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PubMed:7662982 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 90-94 gene:9623 denotes TCL1
T1 280-296 disease:C0023492 denotes T-cell leukemias
T2 90-94 gene:8115 denotes TCL1
T3 280-296 disease:C0023492 denotes T-cell leukemias
T4 90-94 gene:9623 denotes TCL1
T5 326-329 disease:C0023486 denotes PLL
T6 90-94 gene:8115 denotes TCL1
T7 326-329 disease:C0023486 denotes PLL
R1 T0 T1 associated_with TCL1,T-cell leukemias
R2 T2 T3 associated_with TCL1,T-cell leukemias
R3 T4 T5 associated_with TCL1,PLL
R4 T6 T7 associated_with TCL1,PLL

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 28-47 cell_type denotes preleukemic T cells
T2 90-103 DNA denotes TCL1 oncogene
T3 107-123 DNA denotes human chromosome
T4 124-131 DNA denotes 14q32.1
T5 174-193 DNA denotes t(14;14)(q11;q32.1)
T6 198-216 DNA denotes t(7;14)(q35;q32.1)
T7 234-250 DNA denotes inv14(q11;q32.1)
T8 257-276 DNA denotes TCR alpha/beta loci
T9 535-542 cell_type denotes T cells
T10 638-647 RNA denotes TCL1 mRNA
T11 652-659 protein denotes protein
T12 663-691 cell_type denotes peripheral blood lymphocytes
T13 693-697 cell_type denotes PBLs
T14 763-772 DNA denotes TCL1 gene
T15 798-802 cell_type denotes PBLs
T16 827-857 cell_line denotes large clonal T-cell population
T17 911-922 cell_type denotes lymphocytes
T18 985-1003 DNA denotes TCL1 genomic locus
T19 1155-1165 DNA denotes TCL1 locus
T20 1219-1230 DNA denotes distal part
T21 1234-1247 DNA denotes chromosome 14
T22 1274-1278 DNA denotes TCL1
T23 1295-1319 cell_line denotes preleukemic clonal cells
T24 1394-1403 DNA denotes TCR locus
T25 1407-1412 DNA denotes 14q11
T26 1430-1434 DNA denotes TCL1

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
7662982-1#171#174#gene6962 257-260 gene6962 denotes TCR
7662982-1#194#210#diseaseC0023492 280-296 diseaseC0023492 denotes T-cell leukemias
171#174#gene6962194#210#diseaseC0023492 7662982-1#171#174#gene6962 7662982-1#194#210#diseaseC0023492 associated_with TCR,T-cell leukemias

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 53-84 NP denotes a case of ataxia-telangiectasia
C2 280-296 NP denotes T-cell leukemias
C3 406-432 NP denotes ataxia-telangiectasia (AT)
C4 434-462 NP denotes an immunodeficiency syndrome
C5 806-857 NP denotes an AT patient with a large clonal T-cell population
C6 869-895 NP denotes the t(14;14) translocation
C7 981-1003 NP denotes the TCL1 genomic locus
C8 1034-1081 NP denotes the AT patient with the T-cell clonal expansion
C9 1112-1138 NP denotes the t(14;14) translocation
C10 1151-1165 NP denotes the TCL1 locus
C11 1274-1278 NP denotes TCL1
C12 1430-1434 NP denotes TCL1
C13 1489-1513 NP denotes these types of leukemias
R1 C4 C3 coref-appos an immunodeficiency syndrome,ataxia-telangiectasia (AT)
R2 C5 C1 coref-ident an AT patient with a large clonal T-cell population,a case of ataxia-telangiectasia
R3 C8 C5 coref-ident the AT patient with the T-cell clonal expansion,an AT patient with a large clonal T-cell population
R4 C9 C6 coref-ident the t(14;14) translocation,the t(14;14) translocation
R5 C10 C7 coref-ident the TCL1 locus,the TCL1 genomic locus
R6 C12 C11 coref-ident TCL1,TCL1
R7 C13 C2 coref-ident these types of leukemias,T-cell leukemias

semrep-sample

Id Subject Object Predicate Lexical cue
E1-ti-1 0-4 entrez:8115 denotes TCL1
E2-ti-1 5-24 cui:C1518575 denotes oncogene activation
E3-ti-1 28-39 cui:C0026986 denotes preleukemic
E4-ti-1 40-47 cui:C0039194 denotes T cells
E5-ti-1 63-84 cui:C0004135 denotes ataxia-telangiectasia
E1-ab-1 90-94 entrez:8115 denotes TCL1
E2-ab-1 95-103 cui:C0029016 denotes oncogene
E3-ab-1 107-123 cui:C0008643 denotes human chromosome
E4-ab-1 124-131 cui:C1520600 denotes 14q32.1
E5-ab-1 147-172 cui:C0040715 denotes chromosome translocations
E6-ab-1 183-186 cui:C1549863 denotes q11
E7-ab-1 240-243 cui:C1549863 denotes q11
E8-ab-1 257-271 cui:C0085247 denotes TCR alpha/beta
E9-ab-1 280-296 cui:C0023492 denotes T-cell leukemias
T1 135-143 ASSOCIATED_WITH denotes involved
E1-ab-2 357-362 cui:C0205178 denotes acute
E2-ab-2 368-385 cui:C1279296 denotes chronic leukemias
E3-ab-2 397-402 cui:C0868928 denotes cases
E4-ab-2 406-427 cui:C0004135 denotes ataxia-telangiectasia
E5-ab-2 437-462 cui:C0021051 denotes immunodeficiency syndrome
E1-ab-3 464-471 cui:C0871364 denotes Similar
E2-ab-3 472-498 cui:C1516520 denotes chromosomal rearrangements
E3-ab-3 526-534 cui:C0205229 denotes expanded
E4-ab-3 535-542 cui:C0039194 denotes T cells
E5-ab-3 546-548 cui:C0004135 denotes AT
E6-ab-3 549-557 cui:C0030705 denotes patients
E7-ab-3 569-579 cui:C0700364 denotes appearance
E8-ab-3 593-601 cui:C0023418 denotes leukemia
T2 546-557 PROCESS_OF denotes AT patients
T3 543-545 PROCESS_OF denotes in
E1-ab-4 624-634 cui:C0185117 denotes expression
E2-ab-4 638-642 entrez:8115 denotes TCL1
E3-ab-4 643-647 cui:C0035696 denotes mRNA
E4-ab-4 652-659 cui:C0033684 denotes protein
E5-ab-4 663-691 cui:C1518997 denotes peripheral blood lymphocytes
E6-ab-4 704-708 cui:C0205450 denotes four
E7-ab-4 709-711 cui:C0004135 denotes AT
E8-ab-4 712-717 cui:C0868928 denotes cases
E9-ab-4 727-734 cui:C0018684 denotes healthy
E10-ab-4 735-743 cui:C0243148 denotes controls
T4 660-662 LOCATION_OF denotes in
E1-ab-5 763-767 entrez:8115 denotes TCL1
E2-ab-5 768-772 cui:C0017337 denotes gene
E3-ab-5 798-802 cui:C0033684 denotes PBLs
E4-ab-5 798-802 cui:C1518997 denotes PBLs
E5-ab-5 809-811 cui:C0004135 denotes AT
E6-ab-5 812-819 cui:C0030705 denotes patient
E7-ab-5 827-832 cui:C0549177 denotes large
E8-ab-5 833-839 cui:C1522642 denotes clonal
E9-ab-5 840-846 cui:C0039194 denotes T-cell
E10-ab-5 900-903 cui:C1518422 denotes not
E11-ab-5 911-922 cui:C0024264 denotes lymphocytes
E12-ab-5 936-941 cui:C0868928 denotes cases
T5 791-793 LOCATION_OF denotes in
T6 809-819 PROCESS_OF denotes AT patient
T7 803-805 PART_OF denotes of
E1-ab-6 943-955 cui:C0016315 denotes Fluorescence
E2-ab-6 964-977 cui:C0020202 denotes hybridization
E3-ab-6 985-989 entrez:8115 denotes TCL1
E4-ab-6 1007-1017 cui:C0024264 denotes lymphocyte
E5-ab-6 1018-1028 cui:C0025564 denotes metaphases
E6-ab-6 1038-1040 cui:C0004135 denotes AT
E7-ab-6 1041-1048 cui:C0030705 denotes patient
E8-ab-6 1058-1064 cui:C0039194 denotes T-cell
E9-ab-6 1065-1081 cui:C1516670 denotes clonal expansion
E10-ab-6 1155-1159 entrez:8115 denotes TCL1
E11-ab-6 1191-1199 cui:C0443241 denotes inverted
E12-ab-6 1200-1211 cui:C0332597 denotes duplication
E13-ab-6 1219-1225 cui:C0205108 denotes distal
E14-ab-6 1226-1230 cui:C0449719 denotes part
E15-ab-6 1234-1247 cui:C0008656 denotes chromosome 14
T8 956-958 PROCESS_OF denotes in
T9 1038-1048 PROCESS_OF denotes AT patient
T10 1049-1053 PROCESS_OF denotes with
T11 1226-1230 PART_OF denotes part
E1-ab-7 1255-1259 cui:C1511726 denotes data
E2-ab-7 1274-1278 entrez:8115 denotes TCL1
E3-ab-7 1295-1306 cui:C0026986 denotes preleukemic
E4-ab-7 1307-1319 cui:C0009013 denotes clonal cells
E5-ab-7 1340-1364 cui:C0040715 denotes chromosome translocation
E6-ab-7 1375-1384 cui:C0162326 denotes sequences
E7-ab-7 1394-1397 cui:C0034790 denotes TCR
E8-ab-7 1407-1412 cui:C1520576 denotes 14q11
T12 1282-1291 AUGMENTS denotes activated
T13 1365-1374 ASSOCIATED_WITH denotes involving
E1-ab-8 1430-1434 entrez:8115 denotes TCL1
E2-ab-8 1442-1447 cui:C1279901 denotes first
E3-ab-8 1448-1453 cui:C0441471 denotes event
E4-ab-8 1475-1485 cui:C0006826 denotes malignancy
E5-ab-8 1495-1500 cui:C0332307 denotes types
E6-ab-8 1504-1513 cui:C0023418 denotes leukemias
E7-ab-8 1531-1540 cui:C0237399 denotes potential
E8-ab-8 1541-1545 cui:C0336791 denotes tool
E9-ab-8 1550-1569 cui:C1261322 denotes clinical evaluation
R1 E4-ab-1 T1 subjectOf 14q32.1,involved
R2 E5-ab-1 T1 objectOf chromosome translocations,involved
R3 E5-ab-3 T2 subjectOf AT,AT patients
R4 E6-ab-3 T2 objectOf patients,AT patients
R5 E2-ab-3 T3 subjectOf chromosomal rearrangements,in
R6 E6-ab-3 T3 objectOf patients,in
R7 E5-ab-4 T4 subjectOf peripheral blood lymphocytes,in
R8 E2-ab-4 T4 objectOf TCL1,in
R9 E4-ab-5 T5 subjectOf PBLs,in
R10 E1-ab-5 T5 objectOf TCL1,in
R11 E5-ab-5 T6 subjectOf AT,AT patient
R12 E6-ab-5 T6 objectOf patient,AT patient
R13 E4-ab-5 T7 subjectOf PBLs,of
R14 E6-ab-5 T7 objectOf patient,of
R15 E1-ab-6 T8 subjectOf Fluorescence,in
R16 E2-ab-6 T8 objectOf hybridization,in
R17 E6-ab-6 T9 subjectOf AT,AT patient
R18 E7-ab-6 T9 objectOf patient,AT patient
R19 E9-ab-6 T10 subjectOf clonal expansion,with
R20 E7-ab-6 T10 objectOf patient,with
R21 E10-ab-6 T11 subjectOf TCL1,part
R22 E15-ab-6 T11 objectOf chromosome 14,part
R23 E2-ab-7 T12 subjectOf TCL1,activated
R24 E4-ab-7 T12 objectOf clonal cells,activated
R25 E6-ab-7 T13 subjectOf sequences,involving
R26 E5-ab-7 T13 objectOf chromosome translocation,involving

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-85 Sentence denotes TCL1 oncogene activation in preleukemic T cells from a case of ataxia-telangiectasia.
S2 86-331 Sentence denotes The TCL1 oncogene on human chromosome 14q32.1 is involved in chromosome translocations [t(14;14)(q11;q32.1) and t(7;14)(q35;q32.1)] and inversions [inv14(q11;q32.1)] with TCR alpha/beta loci in T-cell leukemias, such as T-prolymphocytic (T-PLL).
S3 332-463 Sentence denotes It is also involved in T-acute and -chronic leukemias arising in cases of ataxia-telangiectasia (AT), an immunodeficiency syndrome.
S4 464-602 Sentence denotes Similar chromosomal rearrangements occur also in the clonally expanded T cells in AT patients before the appearance of the overt leukemia.
S5 603-744 Sentence denotes We have analyzed the expression of TCL1 mRNA and protein in peripheral blood lymphocytes (PBLs) from four AT cases and from healthy controls.
S6 745-942 Sentence denotes We found that the TCL1 gene was overexpressed in the PBLs of an AT patient with a large clonal T-cell population exhibiting the t(14;14) translocation but not in the lymphocytes of the other cases.
S7 943-1248 Sentence denotes Fluorescence in situ hybridization of the TCL1 genomic locus to lymphocyte metaphases from the AT patient with the T-cell clonal expansion showed that the breakpoint of the t(14;14) translocation lies within the TCL1 locus and is accompanied by an inverted duplication of the distal part of chromosome 14.
S8 1249-1413 Sentence denotes These data indicate that TCL1 is activated in preleukemic clonal cells as a consequence of chromosome translocation involving sequences from the TCR locus at 14q11.
S9 1414-1570 Sentence denotes Deregulation of TCL1 is the first event in the initiation of malignancy in these types of leukemias and represents a potential tool for clinical evaluation.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 28-39 cell_type denotes preleukemic
T2 40-47 cell_type denotes T cells
T3 63-84 other_name denotes ataxia-telangiectasia
T4 90-103 DNA_domain_or_region denotes TCL1 oncogene
T5 107-123 DNA_molecule denotes human chromosome
T6 124-131 DNA_molecule denotes 14q32.1
T7 147-172 other_name denotes chromosome translocations
T8 174-193 DNA_domain_or_region denotes t(14;14)(q11;q32.1)
T9 198-216 DNA_domain_or_region denotes t(7;14)(q35;q32.1)
T10 222-232 other_name denotes inversions
T11 234-250 DNA_domain_or_region denotes inv14(q11;q32.1)
T12 257-276 DNA_domain_or_region denotes TCR alpha/beta loci
T13 280-296 other_name denotes T-cell leukemias
T14 306-322 other_name denotes T-prolymphocytic
T15 324-329 other_name denotes T-PLL
T16 406-427 other_name denotes ataxia-telangiectasia
T17 429-431 other_name denotes AT
T18 437-462 other_name denotes immunodeficiency syndrome
T19 535-542 cell_type denotes T cells
T20 546-548 other_name denotes AT
T21 549-557 multi_cell denotes patients
T22 587-601 other_name denotes overt leukemia
T23 638-647 RNA_molecule denotes TCL1 mRNA
T24 652-659 protein_molecule denotes protein
T25 663-691 cell_type denotes peripheral blood lymphocytes
T26 693-697 cell_type denotes PBLs
T27 709-711 other_name denotes AT
T28 727-743 multi_cell denotes healthy controls
T29 763-772 DNA_domain_or_region denotes TCL1 gene
T30 798-802 cell_type denotes PBLs
T31 809-811 other_name denotes AT
T32 827-857 cell_line denotes large clonal T-cell population
T33 873-895 other_name denotes t(14;14) translocation
T34 911-922 cell_type denotes lymphocytes
T35 943-977 other_name denotes Fluorescence in situ hybridization
T36 985-1003 DNA_domain_or_region denotes TCL1 genomic locus
T37 1007-1028 other_name denotes lymphocyte metaphases
T38 1038-1040 other_name denotes AT
T39 1058-1081 other_name denotes T-cell clonal expansion
T40 1155-1165 DNA_domain_or_region denotes TCL1 locus
T41 1191-1211 DNA_substructure denotes inverted duplication
T42 1219-1230 DNA_domain_or_region denotes distal part
T43 1234-1247 DNA_molecule denotes chromosome 14
T44 1274-1278 DNA_domain_or_region denotes TCL1
T45 1295-1319 cell_line denotes preleukemic clonal cells
T46 1340-1364 other_name denotes chromosome translocation
T47 1394-1403 DNA_domain_or_region denotes TCR locus
T48 1407-1412 DNA_domain_or_region denotes 14q11
T49 1430-1434 DNA_domain_or_region denotes TCL1
T50 1504-1513 other_name denotes leukemias
T51 1550-1569 other_name denotes clinical evaluation

metamap-sample

Id Subject Object Predicate Lexical cue
T1 1039-1041 C0004135 denotes T
T2 810-812 C0004135 denotes T
T3 710-712 C0004135 denotes T
T4 547-549 C0004135 denotes T
T5 407-428 C0004135 denotes taxia-telangiectasia
T6 64-85 C0004135 denotes taxia-telangiectasia.
T7 56-60 C0868928 denotes ase
T8 91-104 C2985258 denotes CL1 oncogene
T9 1-14 C2985258 denotes CL1 oncogene
T10 91-104 C2985257 denotes CL1 oncogene
T11 1-14 C2985257 denotes CL1 oncogene
T12 1059-1065 C0039194 denotes -cell
T13 841-847 C0039194 denotes -cell
T14 536-543 C0039194 denotes cells
T15 1341-1365 C0040715 denotes hromosome translocation
T16 1126-1139 C0040715 denotes ranslocation
T17 883-896 C0040715 denotes ranslocation
T18 1008-1017 C0024264 denotes ymphocyte
T19 912-923 C0024264 denotes ymphocytes
T20 944-978 C0162789 denotes luorescence in situ hybridization
T21 258-272 C0085247 denotes CR alpha/beta
T22 1431-1435 C1420650 denotes CL1
T23 1275-1279 C1420650 denotes CL1
T24 764-768 C1420650 denotes CL1
T25 639-643 C1420650 denotes CL1
T26 1019-1029 C1621812 denotes etaphases
T27 1395-1398 C0034790 denotes CR
T28 1042-1049 C0030705 denotes atient
T29 813-820 C0030705 denotes atient
T30 550-558 C0030705 denotes atients
T31 1505-1514 C0023418 denotes eukemias
T32 594-602 C0023418 denotes eukemia.
T33 859-869 C0015272 denotes xhibiting
T34 281-297 C0023492 denotes -cell leukemias,
T35 223-232 C0021943 denotes nversions
T36 769-773 C0017337 denotes ene
T37 1376-1385 C0162326 denotes equences
T38 108-124 C0008643 denotes uman chromosome
T39 874-875 C2603360 denotes (
T40 307-308 C2603360 denotes -
T41 1399-1404 C1708726 denotes ocus
T42 273-277 C1708726 denotes oci
T43 799-803 C0033684 denotes BLs
T44 653-660 C0033684 denotes rotein
T45 937-942 C1533148 denotes ases.
T46 713-718 C1533148 denotes ases
T47 398-403 C1533148 denotes ases
T48 1366-1375 C1314939 denotes nvolving
T49 344-352 C1314939 denotes nvolved
T50 136-144 C1314939 denotes nvolved
T51 848-858 C1257890 denotes opulation
T52 1308-1320 C0009013 denotes lonal cells
T53 991-998 C0017428 denotes enomic
T54 438-463 C0021051 denotes mmunodeficiency syndrome.
T55 799-803 C1518997 denotes BLs
T56 664-692 C1518997 denotes eripheral blood lymphocytes
T57 1408-1413 C1520576 denotes 4q11.
T58 612-620 C0936012 denotes nalyzed
T59 369-385 C1279296 denotes hronic leukemias
T60 1326-1336 C0686907 denotes onsequence
T61 1256-1260 C1511726 denotes ata
T62 500-505 C2745955 denotes ccur
T63 570-580 C0233426 denotes ppearance
T64 749-754 C0150312 denotes ound
T65 1519-1529 C1882932 denotes epresents
T66 1496-1501 C0332307 denotes ypes
T67 1083-1089 C1547282 denotes howed
T68 473-499 C1515001 denotes hromosomal rearrangements
T69 1066-1082 C1516670 denotes lonal expansion
T70 728-744 C2986479 denotes ealthy controls.
T71 387-397 C0332284 denotes rising in
T72 1415-1427 C1880287 denotes eregulation
T73 719-722 C1515981 denotes nd
T74 358-363 C0205178 denotes cute
T75 1283-1292 C1879547 denotes ctivated
T76 901-904 C1518422 denotes ot
T77 1542-1546 C2827396 denotes ool
T78 527-535 C0205229 denotes xpanded
T79 1449-1454 C0441471 denotes vent
T80 1220-1226 C0205108 denotes istal
T81 1192-1200 C0443241 denotes nverted
T82 1227-1231 C0449719 denotes art
T83 778-791 C1514559 denotes verexpressed
T84 465-472 C2348205 denotes imilar
T85 705-709 C0205450 denotes our
T86 834-840 C1704387 denotes lonal
T87 828-833 C0549177 denotes arge
T88 1551-1570 C1261322 denotes linical evaluation.
T89 125-132 C1520600 denotes 4q32.1
T90 1532-1541 C3245505 denotes otential
T91 1443-1448 C1279901 denotes irst
T92 1476-1486 C1306459 denotes alignancy
T93 1462-1472 C1158830 denotes nitiation