin":503,"end":506},"obj":"protein"},{"id":"T6","span":{"begin":537,"end":540},"obj":"protein"},{"id":"T7","span":{"begin":648,"end":651},"obj":"protein"},{"id":"T8","span":{"begin":675,"end":678},"obj":"protein"},{"id":"T9","span":{"begin":696,"end":699},"obj":"protein"},{"id":"T10","span":{"begin":828,"end":831},"obj":"protein"},{"id":"T11","span":{"begin":836,"end":839},"obj":"protein"}],"text":"The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH.\nThe hereditary disease Cockayne syndrome (CS) is characterized by a complex clinical phenotype. CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. The cloned CSB gene encodes a member of a protein family that includes the yeast Snf2 protein, a component of the transcriptional regulator Swi/Snf. We report the cloning of the CSA cDNA, which can encode a WD repeat protein. Mutations in the cDNA have been identified in CS-A cell lines. CSA protein interacts with CSB protein and with p44 protein, a subunit of the human RNA polymerase II transcription factor IIH. These observations suggest that the products of the CSA and CSB genes are involved in transcription."}

{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":4,"end":21},"obj":"Disease"},{"id":"T2","span":{"begin":83,"end":86},"obj":"Disease"},{"id":"T3","span":{"begin":141,"end":159},"obj":"Disease"},{"id":"T4","span":{"begin":160,"end":177},"obj":"Disease"},{"id":"T5","span":{"begin":179,"end":181},"obj":"Disease"},{"id":"T6","span":{"begin":233,"end":235},"obj":"Disease"},{"id":"T7","span":{"begin":370,"end":373},"obj":"Disease"},{"id":"T8","span":{"begin":537,"end":540},"obj":"Disease"},{"id":"T9","span":{"begin":631,"end":635},"obj":"Disease"},{"id":"T10","span":{"begin":631,"end":633},"obj":"Disease"},{"id":"T11","span":{"begin":648,"end":651},"obj":"Disease"},{"id":"T12","span":{"begin":675,"end":678},"obj":"Disease"},{"id":"T13","span":{"begin":771,"end":774},"obj":"Disease"},{"id":"T14","span":{"begin":828,"end":831},"obj":"Disease"},{"id":"T15","span":{"begin":836,"end":839},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0016006"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0019570"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0003847"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0016006"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0016006"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0016006"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0019570"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0019569"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0019569"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0016006"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0019569"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0019570"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0009468"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0019569"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0019570"}],"text":"The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH.\nThe hereditary disease Cockayne syndrome (CS) is characterized by a complex clinical phenotype. CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. The cloned CSB gene encodes a member of a protein family that includes the yeast Snf2 protein, a component of the transcriptional regulator Swi/Snf. We report the cloning of the CSA cDNA, which can encode a WD repeat protein. Mutations in the cDNA have been identified in CS-A cell lines. CSA protein interacts with CSB protein and with p44 protein, a subunit of the human RNA polymerase II transcription factor IIH. These observations suggest that the products of the CSA and CSB genes are involved in transcription."}

{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":726,"end":731},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"9606"}],"text":"The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH.\nThe hereditary disease Cockayne syndrome (CS) is characterized by a complex clinical phenotype. CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. The cloned CSB gene encodes a member of a protein family that includes the yeast Snf2 protein, a component of the transcriptional regulator Swi/Snf. We report the cloning of the CSA cDNA, which can encode a WD repeat protein. Mutations in the cDNA have been identified in CS-A cell lines. CSA protein interacts with CSB protein and with p44 protein, a subunit of the human RNA polymerase II transcription factor IIH. These observations suggest that the products of the CSA and CSB genes are involved in transcription."}