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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 37-46 protein denotes IFN-gamma
T2 69-73 protein denotes IL-2
T3 78-83 protein denotes IL-12
T4 89-107 cell_line denotes human NK cell line
T5 109-125 protein denotes Interferon-gamma
T6 127-136 protein denotes IFN-gamma
T7 154-178 protein denotes immunoregulatory protein
T8 205-212 cell_type denotes T cells
T9 217-243 cell_type denotes large granular lymphocytes
T10 245-248 cell_type denotes LGL
T11 317-329 protein denotes interleukins
T12 331-334 protein denotes ILs
T13 337-341 protein denotes IL-2
T14 346-351 protein denotes IL-12
T15 394-403 protein denotes IFN-gamma
T16 428-435 cell_type denotes T cells
T17 440-443 cell_type denotes LGL
T18 495-507 cell_line denotes T cell lines
T19 521-530 protein denotes IFN-gamma
T20 611-640 cell_line denotes natural killer (NK) cell line
T21 720-735 cell_line denotes cell line NK3.3
T22 749-763 cell_type denotes human NK cells
T23 782-786 protein denotes IL-2
T24 791-796 protein denotes IL-12
T25 826-835 protein denotes IFN-gamma
T26 840-888 protein denotes granulocyte-macrophage colony-stimulating factor
T27 890-896 protein denotes GM-CSF
T28 971-975 protein denotes IL-2
T29 980-985 protein denotes IL-12
T30 1017-1026 protein denotes IFN-gamma
T31 1031-1037 protein denotes GM-CSF
T32 1120-1146 RNA denotes IFN-gamma and GM-CSF mRNAs
T33 1256-1287 protein denotes transforming growth factor-beta
T34 1374-1378 protein denotes IL-2
T35 1383-1388 protein denotes IL-12
T36 1392-1403 cell_line denotes NK3.3 cells
T37 1444-1460 protein denotes protein kinase C
T38 1509-1513 protein denotes IL-2
T39 1527-1564 RNA denotes IFN-gamma and GM-CSF cytoplasmic mRNA
T40 1579-1584 protein denotes IL-12
T41 1598-1624 RNA denotes IFN-gamma cytoplasmic mRNA
T42 1675-1691 protein denotes protein kinase C
T43 1711-1742 protein denotes transforming growth factor-beta
T44 1802-1806 protein denotes IL-2
T45 1811-1816 protein denotes IL-12
T46 1900-1913 DNA denotes cytokine gene
T47 2006-2010 protein denotes IL-2
T48 2019-2024 protein denotes IL-12
T49 2033-2048 protein denotes nuclear factors
T50 2049-2059 protein denotes NF-kappa B
T51 2064-2067 protein denotes AP1
T52 2119-2148 protein denotes DNA binding protein complexes
T53 2231-2235 protein denotes IL-2
T54 2240-2245 protein denotes IL-12
T55 2311-2320 protein denotes IFN-gamma
T56 2325-2331 protein denotes GM-CSF
T57 2362-2377 cell_line denotes NK3.3 cell line

genia-medco-coref

Id Subject Object Predicate Lexical cue
C58 69-73 NP denotes IL-2
C59 78-83 NP denotes IL-12
C72 87-107 NP denotes a human NK cell line
C3 109-137 NP denotes Interferon-gamma (IFN-gamma)
C9 205-212 NP denotes T cells
C4 217-249 NP denotes large granular lymphocytes (LGL)
C5 313-335 NP denotes two interleukins (ILs)
C60 337-341 NP denotes IL-2
C61 346-351 NP denotes IL-12
C10 428-435 NP denotes T cells
C11 440-443 NP denotes LGL
C12 490-507 NP denotes some T cell lines
C13 508-512 NP denotes that
C14 521-530 NP denotes IFN-gamma
C15 609-640 NP denotes a natural killer (NK) cell line
C16 641-645 NP denotes that
C17 702-710 NP denotes evidence
C18 711-715 NP denotes that
C28 716-763 NP denotes the cell line NK3.3 derived from human NK cells
C62 782-786 NP denotes IL-2
C63 791-796 NP denotes IL-12
C23 826-835 NP denotes IFN-gamma
C31 840-914 NP denotes granulocyte-macrophage colony-stimulating factor (GM-CSF) cytoplasmic mRNA
C64 971-975 NP denotes IL-2
C65 980-985 NP denotes IL-12
C25 1017-1026 NP denotes IFN-gamma
C26 1116-1129 NP denotes the IFN-gamma
C45 1218-1233 NP denotes five inhibitors
C46 1235-1254 NP denotes cyclosporin A (CsA)
C43 1235-1334 NP denotes cyclosporin A (CsA), transforming growth factor-beta, cycloheximide, genistein, and staurosporine A
C66 1374-1378 NP denotes IL-2
C67 1383-1388 NP denotes IL-12
C29 1392-1403 NP denotes NK3.3 cells
C36 1444-1460 NP denotes protein kinase C
C38 1430-1460 NP denotes activation of protein kinase C
C30 1527-1536 NP denotes IFN-gamma
C32 1541-1564 NP denotes GM-CSF cytoplasmic mRNA
C34 1509-1564 NP denotes IL-2 induction of IFN-gamma and GM-CSF cytoplasmic mRNA
C35 1579-1624 NP denotes IL-12 induction of IFN-gamma cytoplasmic mRNA
C37 1675-1691 NP denotes protein kinase C
C39 1661-1691 NP denotes activation of protein kinase C
C48 1706-1710 NP denotes both
C41 1724-1756 NP denotes growth factor-beta and genistein
C42 1758-1785 NP denotes a tyrosine kinase inhibitor
C40 1706-1785 NP denotes both transforming growth factor-beta and genistein, a tyrosine kinase inhibitor
C44 1831-1834 NP denotes CsA
C47 1928-1940 NP denotes these agents
C68 2006-2010 NP denotes IL-2
C69 2019-2024 NP denotes IL-12
C51 2033-2067 NP denotes nuclear factors NF-kappa B and AP1
C49 2109-2148 NP denotes these two DNA binding protein complexes
C50 2168-2177 NP denotes IFN-gamma
C53 2182-2204 NP denotes GM-CSF gene expression
C70 2231-2235 NP denotes IL-2
C71 2240-2245 NP denotes IL-12
C52 2311-2320 NP denotes IFN-gamma
C54 2325-2347 NP denotes GM-CSF gene expression
C56 2255-2347 NP denotes distinct signaling pathways leading to the induction of IFN-gamma and GM-CSF gene expression
C55 2358-2377 NP denotes the NK3.3 cell line
C57 2469-2483 NP denotes these pathways
R1 C60 C5 coref-part-whole IL-2,two interleukins (ILs)
R2 C61 C5 coref-part-whole IL-12,two interleukins (ILs)
R3 C10 C9 coref-ident T cells,T cells
R4 C11 C4 coref-ident LGL,large granular lymphocytes (LGL)
R5 C12 C10 coref-part-whole some T cell lines,T cells
R6 C13 C12 coref-relat that,some T cell lines
R7 C14 C3 coref-ident IFN-gamma,Interferon-gamma (IFN-gamma)
R8 C16 C15 coref-relat that,a natural killer (NK) cell line
R9 C18 C17 coref-relat that,evidence
R10 C28 C72 coref-ident the cell line NK3.3 derived from human NK cells,a human NK cell line
R11 C62 C58 coref-ident IL-2,IL-2
R12 C63 C59 coref-ident IL-12,IL-12
R13 C23 C14 coref-ident IFN-gamma,IFN-gamma
R14 C64 C62 coref-ident IL-2,IL-2
R15 C65 C63 coref-ident IL-12,IL-12
R16 C25 C23 coref-ident IFN-gamma,IFN-gamma
R17 C26 C25 coref-ident the IFN-gamma,IFN-gamma
R18 C46 C45 coref-appos cyclosporin A (CsA),five inhibitors
R19 C66 C64 coref-ident IL-2,IL-2
R20 C67 C65 coref-ident IL-12,IL-12
R21 C29 C28 coref-ident NK3.3 cells,the cell line NK3.3 derived from human NK cells
R22 C30 C26 coref-ident IFN-gamma,the IFN-gamma
R23 C32 C31 coref-ident GM-CSF cytoplasmic mRNA,granulocyte-macrophage colony-stimulating factor (GM-CSF) cytoplasmic mRNA
R24 C37 C36 coref-ident protein kinase C,protein kinase C
R25 C39 C38 coref-ident activation of protein kinase C,activation of protein kinase C
R26 C42 C41 coref-appos a tyrosine kinase inhibitor,growth factor-beta and genistein
R27 C40 C34 coref-whole-part "both transforming growth factor-beta and genistein, a tyrosine kinase inhibitor",IL-2 induction of IFN-gamma and GM-CSF cytoplasmic mRNA
R28 C44 C43 coref-ident CsA,"cyclosporin A (CsA), transforming growth factor-beta, cycloheximide, genistein, and staurosporine A"
R29 C47 C48 coref-ident these agents,both
R30 C68 C66 coref-ident IL-2,IL-2
R31 C69 C67 coref-ident IL-12,IL-12
R32 C49 C51 coref-ident these two DNA binding protein complexes,nuclear factors NF-kappa B and AP1
R33 C50 C30 coref-ident IFN-gamma,IFN-gamma
R34 C70 C68 coref-ident IL-2,IL-2
R35 C71 C69 coref-ident IL-12,IL-12
R36 C52 C50 coref-ident IFN-gamma,IFN-gamma
R37 C54 C53 coref-ident GM-CSF gene expression,GM-CSF gene expression
R38 C55 C29 coref-ident the NK3.3 cell line,NK3.3 cells
R39 C57 C56 coref-ident these pathways,distinct signaling pathways leading to the induction of IFN-gamma and GM-CSF gene expression

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-108 Sentence denotes Cellular and molecular mechanisms of IFN-gamma production induced by IL-2 and IL-12 in a human NK cell line.
S2 109-297 Sentence denotes Interferon-gamma (IFN-gamma) is an important immunoregulatory protein produced predominantly by T cells and large granular lymphocytes (LGL) in response to different extracellular signals.
S3 298-444 Sentence denotes In particular, two interleukins (ILs), IL-2 and IL-12, have been shown to be potent inducers of IFN-gamma gene expression in both T cells and LGL.
S4 445-675 Sentence denotes Although it has been reported that there are some T cell lines that produce IFN-gamma in response to IL-2 and IL-12 stimulation, there has as yet been no report of a natural killer (NK) cell line that responds in a similar manner.
S5 676-938 Sentence denotes In this report we present evidence that the cell line NK3.3 derived from human NK cells, responds to both IL-2 and IL-12, as measured by increases in IFN-gamma and granulocyte-macrophage colony-stimulating factor (GM-CSF) cytoplasmic mRNA and protein expression.
S6 939-1147 Sentence denotes In addition, when used together IL-2 and IL-12 synergized in the induction of IFN-gamma and GM-CSF and this synergy was attributed to an increased accumulation and stability of the IFN-gamma and GM-CSF mRNAs.
S7 1148-1404 Sentence denotes To investigate the signaling pathways involved in the gene induction, five inhibitors, cyclosporin A (CsA), transforming growth factor-beta, cycloheximide, genistein, and staurosporine A, were used in analyzing the effects of IL-2 and IL-12 on NK3.3 cells.
S8 1405-1565 Sentence denotes The results suggest that activation of protein kinase C, but not new protein synthesis, is required for IL-2 induction of IFN-gamma and GM-CSF cytoplasmic mRNA.
S9 1566-1692 Sentence denotes In contrast, IL-12 induction of IFN-gamma cytoplasmic mRNA appears to only partially depend on activation of protein kinase C.
S10 1693-1858 Sentence denotes Furthermore, both transforming growth factor-beta and genistein, a tyrosine kinase inhibitor, could suppress IL-2 and IL-12 signaling but CsA was generally inactive.
S11 1859-1992 Sentence denotes It also was observed that suppression of cytokine gene expression by these agents was independent of the inhibition of proliferation.
S12 1993-2205 Sentence denotes In addition, IL-2 but not IL-12 induced nuclear factors NF-kappa B and AP1, and regulation of the nuclear levels of these two DNA binding protein complexes is correlated with IFN-gamma and GM-CSF gene expression.
S13 2206-2484 Sentence denotes These data indicate that IL-2 and IL-12 may have distinct signaling pathways leading to the induction of IFN-gamma and GM-CSF gene expression, and that the NK3.3 cell line may serve as a novel model for dissecting the biochemical and molecular events involved in these pathways.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 37-46 protein_molecule denotes IFN-gamma
T2 69-73 protein_molecule denotes IL-2
T3 78-83 protein_molecule denotes IL-12
T4 89-107 cell_line denotes human NK cell line
T5 109-125 protein_molecule denotes Interferon-gamma
T6 127-136 protein_molecule denotes IFN-gamma
T7 154-178 protein_molecule denotes immunoregulatory protein
T8 205-212 cell_type denotes T cells
T9 217-243 cell_type denotes large granular lymphocytes
T10 245-248 cell_type denotes LGL
T11 275-296 other_name denotes extracellular signals
T12 317-329 protein_family_or_group denotes interleukins
T13 331-334 protein_family_or_group denotes ILs
T14 337-341 protein_molecule denotes IL-2
T15 346-351 protein_molecule denotes IL-12
T16 394-403 protein_molecule denotes IFN-gamma
T17 428-435 cell_type denotes T cells
T18 440-443 cell_type denotes LGL
T19 495-507 cell_line denotes T cell lines
T20 521-530 protein_molecule denotes IFN-gamma
T21 611-640 cell_line denotes natural killer (NK) cell line
T22 720-735 cell_line denotes cell line NK3.3
T23 749-763 cell_type denotes human NK cells
T24 782-786 protein_molecule denotes IL-2
T25 791-796 protein_molecule denotes IL-12
T26 826-835 protein_molecule denotes IFN-gamma
T27 840-888 protein_molecule denotes granulocyte-macrophage colony-stimulating factor
T28 890-896 protein_molecule denotes GM-CSF
T29 971-975 protein_molecule denotes IL-2
T30 980-985 protein_molecule denotes IL-12
T31 1017-1026 protein_molecule denotes IFN-gamma
T32 1031-1037 protein_molecule denotes GM-CSF
T33 1120-1129 RNA_molecule denotes IFN-gamma
T34 1134-1140 protein_molecule denotes GM-CSF
T35 1235-1248 other_organic_compound denotes cyclosporin A
T36 1250-1253 other_organic_compound denotes CsA
T37 1256-1287 protein_molecule denotes transforming growth factor-beta
T38 1289-1302 other_organic_compound denotes cycloheximide
T39 1304-1313 other_organic_compound denotes genistein
T40 1319-1334 other_organic_compound denotes staurosporine A
T41 1374-1378 protein_molecule denotes IL-2
T42 1383-1388 protein_molecule denotes IL-12
T43 1392-1403 cell_line denotes NK3.3 cells
T44 1444-1460 protein_molecule denotes protein kinase C
T45 1470-1491 other_name denotes new protein synthesis
T46 1509-1513 protein_molecule denotes IL-2
T47 1579-1584 protein_molecule denotes IL-12
T48 1598-1607 protein_molecule denotes IFN-gamma
T49 1675-1691 protein_molecule denotes protein kinase C
T50 1711-1742 protein_molecule denotes transforming growth factor-beta
T51 1747-1756 other_organic_compound denotes genistein
T52 1760-1785 other_name denotes tyrosine kinase inhibitor
T53 1802-1806 protein_molecule denotes IL-2
T54 1811-1816 protein_molecule denotes IL-12
T55 1831-1834 other_organic_compound denotes CsA
T56 1900-1913 DNA_family_or_group denotes cytokine gene
T57 1964-1991 other_name denotes inhibition of proliferation
T58 2006-2010 protein_molecule denotes IL-2
T59 2019-2024 protein_molecule denotes IL-12
T60 2033-2048 protein_family_or_group denotes nuclear factors
T61 2049-2059 protein_molecule denotes NF-kappa B
T62 2064-2067 protein_molecule denotes AP1
T63 2091-2105 other_name denotes nuclear levels
T64 2119-2148 protein_complex denotes DNA binding protein complexes
T65 2231-2235 protein_molecule denotes IL-2
T66 2240-2245 protein_molecule denotes IL-12
T67 2264-2282 other_name denotes signaling pathways
T68 2311-2320 protein_molecule denotes IFN-gamma
T69 2325-2331 protein_molecule denotes GM-CSF
T70 2362-2377 cell_line denotes NK3.3 cell line
T71 2424-2456 other_name denotes biochemical and molecular events