PubMed:7598712 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PubMed/sourceid/7598712","sourcedb":"PubMed","sourceid":"7598712","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/7598712","text":"Genetic variability in the TNF-alpha promoter is not associated with type II diabetes mellitus (NIDDM).\nRecent evidence suggests that expression of tumor necrosis factor-alpha (TNF-alpha) by adipocytes is a molecular mediator of insulin resistance in obesity. We have therefore tested the hypothesis that variations within the regulatory region of the TNF-alpha gene, which might cause increased adipocyte or generalized TNF-alpha synthesis, are associated with NIDDM, a state in which insulin resistance is routinely observed. Neither the previously known variants within the TNF-alpha promoter at position -308 and -238, nor two newly identified polymorphisms at position -376 and -163, were found at a significantly higher frequency in Caucasian NIDDM patients compared to non-diabetic controls. No genetic variants were found in Pima Indians. These data make it unlikely that mutations within regulatory elements of the TNF-alpha gene are associated with an increase in the prevalence of NIDDM.","tracks":[{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":148,"end":175},"obj":"gene:7124"},{"id":"T1","span":{"begin":251,"end":258},"obj":"disease:C0028754"},{"id":"T2","span":{"begin":177,"end":186},"obj":"gene:7124"},{"id":"T3","span":{"begin":251,"end":258},"obj":"disease:C0028754"},{"id":"T4","span":{"begin":229,"end":236},"obj":"gene:723961"},{"id":"T5","span":{"begin":251,"end":258},"obj":"disease:C0028754"},{"id":"T6","span":{"begin":229,"end":236},"obj":"gene:3630"},{"id":"T7","span":{"begin":251,"end":258},"obj":"disease:C0028754"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"},{"subj":"T6","pred":"source","obj":"DisGeNET"},{"subj":"T7","pred":"source","obj":"DisGeNET"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"7598712-1#44#71#gene7124","span":{"begin":148,"end":175},"obj":"gene7124"},{"id":"7598712-1#73#82#gene7124","span":{"begin":177,"end":186},"obj":"gene7124"},{"id":"7598712-1#147#154#diseaseC0028754","span":{"begin":251,"end":258},"obj":"diseaseC0028754"}],"relations":[{"id":"44#71#gene7124147#154#diseaseC0028754","pred":"associated_with","subj":"7598712-1#44#71#gene7124","obj":"7598712-1#147#154#diseaseC0028754"},{"id":"73#82#gene7124147#154#diseaseC0028754","pred":"associated_with","subj":"7598712-1#73#82#gene7124","obj":"7598712-1#147#154#diseaseC0028754"}],"attributes":[{"subj":"7598712-1#44#71#gene7124","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"7598712-1#73#82#gene7124","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"7598712-1#147#154#diseaseC0028754","pred":"source","obj":"DisGeNET5_gene_disease"}]},{"project":"123123123","denotations":[{"id":"T1","span":{"begin":880,"end":889},"obj":"B-Variation"}],"attributes":[{"subj":"T1","pred":"source","obj":"123123123"}]},{"project":"Wangshuguang","denotations":[{"id":"T1","span":{"begin":880,"end":889},"obj":"B-Variation"},{"id":"T1","span":{"begin":880,"end":889},"obj":"B-Variation"}],"attributes":[{"subj":"T1","pred":"source","obj":"Wangshuguang"},{"subj":"T1","pred":"source","obj":"Wangshuguang"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"DisGeNET","color":"#9dec93","default":true},{"id":"DisGeNET5_gene_disease","color":"#ec93b7"},{"id":"123123123","color":"#93d1ec"},{"id":"Wangshuguang","color":"#ebec93"}]}]}}