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PubMed:7605990 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 494-498 gene:861 denotes AML1
T1 555-572 disease:C0023470 denotes myeloid leukemias
R1 T0 T1 associated_with AML1,myeloid leukemias

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 36-84 protein denotes granulocyte-macrophage colony-stimulating factor
T2 106-139 protein denotes AML1-related transcription factor
T3 141-146 protein denotes PEBP2
T4 152-223 DNA denotes granulocyte-macrophage colony-stimulating factor (GM-CSF) gene promoter
T5 262-330 protein denotes polyomavirus enhancer binding-protein 2 (PEBP2) transcription factor
T6 350-373 protein denotes alpha and beta subunits
T7 405-412 DNA denotes alpha A
T8 417-424 DNA denotes alpha B
T9 439-452 protein denotes alpha subunit
T10 454-461 DNA denotes alpha B
T11 469-484 DNA denotes mouse homologue
T12 488-503 DNA denotes human AML1 gene
T13 586-594 protein denotes alpha A1
T14 599-619 protein denotes alpha A-gene product
T15 625-633 protein denotes alpha B1
T16 638-646 protein denotes alpha B2
T17 652-675 protein denotes alpha B-encoded isomers
T18 702-717 DNA denotes GM-CSF promoter
T19 719-733 protein denotes PEBP2 alpha A1
T20 735-743 protein denotes alpha B1
T21 749-766 protein denotes alpha B2 proteins
T22 777-787 DNA denotes PEBP2 site
T23 799-820 DNA denotes mouse GM-CSF promoter
T24 822-836 protein denotes PEBP2 alpha A1
T25 841-849 protein denotes alpha B1
T26 881-920 DNA denotes GM-CSF promoter-driven reporter plasmid
T27 924-1028 cell_line denotes unstimulated and 12-O-tetradecanoylphorbol 13-acetate/phytohemagglutinin-stimulated human Jurkat T cells
T28 1083-1091 protein denotes alpha B2
T29 1109-1117 protein denotes alpha B1
T30 1122-1130 protein denotes alpha B2
T31 1192-1200 protein denotes alpha B1
T32 1200-1209 protein denotes /alpha B2
T33 1247-1273 protein denotes PEBP2 site-binding protein
T34 1301-1330 protein denotes antimouse alpha A1 antibodies
T35 1389-1402 protein denotes PEBP2 alpha A
T36 1404-1411 DNA denotes alpha B
T37 1413-1417 DNA denotes AML1
T38 1424-1434 DNA denotes beta genes
T39 1438-1450 cell_line denotes Jurkat cells
T40 1523-1528 protein denotes PEBP2
T41 1536-1542 protein denotes GM-CSF
T42 1643-1657 protein denotes PEBP2 isoforms

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
7605990-2#119#123#gene861 494-498 gene861 denotes AML1
7605990-2#180#197#diseaseC0023470 555-572 diseaseC0023470 denotes myeloid leukemias
119#123#gene861180#197#diseaseC0023470 7605990-2#119#123#gene861 7605990-2#180#197#diseaseC0023470 associated_with AML1,myeloid leukemias

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-147 Sentence denotes Positive and negative regulation of granulocyte-macrophage colony-stimulating factor promoter activity by AML1-related transcription factor, PEBP2.
S2 148-374 Sentence denotes The granulocyte-macrophage colony-stimulating factor (GM-CSF) gene promoter contains a consensus sequence for the polyomavirus enhancer binding-protein 2 (PEBP2) transcription factor, which consists of alpha and beta subunits.
S3 375-453 Sentence denotes There are at least two genes, alpha A and alpha B, encoding the alpha subunit.
S4 454-573 Sentence denotes alpha B is the mouse homologue of human AML1 gene detected at the breakpoints of t(8;21) and t(3;21) myeloid leukemias.
S5 574-718 Sentence denotes We examined alpha A1 (an alpha A-gene product) and alpha B1 and alpha B2 (two alpha B-encoded isomers) for their effects on the GM-CSF promoter.
S6 719-821 Sentence denotes PEBP2 alpha A1, alpha B1, and alpha B2 proteins bound the PEBP2 site within the mouse GM-CSF promoter.
S7 822-1029 Sentence denotes PEBP2 alpha A1 and alpha B1 enhanced the expression of the GM-CSF promoter-driven reporter plasmid in unstimulated and 12-O-tetradecanoylphorbol 13-acetate/phytohemagglutinin-stimulated human Jurkat T cells.
S8 1030-1092 Sentence denotes In contrast, the promoter activity was suppressed by alpha B2.
S9 1093-1216 Sentence denotes Coexpression of alpha B1 and alpha B2 showed that the promoter activity could be determined by the alpha B1/alpha B2 ratio.
S10 1217-1331 Sentence denotes Jurkat cell extract contained PEBP2 site-binding protein(s) that cross-reacted with antimouse alpha A1 antibodies.
S11 1332-1451 Sentence denotes Northern blot analysis indicated the expression of human PEBP2 alpha A, alpha B (AML1), and beta genes in Jurkat cells.
S12 1452-1708 Sentence denotes Although further studies are required to determine the precise role of PEBP2 in the GM-CSF promoter activity, the present findings suggested the importance of the relative ratio of different PEBP2 isoforms in regulating the levels of the promoter activity.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C26 36-102 NP denotes granulocyte-macrophage colony-stimulating factor promoter activity
C1 106-139 NP denotes AML1-related transcription factor
C2 141-146 NP denotes PEBP2
C3 148-223 NP denotes The granulocyte-macrophage colony-stimulating factor (GM-CSF) gene promoter
C4 233-330 NP denotes a consensus sequence for the polyomavirus enhancer binding-protein 2 (PEBP2) transcription factor
C5 332-337 NP denotes which
C6 350-373 NP denotes alpha and beta subunits
C8 394-403 NP denotes two genes
C10 405-412 NP denotes alpha A
C11 417-424 NP denotes alpha B
C7 435-452 NP denotes the alpha subunit
C12 454-461 NP denotes alpha B
C16 586-620 NP denotes alpha A1 (an alpha A-gene product)
C14 625-633 NP denotes alpha B1
C15 638-646 NP denotes alpha B2
C13 586-676 NP denotes alpha A1 (an alpha A-gene product) and alpha B1 and alpha B2 (two alpha B-encoded isomers)
C17 681-686 NP denotes their
C18 698-717 NP denotes the GM-CSF promoter
C19 719-733 NP denotes PEBP2 alpha A1
C20 735-743 NP denotes alpha B1
C21 749-757 NP denotes alpha B2
C22 795-820 NP denotes the mouse GM-CSF promoter
C23 822-836 NP denotes PEBP2 alpha A1
C24 841-849 NP denotes alpha B1
C25 877-903 NP denotes the GM-CSF promoter-driven
C27 1043-1064 NP denotes the promoter activity
C28 1083-1091 NP denotes alpha B2
C29 1109-1117 NP denotes alpha B1
C30 1122-1130 NP denotes alpha B2
C31 1143-1164 NP denotes the promoter activity
C32 1247-1276 NP denotes PEBP2 site-binding protein(s)
C33 1277-1281 NP denotes that
C34 1383-1402 NP denotes human PEBP2 alpha A
C35 1404-1418 NP denotes alpha B (AML1)
C36 1523-1528 NP denotes PEBP2
C37 1532-1560 NP denotes the GM-CSF promoter activity
C38 1686-1707 NP denotes the promoter activity
R1 C2 C1 coref-appos PEBP2,AML1-related transcription factor
R2 C5 C4 coref-relat which,a consensus sequence for the polyomavirus enhancer binding-protein 2 (PEBP2) transcription factor
R3 C10 C8 coref-part-whole alpha A,two genes
R4 C11 C8 coref-part-whole alpha B,two genes
R5 C7 C6 coref-part-whole the alpha subunit,alpha and beta subunits
R6 C12 C11 coref-ident alpha B,alpha B
R7 C17 C16 coref-pron their,alpha A1 (an alpha A-gene product)
R8 C18 C3 coref-ident the GM-CSF promoter,The granulocyte-macrophage colony-stimulating factor (GM-CSF) gene promoter
R9 C19 C13 coref-ident PEBP2 alpha A1,alpha A1 (an alpha A-gene product) and alpha B1 and alpha B2 (two alpha B-encoded isomers)
R10 C20 C14 coref-ident alpha B1,alpha B1
R11 C21 C15 coref-ident alpha B2,alpha B2
R12 C22 C18 coref-ident the mouse GM-CSF promoter,the GM-CSF promoter
R13 C23 C19 coref-ident PEBP2 alpha A1,PEBP2 alpha A1
R14 C24 C20 coref-ident alpha B1,alpha B1
R15 C25 C22 coref-ident the GM-CSF promoter-driven,the mouse GM-CSF promoter
R16 C27 C26 coref-ident the promoter activity,granulocyte-macrophage colony-stimulating factor promoter activity
R17 C28 C21 coref-ident alpha B2,alpha B2
R18 C29 C24 coref-ident alpha B1,alpha B1
R19 C30 C28 coref-ident alpha B2,alpha B2
R20 C31 C27 coref-ident the promoter activity,the promoter activity
R21 C33 C32 coref-relat that,PEBP2 site-binding protein(s)
R22 C34 C10 coref-ident human PEBP2 alpha A,alpha A
R23 C35 C11 coref-ident alpha B (AML1),alpha B
R24 C36 C2 coref-ident PEBP2,PEBP2
R25 C37 C31 coref-ident the GM-CSF promoter activity,the promoter activity
R26 C38 C37 coref-ident the promoter activity,the GM-CSF promoter activity

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 36-84 protein_molecule denotes granulocyte-macrophage colony-stimulating factor
T2 106-139 protein_molecule denotes AML1-related transcription factor
T3 141-146 protein_molecule denotes PEBP2
T4 152-200 protein_molecule denotes granulocyte-macrophage colony-stimulating factor
T5 202-208 protein_molecule denotes GM-CSF
T6 262-301 protein_molecule denotes polyomavirus enhancer binding-protein 2
T7 303-308 protein_molecule denotes PEBP2
T8 405-412 DNA_domain_or_region denotes alpha A
T9 417-424 DNA_domain_or_region denotes alpha B
T10 439-452 protein_subunit denotes alpha subunit
T11 454-461 DNA_domain_or_region denotes alpha B
T12 469-484 DNA_family_or_group denotes mouse homologue
T13 488-503 DNA_domain_or_region denotes human AML1 gene
T14 586-594 protein_subunit denotes alpha A1
T15 599-606 DNA_domain_or_region denotes alpha A
T16 625-633 protein_subunit denotes alpha B1
T17 638-646 protein_subunit denotes alpha B2
T18 652-659 protein_subunit denotes alpha B
T19 702-717 DNA_domain_or_region denotes GM-CSF promoter
T20 719-724 protein_molecule denotes PEBP2
T21 725-733 protein_subunit denotes alpha A1
T22 735-743 protein_subunit denotes alpha B1
T23 749-766 protein_family_or_group denotes alpha B2 proteins
T24 777-782 protein_molecule denotes PEBP2
T25 799-804 DNA_domain_or_region denotes mouse
T26 805-811 protein_molecule denotes GM-CSF
T27 822-827 protein_molecule denotes PEBP2
T28 828-836 protein_subunit denotes alpha A1
T29 841-849 protein_subunit denotes alpha B1
T30 881-887 protein_molecule denotes GM-CSF
T31 1047-1064 other_name denotes promoter activity
T32 1083-1091 protein_subunit denotes alpha B2
T33 1109-1117 protein_subunit denotes alpha B1
T34 1122-1130 protein_subunit denotes alpha B2
T35 1147-1164 other_name denotes promoter activity
T36 1192-1200 protein_subunit denotes alpha B1
T37 1200-1209 protein_subunit denotes /alpha B2
T38 1217-1236 cell_component denotes Jurkat cell extract
T39 1247-1252 protein_molecule denotes PEBP2
T40 1301-1310 protein_family_or_group denotes antimouse
T41 1311-1319 protein_subunit denotes alpha A1
T42 1332-1354 other_name denotes Northern blot analysis
T43 1389-1394 protein_molecule denotes PEBP2
T44 1404-1411 protein_subunit denotes alpha B
T45 1413-1417 DNA_domain_or_region denotes AML1
T46 1424-1434 DNA_domain_or_region denotes beta genes
T47 1438-1450 cell_line denotes Jurkat cells
T48 1523-1528 protein_molecule denotes PEBP2
T49 1536-1542 protein_molecule denotes GM-CSF
T50 1543-1560 other_name denotes promoter activity
T51 1643-1648 protein_molecule denotes PEBP2
T52 1690-1707 other_name denotes promoter activity