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PubMed:7640301 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-21 protein denotes Transcription factors
T2 182-195 cell_type denotes T lymphocytes
T3 524-558 cell_type denotes human peripheral blood lymphocytes
T4 1031-1040 DNA denotes IL-2 gene
T5 1107-1117 DNA denotes early gene
T6 1182-1203 protein denotes transcription factors
T7 1204-1208 protein denotes AP-1
T8 1210-1220 protein denotes NF-kappa B
T9 1222-1227 protein denotes NF-AT
T10 1232-1236 protein denotes Oct1
T11 1289-1293 protein denotes IL-2
T12 1354-1363 RNA denotes IL-2 mRNA
T13 1381-1385 protein denotes IL-2
T14 1496-1516 protein denotes transcription factor
T15 1560-1564 protein denotes AP-1
T16 1569-1579 protein denotes NF-kappa B
T17 1595-1619 cell_type denotes mitogen-stimulated cells
T18 1868-1887 protein denotes regulatory proteins
T19 1897-1918 protein denotes transcription factors
T20 2091-2104 cell_type denotes T lymphocytes

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-87 Sentence denotes Transcription factors as targets for oxidative signalling during lymphocyte activation.
S2 88-319 Sentence denotes We previously have demonstrated a requirement for oxidative events during cell cycle entry in T lymphocytes and have hypothesised that reactive oxygen species may act as intracellular signalling agents during lymphocyte activation.
S3 320-503 Sentence denotes In the current study, cysteamine, an aminothiol compound with antioxidant activity, has been used to further investigate the role of oxidative signalling during lymphocyte activation.
S4 504-718 Sentence denotes Treatment of normal human peripheral blood lymphocytes with cysteamine in vitro was found to inhibit proliferation in a dose-dependent manner, with essentially complete inhibition occurring at a dose of 400 microM.
S5 719-881 Sentence denotes This inhibitory effect was limited to the first 2 h after mitogenic activation, localizing the time-frame of action of cysteamine to within the commitment period.
S6 882-1019 Sentence denotes It therefore was of interest to establish which, if any, commitment events were affected by oxidative signalling during cell cycle entry.
S7 1020-1299 Sentence denotes Taking the IL-2 gene as a candidate, we examined the effect of cysteamine treatment on early gene expression during lymphocyte activation, and on the activity of transcription factors AP-1, NF-kappa B, NF-AT and Oct1, whose functions are required for expression of the IL-2 mRNA.
S8 1300-1410 Sentence denotes Cysteamine treatment inhibited both expression of the IL-2 mRNA and secretion of IL-2 into the culture medium.
S9 1411-1673 Sentence denotes The inhibitory effect of cysteamine may be mediated at least in part by an effect on transcription factor function, as the DNA binding activities of AP-1 and NF-kappa B extracted from mitogen-stimulated cells were significantly inhibited by cysteamine treatment.
S10 1674-1845 Sentence denotes Interestingly, Oct1 and NF-AT DNA binding activity were not affected by cysteamine treatment, suggesting that oxidative signalling processes operate in a selective manner.
S11 1846-2105 Sentence denotes The identification of regulatory proteins, such as transcription factors, as molecular targets for oxidative signalling provides further evidence to implicate oxidative signalling as being intimately involved in the G0 to G1 phase transition in T lymphocytes.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 37-57 NP denotes oxidative signalling
C1 25-57 NP denotes targets for oxidative signalling
C3 65-86 NP denotes lymphocyte activation
C4 182-195 NP denotes T lymphocytes
C5 297-318 NP denotes lymphocyte activation
C6 342-352 NP denotes cysteamine
C7 354-402 NP denotes an aminothiol compound with antioxidant activity
C8 453-473 NP denotes oxidative signalling
C9 481-502 NP denotes lymphocyte activation
C11 564-574 NP denotes cysteamine
C10 504-583 NP denotes Treatment of normal human peripheral blood lymphocytes with cysteamine in vitro
C12 838-848 NP denotes cysteamine
C13 974-994 NP denotes oxidative signalling
C14 1083-1103 NP denotes cysteamine treatment
C15 1136-1157 NP denotes lymphocyte activation
C16 1182-1236 NP denotes transcription factors AP-1, NF-kappa B, NF-AT and Oct1
C17 1238-1243 NP denotes whose
C18 1271-1298 NP denotes expression of the IL-2 mRNA
C19 1300-1320 NP denotes Cysteamine treatment
C20 1336-1363 NP denotes expression of the IL-2 mRNA
C21 1436-1446 NP denotes cysteamine
C22 1652-1672 NP denotes cysteamine treatment
C23 1746-1766 NP denotes cysteamine treatment
C25 1945-1965 NP denotes oxidative signalling
C24 1923-1965 NP denotes molecular targets for oxidative signalling
C26 2005-2025 NP denotes oxidative signalling
C27 2091-2104 NP denotes T lymphocytes
R1 C5 C3 coref-ident lymphocyte activation,lymphocyte activation
R2 C7 C6 coref-appos an aminothiol compound with antioxidant activity,cysteamine
R3 C8 C2 coref-ident oxidative signalling,oxidative signalling
R4 C9 C5 coref-ident lymphocyte activation,lymphocyte activation
R5 C11 C6 coref-ident cysteamine,cysteamine
R6 C12 C11 coref-ident cysteamine,cysteamine
R7 C13 C8 coref-ident oxidative signalling,oxidative signalling
R8 C14 C10 coref-ident cysteamine treatment,Treatment of normal human peripheral blood lymphocytes with cysteamine in vitro
R9 C15 C9 coref-ident lymphocyte activation,lymphocyte activation
R10 C17 C16 coref-relat whose,"transcription factors AP-1, NF-kappa B, NF-AT and Oct1"
R11 C19 C14 coref-ident Cysteamine treatment,cysteamine treatment
R12 C20 C18 coref-ident expression of the IL-2 mRNA,expression of the IL-2 mRNA
R13 C21 C12 coref-ident cysteamine,cysteamine
R14 C22 C19 coref-ident cysteamine treatment,Cysteamine treatment
R15 C23 C22 coref-ident cysteamine treatment,cysteamine treatment
R16 C25 C13 coref-ident oxidative signalling,oxidative signalling
R17 C24 C1 coref-ident molecular targets for oxidative signalling,targets for oxidative signalling
R18 C26 C25 coref-ident oxidative signalling,oxidative signalling
R19 C27 C4 coref-ident T lymphocytes,T lymphocytes

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-21 protein_family_or_group denotes Transcription factors
T2 65-86 other_name denotes lymphocyte activation
T3 182-195 cell_type denotes T lymphocytes
T4 223-246 inorganic denotes reactive oxygen species
T5 258-289 other_name denotes intracellular signalling agents
T6 297-318 other_name denotes lymphocyte activation
T7 342-352 other_organic_compound denotes cysteamine
T8 357-376 other_organic_compound denotes aminothiol compound
T9 382-402 other_name denotes antioxidant activity
T10 453-473 other_name denotes oxidative signalling
T11 481-502 other_name denotes lymphocyte activation
T12 524-558 cell_type denotes human peripheral blood lymphocytes
T13 564-574 other_organic_compound denotes cysteamine
T14 605-618 other_name denotes proliferation
T15 624-645 other_name denotes dose-dependent manner
T16 777-797 other_name denotes mitogenic activation
T17 838-848 other_organic_compound denotes cysteamine
T18 863-880 other_name denotes commitment period
T19 974-994 other_name denotes oxidative signalling
T20 1002-1018 other_name denotes cell cycle entry
T21 1031-1035 protein_molecule denotes IL-2
T22 1083-1093 other_organic_compound denotes cysteamine
T23 1107-1117 DNA_family_or_group denotes early gene
T24 1136-1157 other_name denotes lymphocyte activation
T25 1182-1203 protein_family_or_group denotes transcription factors
T26 1204-1208 protein_molecule denotes AP-1
T27 1210-1220 protein_molecule denotes NF-kappa B
T28 1222-1227 protein_molecule denotes NF-AT
T29 1232-1236 protein_molecule denotes Oct1
T30 1289-1293 protein_molecule denotes IL-2
T31 1300-1310 other_organic_compound denotes Cysteamine
T32 1354-1358 protein_molecule denotes IL-2
T33 1381-1385 protein_molecule denotes IL-2
T34 1395-1409 other_organic_compound denotes culture medium
T35 1436-1446 other_organic_compound denotes cysteamine
T36 1496-1516 protein_family_or_group denotes transcription factor
T37 1538-1556 other_name denotes binding activities
T38 1560-1564 protein_molecule denotes AP-1
T39 1569-1579 protein_molecule denotes NF-kappa B
T40 1595-1619 cell_type denotes mitogen-stimulated cells
T41 1652-1662 other_organic_compound denotes cysteamine
T42 1746-1756 other_organic_compound denotes cysteamine
T43 1784-1814 other_name denotes oxidative signalling processes
T44 1868-1887 protein_family_or_group denotes regulatory proteins
T45 1897-1918 protein_family_or_group denotes transcription factors
T46 1945-1965 other_name denotes oxidative signalling
T47 2005-2025 other_name denotes oxidative signalling
T48 2062-2087 other_name denotes G0 to G1 phase transition
T49 2091-2104 cell_type denotes T lymphocytes

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 524-529 OrganismTaxon denotes human 9606

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 541-546 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 65-75 Body_part denotes lymphocyte http://purl.obolibrary.org/obo/CL_0000542
T2 162-172 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T3 182-195 Body_part denotes T lymphocytes http://purl.obolibrary.org/obo/CL_0000084
T4 258-271 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T5 297-307 Body_part denotes lymphocyte http://purl.obolibrary.org/obo/CL_0000542
T6 481-491 Body_part denotes lymphocyte http://purl.obolibrary.org/obo/CL_0000542
T7 541-558 Body_part denotes blood lymphocytes http://purl.obolibrary.org/obo/CL_4030029
T8 1002-1012 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T9 1136-1146 Body_part denotes lymphocyte http://purl.obolibrary.org/obo/CL_0000542
T10 2091-2104 Body_part denotes T lymphocytes http://purl.obolibrary.org/obo/CL_0000084

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 65-75 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542
T2 182-195 Cell denotes T lymphocytes http://purl.obolibrary.org/obo/CL:0000084
T3 297-307 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542
T4 481-491 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542
T5 530-558 Cell denotes peripheral blood lymphocytes http://purl.obolibrary.org/obo/CL:4030030
T6 1136-1146 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542
T7 2091-2104 Cell denotes T lymphocytes http://purl.obolibrary.org/obo/CL:0000084