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PubMed:7636179 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 1249-1258 gene:894 denotes cyclin D2
T1 1301-1309 disease:C0024299 denotes lymphoma
R1 T0 T1 associated_with cyclin D2,lymphoma

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-25 protein denotes Latent membrane protein-1
T2 34-43 protein denotes cyclin D2
T3 56-59 protein denotes pRb
T4 94-104 protein denotes TGF-beta 1
T5 135-155 cell_type denotes EBV-positive B cells
T6 226-254 protein denotes tumor-suppressor protein pRb
T7 260-270 protein denotes G1 cyclins
T8 276-300 protein denotes cyclin-dependent kinases
T9 418-426 protein denotes TGF-beta
T10 491-529 protein denotes transforming latent membrane protein-1
T11 531-536 protein denotes LMP-1
T12 561-571 protein denotes TGF-beta 1
T13 602-615 cell_type denotes human B cells
T14 645-668 protein denotes 125I-labeled TGF-beta 1
T15 698-715 protein denotes TGF-beta receptor
T16 727-786 cell_line denotes EBV-positive and EBV-negative Burkitt's lymphoma cell lines
T17 880-890 protein denotes TGF-beta 1
T18 914-923 DNA denotes junB gene
T19 945-955 protein denotes TGF-beta 1
T20 992-995 protein denotes pRb
T21 999-1028 cell_line denotes EBV (or LMP-1)-positive cells
T22 1043-1061 cell_line denotes EBV-negative cells
T23 1093-1103 protein denotes TGF-beta 1
T24 1205-1210 protein denotes LMP-1
T25 1249-1258 protein denotes cyclin D2
T26 1267-1274 cell_type denotes B cells
T27 1278-1315 cell_line denotes EBV-negative Burkitt's lymphoma cells
T28 1331-1345 protein denotes D-type cyclins
T29 1485-1510 protein denotes key cell cycle regulators
T30 1514-1519 protein denotes LMP-1
T31 1532-1535 protein denotes pRb

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
7636179-4#41#51#gene7040 658-668 gene7040 denotes TGF-beta 1
7636179-4#263#273#gene7040 880-890 gene7040 denotes TGF-beta 1
7636179-4#297#301#gene3726 914-918 gene3726 denotes junB
7636179-4#140#158#diseaseC0006413 757-775 diseaseC0006413 denotes Burkitt's lymphoma
7636179-6#13#18#gene9260 1205-1210 gene9260 denotes LMP-1
7636179-6#57#66#gene894 1249-1258 gene894 denotes cyclin D2
7636179-6#99#117#diseaseC0006413 1291-1309 diseaseC0006413 denotes Burkitt's lymphoma
41#51#gene7040140#158#diseaseC0006413 7636179-4#41#51#gene7040 7636179-4#140#158#diseaseC0006413 associated_with TGF-beta 1,Burkitt's lymphoma
263#273#gene7040140#158#diseaseC0006413 7636179-4#263#273#gene7040 7636179-4#140#158#diseaseC0006413 associated_with TGF-beta 1,Burkitt's lymphoma
297#301#gene3726140#158#diseaseC0006413 7636179-4#297#301#gene3726 7636179-4#140#158#diseaseC0006413 associated_with junB,Burkitt's lymphoma
13#18#gene926099#117#diseaseC0006413 7636179-6#13#18#gene9260 7636179-6#99#117#diseaseC0006413 associated_with LMP-1,Burkitt's lymphoma
57#66#gene89499#117#diseaseC0006413 7636179-6#57#66#gene894 7636179-6#99#117#diseaseC0006413 associated_with cyclin D2,Burkitt's lymphoma

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-156 Sentence denotes Latent membrane protein-1 induces cyclin D2 expression, pRb hyperphosphorylation, and loss of TGF-beta 1-mediated growth inhibition in EBV-positive B cells.
S2 157-323 Sentence denotes The normal cell cycle is regulated by several molecules, such as the tumor-suppressor protein pRb, the G1 cyclins, the cyclin-dependent kinases, and their inhibitors.
S3 324-427 Sentence denotes These regulators are targeted by negative growth regulatory signals, such as that provided by TGF-beta.
S4 428-616 Sentence denotes Here, we show that the presence of either wild-type EBV or its transforming latent membrane protein-1 (LMP-1) results in the loss of TGF-beta 1-mediated growth inhibition in human B cells.
S5 617-935 Sentence denotes Chemical cross-linking with 125I-labeled TGF-beta 1 showed an essentially normal TGF-beta receptor profile in EBV-positive and EBV-negative Burkitt's lymphoma cell lines, and these receptors were shown to be functional in transducing signals, as evidenced by the TGF-beta 1-mediated modulation of junB gene expression.
S6 936-1191 Sentence denotes However, TGF-beta 1 did not induce dephosphorylation of pRb in EBV (or LMP-1)-positive cells as opposed to EBV-negative cells, suggesting a dichotomy in the TGF-beta 1 signaling pathway leading to separable gene regulatory and growth inhibitory responses.
S7 1192-1346 Sentence denotes Furthermore, LMP-1 was found to induce the expression of cyclin D2; normal B cells or EBV-negative Burkitt's lymphoma cells do not express D-type cyclins.
S8 1347-1593 Sentence denotes Taken together, these data point to a potential mechanism underlying EBV-mediated B cell transformation whereby constitutive induction of key cell cycle regulators by LMP-1 can lead to pRb hyperphosphorylation and uncontrolled cell proliferation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-25 NP denotes Latent membrane protein-1
C2 34-54 NP denotes cyclin D2 expression
C3 56-80 NP denotes pRb hyperphosphorylation
C4 86-131 NP denotes loss of TGF-beta 1-mediated growth inhibition
C5 195-212 NP denotes several molecules
C6 222-254 NP denotes the tumor-suppressor protein pRb
C7 306-311 NP denotes their
C8 357-391 NP denotes negative growth regulatory signals
C9 401-405 NP denotes that
C10 470-483 NP denotes wild-type EBV
C12 487-490 NP denotes its
C11 487-537 NP denotes its transforming latent membrane protein-1 (LMP-1)
C13 549-598 NP denotes the loss of TGF-beta 1-mediated growth inhibition
C14 992-995 NP denotes pRb
C15 1205-1210 NP denotes LMP-1
C16 1231-1258 NP denotes the expression of cyclin D2
C17 1514-1519 NP denotes LMP-1
C18 1532-1556 NP denotes pRb hyperphosphorylation
R1 C7 C5 coref-pron their,several molecules
R2 C9 C8 coref-pron that,negative growth regulatory signals
R3 C12 C10 coref-pron its,wild-type EBV
R4 C11 C1 coref-ident its transforming latent membrane protein-1 (LMP-1),Latent membrane protein-1
R5 C13 C4 coref-ident the loss of TGF-beta 1-mediated growth inhibition,loss of TGF-beta 1-mediated growth inhibition
R6 C14 C6 coref-ident pRb,the tumor-suppressor protein pRb
R7 C15 C11 coref-ident LMP-1,its transforming latent membrane protein-1 (LMP-1)
R8 C16 C2 coref-ident the expression of cyclin D2,cyclin D2 expression
R9 C17 C15 coref-ident LMP-1,LMP-1
R10 C18 C3 coref-ident pRb hyperphosphorylation,pRb hyperphosphorylation

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-25 protein_molecule denotes Latent membrane protein-1
T2 34-43 protein_molecule denotes cyclin D2
T3 56-59 protein_molecule denotes pRb
T4 94-104 protein_molecule denotes TGF-beta 1
T5 135-147 cell_type denotes EBV-positive
T6 148-155 cell_type denotes B cells
T7 226-250 protein_molecule denotes tumor-suppressor protein
T8 251-254 protein_molecule denotes pRb
T9 260-270 protein_family_or_group denotes G1 cyclins
T10 276-300 protein_family_or_group denotes cyclin-dependent kinases
T11 312-322 other_name denotes inhibitors
T12 373-391 other_name denotes regulatory signals
T13 418-426 protein_molecule denotes TGF-beta
T14 470-483 virus denotes wild-type EBV
T15 491-529 protein_molecule denotes transforming latent membrane protein-1
T16 531-536 protein_molecule denotes LMP-1
T17 561-569 protein_molecule denotes TGF-beta
T18 602-607 cell_type denotes human
T19 608-615 cell_type denotes B cells
T20 645-657 protein_molecule denotes 125I-labeled
T21 658-666 protein_molecule denotes TGF-beta
T22 698-715 protein_molecule denotes TGF-beta receptor
T23 839-858 other_name denotes transducing signals
T24 880-890 protein_molecule denotes TGF-beta 1
T25 914-923 DNA_family_or_group denotes junB gene
T26 945-955 protein_molecule denotes TGF-beta 1
T27 992-995 protein_molecule denotes pRb
T28 999-1002 virus denotes EBV
T29 1007-1012 protein_molecule denotes LMP-1
T30 1043-1046 virus denotes EBV
T31 1093-1103 protein_molecule denotes TGF-beta 1
T32 1163-1190 other_name denotes growth inhibitory responses
T33 1205-1210 protein_molecule denotes LMP-1
T34 1249-1258 protein_molecule denotes cyclin D2
T35 1267-1274 cell_type denotes B cells
T36 1278-1281 virus denotes EBV
T37 1331-1345 protein_family_or_group denotes D-type cyclins
T38 1416-1419 virus denotes EBV
T39 1485-1510 protein_family_or_group denotes key cell cycle regulators
T40 1514-1519 protein_molecule denotes LMP-1
T41 1532-1535 protein_molecule denotes pRb
T42 1561-1592 other_name denotes uncontrolled cell proliferation