PubMed:7622448 JSONTXT

{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":78},"obj":"Sentence"},{"id":"T2","span":{"begin":79,"end":401},"obj":"Sentence"},{"id":"T3","span":{"begin":402,"end":537},"obj":"Sentence"},{"id":"T4","span":{"begin":538,"end":753},"obj":"Sentence"},{"id":"T5","span":{"begin":754,"end":919},"obj":"Sentence"},{"id":"T6","span":{"begin":920,"end":1038},"obj":"Sentence"},{"id":"T7","span":{"begin":1039,"end":1156},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":78},"obj":"Sentence"},{"id":"T2","span":{"begin":79,"end":401},"obj":"Sentence"},{"id":"T3","span":{"begin":402,"end":537},"obj":"Sentence"},{"id":"T4","span":{"begin":538,"end":753},"obj":"Sentence"},{"id":"T5","span":{"begin":754,"end":919},"obj":"Sentence"},{"id":"T6","span":{"begin":920,"end":1038},"obj":"Sentence"},{"id":"T7","span":{"begin":1039,"end":1156},"obj":"Sentence"}],"text":"Cloning and functional expression of a human eosinophil CC chemokine receptor.\nEosinophils undergo chemotaxis, degranulate, and exhibit [C2+]i changes in response to the human CC chemokines macrophage inflammatory protein (MIP)-1 alpha, regulated on activation, normal T expressed and secreted (RANTES), and monocyte chemoattractant protein-3 (MCP-3), but the receptors involved have not been defined. We have isolated a human cDNA encoding the first eosinophil-selective chemokine receptor, designated CC chemokine receptor 3 (CC CKR3). CC CKR3 is a seven-transmembrane domain G protein-coupled receptor most closely related to the previously reported monocyte- and neutrophil-selective receptor CC CKR1 (also known as the MIP-1 alpha/RANTES receptor). When [Ca2+]i changes were monitored in stably transfected human embryonic kidney 293 cells, MIP-1 alpha and RANTES were both potent agonists for CC CKR3 and CC CKR1. However, MIP-1 beta was also an agonist for CC CKR3 but not CC CKR1; MCP-3 was an agonist for CC CKR1 but not CC CKR3. CC CKR3 may be one of the host factors responsible for selective recruitment of eosinophils to sites of inflammation."}

{"project":"sentences","denotations":[{"id":"T1","span":{"begin":0,"end":78},"obj":"Sentence"},{"id":"T2","span":{"begin":79,"end":401},"obj":"Sentence"},{"id":"T3","span":{"begin":402,"end":537},"obj":"Sentence"},{"id":"T4","span":{"begin":538,"end":753},"obj":"Sentence"},{"id":"T5","span":{"begin":754,"end":919},"obj":"Sentence"},{"id":"T6","span":{"begin":920,"end":1038},"obj":"Sentence"},{"id":"T7","span":{"begin":1039,"end":1156},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":78},"obj":"Sentence"},{"id":"T2","span":{"begin":79,"end":401},"obj":"Sentence"},{"id":"T3","span":{"begin":402,"end":537},"obj":"Sentence"},{"id":"T4","span":{"begin":538,"end":753},"obj":"Sentence"},{"id":"T5","span":{"begin":754,"end":919},"obj":"Sentence"},{"id":"T6","span":{"begin":920,"end":1038},"obj":"Sentence"},{"id":"T7","span":{"begin":1039,"end":1156},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Cloning and functional expression of a human eosinophil CC chemokine receptor.\nEosinophils undergo chemotaxis, degranulate, and exhibit [C2+]i changes in response to the human CC chemokines macrophage inflammatory protein (MIP)-1 alpha, regulated on activation, normal T expressed and secreted (RANTES), and monocyte chemoattractant protein-3 (MCP-3), but the receptors involved have not been defined. We have isolated a human cDNA encoding the first eosinophil-selective chemokine receptor, designated CC chemokine receptor 3 (CC CKR3). CC CKR3 is a seven-transmembrane domain G protein-coupled receptor most closely related to the previously reported monocyte- and neutrophil-selective receptor CC CKR1 (also known as the MIP-1 alpha/RANTES receptor). When [Ca2+]i changes were monitored in stably transfected human embryonic kidney 293 cells, MIP-1 alpha and RANTES were both potent agonists for CC CKR3 and CC CKR1. However, MIP-1 beta was also an agonist for CC CKR3 but not CC CKR1; MCP-3 was an agonist for CC CKR1 but not CC CKR3. CC CKR3 may be one of the host factors responsible for selective recruitment of eosinophils to sites of inflammation."}

{"project":"Glycosmos6-MAT","denotations":[{"id":"T1","span":{"begin":828,"end":834},"obj":"http://purl.obolibrary.org/obo/MAT_0000119"}],"text":"Cloning and functional expression of a human eosinophil CC chemokine receptor.\nEosinophils undergo chemotaxis, degranulate, and exhibit [C2+]i changes in response to the human CC chemokines macrophage inflammatory protein (MIP)-1 alpha, regulated on activation, normal T expressed and secreted (RANTES), and monocyte chemoattractant protein-3 (MCP-3), but the receptors involved have not been defined. We have isolated a human cDNA encoding the first eosinophil-selective chemokine receptor, designated CC chemokine receptor 3 (CC CKR3). CC CKR3 is a seven-transmembrane domain G protein-coupled receptor most closely related to the previously reported monocyte- and neutrophil-selective receptor CC CKR1 (also known as the MIP-1 alpha/RANTES receptor). When [Ca2+]i changes were monitored in stably transfected human embryonic kidney 293 cells, MIP-1 alpha and RANTES were both potent agonists for CC CKR3 and CC CKR1. However, MIP-1 beta was also an agonist for CC CKR3 but not CC CKR1; MCP-3 was an agonist for CC CKR1 but not CC CKR3. CC CKR3 may be one of the host factors responsible for selective recruitment of eosinophils to sites of inflammation."}

{"project":"AIMed","denotations":[{"id":"T1","span":{"begin":222,"end":235},"obj":"protein"},{"id":"T2","span":{"begin":295,"end":301},"obj":"protein"},{"id":"T3","span":{"begin":308,"end":342},"obj":"protein"},{"id":"T4","span":{"begin":344,"end":349},"obj":"protein"},{"id":"T5","span":{"begin":503,"end":526},"obj":"protein"},{"id":"T6","span":{"begin":528,"end":535},"obj":"protein"},{"id":"T7","span":{"begin":538,"end":545},"obj":"protein"},{"id":"T8","span":{"begin":697,"end":704},"obj":"protein"},{"id":"T9","span":{"begin":724,"end":735},"obj":"protein"},{"id":"T10","span":{"begin":736,"end":742},"obj":"protein"},{"id":"T11","span":{"begin":846,"end":857},"obj":"protein"},{"id":"T13","span":{"begin":862,"end":868},"obj":"protein"},{"id":"T14","span":{"begin":899,"end":906},"obj":"protein"},{"id":"T15","span":{"begin":911,"end":918},"obj":"protein"},{"id":"T16","span":{"begin":929,"end":939},"obj":"protein"},{"id":"T17","span":{"begin":964,"end":971},"obj":"protein"},{"id":"T18","span":{"begin":980,"end":987},"obj":"protein"},{"id":"T19","span":{"begin":989,"end":994},"obj":"protein"},{"id":"T20","span":{"begin":1014,"end":1021},"obj":"protein"},{"id":"T21","span":{"begin":1030,"end":1037},"obj":"protein"},{"id":"T22","span":{"begin":1039,"end":1046},"obj":"protein"}],"text":"Cloning and functional expression of a human eosinophil CC chemokine receptor.\nEosinophils undergo chemotaxis, degranulate, and exhibit [C2+]i changes in response to the human CC chemokines macrophage inflammatory protein (MIP)-1 alpha, regulated on activation, normal T expressed and secreted (RANTES), and monocyte chemoattractant protein-3 (MCP-3), but the receptors involved have not been defined. We have isolated a human cDNA encoding the first eosinophil-selective chemokine receptor, designated CC chemokine receptor 3 (CC CKR3). CC CKR3 is a seven-transmembrane domain G protein-coupled receptor most closely related to the previously reported monocyte- and neutrophil-selective receptor CC CKR1 (also known as the MIP-1 alpha/RANTES receptor). When [Ca2+]i changes were monitored in stably transfected human embryonic kidney 293 cells, MIP-1 alpha and RANTES were both potent agonists for CC CKR3 and CC CKR1. However, MIP-1 beta was also an agonist for CC CKR3 but not CC CKR1; MCP-3 was an agonist for CC CKR1 but not CC CKR3. CC CKR3 may be one of the host factors responsible for selective recruitment of eosinophils to sites of inflammation."}

{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":828,"end":834},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000119"}],"text":"Cloning and functional expression of a human eosinophil CC chemokine receptor.\nEosinophils undergo chemotaxis, degranulate, and exhibit [C2+]i changes in response to the human CC chemokines macrophage inflammatory protein (MIP)-1 alpha, regulated on activation, normal T expressed and secreted (RANTES), and monocyte chemoattractant protein-3 (MCP-3), but the receptors involved have not been defined. We have isolated a human cDNA encoding the first eosinophil-selective chemokine receptor, designated CC chemokine receptor 3 (CC CKR3). CC CKR3 is a seven-transmembrane domain G protein-coupled receptor most closely related to the previously reported monocyte- and neutrophil-selective receptor CC CKR1 (also known as the MIP-1 alpha/RANTES receptor). When [Ca2+]i changes were monitored in stably transfected human embryonic kidney 293 cells, MIP-1 alpha and RANTES were both potent agonists for CC CKR3 and CC CKR1. However, MIP-1 beta was also an agonist for CC CKR3 but not CC CKR1; MCP-3 was an agonist for CC CKR1 but not CC CKR3. CC CKR3 may be one of the host factors responsible for selective recruitment of eosinophils to sites of inflammation."}

{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":1143,"end":1155},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"Cloning and functional expression of a human eosinophil CC chemokine receptor.\nEosinophils undergo chemotaxis, degranulate, and exhibit [C2+]i changes in response to the human CC chemokines macrophage inflammatory protein (MIP)-1 alpha, regulated on activation, normal T expressed and secreted (RANTES), and monocyte chemoattractant protein-3 (MCP-3), but the receptors involved have not been defined. We have isolated a human cDNA encoding the first eosinophil-selective chemokine receptor, designated CC chemokine receptor 3 (CC CKR3). CC CKR3 is a seven-transmembrane domain G protein-coupled receptor most closely related to the previously reported monocyte- and neutrophil-selective receptor CC CKR1 (also known as the MIP-1 alpha/RANTES receptor). When [Ca2+]i changes were monitored in stably transfected human embryonic kidney 293 cells, MIP-1 alpha and RANTES were both potent agonists for CC CKR3 and CC CKR1. However, MIP-1 beta was also an agonist for CC CKR3 but not CC CKR1; MCP-3 was an agonist for CC CKR1 but not CC CKR3. CC CKR3 may be one of the host factors responsible for selective recruitment of eosinophils to sites of inflammation."}

{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":39,"end":44},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":170,"end":175},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":421,"end":426},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":812,"end":817},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"9606"},{"id":"A2","pred":"db_id","subj":"T2","obj":"9606"},{"id":"A3","pred":"db_id","subj":"T3","obj":"9606"},{"id":"A4","pred":"db_id","subj":"T4","obj":"9606"}],"text":"Cloning and functional expression of a human eosinophil CC chemokine receptor.\nEosinophils undergo chemotaxis, degranulate, and exhibit [C2+]i changes in response to the human CC chemokines macrophage inflammatory protein (MIP)-1 alpha, regulated on activation, normal T expressed and secreted (RANTES), and monocyte chemoattractant protein-3 (MCP-3), but the receptors involved have not been defined. We have isolated a human cDNA encoding the first eosinophil-selective chemokine receptor, designated CC chemokine receptor 3 (CC CKR3). CC CKR3 is a seven-transmembrane domain G protein-coupled receptor most closely related to the previously reported monocyte- and neutrophil-selective receptor CC CKR1 (also known as the MIP-1 alpha/RANTES receptor). When [Ca2+]i changes were monitored in stably transfected human embryonic kidney 293 cells, MIP-1 alpha and RANTES were both potent agonists for CC CKR3 and CC CKR1. However, MIP-1 beta was also an agonist for CC CKR3 but not CC CKR1; MCP-3 was an agonist for CC CKR1 but not CC CKR3. CC CKR3 may be one of the host factors responsible for selective recruitment of eosinophils to sites of inflammation."}

{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":45,"end":55},"obj":"Body_part"},{"id":"T2","span":{"begin":190,"end":200},"obj":"Body_part"},{"id":"T3","span":{"begin":308,"end":316},"obj":"Body_part"},{"id":"T5","span":{"begin":451,"end":461},"obj":"Body_part"},{"id":"T6","span":{"begin":557,"end":570},"obj":"Body_part"},{"id":"T7","span":{"begin":653,"end":661},"obj":"Body_part"},{"id":"T9","span":{"begin":667,"end":677},"obj":"Body_part"},{"id":"T10","span":{"begin":818,"end":834},"obj":"Body_part"},{"id":"T11","span":{"begin":1119,"end":1130},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL_0017502"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL_0000235"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A4","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL_0017502"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/GO_0016020"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A8","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CL_0000775"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0002120"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CL_0017502"}],"text":"Cloning and functional expression of a human eosinophil CC chemokine receptor.\nEosinophils undergo chemotaxis, degranulate, and exhibit [C2+]i changes in response to the human CC chemokines macrophage inflammatory protein (MIP)-1 alpha, regulated on activation, normal T expressed and secreted (RANTES), and monocyte chemoattractant protein-3 (MCP-3), but the receptors involved have not been defined. We have isolated a human cDNA encoding the first eosinophil-selective chemokine receptor, designated CC chemokine receptor 3 (CC CKR3). CC CKR3 is a seven-transmembrane domain G protein-coupled receptor most closely related to the previously reported monocyte- and neutrophil-selective receptor CC CKR1 (also known as the MIP-1 alpha/RANTES receptor). When [Ca2+]i changes were monitored in stably transfected human embryonic kidney 293 cells, MIP-1 alpha and RANTES were both potent agonists for CC CKR3 and CC CKR1. However, MIP-1 beta was also an agonist for CC CKR3 but not CC CKR1; MCP-3 was an agonist for CC CKR1 but not CC CKR3. CC CKR3 may be one of the host factors responsible for selective recruitment of eosinophils to sites of inflammation."}

{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":45,"end":55},"obj":"Cell"},{"id":"T2","span":{"begin":79,"end":90},"obj":"Cell"},{"id":"T3","span":{"begin":190,"end":200},"obj":"Cell"},{"id":"T5","span":{"begin":308,"end":316},"obj":"Cell"},{"id":"T7","span":{"begin":451,"end":461},"obj":"Cell"},{"id":"T8","span":{"begin":653,"end":661},"obj":"Cell"},{"id":"T10","span":{"begin":667,"end":677},"obj":"Cell"},{"id":"T11","span":{"begin":1119,"end":1130},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000771"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0000771"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000235"},{"id":"A4","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000394"},{"id":"A5","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A6","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A7","pred":"cl_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL:0000771"},{"id":"A8","pred":"cl_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A9","pred":"cl_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A10","pred":"cl_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CL:0000775"},{"id":"A11","pred":"cl_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CL:0000771"}],"text":"Cloning and functional expression of a human eosinophil CC chemokine receptor.\nEosinophils undergo chemotaxis, degranulate, and exhibit [C2+]i changes in response to the human CC chemokines macrophage inflammatory protein (MIP)-1 alpha, regulated on activation, normal T expressed and secreted (RANTES), and monocyte chemoattractant protein-3 (MCP-3), but the receptors involved have not been defined. We have isolated a human cDNA encoding the first eosinophil-selective chemokine receptor, designated CC chemokine receptor 3 (CC CKR3). CC CKR3 is a seven-transmembrane domain G protein-coupled receptor most closely related to the previously reported monocyte- and neutrophil-selective receptor CC CKR1 (also known as the MIP-1 alpha/RANTES receptor). When [Ca2+]i changes were monitored in stably transfected human embryonic kidney 293 cells, MIP-1 alpha and RANTES were both potent agonists for CC CKR3 and CC CKR1. However, MIP-1 beta was also an agonist for CC CKR3 but not CC CKR1; MCP-3 was an agonist for CC CKR1 but not CC CKR3. CC CKR3 may be one of the host factors responsible for selective recruitment of eosinophils to sites of inflammation."}