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PubMed:7640302 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 14-24 RNA denotes c-jun mRNA
T2 54-70 cell_line denotes human K562 cells
T3 259-275 protein denotes fetal hemoglobin
T4 406-411 DNA denotes c-jun
T5 474-484 cell_line denotes K562 cells
T6 529-534 DNA denotes c-jun
T7 560-570 RNA denotes c-jun mRNA
T8 775-785 RNA denotes c-jun mRNA
T9 860-870 RNA denotes c-jun mRNA
T10 898-909 protein denotes jun protein
T11 952-968 cell_line denotes HU treated cells
T12 1047-1051 protein denotes AP-1
T13 1051-1055 protein denotes /CAT
T14 1171-1176 DNA denotes c-jun

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-104 Sentence denotes Regulation of c-jun mRNA expression by hydroxyurea in human K562 cells during erythroid differentiation.
S2 105-214 Sentence denotes Hydroxyurea (HU) is an antitumor agent which also induces hemoglobinization during erythroid differentiation.
S3 215-307 Sentence denotes In addition, HU stimulates the synthesis of fetal hemoglobin in sickle cell anemia patients.
S4 308-485 Sentence denotes To further understand its mechanism of action, we investigated the effects of HU on regulation of c-jun expression prior to the onset of erythroid differentiation of K562 cells.
S5 486-545 Sentence denotes HU induced a dose-dependent stimulation of c-jun synthesis.
S6 546-615 Sentence denotes The levels of c-jun mRNA was elevated 4 to 7.5-fold by HU within 2 h.
S7 616-682 Sentence denotes This was followed by a gradual decline to the basal level by 24 h.
S8 683-871 Sentence denotes Both nuclear run-on and actinomycin D pulse experiments strongly indicate that HU regulates c-jun mRNA expression by increasing the rate of synthesis as well as stabilizing the c-jun mRNA.
S9 872-969 Sentence denotes In addition, the level of jun protein was elevated by 2 to 5-fold within 4 h in HU treated cells.
S10 970-1065 Sentence denotes Furthermore, concentrations of HU below 250 microM slightly increased the 5X AP-1/CAT activity.
S11 1066-1210 Sentence denotes These results strongly suggest that HU induces both transcriptional and post-transcription regulation of c-jun during erythroid differentiation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 14-35 NP denotes c-jun mRNA expression
C1 0-35 NP denotes Regulation of c-jun mRNA expression
C3 39-50 NP denotes hydroxyurea
C4 54-70 NP denotes human K562 cells
C5 78-103 NP denotes erythroid differentiation
C6 105-121 NP denotes Hydroxyurea (HU)
C7 125-143 NP denotes an antitumor agent
C8 144-149 NP denotes which
C9 188-213 NP denotes erythroid differentiation
C10 228-230 NP denotes HU
C11 330-333 NP denotes its
C12 386-388 NP denotes HU
C14 406-422 NP denotes c-jun expression
C13 392-422 NP denotes regulation of c-jun expression
C16 474-484 NP denotes K562 cells
C15 445-484 NP denotes erythroid differentiation of K562 cells
C17 486-488 NP denotes HU
C18 560-570 NP denotes c-jun mRNA
C19 601-603 NP denotes HU
C20 762-764 NP denotes HU
C21 775-796 NP denotes c-jun mRNA expression
C22 856-870 NP denotes the c-jun mRNA
C23 1001-1003 NP denotes HU
C24 1102-1104 NP denotes HU
C25 1184-1209 NP denotes erythroid differentiation
R1 C6 C3 coref-ident Hydroxyurea (HU),hydroxyurea
R2 C8 C7 coref-relat which,an antitumor agent
R3 C9 C5 coref-ident erythroid differentiation,erythroid differentiation
R4 C10 C6 coref-ident HU,Hydroxyurea (HU)
R5 C11 C10 coref-pron its,HU
R6 C12 C10 coref-ident HU,HU
R7 C14 C2 coref-ident c-jun expression,c-jun mRNA expression
R8 C13 C1 coref-ident regulation of c-jun expression,Regulation of c-jun mRNA expression
R9 C16 C4 coref-ident K562 cells,human K562 cells
R10 C15 C5 coref-ident erythroid differentiation of K562 cells,erythroid differentiation
R11 C17 C12 coref-ident HU,HU
R12 C19 C17 coref-ident HU,HU
R13 C20 C19 coref-ident HU,HU
R14 C21 C14 coref-ident c-jun mRNA expression,c-jun expression
R15 C22 C18 coref-ident the c-jun mRNA,c-jun mRNA
R16 C23 C20 coref-ident HU,HU
R17 C24 C23 coref-ident HU,HU
R18 C25 C9 coref-ident erythroid differentiation,erythroid differentiation

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-19 DNA_domain_or_region denotes c-jun
T2 39-50 other_organic_compound denotes hydroxyurea
T3 54-70 cell_line denotes human K562 cells
T4 78-103 other_name denotes erythroid differentiation
T5 105-116 other_organic_compound denotes Hydroxyurea
T6 118-120 other_organic_compound denotes HU
T7 128-143 other_name denotes antitumor agent
T8 163-180 other_name denotes hemoglobinization
T9 188-213 other_name denotes erythroid differentiation
T10 228-230 other_organic_compound denotes HU
T11 259-275 protein_complex denotes fetal hemoglobin
T12 298-306 multi_cell denotes patients
T13 386-388 other_organic_compound denotes HU
T14 406-411 DNA_domain_or_region denotes c-jun
T15 445-470 other_name denotes erythroid differentiation
T16 474-484 cell_line denotes K562 cells
T17 486-488 other_organic_compound denotes HU
T18 529-534 DNA_domain_or_region denotes c-jun
T19 560-565 DNA_domain_or_region denotes c-jun
T20 601-603 other_organic_compound denotes HU
T21 707-720 other_organic_compound denotes actinomycin D
T22 762-764 other_organic_compound denotes HU
T23 775-785 RNA_molecule denotes c-jun mRNA
T24 860-865 DNA_domain_or_region denotes c-jun
T25 898-909 protein_family_or_group denotes jun protein
T26 952-954 other_organic_compound denotes HU
T27 1001-1003 other_organic_compound denotes HU
T28 1047-1051 protein_molecule denotes AP-1
T29 1051-1055 protein_molecule denotes /CAT
T30 1102-1104 other_organic_compound denotes HU
T31 1171-1176 DNA_domain_or_region denotes c-jun
T32 1184-1209 other_name denotes erythroid differentiation

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 291-297 Phenotype denotes anemia HP:0001903

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 279-297 Disease denotes sickle cell anemia http://purl.obolibrary.org/obo/MONDO_0011382

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 54-59 OrganismTaxon denotes human 9606
T2 291-297 OrganismTaxon denotes anemia 12939

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 662-667 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324