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sentences

Id Subject Object Predicate Lexical cue
T1 0-119 Sentence denotes Identification of essential GATA and Ets binding motifs within the promoter of the platelet glycoprotein Ib alpha gene.
T2 120-278 Sentence denotes Platelet glycoprotein (GP) Ib-IX-V is a multisubunit adhesion receptor that supports platelet attachment to thrombogenic surfaces at sites of vascular injury.
T3 279-460 Sentence denotes The congenital absence of the receptor results in a bleeding disorder associated with "giant" platelets, a condition linking the expression of the complex to platelet morphogenesis.
T4 461-665 Sentence denotes To understand better the expression of the GP Ib-IX-V complex, studies were undertaken to define the essential genetic elements supporting the expression of the alpha-subunit of the complex (GP Ib alpha).
T5 666-814 Sentence denotes GP Ib alpha promoter activity was evaluated by transfection of human erythroleukemia cells with reporter plasmids coding for the enzyme, luciferase.
T6 815-1031 Sentence denotes Studies were initiated with a fragment extending 2,738 nucleotides 5' to the transcription start site and lead to the identification of 253 nucleotides retaining full promoter activity in human erythroleukemia cells.
T7 1032-1214 Sentence denotes In cells of nonhematopoietic lineage, human endothelial and HeLa cells, the GP Ib alpha promoter activity was no greater than background levels obtained with promoterless constructs.
T8 1215-1494 Sentence denotes Gel shift assays and site-directed mutagenesis studies defined essential GATA and Ets binding motifs 93 and 150 nucleotides upstream of the transcription start site, a finding which further substantiates these elements as important determinants of megakaryocytic gene expression.
T9 1495-1702 Sentence denotes The results define essential cis-acting elements responsible for the expression of GP Ib alpha and provide insights into molecular events coinciding with the release of normal platelets into the bloodstream.
T1 0-119 Sentence denotes Identification of essential GATA and Ets binding motifs within the promoter of the platelet glycoprotein Ib alpha gene.
T2 120-278 Sentence denotes Platelet glycoprotein (GP) Ib-IX-V is a multisubunit adhesion receptor that supports platelet attachment to thrombogenic surfaces at sites of vascular injury.
T3 279-460 Sentence denotes The congenital absence of the receptor results in a bleeding disorder associated with "giant" platelets, a condition linking the expression of the complex to platelet morphogenesis.
T4 461-665 Sentence denotes To understand better the expression of the GP Ib-IX-V complex, studies were undertaken to define the essential genetic elements supporting the expression of the alpha-subunit of the complex (GP Ib alpha).
T5 666-814 Sentence denotes GP Ib alpha promoter activity was evaluated by transfection of human erythroleukemia cells with reporter plasmids coding for the enzyme, luciferase.
T6 815-1031 Sentence denotes Studies were initiated with a fragment extending 2,738 nucleotides 5' to the transcription start site and lead to the identification of 253 nucleotides retaining full promoter activity in human erythroleukemia cells.
T7 1032-1214 Sentence denotes In cells of nonhematopoietic lineage, human endothelial and HeLa cells, the GP Ib alpha promoter activity was no greater than background levels obtained with promoterless constructs.
T8 1215-1494 Sentence denotes Gel shift assays and site-directed mutagenesis studies defined essential GATA and Ets binding motifs 93 and 150 nucleotides upstream of the transcription start site, a finding which further substantiates these elements as important determinants of megakaryocytic gene expression.
T9 1495-1702 Sentence denotes The results define essential cis-acting elements responsible for the expression of GP Ib alpha and provide insights into molecular events coinciding with the release of normal platelets into the bloodstream.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 666-677 gene:2811 denotes GP Ib alpha
T1 735-750 disease:C0023440 denotes erythroleukemia
R1 T0 T1 associated_with GP Ib alpha,erythroleukemia

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 28-32 DNA denotes GATA
T2 37-55 DNA denotes Ets binding motifs
T3 83-118 DNA denotes platelet glycoprotein Ib alpha gene
T4 120-141 protein denotes Platelet glycoprotein
T5 143-145 protein denotes GP
T6 147-154 protein denotes Ib-IX-V
T7 160-190 protein denotes multisubunit adhesion receptor
T8 365-382 cell_type denotes "giant" platelets
T9 504-522 protein denotes GP Ib-IX-V complex
T10 572-588 DNA denotes genetic elements
T11 622-635 protein denotes alpha-subunit
T12 652-663 protein denotes GP Ib alpha
T13 666-686 DNA denotes GP Ib alpha promoter
T14 729-756 cell_type denotes human erythroleukemia cells
T15 795-801 protein denotes enzyme
T16 803-813 protein denotes luciferase
T17 892-916 DNA denotes transcription start site
T18 1003-1030 cell_type denotes human erythroleukemia cells
T19 1044-1068 cell_type denotes nonhematopoietic lineage
T20 1070-1087 cell_type denotes human endothelial
T21 1092-1102 cell_type denotes HeLa cells
T22 1108-1128 DNA denotes GP Ib alpha promoter
T23 1190-1213 DNA denotes promoterless constructs
T24 1288-1292 DNA denotes GATA
T25 1297-1315 DNA denotes Ets binding motifs
T26 1316-1347 DNA denotes 93 and 150 nucleotides upstream
T27 1355-1379 DNA denotes transcription start site
T28 1524-1543 DNA denotes cis-acting elements
T29 1578-1589 protein denotes GP Ib alpha
T30 1664-1680 cell_type denotes normal platelets

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
7592671-4#0#11#gene2811 666-677 gene2811 denotes GP Ib alpha
7592671-4#69#84#diseaseC0023440 735-750 diseaseC0023440 denotes erythroleukemia
0#11#gene281169#84#diseaseC0023440 7592671-4#0#11#gene2811 7592671-4#69#84#diseaseC0023440 associated_with GP Ib alpha,erythroleukemia

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-119 Sentence denotes Identification of essential GATA and Ets binding motifs within the promoter of the platelet glycoprotein Ib alpha gene.
S2 120-278 Sentence denotes Platelet glycoprotein (GP) Ib-IX-V is a multisubunit adhesion receptor that supports platelet attachment to thrombogenic surfaces at sites of vascular injury.
S3 279-460 Sentence denotes The congenital absence of the receptor results in a bleeding disorder associated with "giant" platelets, a condition linking the expression of the complex to platelet morphogenesis.
S4 461-665 Sentence denotes To understand better the expression of the GP Ib-IX-V complex, studies were undertaken to define the essential genetic elements supporting the expression of the alpha-subunit of the complex (GP Ib alpha).
S5 666-814 Sentence denotes GP Ib alpha promoter activity was evaluated by transfection of human erythroleukemia cells with reporter plasmids coding for the enzyme, luciferase.
S6 815-1031 Sentence denotes Studies were initiated with a fragment extending 2,738 nucleotides 5' to the transcription start site and lead to the identification of 253 nucleotides retaining full promoter activity in human erythroleukemia cells.
S7 1032-1214 Sentence denotes In cells of nonhematopoietic lineage, human endothelial and HeLa cells, the GP Ib alpha promoter activity was no greater than background levels obtained with promoterless constructs.
S8 1215-1494 Sentence denotes Gel shift assays and site-directed mutagenesis studies defined essential GATA and Ets binding motifs 93 and 150 nucleotides upstream of the transcription start site, a finding which further substantiates these elements as important determinants of megakaryocytic gene expression.
S9 1495-1702 Sentence denotes The results define essential cis-acting elements responsible for the expression of GP Ib alpha and provide insights into molecular events coinciding with the release of normal platelets into the bloodstream.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 18-55 NP denotes essential GATA and Ets binding motifs
C2 120-154 NP denotes Platelet glycoprotein (GP) Ib-IX-V
C3 158-190 NP denotes a multisubunit adhesion receptor
C4 191-195 NP denotes that
C5 305-317 NP denotes the receptor
C6 329-382 NP denotes a bleeding disorder associated with "giant" platelets
C8 422-433 NP denotes the complex
C7 384-459 NP denotes a condition linking the expression of the complex to platelet morphogenesis
C9 500-522 NP denotes the GP Ib-IX-V complex
C11 639-650 NP denotes the complex
C10 618-664 NP denotes the alpha-subunit of the complex (GP Ib alpha)
C12 666-695 NP denotes GP Ib alpha promoter activity
C13 729-756 NP denotes human erythroleukemia cells
C14 791-801 NP denotes the enzyme
C15 803-813 NP denotes luciferase
C16 888-916 NP denotes the transcription start site
C17 1003-1030 NP denotes human erythroleukemia cells
C18 1035-1068 NP denotes cells of nonhematopoietic lineage
C19 1070-1102 NP denotes human endothelial and HeLa cells
C20 1104-1137 NP denotes the GP Ib alpha promoter activity
C22 1351-1379 NP denotes the transcription start site
C21 1278-1379 NP denotes essential GATA and Ets binding motifs 93 and 150 nucleotides upstream of the transcription start site
C23 1381-1390 NP denotes a finding
C24 1391-1396 NP denotes which
C25 1419-1433 NP denotes these elements
C26 1578-1589 NP denotes GP Ib alpha
R1 C4 C3 coref-relat that,a multisubunit adhesion receptor
R2 C5 C2 coref-ident the receptor,Platelet glycoprotein (GP) Ib-IX-V
R3 C7 C6 coref-appos a condition linking the expression of the complex to platelet morphogenesis,"a bleeding disorder associated with ""giant"" platelets"
R4 C9 C8 coref-ident the GP Ib-IX-V complex,the complex
R5 C11 C9 coref-ident the complex,the GP Ib-IX-V complex
R6 C15 C14 coref-appos luciferase,the enzyme
R7 C17 C13 coref-ident human erythroleukemia cells,human erythroleukemia cells
R8 C19 C18 coref-appos human endothelial and HeLa cells,cells of nonhematopoietic lineage
R9 C20 C12 coref-ident the GP Ib alpha promoter activity,GP Ib alpha promoter activity
R10 C22 C16 coref-ident the transcription start site,the transcription start site
R11 C21 C1 coref-ident essential GATA and Ets binding motifs 93 and 150 nucleotides upstream of the transcription start site,essential GATA and Ets binding motifs
R12 C24 C23 coref-relat which,a finding
R13 C25 C21 coref-ident these elements,essential GATA and Ets binding motifs 93 and 150 nucleotides upstream of the transcription start site
R14 C26 C10 coref-ident GP Ib alpha,the alpha-subunit of the complex (GP Ib alpha)

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 28-32 DNA_domain_or_region denotes GATA
T2 37-55 DNA_domain_or_region denotes Ets binding motifs
T3 83-118 DNA_domain_or_region denotes platelet glycoprotein Ib alpha gene
T4 120-141 protein_family_or_group denotes Platelet glycoprotein
T5 143-145 protein_family_or_group denotes GP
T6 147-154 protein_molecule denotes Ib-IX-V
T7 160-190 protein_family_or_group denotes multisubunit adhesion receptor
T8 262-277 other_name denotes vascular injury
T9 365-382 cell_type denotes "giant" platelets
T10 437-459 other_name denotes platelet morphogenesis
T11 504-506 protein_family_or_group denotes GP
T12 507-514 protein_molecule denotes Ib-IX-V
T13 572-588 DNA_family_or_group denotes genetic elements
T14 622-635 protein_subunit denotes alpha-subunit
T15 652-654 protein_family_or_group denotes GP
T16 666-668 protein_family_or_group denotes GP
T17 729-756 cell_type denotes human erythroleukemia cells
T18 795-801 protein_family_or_group denotes enzyme
T19 803-813 protein_molecule denotes luciferase
T20 864-881 polynucleotide denotes 2,738 nucleotides
T21 892-916 DNA_domain_or_region denotes transcription start site
T22 951-966 polynucleotide denotes 253 nucleotides
T23 982-999 other_name denotes promoter activity
T24 1003-1030 cell_type denotes human erythroleukemia cells
T25 1044-1068 cell_type denotes nonhematopoietic lineage
T26 1070-1087 cell_type denotes human endothelial
T27 1092-1102 cell_type denotes HeLa cells
T28 1108-1110 protein_family_or_group denotes GP
T29 1190-1213 DNA_family_or_group denotes promoterless constructs
T30 1236-1261 other_name denotes site-directed mutagenesis
T31 1288-1292 DNA_domain_or_region denotes GATA
T32 1297-1315 DNA_domain_or_region denotes Ets binding motifs
T33 1316-1347 DNA_domain_or_region denotes 93 and 150 nucleotides upstream
T34 1355-1379 DNA_domain_or_region denotes transcription start site
T35 1463-1493 other_name denotes megakaryocytic gene expression
T36 1524-1543 DNA_domain_or_region denotes cis-acting elements
T37 1564-1574 other_name denotes expression
T38 1578-1580 protein_family_or_group denotes GP
T39 1664-1680 cell_type denotes normal platelets
T40 1690-1701 other_name denotes bloodstream

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 366-382 Phenotype denotes giant" platelets HP:0001902

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 271-277 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T2 331-348 Disease denotes bleeding disorder http://purl.obolibrary.org/obo/MONDO_0002243
T3 735-750 Disease denotes erythroleukemia http://purl.obolibrary.org/obo/MONDO_0017858
T4 1009-1024 Disease denotes erythroleukemia http://purl.obolibrary.org/obo/MONDO_0017858

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 729-734 OrganismTaxon denotes human 9606
T2 1003-1008 OrganismTaxon denotes human 9606
T3 1070-1075 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 83-91 Body_part denotes platelet http://purl.obolibrary.org/obo/CL_0000233
T2 120-128 Body_part denotes Platelet http://purl.obolibrary.org/obo/CL_0000233
T3 205-213 Body_part denotes platelet http://purl.obolibrary.org/obo/CL_0000233
T4 373-382 Body_part denotes platelets http://purl.obolibrary.org/obo/CL_0000233
T5 437-445 Body_part denotes platelet http://purl.obolibrary.org/obo/CL_0000233
T6 1463-1477 Body_part denotes megakaryocytic http://purl.obolibrary.org/obo/CL_0000556
T7 1671-1680 Body_part denotes platelets http://purl.obolibrary.org/obo/CL_0000233

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 83-91 Cell denotes platelet http://purl.obolibrary.org/obo/CL:0000233
T2 120-128 Cell denotes Platelet http://purl.obolibrary.org/obo/CL:0000233
T3 205-213 Cell denotes platelet http://purl.obolibrary.org/obo/CL:0000233
T4 373-382 Cell denotes platelets http://purl.obolibrary.org/obo/CL:0000233
T5 437-445 Cell denotes platelet http://purl.obolibrary.org/obo/CL:0000233
T6 1463-1477 Cell denotes megakaryocytic http://purl.obolibrary.org/obo/CL:0000556
T7 1671-1680 Cell denotes platelets http://purl.obolibrary.org/obo/CL:0000233