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PubMed:7623828 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 13-28 protein denotes T-cell receptor
T2 63-69 protein denotes p95vav
T3 99-122 protein denotes T-cell antigen receptor
T4 124-127 protein denotes TCR
T5 160-176 protein denotes tyrosine kinases
T6 262-268 protein denotes p95vav
T7 304-339 cell_type denotes hematopoietic and trophoblast cells
T8 365-382 protein denotes structural motifs
T9 394-457 protein denotes Src homology 2, Src homology 3, and pleckstrin homology domains
T10 464-507 protein denotes putative guanine nucleotide exchange domain
T11 521-527 protein denotes p95vav
T12 531-534 protein denotes TCR
T13 613-619 protein denotes p95vav
T14 636-643 cell_type denotes T cells
T15 671-686 protein denotes nuclear factors
T16 698-702 protein denotes NFAT
T17 716-729 protein denotes interleukin-2
T18 755-761 protein denotes p95vav
T19 778-781 protein denotes TCR
T20 868-872 protein denotes NFAT
T21 889-915 protein denotes G-protein-coupled receptor
T22 936-942 protein denotes p95vav
T23 1005-1008 protein denotes TCR
T24 1053-1073 protein denotes first 67 amino acids
T25 1077-1083 protein denotes p95vav
T26 1124-1137 cell_line denotes NIH 3T3 cells
T27 1194-1201 cell_type denotes T cells
T28 1235-1241 protein denotes p95vav
T29 1250-1254 protein denotes NFAT
T30 1285-1288 protein denotes Ras
T31 1339-1342 protein denotes Ras
T32 1347-1350 protein denotes Raf
T33 1392-1398 protein denotes p95vav
T34 1465-1476 protein denotes calcineurin
T35 1497-1503 protein denotes p95vav
T36 1519-1522 protein denotes TCR
T37 1554-1568 cell_line denotes Jurkat mutants
T38 1582-1585 protein denotes TCR
T39 1608-1611 protein denotes TCR
T40 1649-1652 protein denotes TCR
T41 1687-1693 protein denotes p95vav
T42 1734-1740 protein denotes p95vav
T43 1770-1773 protein denotes TCR
T44 1895-1901 protein denotes p95vav
T45 1974-1977 protein denotes TCR

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-79 Sentence denotes A functional T-cell receptor signaling pathway is required for p95vav activity.
S2 80-244 Sentence denotes Stimulation of the T-cell antigen receptor (TCR) induces activation of multiple tyrosine kinases, resulting in phosphorylation of numerous intracellular substrates.
S3 245-340 Sentence denotes One substrate is p95vav, which is expressed exclusively in hematopoietic and trophoblast cells.
S4 341-508 Sentence denotes It contains a number of structural motifs, including Src homology 2, Src homology 3, and pleckstrin homology domains and a putative guanine nucleotide exchange domain.
S5 509-575 Sentence denotes The role of p95vav in TCR-mediated signaling processes is unclear.
S6 576-741 Sentence denotes Here, we show that overexpression of p95vav alone in Jurkat T cells leads to activation of the nuclear factors, including NFAT, involved in interleukin-2 expression.
S7 742-854 Sentence denotes Furthermore, p95vav synergizes with TCR stimulation in inducing NFAT- and interleukin-2-dependent transcription.
S8 855-1028 Sentence denotes In contrast, NFAT activation by a G-protein-coupled receptor is not modulated by p95vav overexpression, suggesting that the effect is specific to the TCR signaling pathways.
S9 1029-1202 Sentence denotes Although removal of the first 67 amino acids of p95vav activates its transforming potential in NIH 3T3 cells, this region appears to be required for its function in T cells.
S10 1203-1351 Sentence denotes We further demonstrate that the p95vav-induced NFAT activation is not mimicked by Ras activation, though its function is dependent upon Ras and Raf.
S11 1352-1477 Sentence denotes Furthermore, the activating function of p95vav is blocked by FK506, suggesting that its activity also depends on calcineurin.
S12 1478-1706 Sentence denotes To further dissect p95vav involvement in TCR signaling, we analyzed various Jurkat mutants deficient in TCR signaling function or TCR expression and showed that an intact TCR signaling pathway is required for p95vav to function.
S13 1707-1856 Sentence denotes However, overexpression of p95vav does not appear to influence TCR-induced protein tyrosine phosphorylation or increases in cytoplasmic free calcium.
S14 1857-1996 Sentence denotes Taken together, our data suggest that p95vav plays an important role at an yet unidentified proximal position in the TCR signaling cascade.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C15 0-46 NP denotes A functional T-cell receptor signaling pathway
C25 63-78 NP denotes p95vav activity
C1 95-128 NP denotes the T-cell antigen receptor (TCR)
C2 210-243 NP denotes numerous intracellular substrates
C3 245-258 NP denotes One substrate
C4 262-268 NP denotes p95vav
C5 270-275 NP denotes which
C6 341-343 NP denotes It
C7 521-527 NP denotes p95vav
C8 531-535 NP denotes TCR-
C9 613-619 NP denotes p95vav
C13 595-619 NP denotes overexpression of p95vav
C11 698-702 NP denotes NFAT
C10 755-761 NP denotes p95vav
C12 806-811 NP denotes NFAT-
C14 936-957 NP denotes p95vav overexpression
C16 1001-1027 NP denotes the TCR signaling pathways
C17 1077-1083 NP denotes p95vav
C18 1094-1097 NP denotes its
C19 1178-1181 NP denotes its
C20 1235-1242 NP denotes p95vav-
C21 1231-1265 NP denotes the p95vav-induced NFAT activation
C22 1308-1311 NP denotes its
C23 1392-1398 NP denotes p95vav
C24 1436-1439 NP denotes its
C26 1436-1448 NP denotes its activity
C27 1687-1693 NP denotes p95vav
C29 1734-1740 NP denotes p95vav
C28 1716-1740 NP denotes overexpression of p95vav
C30 1770-1774 NP denotes TCR-
C31 1895-1901 NP denotes p95vav
R1 C3 C2 coref-part-whole One substrate,numerous intracellular substrates
R2 C5 C4 coref-relat which,p95vav
R3 C6 C4 coref-pron It,p95vav
R4 C7 C4 coref-ident p95vav,p95vav
R5 C8 C1 coref-ident TCR-,the T-cell antigen receptor (TCR)
R6 C9 C7 coref-ident p95vav,p95vav
R7 C10 C9 coref-ident p95vav,p95vav
R8 C12 C11 coref-ident NFAT-,NFAT
R9 C14 C13 coref-ident p95vav overexpression,overexpression of p95vav
R10 C16 C15 coref-ident the TCR signaling pathways,A functional T-cell receptor signaling pathway
R11 C17 C10 coref-ident p95vav,p95vav
R12 C18 C17 coref-pron its,p95vav
R13 C19 C17 coref-pron its,p95vav
R14 C20 C17 coref-ident p95vav-,p95vav
R15 C22 C21 coref-pron its,the p95vav-induced NFAT activation
R16 C23 C20 coref-ident p95vav,p95vav-
R17 C24 C23 coref-pron its,p95vav
R18 C26 C25 coref-ident its activity,p95vav activity
R19 C27 C23 coref-ident p95vav,p95vav
R20 C29 C27 coref-ident p95vav,p95vav
R21 C28 C13 coref-ident overexpression of p95vav,overexpression of p95vav
R22 C30 C8 coref-ident TCR-,TCR-
R23 C31 C29 coref-ident p95vav,p95vav

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 2-12 other_name denotes functional
T2 13-28 protein_family_or_group denotes T-cell receptor
T3 63-69 protein_molecule denotes p95vav
T4 99-122 protein_molecule denotes T-cell antigen receptor
T5 124-127 protein_molecule denotes TCR
T6 160-176 protein_molecule denotes tyrosine kinases
T7 191-206 other_name denotes phosphorylation
T8 219-243 other_organic_compound denotes intracellular substrates
T9 262-268 protein_molecule denotes p95vav
T10 394-408 protein_domain_or_region denotes Src homology 2
T11 410-424 protein_domain_or_region denotes Src homology 3
T12 430-457 protein_domain_or_region denotes pleckstrin homology domains
T13 464-507 protein_domain_or_region denotes putative guanine nucleotide exchange domain
T14 521-527 protein_molecule denotes p95vav
T15 531-534 protein_molecule denotes TCR
T16 613-619 protein_molecule denotes p95vav
T17 636-643 cell_type denotes T cells
T18 671-686 protein_family_or_group denotes nuclear factors
T19 698-702 protein_family_or_group denotes NFAT
T20 716-729 protein_molecule denotes interleukin-2
T21 755-761 protein_molecule denotes p95vav
T22 778-781 protein_molecule denotes TCR
T23 868-872 protein_family_or_group denotes NFAT
T24 889-915 protein_family_or_group denotes G-protein-coupled receptor
T25 936-942 protein_molecule denotes p95vav
T26 1005-1008 protein_molecule denotes TCR
T27 1009-1027 other_name denotes signaling pathways
T28 1053-1073 protein_domain_or_region denotes first 67 amino acids
T29 1077-1083 protein_molecule denotes p95vav
T30 1098-1120 other_name denotes transforming potential
T31 1124-1137 cell_line denotes NIH 3T3 cells
T32 1194-1201 cell_type denotes T cells
T33 1235-1241 protein_molecule denotes p95vav
T34 1250-1254 protein_family_or_group denotes NFAT
T35 1285-1288 protein_family_or_group denotes Ras
T36 1339-1342 protein_family_or_group denotes Ras
T37 1347-1350 protein_family_or_group denotes Raf
T38 1369-1388 other_name denotes activating function
T39 1392-1398 protein_molecule denotes p95vav
T40 1413-1418 other_organic_compound denotes FK506
T41 1465-1476 protein_molecule denotes calcineurin
T42 1497-1503 protein_molecule denotes p95vav
T43 1519-1522 protein_molecule denotes TCR
T44 1554-1568 cell_line denotes Jurkat mutants
T45 1582-1585 protein_molecule denotes TCR
T46 1608-1611 protein_molecule denotes TCR
T47 1649-1652 protein_molecule denotes TCR
T48 1687-1693 protein_molecule denotes p95vav
T49 1716-1730 other_name denotes overexpression
T50 1734-1740 protein_molecule denotes p95vav
T51 1770-1773 protein_molecule denotes TCR
T52 1790-1798 amino_acid_monomer denotes tyrosine
T53 1799-1814 other_name denotes phosphorylation
T54 1831-1855 atom denotes cytoplasmic free calcium
T55 1895-1901 protein_molecule denotes p95vav
T56 1936-1966 other_name denotes unidentified proximal position
T57 1974-1977 protein_molecule denotes TCR