PubMed:7630397 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/7630397","sourcedb":"PubMed","sourceid":"7630397","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/7630397","text":"Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex.\nThe crystal structure of the human cyclinA-cyclin-dependent kinase2 (CDK2)-ATP complex has been determined at 2.3 A resolution. CyclinA binds to one side of CDK2's catalytic cleft, inducing large conformational changes in its PSTAIRE helix and T-loop. These changes activate the kinase by realigning active site residues and relieving the steric blockade at the entrance of the catalytic cleft.","tracks":[{"project":"AIMed","denotations":[{"id":"T1","span":{"begin":59,"end":66},"obj":"protein"},{"id":"T2","span":{"begin":67,"end":71},"obj":"protein"},{"id":"T3","span":{"begin":116,"end":123},"obj":"protein"},{"id":"T4","span":{"begin":124,"end":148},"obj":"protein"},{"id":"T5","span":{"begin":150,"end":154},"obj":"protein"},{"id":"T6","span":{"begin":238,"end":242},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"AIMed"},{"subj":"T2","pred":"source","obj":"AIMed"},{"subj":"T3","pred":"source","obj":"AIMed"},{"subj":"T4","pred":"source","obj":"AIMed"},{"subj":"T5","pred":"source","obj":"AIMed"},{"subj":"T6","pred":"source","obj":"AIMed"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"AIMed","color":"#9394ec","default":true}]}]}}