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PubMed:7638186 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-14 protein denotes Interleukin 12
T2 66-71 protein denotes STAT4
T3 75-92 cell_type denotes human lymphocytes
T4 94-108 protein denotes Interleukin 12
T5 110-115 protein denotes IL-12
T6 133-158 protein denotes immunoregulatory cytokine
T7 193-227 protein denotes hematopoietin receptor superfamily
T8 279-311 cell_type denotes human T and natural killer cells
T9 317-322 protein denotes IL-12
T10 363-391 protein denotes Janus family tyrosine kinase
T11 392-396 protein denotes JAK2
T12 401-405 protein denotes Tyk2
T13 425-432 protein denotes kinases
T14 474-479 protein denotes IL-12
T15 491-512 protein denotes transcription factors
T16 522-527 protein denotes STATs
T17 529-579 protein denotes signal transducers and activators of transcription
T18 668-677 protein denotes cytokines
T19 688-711 protein denotes hematopoietin receptors
T20 725-736 protein denotes JAK kinases
T21 773-778 protein denotes IL-12
T22 837-855 protein denotes STAT family member
T23 857-862 protein denotes STAT4
T24 878-883 protein denotes STAT4
T25 956-961 protein denotes IL-12
T26 988-1007 protein denotes DNA-binding complex
T27 1064-1077 protein denotes STAT proteins
T28 1109-1114 protein denotes STAT4
T29 1160-1163 protein denotes JAK
T30 1183-1188 protein denotes IL-12
T31 1253-1258 protein denotes IL-12

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-93 Sentence denotes Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.
S2 94-228 Sentence denotes Interleukin 12 (IL-12) is an important immunoregulatory cytokine whose receptor is a member of the hematopoietin receptor superfamily.
S3 229-480 Sentence denotes We have recently demonstrated that stimulation of human T and natural killer cells with IL-12 induces tyrosine phosphorylation of the Janus family tyrosine kinase JAK2 and Tyk2, implicating these kinases in the immediate biochemical response to IL-12.
S4 481-737 Sentence denotes Recently, transcription factors known as STATs (signal transducers and activators of transcription) have been shown to be tyrosine phosphorylated and activated in response to a number of cytokines that bind hematopoietin receptors and activate JAK kinases.
S5 738-929 Sentence denotes In this report we demonstrate that IL-12 induces tyrosine phosphorylation of a recently identified STAT family member, STAT4, and show that STAT4 expression is regulated by T-cell activation.
S6 930-1115 Sentence denotes Furthermore, we show that IL-12 stimulates formation of a DNA-binding complex that recognizes a DNA sequence previously shown to bind STAT proteins and that this complex contains STAT4.
S7 1116-1283 Sentence denotes These data, and the recent demonstration of JAK phosphorylation by IL-12, identify a rapid signal-transduction pathway likely to mediate IL-12-induced gene expression.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-14 NP denotes Interleukin 12
C2 66-71 NP denotes STAT4
C3 94-116 NP denotes Interleukin 12 (IL-12)
C4 120-158 NP denotes an important immunoregulatory cytokine
C5 159-164 NP denotes whose
C6 317-322 NP denotes IL-12
C7 359-405 NP denotes the Janus family tyrosine kinase JAK2 and Tyk2
C8 419-432 NP denotes these kinases
C9 474-479 NP denotes IL-12
C10 491-512 NP denotes transcription factors
C11 522-580 NP denotes STATs (signal transducers and activators of transcription)
C12 668-677 NP denotes cytokines
C13 678-682 NP denotes that
C14 773-778 NP denotes IL-12
C15 815-855 NP denotes a recently identified STAT family member
C16 857-862 NP denotes STAT4
C17 956-961 NP denotes IL-12
C19 986-1007 NP denotes a DNA-binding complex
C20 1008-1012 NP denotes that
C18 986-1077 NP denotes a DNA-binding complex that recognizes a DNA sequence previously shown to bind STAT proteins
C21 1087-1099 NP denotes this complex
C22 1109-1114 NP denotes STAT4
C23 1183-1188 NP denotes IL-12
R1 C3 C1 coref-ident Interleukin 12 (IL-12),Interleukin 12
R2 C5 C4 coref-relat whose,an important immunoregulatory cytokine
R3 C6 C3 coref-ident IL-12,Interleukin 12 (IL-12)
R4 C8 C7 coref-ident these kinases,the Janus family tyrosine kinase JAK2 and Tyk2
R5 C9 C6 coref-ident IL-12,IL-12
R6 C11 C10 coref-ident STATs (signal transducers and activators of transcription),transcription factors
R7 C13 C12 coref-relat that,cytokines
R8 C14 C9 coref-ident IL-12,IL-12
R9 C15 C2 coref-ident a recently identified STAT family member,STAT4
R10 C16 C15 coref-appos STAT4,a recently identified STAT family member
R11 C17 C14 coref-ident IL-12,IL-12
R12 C20 C19 coref-relat that,a DNA-binding complex
R13 C21 C18 coref-ident this complex,a DNA-binding complex that recognizes a DNA sequence previously shown to bind STAT proteins
R14 C22 C15 coref-ident STAT4,a recently identified STAT family member
R15 C23 C17 coref-ident IL-12,IL-12

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-14 protein_molecule denotes Interleukin 12
T2 23-31 amino_acid_monomer denotes tyrosine
T3 66-71 protein_molecule denotes STAT4
T4 75-92 cell_type denotes human lymphocytes
T5 94-108 protein_molecule denotes Interleukin 12
T6 110-115 protein_molecule denotes IL-12
T7 133-158 protein_family_or_group denotes immunoregulatory cytokine
T8 193-227 protein_family_or_group denotes hematopoietin receptor superfamily
T9 317-322 protein_molecule denotes IL-12
T10 331-339 amino_acid_monomer denotes tyrosine
T11 363-375 protein_family_or_group denotes Janus family
T12 376-384 amino_acid_monomer denotes tyrosine
T13 392-396 protein_molecule denotes JAK2
T14 401-405 protein_molecule denotes Tyk2
T15 425-432 protein_family_or_group denotes kinases
T16 474-479 protein_molecule denotes IL-12
T17 491-512 protein_family_or_group denotes transcription factors
T18 522-527 protein_family_or_group denotes STATs
T19 529-579 protein_family_or_group denotes signal transducers and activators of transcription
T20 603-611 amino_acid_monomer denotes tyrosine
T21 668-677 protein_family_or_group denotes cytokines
T22 688-711 protein_family_or_group denotes hematopoietin receptors
T23 725-736 protein_family_or_group denotes JAK kinases
T24 773-778 protein_molecule denotes IL-12
T25 787-795 amino_acid_monomer denotes tyrosine
T26 837-855 protein_family_or_group denotes STAT family member
T27 857-862 protein_molecule denotes STAT4
T28 878-883 protein_molecule denotes STAT4
T29 911-928 other_name denotes T-cell activation
T30 956-961 protein_molecule denotes IL-12
T31 988-1007 protein_complex denotes DNA-binding complex
T32 1064-1077 protein_family_or_group denotes STAT proteins
T33 1109-1114 protein_molecule denotes STAT4
T34 1160-1163 protein_family_or_group denotes JAK
T35 1183-1188 protein_molecule denotes IL-12
T36 1207-1234 other_name denotes signal-transduction pathway
T37 1253-1258 protein_molecule denotes IL-12