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sentences

Id Subject Object Predicate Lexical cue
T1 0-133 Sentence denotes Activation of NF-kappa B by phosphatase inhibitors involves the phosphorylation of I kappa B alpha at phosphatase 2A-sensitive sites.
T2 134-328 Sentence denotes Activation of NF-kappa B by various cellular stimuli involves the phosphorylation and subsequent degradation of its inhibitor, I kappa B alpha, although the underlying mechanism remains unclear.
T3 329-463 Sentence denotes In the present study, the role of serine/threonine phosphatases in the regulation of I kappa B alpha phosphorylation was investigated.
T4 464-768 Sentence denotes Our studies demonstrate that incubation of human T cells with low concentrations (approximately 1-5 nM) of calyculin A or okadaic acid, potent inhibitors of protein phosphatase type 1 (PP-1) and type 2A (PP-2A), induces the phosphorylation of I kappa B alpha even in the absence of any cellular stimulus.
T5 769-1021 Sentence denotes This action of the phosphatase inhibitors, which is associated with the activation of the RelA.p50 NF-kappa B heterodimer, is not affected by agents that block the induction of I kappa B alpha phosphorylation by tumor necrosis factor alpha (TNF-alpha).
T6 1022-1323 Sentence denotes Furthermore, the phosphorylated I kappa B alpha from calyculin A-treated cells, but not that from TNF-alpha-stimulated cells, is sensitive to PP-2A in vitro, suggesting the existence of fundamental differences in the phosphorylation of I kappa B alpha induced by the two different NF-kappa B inducers.
T7 1324-1492 Sentence denotes However, induction of I kappa B alpha phosphorylation by both TNF-alpha and the phosphatase inhibitors is associated with the subsequent degradation of I kappa B alpha.
T8 1493-1659 Sentence denotes We further demonstrate that TNF-alpha- and calyculin A-induced I kappa B alpha degradation exhibits similar but not identical sensitivities to a proteasome inhibitor.
T9 1660-1883 Sentence denotes Together, these results suggest that phosphorylation of I kappa B alpha, mediated through both the TNF-alpha-inducible and the PP-2A-opposing kinases, may serve to target I kappa B alpha for proteasome-mediated degradation.
T1 0-133 Sentence denotes Activation of NF-kappa B by phosphatase inhibitors involves the phosphorylation of I kappa B alpha at phosphatase 2A-sensitive sites.
T2 134-328 Sentence denotes Activation of NF-kappa B by various cellular stimuli involves the phosphorylation and subsequent degradation of its inhibitor, I kappa B alpha, although the underlying mechanism remains unclear.
T3 329-463 Sentence denotes In the present study, the role of serine/threonine phosphatases in the regulation of I kappa B alpha phosphorylation was investigated.
T4 464-768 Sentence denotes Our studies demonstrate that incubation of human T cells with low concentrations (approximately 1-5 nM) of calyculin A or okadaic acid, potent inhibitors of protein phosphatase type 1 (PP-1) and type 2A (PP-2A), induces the phosphorylation of I kappa B alpha even in the absence of any cellular stimulus.
T5 769-1021 Sentence denotes This action of the phosphatase inhibitors, which is associated with the activation of the RelA.p50 NF-kappa B heterodimer, is not affected by agents that block the induction of I kappa B alpha phosphorylation by tumor necrosis factor alpha (TNF-alpha).
T6 1022-1323 Sentence denotes Furthermore, the phosphorylated I kappa B alpha from calyculin A-treated cells, but not that from TNF-alpha-stimulated cells, is sensitive to PP-2A in vitro, suggesting the existence of fundamental differences in the phosphorylation of I kappa B alpha induced by the two different NF-kappa B inducers.
T7 1324-1492 Sentence denotes However, induction of I kappa B alpha phosphorylation by both TNF-alpha and the phosphatase inhibitors is associated with the subsequent degradation of I kappa B alpha.
T8 1493-1659 Sentence denotes We further demonstrate that TNF-alpha- and calyculin A-induced I kappa B alpha degradation exhibits similar but not identical sensitivities to a proteasome inhibitor.
T9 1660-1883 Sentence denotes Together, these results suggest that phosphorylation of I kappa B alpha, mediated through both the TNF-alpha-inducible and the PP-2A-opposing kinases, may serve to target I kappa B alpha for proteasome-mediated degradation.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 14-24 protein denotes NF-kappa B
T2 28-39 protein denotes phosphatase
T3 83-98 protein denotes I kappa B alpha
T4 102-132 protein denotes phosphatase 2A-sensitive sites
T5 148-158 protein denotes NF-kappa B
T6 261-276 protein denotes I kappa B alpha
T7 363-392 protein denotes serine/threonine phosphatases
T8 414-429 protein denotes I kappa B alpha
T9 507-520 cell_type denotes human T cells
T10 621-666 protein denotes protein phosphatase type 1 (PP-1) and type 2A
T11 668-673 protein denotes PP-2A
T12 707-722 protein denotes I kappa B alpha
T13 859-890 protein denotes RelA.p50 NF-kappa B heterodimer
T14 946-961 protein denotes I kappa B alpha
T15 981-1008 protein denotes tumor necrosis factor alpha
T16 1010-1019 protein denotes TNF-alpha
T17 1039-1069 protein denotes phosphorylated I kappa B alpha
T18 1075-1100 cell_line denotes calyculin A-treated cells
T19 1120-1146 cell_line denotes TNF-alpha-stimulated cells
T20 1164-1169 protein denotes PP-2A
T21 1258-1273 protein denotes I kappa B alpha
T22 1303-1313 protein denotes NF-kappa B
T23 1346-1361 protein denotes I kappa B alpha
T24 1386-1395 protein denotes TNF-alpha
T25 1476-1491 protein denotes I kappa B alpha
T26 1716-1731 protein denotes I kappa B alpha
T27 1759-1768 protein denotes TNF-alpha
T28 1787-1809 protein denotes PP-2A-opposing kinases
T29 1831-1846 protein denotes I kappa B alpha
T30 1851-1861 protein denotes proteasome

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-133 Sentence denotes Activation of NF-kappa B by phosphatase inhibitors involves the phosphorylation of I kappa B alpha at phosphatase 2A-sensitive sites.
S2 134-328 Sentence denotes Activation of NF-kappa B by various cellular stimuli involves the phosphorylation and subsequent degradation of its inhibitor, I kappa B alpha, although the underlying mechanism remains unclear.
S3 329-463 Sentence denotes In the present study, the role of serine/threonine phosphatases in the regulation of I kappa B alpha phosphorylation was investigated.
S4 464-768 Sentence denotes Our studies demonstrate that incubation of human T cells with low concentrations (approximately 1-5 nM) of calyculin A or okadaic acid, potent inhibitors of protein phosphatase type 1 (PP-1) and type 2A (PP-2A), induces the phosphorylation of I kappa B alpha even in the absence of any cellular stimulus.
S5 769-1021 Sentence denotes This action of the phosphatase inhibitors, which is associated with the activation of the RelA.p50 NF-kappa B heterodimer, is not affected by agents that block the induction of I kappa B alpha phosphorylation by tumor necrosis factor alpha (TNF-alpha).
S6 1022-1323 Sentence denotes Furthermore, the phosphorylated I kappa B alpha from calyculin A-treated cells, but not that from TNF-alpha-stimulated cells, is sensitive to PP-2A in vitro, suggesting the existence of fundamental differences in the phosphorylation of I kappa B alpha induced by the two different NF-kappa B inducers.
S7 1324-1492 Sentence denotes However, induction of I kappa B alpha phosphorylation by both TNF-alpha and the phosphatase inhibitors is associated with the subsequent degradation of I kappa B alpha.
S8 1493-1659 Sentence denotes We further demonstrate that TNF-alpha- and calyculin A-induced I kappa B alpha degradation exhibits similar but not identical sensitivities to a proteasome inhibitor.
S9 1660-1883 Sentence denotes Together, these results suggest that phosphorylation of I kappa B alpha, mediated through both the TNF-alpha-inducible and the PP-2A-opposing kinases, may serve to target I kappa B alpha for proteasome-mediated degradation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 14-24 NP denotes NF-kappa B
C2 28-50 NP denotes phosphatase inhibitors
C4 83-98 NP denotes I kappa B alpha
C3 60-98 NP denotes the phosphorylation of I kappa B alpha
C5 148-158 NP denotes NF-kappa B
C7 246-249 NP denotes its
C6 246-259 NP denotes its inhibitor
C8 261-276 NP denotes I kappa B alpha
C9 414-445 NP denotes I kappa B alpha phosphorylation
C10 571-598 NP denotes calyculin A or okadaic acid
C11 600-674 NP denotes potent inhibitors of protein phosphatase type 1 (PP-1) and type 2A (PP-2A)
C13 707-722 NP denotes I kappa B alpha
C12 684-722 NP denotes the phosphorylation of I kappa B alpha
C15 784-810 NP denotes the phosphatase inhibitors
C14 769-810 NP denotes This action of the phosphatase inhibitors
C16 812-817 NP denotes which
C17 911-917 NP denotes agents
C18 918-922 NP denotes that
C19 946-977 NP denotes I kappa B alpha phosphorylation
C20 981-1020 NP denotes tumor necrosis factor alpha (TNF-alpha)
C21 1035-1069 NP denotes the phosphorylated I kappa B alpha
C22 1110-1114 NP denotes that
C24 1258-1273 NP denotes I kappa B alpha
C23 1235-1273 NP denotes the phosphorylation of I kappa B alpha
C25 1346-1377 NP denotes I kappa B alpha phosphorylation
C26 1386-1395 NP denotes TNF-alpha
C27 1400-1426 NP denotes the phosphatase inhibitors
C28 1476-1491 NP denotes I kappa B alpha
C30 1716-1731 NP denotes I kappa B alpha
C29 1697-1731 NP denotes phosphorylation of I kappa B alpha
C31 1831-1846 NP denotes I kappa B alpha
R1 C5 C1 coref-ident NF-kappa B,NF-kappa B
R2 C7 C5 coref-pron its,NF-kappa B
R3 C6 C4 coref-ident its inhibitor,I kappa B alpha
R4 C8 C6 coref-appos I kappa B alpha,its inhibitor
R5 C9 C3 coref-ident I kappa B alpha phosphorylation,the phosphorylation of I kappa B alpha
R6 C11 C10 coref-appos potent inhibitors of protein phosphatase type 1 (PP-1) and type 2A (PP-2A),calyculin A or okadaic acid
R7 C13 C8 coref-ident I kappa B alpha,I kappa B alpha
R8 C12 C9 coref-ident the phosphorylation of I kappa B alpha,I kappa B alpha phosphorylation
R9 C15 C2 coref-ident the phosphatase inhibitors,phosphatase inhibitors
R10 C16 C14 coref-relat which,This action of the phosphatase inhibitors
R11 C18 C17 coref-relat that,agents
R12 C19 C12 coref-ident I kappa B alpha phosphorylation,the phosphorylation of I kappa B alpha
R13 C22 C21 coref-pron that,the phosphorylated I kappa B alpha
R14 C24 C13 coref-ident I kappa B alpha,I kappa B alpha
R15 C23 C19 coref-ident the phosphorylation of I kappa B alpha,I kappa B alpha phosphorylation
R16 C25 C23 coref-ident I kappa B alpha phosphorylation,the phosphorylation of I kappa B alpha
R17 C26 C20 coref-ident TNF-alpha,tumor necrosis factor alpha (TNF-alpha)
R18 C27 C15 coref-ident the phosphatase inhibitors,the phosphatase inhibitors
R19 C28 C24 coref-ident I kappa B alpha,I kappa B alpha
R20 C30 C28 coref-ident I kappa B alpha,I kappa B alpha
R21 C29 C25 coref-ident phosphorylation of I kappa B alpha,I kappa B alpha phosphorylation
R22 C31 C30 coref-ident I kappa B alpha,I kappa B alpha

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-24 protein_molecule denotes NF-kappa B
T2 28-39 protein_family_or_group denotes phosphatase
T3 64-79 other_name denotes phosphorylation
T4 83-98 protein_molecule denotes I kappa B alpha
T5 102-132 protein_domain_or_region denotes phosphatase 2A-sensitive sites
T6 148-158 protein_molecule denotes NF-kappa B
T7 170-186 other_name denotes cellular stimuli
T8 200-215 other_name denotes phosphorylation
T9 250-260 other_name denotes inhibitor,
T10 261-276 protein_molecule denotes I kappa B alpha
T11 363-392 protein_molecule denotes serine/threonine phosphatases
T12 414-429 protein_molecule denotes I kappa B alpha
T13 507-520 cell_type denotes human T cells
T14 571-582 other_organic_compound denotes calyculin A
T15 586-598 other_organic_compound denotes okadaic acid
T16 668-673 protein_family_or_group denotes PP-2A
T17 688-703 other_name denotes phosphorylation
T18 707-722 protein_molecule denotes I kappa B alpha
T19 788-810 other_organic_compound denotes phosphatase inhibitors
T20 859-867 protein_complex denotes RelA.p50
T21 868-878 protein_molecule denotes NF-kappa B
T22 946-961 protein_molecule denotes I kappa B alpha
T23 981-1008 protein_molecule denotes tumor necrosis factor alpha
T24 1010-1019 protein_molecule denotes TNF-alpha
T25 1039-1053 protein_molecule denotes phosphorylated
T26 1054-1069 protein_molecule denotes I kappa B alpha
T27 1075-1086 other_organic_compound denotes calyculin A
T28 1120-1129 protein_molecule denotes TNF-alpha
T29 1164-1169 protein_family_or_group denotes PP-2A
T30 1239-1254 other_name denotes phosphorylation
T31 1258-1273 protein_molecule denotes I kappa B alpha
T32 1303-1313 protein_molecule denotes NF-kappa B
T33 1346-1361 protein_molecule denotes I kappa B alpha
T34 1386-1395 protein_molecule denotes TNF-alpha
T35 1404-1426 other_organic_compound denotes phosphatase inhibitors
T36 1476-1491 protein_molecule denotes I kappa B alpha
T37 1638-1658 other_organic_compound denotes proteasome inhibitor
T38 1697-1712 other_name denotes phosphorylation
T39 1716-1731 protein_molecule denotes I kappa B alpha
T40 1759-1768 protein_molecule denotes TNF-alpha
T41 1787-1792 protein_family_or_group denotes PP-2A
T42 1831-1846 protein_molecule denotes I kappa B alpha
T43 1851-1861 protein_complex denotes proteasome

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 981-986 Phenotype denotes tumor HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 981-986 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 507-512 OrganismTaxon denotes human 9606

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 513-520 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084