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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 78-85 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T2 114-121 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T3 268-274 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T4 294-301 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T5 633-639 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T6 1202-1209 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T7 1233-1240 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T8 1439-1446 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T9 1536-1547 Cell denotes granulocyte http://purl.obolibrary.org/obo/CL:0000094
T10 1548-1558 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T12 1611-1617 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084

sentences

Id Subject Object Predicate Lexical cue
T1 0-86 Sentence denotes HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells.
T2 87-473 Sentence denotes Activation of CD4 positive T cells is a primary requirement for human immunodeficiency virus (HIV) entry, efficient HIV replication, and progression to AIDS, Utilizing CD4 positive T cell lines and purified T cells from normal individuals, we have demonstrated that native envelope glycoproteins of HIV, gp 160, can induce activation of transcription factor, activated protein-1 (AP-1).
T3 474-679 Sentence denotes The stimulatory effects of gp160 are mediated through the CD4 molecule, since treatment of gp160 with soluble CD4-IgG abrogates its activity, and CD4 negative T cell lines fail to be stimulated with gp160.
T4 680-870 Sentence denotes Immunoprecipitation of the gp 160-induced nuclear extracts with polyclonal antibodies to Fos and Jun proteins indicates that AP-1 complex is comprised of members of these family of proteins.
T5 871-990 Sentence denotes The gp160-induced AP-1 complex is dependent upon protein tyrosine phosphorylation and is protein synthesis-independent.
T6 991-1131 Sentence denotes This stimulation can also be abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blocker or cyclosporine A.
T7 1132-1327 Sentence denotes This gp160 treatment adversely affects the functional capabilities of T cells: pre-treatment of CD4+ T cells with gp160 for 4 h at 37 degrees C inhibited anti-CD3-induced interleukin-2 secretion.
T8 1328-1381 Sentence denotes Effects similar to gp160 were seen with anti-CD4 mAb.
T9 1382-1673 Sentence denotes The aberrant activation of AP-1 by gp160 in CD4 positive T cells could result in up-regulation of cytokines containing AP-1 sites, e.g. interleukin-3 and granulocyte macrophage colony-stimulating factor, and concurrently lead to T cell unresponsiveness by inhibiting interleukin-2 secretion.
T1 0-86 Sentence denotes HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells.
T2 87-473 Sentence denotes Activation of CD4 positive T cells is a primary requirement for human immunodeficiency virus (HIV) entry, efficient HIV replication, and progression to AIDS, Utilizing CD4 positive T cell lines and purified T cells from normal individuals, we have demonstrated that native envelope glycoproteins of HIV, gp 160, can induce activation of transcription factor, activated protein-1 (AP-1).
T3 474-679 Sentence denotes The stimulatory effects of gp160 are mediated through the CD4 molecule, since treatment of gp160 with soluble CD4-IgG abrogates its activity, and CD4 negative T cell lines fail to be stimulated with gp160.
T4 680-870 Sentence denotes Immunoprecipitation of the gp 160-induced nuclear extracts with polyclonal antibodies to Fos and Jun proteins indicates that AP-1 complex is comprised of members of these family of proteins.
T5 871-990 Sentence denotes The gp160-induced AP-1 complex is dependent upon protein tyrosine phosphorylation and is protein synthesis-independent.
T6 991-1131 Sentence denotes This stimulation can also be abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blocker or cyclosporine A.
T7 1132-1327 Sentence denotes This gp160 treatment adversely affects the functional capabilities of T cells: pre-treatment of CD4+ T cells with gp160 for 4 h at 37 degrees C inhibited anti-CD3-induced interleukin-2 secretion.
T8 1328-1381 Sentence denotes Effects similar to gp160 were seen with anti-CD4 mAb.
T9 1382-1673 Sentence denotes The aberrant activation of AP-1 by gp160 in CD4 positive T cells could result in up-regulation of cytokines containing AP-1 sites, e.g. interleukin-3 and granulocyte macrophage colony-stimulating factor, and concurrently lead to T cell unresponsiveness by inhibiting interleukin-2 secretion.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-28 protein denotes HIV-1 envelope glycoproteins
T2 60-69 protein denotes protein-1
T3 73-85 cell_type denotes CD4+ T cells
T4 101-121 cell_type denotes CD4 positive T cells
T5 255-280 cell_line denotes CD4 positive T cell lines
T6 285-301 cell_type denotes purified T cells
T7 353-382 protein denotes native envelope glycoproteins
T8 391-397 protein denotes gp 160
T9 424-465 protein denotes transcription factor, activated protein-1
T10 467-471 protein denotes AP-1
T11 501-506 protein denotes gp160
T12 532-544 protein denotes CD4 molecule
T13 565-570 protein denotes gp160
T14 584-591 protein denotes CD4-IgG
T15 620-645 cell_line denotes CD4 negative T cell lines
T16 673-678 protein denotes gp160
T17 707-713 protein denotes gp 160
T18 744-765 protein denotes polyclonal antibodies
T19 769-772 protein denotes Fos
T20 777-789 protein denotes Jun proteins
T21 805-817 protein denotes AP-1 complex
T22 875-901 protein denotes gp160-induced AP-1 complex
T23 1047-1063 protein denotes protein kinase C
T24 1137-1142 protein denotes gp160
T25 1202-1209 cell_type denotes T cells
T26 1228-1240 cell_type denotes CD4+ T cells
T27 1246-1251 protein denotes gp160
T28 1286-1294 protein denotes anti-CD3
T29 1303-1316 protein denotes interleukin-2
T30 1347-1352 protein denotes gp160
T31 1368-1380 protein denotes anti-CD4 mAb
T32 1409-1413 protein denotes AP-1
T33 1417-1422 protein denotes gp160
T34 1426-1446 cell_type denotes CD4 positive T cells
T35 1480-1489 protein denotes cytokines
T36 1501-1511 DNA denotes AP-1 sites
T37 1518-1531 protein denotes interleukin-3
T38 1536-1584 protein denotes granulocyte macrophage colony-stimulating factor
T39 1611-1617 cell_type denotes T cell
T40 1649-1662 protein denotes interleukin-2

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-86 Sentence denotes HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells.
S2 87-244 Sentence denotes Activation of CD4 positive T cells is a primary requirement for human immunodeficiency virus (HIV) entry, efficient HIV replication, and progression to AIDS,
S3 245-473 Sentence denotes Utilizing CD4 positive T cell lines and purified T cells from normal individuals, we have demonstrated that native envelope glycoproteins of HIV, gp 160, can induce activation of transcription factor, activated protein-1 (AP-1).
S4 474-679 Sentence denotes The stimulatory effects of gp160 are mediated through the CD4 molecule, since treatment of gp160 with soluble CD4-IgG abrogates its activity, and CD4 negative T cell lines fail to be stimulated with gp160.
S5 680-870 Sentence denotes Immunoprecipitation of the gp 160-induced nuclear extracts with polyclonal antibodies to Fos and Jun proteins indicates that AP-1 complex is comprised of members of these family of proteins.
S6 871-990 Sentence denotes The gp160-induced AP-1 complex is dependent upon protein tyrosine phosphorylation and is protein synthesis-independent.
S7 991-1131 Sentence denotes This stimulation can also be abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blocker or cyclosporine A.
S8 1132-1327 Sentence denotes This gp160 treatment adversely affects the functional capabilities of T cells: pre-treatment of CD4+ T cells with gp160 for 4 h at 37 degrees C inhibited anti-CD3-induced interleukin-2 secretion.
S9 1328-1381 Sentence denotes Effects similar to gp160 were seen with anti-CD4 mAb.
S10 1382-1673 Sentence denotes The aberrant activation of AP-1 by gp160 in CD4 positive T cells could result in up-regulation of cytokines containing AP-1 sites, e.g. interleukin-3 and granulocyte macrophage colony-stimulating factor, and concurrently lead to T cell unresponsiveness by inhibiting interleukin-2 secretion.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-28 NP denotes HIV-1 envelope glycoproteins
C3 50-69 NP denotes activated protein-1
C2 36-69 NP denotes activation of activated protein-1
C4 73-85 NP denotes CD4+ T cells
C5 101-121 NP denotes CD4 positive T cells
C6 255-280 NP denotes CD4 positive T cell lines
C7 353-389 NP denotes native envelope glycoproteins of HIV
C8 391-397 NP denotes gp 160
C10 424-444 NP denotes transcription factor
C11 446-472 NP denotes activated protein-1 (AP-1)
C9 410-472 NP denotes activation of transcription factor, activated protein-1 (AP-1)
C12 501-506 NP denotes gp160
C13 565-570 NP denotes gp160
C14 602-605 NP denotes its
C15 673-678 NP denotes gp160
C16 769-789 NP denotes Fos and Jun proteins
C17 805-817 NP denotes AP-1 complex
C18 845-869 NP denotes these family of proteins
C19 871-901 NP denotes The gp160-induced AP-1 complex
C20 991-1007 NP denotes This stimulation
C21 1069-1071 NP denotes it
C22 1228-1240 NP denotes CD4+ T cells
C23 1246-1251 NP denotes gp160
C24 1286-1326 NP denotes anti-CD3-induced interleukin-2 secretion
C25 1347-1352 NP denotes gp160
C26 1409-1413 NP denotes AP-1
C27 1417-1422 NP denotes gp160
C28 1426-1446 NP denotes CD4 positive T cells
C29 1649-1672 NP denotes interleukin-2 secretion
R1 C5 C4 coref-ident CD4 positive T cells,CD4+ T cells
R2 C6 C5 coref-ident CD4 positive T cell lines,CD4 positive T cells
R3 C7 C1 coref-ident native envelope glycoproteins of HIV,HIV-1 envelope glycoproteins
R4 C8 C7 coref-appos gp 160,native envelope glycoproteins of HIV
R5 C10 C3 coref-ident transcription factor,activated protein-1
R6 C11 C10 coref-appos activated protein-1 (AP-1),transcription factor
R7 C9 C2 coref-ident "activation of transcription factor, activated protein-1 (AP-1)",activation of activated protein-1
R8 C12 C7 coref-ident gp160,native envelope glycoproteins of HIV
R9 C13 C12 coref-ident gp160,gp160
R10 C14 C13 coref-pron its,gp160
R11 C15 C13 coref-ident gp160,gp160
R12 C18 C16 coref-ident these family of proteins,Fos and Jun proteins
R13 C19 C17 coref-ident The gp160-induced AP-1 complex,AP-1 complex
R14 C21 C20 coref-pron it,This stimulation
R15 C22 C5 coref-ident CD4+ T cells,CD4 positive T cells
R16 C23 C15 coref-ident gp160,gp160
R17 C25 C23 coref-ident gp160,gp160
R18 C26 C10 coref-ident AP-1,transcription factor
R19 C27 C25 coref-ident gp160,gp160
R20 C28 C22 coref-ident CD4 positive T cells,CD4+ T cells
R21 C29 C24 coref-ident interleukin-2 secretion,anti-CD3-induced interleukin-2 secretion

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-5 virus denotes HIV-1
T2 60-69 protein_molecule denotes protein-1
T3 73-77 cell_type denotes CD4+
T4 78-85 cell_type denotes T cells
T5 101-113 cell_type denotes CD4 positive
T6 114-121 cell_type denotes T cells
T7 151-179 virus denotes human immunodeficiency virus
T8 181-184 virus denotes HIV
T9 203-206 virus denotes HIV
T10 239-243 other_name denotes AIDS
T11 255-280 cell_line denotes CD4 positive T cell lines
T12 285-293 cell_type denotes purified
T13 294-301 cell_type denotes T cells
T14 307-325 multi_cell denotes normal individuals
T15 353-382 protein_family_or_group denotes native envelope glycoproteins
T16 386-389 virus denotes HIV
T17 391-397 protein_molecule denotes gp 160
T18 424-465 protein_molecule denotes transcription factor, activated protein-1
T19 467-471 protein_molecule denotes AP-1
T20 501-506 protein_molecule denotes gp160
T21 532-544 protein_molecule denotes CD4 molecule
T22 565-570 protein_molecule denotes gp160
T23 584-591 protein_molecule denotes CD4-IgG
T24 620-645 cell_line denotes CD4 negative T cell lines
T25 673-678 protein_molecule denotes gp160
T26 707-713 protein_molecule denotes gp 160
T27 722-738 cell_component denotes nuclear extracts
T28 744-765 protein_family_or_group denotes polyclonal antibodies
T29 769-772 protein_family_or_group denotes Fos
T30 777-789 protein_family_or_group denotes Jun proteins
T31 805-809 protein_molecule denotes AP-1
T32 875-880 protein_molecule denotes gp160
T33 889-893 protein_molecule denotes AP-1
T34 920-952 other_name denotes protein tyrosine phosphorylation
T35 960-989 other_name denotes protein synthesis-independent
T36 1047-1063 protein_molecule denotes protein kinase C
T37 1089-1112 other_organic_compound denotes calcium channel blocker
T38 1116-1130 other_organic_compound denotes cyclosporine A
T39 1137-1142 protein_molecule denotes gp160
T40 1202-1209 cell_type denotes T cells
T41 1228-1232 cell_type denotes CD4+
T42 1233-1240 cell_type denotes T cells
T43 1246-1251 protein_molecule denotes gp160
T44 1286-1294 protein_molecule denotes anti-CD3
T45 1303-1316 protein_molecule denotes interleukin-2
T46 1347-1352 protein_molecule denotes gp160
T47 1368-1380 protein_molecule denotes anti-CD4 mAb
T48 1409-1413 protein_molecule denotes AP-1
T49 1417-1422 protein_molecule denotes gp160
T50 1426-1438 cell_type denotes CD4 positive
T51 1439-1446 cell_type denotes T cells
T52 1480-1489 protein_family_or_group denotes cytokines
T53 1501-1505 protein_molecule denotes AP-1
T54 1518-1531 protein_molecule denotes interleukin-3
T55 1536-1584 protein_molecule denotes granulocyte macrophage colony-stimulating factor
T56 1611-1617 cell_type denotes T cell
T57 1649-1662 protein_molecule denotes interleukin-2

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 157-173 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T2 239-243 Disease denotes AIDS http://purl.obolibrary.org/obo/MONDO_0012268

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 157-173 Phenotype denotes immunodeficiency HP:0002721
T2 1618-1634 Phenotype denotes unresponsiveness HP:0025237

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 151-156 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 6-14 Body_part denotes envelope http://purl.obolibrary.org/obo/GO_0031975
T2 268-274 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T3 360-368 Body_part denotes envelope http://purl.obolibrary.org/obo/GO_0031975
T4 633-639 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T5 1536-1547 Body_part denotes granulocyte http://purl.obolibrary.org/obo/CL_0000094
T6 1548-1558 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T7 1611-1617 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084