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sentences

Id Subject Object Predicate Lexical cue
T1 0-129 Sentence denotes Phosphorylation of the transcription factor NFATp inhibits its DNA binding activity in cyclosporin A-treated human B and T cells.
T2 130-328 Sentence denotes Cyclosporin A (CsA) exerts its immunosuppressive effect by inhibiting the activity of nuclear factor of activated T cells (NFAT), thus preventing transcriptional induction of several cytokine genes.
T3 329-501 Sentence denotes This effect is thought to be largely mediated through inactivation of the phosphatase calcineurin, which in turn inhibits translocation of an NFAT component to the nucleus.
T4 502-701 Sentence denotes Here we report that CsA treatment of Raji B and Jurkat T cell lines yields a phosphorylated form of NFATp that is inhibited in DNA-binding and in its ability to form an NFAT complex with Fos and Jun.
T5 702-932 Sentence denotes Immunoblot analyses and metabolic labeling with [32P]orthophosphate show that CsA alters NFATp migration on SDS-polyacrylamide gel electrophoresis by increasing its phosphorylation level without affecting subcellular distribution.
T6 933-1124 Sentence denotes Dephosphorylation by in vitro treatment with calcineurin or alkaline phosphatase restores NFATp DNA binding activity and its ability to reconstitute an NFAT complex with Fos and Jun proteins.
T7 1125-1254 Sentence denotes These data point to a new mechanism for CsA-sensitive regulation of NFATp in which dephosphorylation is critical for DNA binding.
T1 0-129 Sentence denotes Phosphorylation of the transcription factor NFATp inhibits its DNA binding activity in cyclosporin A-treated human B and T cells.
T2 130-328 Sentence denotes Cyclosporin A (CsA) exerts its immunosuppressive effect by inhibiting the activity of nuclear factor of activated T cells (NFAT), thus preventing transcriptional induction of several cytokine genes.
T3 329-501 Sentence denotes This effect is thought to be largely mediated through inactivation of the phosphatase calcineurin, which in turn inhibits translocation of an NFAT component to the nucleus.
T4 502-701 Sentence denotes Here we report that CsA treatment of Raji B and Jurkat T cell lines yields a phosphorylated form of NFATp that is inhibited in DNA-binding and in its ability to form an NFAT complex with Fos and Jun.
T5 702-932 Sentence denotes Immunoblot analyses and metabolic labeling with [32P]orthophosphate show that CsA alters NFATp migration on SDS-polyacrylamide gel electrophoresis by increasing its phosphorylation level without affecting subcellular distribution.
T6 933-1124 Sentence denotes Dephosphorylation by in vitro treatment with calcineurin or alkaline phosphatase restores NFATp DNA binding activity and its ability to reconstitute an NFAT complex with Fos and Jun proteins.
T7 1125-1254 Sentence denotes These data point to a new mechanism for CsA-sensitive regulation of NFATp in which dephosphorylation is critical for DNA binding.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 23-43 protein denotes transcription factor
T2 44-49 protein denotes NFATp
T3 87-116 cell_line denotes cyclosporin A-treated human B
T4 121-128 cell_type denotes T cells
T5 216-230 protein denotes nuclear factor
T6 244-251 cell_type denotes T cells
T7 253-257 protein denotes NFAT
T8 415-426 protein denotes calcineurin
T9 471-475 protein denotes NFAT
T10 539-545 cell_line denotes Raji B
T11 550-569 cell_line denotes Jurkat T cell lines
T12 602-607 protein denotes NFATp
T13 671-683 protein denotes NFAT complex
T14 689-692 protein denotes Fos
T15 697-700 protein denotes Jun
T16 791-796 protein denotes NFATp
T17 978-989 protein denotes calcineurin
T18 993-1013 protein denotes alkaline phosphatase
T19 1023-1028 protein denotes NFATp
T20 1085-1097 protein denotes NFAT complex
T21 1103-1106 protein denotes Fos
T22 1111-1114 protein denotes Jun
T23 1193-1198 protein denotes NFATp

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 19-49 NP denotes the transcription factor NFATp
C3 59-62 NP denotes its
C2 59-83 NP denotes its DNA binding activity
C4 130-149 NP denotes Cyclosporin A (CsA)
C5 157-160 NP denotes its
C6 383-426 NP denotes inactivation of the phosphatase calcineurin
C7 428-433 NP denotes which
C9 602-607 NP denotes NFATp
C8 577-607 NP denotes a phosphorylated form of NFATp
C10 608-612 NP denotes that
C12 648-651 NP denotes its
C11 648-700 NP denotes its ability to form an NFAT complex with Fos and Jun
C13 780-783 NP denotes CsA
C14 863-866 NP denotes its
C15 1023-1049 NP denotes NFATp DNA binding activity
C17 1054-1057 NP denotes its
C16 1054-1123 NP denotes its ability to reconstitute an NFAT complex with Fos and Jun proteins
C19 1193-1198 NP denotes NFATp
C18 1165-1198 NP denotes CsA-sensitive regulation of NFATp
C20 1202-1207 NP denotes which
R1 C3 C1 coref-pron its,the transcription factor NFATp
R2 C5 C4 coref-pron its,Cyclosporin A (CsA)
R3 C7 C6 coref-relat which,inactivation of the phosphatase calcineurin
R4 C9 C1 coref-ident NFATp,the transcription factor NFATp
R5 C10 C8 coref-relat that,a phosphorylated form of NFATp
R6 C12 C9 coref-pron its,NFATp
R7 C13 C4 coref-ident CsA,Cyclosporin A (CsA)
R8 C14 C9 coref-pron its,NFATp
R9 C15 C2 coref-ident NFATp DNA binding activity,its DNA binding activity
R10 C17 C11 coref-ident its,its ability to form an NFAT complex with Fos and Jun
R11 C16 C9 coref-pron its ability to reconstitute an NFAT complex with Fos and Jun proteins,NFATp
R12 C19 C9 coref-ident NFATp,NFATp
R13 C20 C18 coref-relat which,CsA-sensitive regulation of NFATp

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-129 Sentence denotes Phosphorylation of the transcription factor NFATp inhibits its DNA binding activity in cyclosporin A-treated human B and T cells.
S2 130-328 Sentence denotes Cyclosporin A (CsA) exerts its immunosuppressive effect by inhibiting the activity of nuclear factor of activated T cells (NFAT), thus preventing transcriptional induction of several cytokine genes.
S3 329-501 Sentence denotes This effect is thought to be largely mediated through inactivation of the phosphatase calcineurin, which in turn inhibits translocation of an NFAT component to the nucleus.
S4 502-701 Sentence denotes Here we report that CsA treatment of Raji B and Jurkat T cell lines yields a phosphorylated form of NFATp that is inhibited in DNA-binding and in its ability to form an NFAT complex with Fos and Jun.
S5 702-932 Sentence denotes Immunoblot analyses and metabolic labeling with [32P]orthophosphate show that CsA alters NFATp migration on SDS-polyacrylamide gel electrophoresis by increasing its phosphorylation level without affecting subcellular distribution.
S6 933-1124 Sentence denotes Dephosphorylation by in vitro treatment with calcineurin or alkaline phosphatase restores NFATp DNA binding activity and its ability to reconstitute an NFAT complex with Fos and Jun proteins.
S7 1125-1254 Sentence denotes These data point to a new mechanism for CsA-sensitive regulation of NFATp in which dephosphorylation is critical for DNA binding.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 23-43 protein_family_or_group denotes transcription factor
T2 44-49 protein_molecule denotes NFATp
T3 63-83 other_name denotes DNA binding activity
T4 87-116 cell_line denotes cyclosporin A-treated human B
T5 121-128 cell_type denotes T cells
T6 130-143 other_organic_compound denotes Cyclosporin A
T7 145-148 other_organic_compound denotes CsA
T8 216-230 protein_family_or_group denotes nuclear factor
T9 244-251 cell_type denotes T cells
T10 253-257 protein_family_or_group denotes NFAT
T11 415-426 protein_molecule denotes calcineurin
T12 471-475 protein_family_or_group denotes NFAT
T13 522-525 other_organic_compound denotes CsA
T14 539-545 cell_line denotes Raji B
T15 550-556 cell_line denotes Jurkat
T16 557-569 cell_line denotes T cell lines
T17 602-607 protein_molecule denotes NFATp
T18 671-683 protein_complex denotes NFAT complex
T19 689-692 protein_family_or_group denotes Fos
T20 697-700 protein_family_or_group denotes Jun
T21 702-721 other_name denotes Immunoblot analyses
T22 750-769 other_organic_compound denotes [32P]orthophosphate
T23 780-783 other_organic_compound denotes CsA
T24 791-796 protein_molecule denotes NFATp
T25 810-848 other_name denotes SDS-polyacrylamide gel electrophoresis
T26 867-888 other_name denotes phosphorylation level
T27 954-972 other_name denotes in vitro treatment
T28 978-989 protein_molecule denotes calcineurin
T29 993-1013 protein_molecule denotes alkaline phosphatase
T30 1023-1028 protein_molecule denotes NFATp
T31 1029-1049 other_name denotes DNA binding activity
T32 1085-1097 protein_complex denotes NFAT complex
T33 1103-1106 protein_family_or_group denotes Fos
T34 1111-1114 protein_family_or_group denotes Jun
T35 1165-1168 other_organic_compound denotes CsA
T36 1193-1198 protein_molecule denotes NFATp
T37 1208-1225 other_name denotes dephosphorylation

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 109-114 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 493-500 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125
T3 557-563 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 121-128 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T2 244-251 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T3 557-563 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084