PubMed:7592631
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 24-47 | Glycan_Motif | denotes | N-acetylneuraminic acid | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G50850NI |
| T3 | 55-58 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T5 | 76-79 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T7 | 99-102 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T9 | 200-203 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T11 | 209-212 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T13 | 271-274 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T15 | 528-531 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T17 | 588-591 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T19 | 629-632 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T21 | 711-722 | Glycan_Motif | denotes | GalNAc-GD1a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G92175CL |
| T22 | 718-722 | Glycan_Motif | denotes | GD1a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G69277LC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46677TE |
| T24 | 787-790 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T26 | 802-813 | Glycan_Motif | denotes | GalNAc-GD1a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G92175CL |
| T27 | 809-813 | Glycan_Motif | denotes | GD1a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G69277LC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46677TE |
| T29 | 953-964 | Glycan_Motif | denotes | GalNAc-GD1a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G92175CL |
| T30 | 960-964 | Glycan_Motif | denotes | GD1a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G69277LC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46677TE |
| T32 | 1012-1016 | Glycan_Motif | denotes | GM1b | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G03277YI |
| T33 | 1053-1064 | Glycan_Motif | denotes | GalNAc-GD1a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G92175CL |
| T34 | 1060-1064 | Glycan_Motif | denotes | GD1a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G69277LC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46677TE |
| T36 | 1239-1242 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T38 | 1282-1285 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T40 | 1311-1314 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T42 | 1326-1337 | Glycan_Motif | denotes | GalNAc-GD1a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G92175CL |
| T43 | 1333-1337 | Glycan_Motif | denotes | GD1a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G69277LC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46677TE |
| T45 | 1345-1348 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T47 | 1412-1415 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-98 | Sentence | denotes | Specific recognition of N-acetylneuraminic acid in the GM2 epitope by human GM2 activator protein. |
| T2 | 99-399 | Sentence | denotes | GM2 Activator is a low molecular weight protein cofactor that stimulates the enzymatic conversion of GM2 into GM3 by human beta-hexosaminidase A and also the conversion of GM2 into GA2 by clostridial sialidase (Wu, Y.-Y., Lockyer, J.M., Sugiyama, E., Pavlova, N.V., Li, Y.-T., and Li, S.-C. (1994) J. |
| T3 | 400-405 | Sentence | denotes | Biol. |
| T4 | 406-411 | Sentence | denotes | Chem. |
| T5 | 412-430 | Sentence | denotes | 269, 16276-16283). |
| T6 | 431-592 | Sentence | denotes | Among the five known activator proteins for the enzymatic hydrolysis of glycosphingolipids, only GM2 activator is effective in stimulating the hydrolysis of GM2. |
| T7 | 593-672 | Sentence | denotes | However, the mechanism of action of GM2 activator is still not well understood. |
| T8 | 673-1017 | Sentence | denotes | Using a unique disialosylganglioside, GalNAc-GD1a, as the substrate, we were able to show that in the presence of GM2 activator, GalNAc-GD1a was specifically converted into GalNAc-GM1a by clostridial sialidase, while in the presence of saposin B, a nonspecific activator protein, GalNAc-GD1a was converted into both GalNAc-GM1a and GalNAc-GM1b. |
| T9 | 1018-1251 | Sentence | denotes | Individual products generated from GalNAc-GD1a by clostridial sialidase were identified by thin layer chromatography, negative secondary ion mass spectrometry, and immunostaining with a monoclonal IgM that recognizes the GM2 epitope. |
| T10 | 1252-1338 | Sentence | denotes | Our results clearly show that GM2 activator recognizes the GM2 epitope in GalNAc-GD1a. |
| T11 | 1339-1529 | Sentence | denotes | Thus, GM2 activator may interact with the trisaccharide structure of the GM2 epitope and render the GalNAc and NeuAc residues accessible to beta-hexosaminidase A and sialidase, respectively. |
| T1 | 0-98 | Sentence | denotes | Specific recognition of N-acetylneuraminic acid in the GM2 epitope by human GM2 activator protein. |
| T2 | 99-399 | Sentence | denotes | GM2 Activator is a low molecular weight protein cofactor that stimulates the enzymatic conversion of GM2 into GM3 by human beta-hexosaminidase A and also the conversion of GM2 into GA2 by clostridial sialidase (Wu, Y.-Y., Lockyer, J.M., Sugiyama, E., Pavlova, N.V., Li, Y.-T., and Li, S.-C. (1994) J. |
| T3 | 400-405 | Sentence | denotes | Biol. |
| T4 | 406-411 | Sentence | denotes | Chem. |
| T5 | 412-430 | Sentence | denotes | 269, 16276-16283). |
| T6 | 431-592 | Sentence | denotes | Among the five known activator proteins for the enzymatic hydrolysis of glycosphingolipids, only GM2 activator is effective in stimulating the hydrolysis of GM2. |
| T7 | 593-672 | Sentence | denotes | However, the mechanism of action of GM2 activator is still not well understood. |
| T8 | 673-1017 | Sentence | denotes | Using a unique disialosylganglioside, GalNAc-GD1a, as the substrate, we were able to show that in the presence of GM2 activator, GalNAc-GD1a was specifically converted into GalNAc-GM1a by clostridial sialidase, while in the presence of saposin B, a nonspecific activator protein, GalNAc-GD1a was converted into both GalNAc-GM1a and GalNAc-GM1b. |
| T9 | 1018-1251 | Sentence | denotes | Individual products generated from GalNAc-GD1a by clostridial sialidase were identified by thin layer chromatography, negative secondary ion mass spectrometry, and immunostaining with a monoclonal IgM that recognizes the GM2 epitope. |
| T10 | 1252-1338 | Sentence | denotes | Our results clearly show that GM2 activator recognizes the GM2 epitope in GalNAc-GD1a. |
| T11 | 1339-1529 | Sentence | denotes | Thus, GM2 activator may interact with the trisaccharide structure of the GM2 epitope and render the GalNAc and NeuAc residues accessible to beta-hexosaminidase A and sialidase, respectively. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 24-47 | https://glytoucan.org/Structures/Glycans/G50850NI | denotes | N-acetylneuraminic acid |
| T2 | 24-47 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | N-acetylneuraminic acid |
| T3 | 55-58 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T4 | 55-58 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T5 | 76-79 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T6 | 76-79 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T7 | 99-102 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T8 | 99-102 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T9 | 200-203 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T10 | 200-203 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T11 | 209-212 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T12 | 209-212 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T13 | 271-274 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T14 | 271-274 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T15 | 528-531 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T16 | 528-531 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T17 | 588-591 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T18 | 588-591 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T19 | 629-632 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T20 | 629-632 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T21 | 711-722 | https://glytoucan.org/Structures/Glycans/G92175CL | denotes | GalNAc-GD1a |
| T22 | 718-722 | https://glytoucan.org/Structures/Glycans/G46677TE | denotes | GD1a |
| T23 | 718-722 | https://glytoucan.org/Structures/Glycans/G69277LC | denotes | GD1a |
| T24 | 787-790 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T25 | 787-790 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T26 | 802-813 | https://glytoucan.org/Structures/Glycans/G92175CL | denotes | GalNAc-GD1a |
| T27 | 809-813 | https://glytoucan.org/Structures/Glycans/G46677TE | denotes | GD1a |
| T28 | 809-813 | https://glytoucan.org/Structures/Glycans/G69277LC | denotes | GD1a |
| T29 | 953-964 | https://glytoucan.org/Structures/Glycans/G92175CL | denotes | GalNAc-GD1a |
| T30 | 960-964 | https://glytoucan.org/Structures/Glycans/G46677TE | denotes | GD1a |
| T31 | 960-964 | https://glytoucan.org/Structures/Glycans/G69277LC | denotes | GD1a |
| T32 | 1012-1016 | https://glytoucan.org/Structures/Glycans/G03277YI | denotes | GM1b |
| T33 | 1053-1064 | https://glytoucan.org/Structures/Glycans/G92175CL | denotes | GalNAc-GD1a |
| T34 | 1060-1064 | https://glytoucan.org/Structures/Glycans/G46677TE | denotes | GD1a |
| T35 | 1060-1064 | https://glytoucan.org/Structures/Glycans/G69277LC | denotes | GD1a |
| T36 | 1239-1242 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T37 | 1239-1242 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T38 | 1282-1285 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T39 | 1282-1285 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T40 | 1311-1314 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T41 | 1311-1314 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T42 | 1326-1337 | https://glytoucan.org/Structures/Glycans/G92175CL | denotes | GalNAc-GD1a |
| T43 | 1333-1337 | https://glytoucan.org/Structures/Glycans/G46677TE | denotes | GD1a |
| T44 | 1333-1337 | https://glytoucan.org/Structures/Glycans/G69277LC | denotes | GD1a |
| T45 | 1345-1348 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T46 | 1345-1348 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T47 | 1412-1415 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T48 | 1412-1415 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 711-722 | http://www.glycoepitope.jp/epitopes/EP0058 | denotes | GalNAc-GD1a |
| T2 | 718-722 | http://www.glycoepitope.jp/epitopes/EP0056 | denotes | GD1a |
| T3 | 802-813 | http://www.glycoepitope.jp/epitopes/EP0058 | denotes | GalNAc-GD1a |
| T4 | 809-813 | http://www.glycoepitope.jp/epitopes/EP0056 | denotes | GD1a |
| T5 | 953-964 | http://www.glycoepitope.jp/epitopes/EP0058 | denotes | GalNAc-GD1a |
| T6 | 960-964 | http://www.glycoepitope.jp/epitopes/EP0056 | denotes | GD1a |
| T7 | 1012-1016 | http://www.glycoepitope.jp/epitopes/EP0048 | denotes | GM1b |
| T8 | 1053-1064 | http://www.glycoepitope.jp/epitopes/EP0058 | denotes | GalNAc-GD1a |
| T9 | 1060-1064 | http://www.glycoepitope.jp/epitopes/EP0056 | denotes | GD1a |
| T10 | 1326-1337 | http://www.glycoepitope.jp/epitopes/EP0058 | denotes | GalNAc-GD1a |
| T11 | 1333-1337 | http://www.glycoepitope.jp/epitopes/EP0056 | denotes | GD1a |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 55-58 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T2 | 76-79 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T3 | 99-102 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T4 | 200-203 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T5 | 209-212 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T6 | 271-274 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T7 | 280-283 | Glycan | denotes | GA2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G90562PB |
| T8 | 528-531 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T9 | 588-591 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T10 | 629-632 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T11 | 711-722 | Glycan | denotes | GalNAc-GD1a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G92175CL |
| T12 | 787-790 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T13 | 802-813 | Glycan | denotes | GalNAc-GD1a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G92175CL |
| T14 | 846-852 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T15 | 853-857 | Glycan | denotes | GM1a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T16 | 953-964 | Glycan | denotes | GalNAc-GD1a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G92175CL |
| T17 | 989-995 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T18 | 996-1000 | Glycan | denotes | GM1a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T19 | 1005-1011 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T20 | 1012-1016 | Glycan | denotes | GM1b | https://api.glycosmos.org/wurcs2image/latest/png/binary/G03277YI |
| T21 | 1053-1064 | Glycan | denotes | GalNAc-GD1a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G92175CL |
| T22 | 1239-1242 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T23 | 1282-1285 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T24 | 1311-1314 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T25 | 1326-1337 | Glycan | denotes | GalNAc-GD1a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G92175CL |
| T26 | 1345-1348 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T27 | 1412-1415 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T28 | 1439-1445 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T29 | 1450-1455 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 711-722 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GalNAc-GD1a | http://www.glycoepitope.jp/epitopes/EP0058 |
| T2 | 802-813 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GalNAc-GD1a | http://www.glycoepitope.jp/epitopes/EP0058 |
| T3 | 953-964 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GalNAc-GD1a | http://www.glycoepitope.jp/epitopes/EP0058 |
| T4 | 1012-1016 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1b | http://www.glycoepitope.jp/epitopes/EP0048 |
| T5 | 1053-1064 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GalNAc-GD1a | http://www.glycoepitope.jp/epitopes/EP0058 |
| T6 | 1326-1337 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GalNAc-GD1a | http://www.glycoepitope.jp/epitopes/EP0058 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 70-75 | OrganismTaxon | denotes | human | 9606 |
| T2 | 216-221 | OrganismTaxon | denotes | human | 9606 |
| T3 | 350-357 | OrganismTaxon | denotes | Pavlova | 2831 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 1114-1119 | Body_part | denotes | layer | http://purl.obolibrary.org/obo/UBERON_0000119|http://purl.obolibrary.org/obo/UBERON_0022303 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-98 | Sentence | denotes | Specific recognition of N-acetylneuraminic acid in the GM2 epitope by human GM2 activator protein. |
| T2 | 99-399 | Sentence | denotes | GM2 Activator is a low molecular weight protein cofactor that stimulates the enzymatic conversion of GM2 into GM3 by human beta-hexosaminidase A and also the conversion of GM2 into GA2 by clostridial sialidase (Wu, Y.-Y., Lockyer, J.M., Sugiyama, E., Pavlova, N.V., Li, Y.-T., and Li, S.-C. (1994) J. |
| T3 | 400-405 | Sentence | denotes | Biol. |
| T4 | 406-411 | Sentence | denotes | Chem. |
| T5 | 412-430 | Sentence | denotes | 269, 16276-16283). |
| T6 | 431-592 | Sentence | denotes | Among the five known activator proteins for the enzymatic hydrolysis of glycosphingolipids, only GM2 activator is effective in stimulating the hydrolysis of GM2. |
| T7 | 593-672 | Sentence | denotes | However, the mechanism of action of GM2 activator is still not well understood. |
| T8 | 673-1017 | Sentence | denotes | Using a unique disialosylganglioside, GalNAc-GD1a, as the substrate, we were able to show that in the presence of GM2 activator, GalNAc-GD1a was specifically converted into GalNAc-GM1a by clostridial sialidase, while in the presence of saposin B, a nonspecific activator protein, GalNAc-GD1a was converted into both GalNAc-GM1a and GalNAc-GM1b. |
| T9 | 1018-1251 | Sentence | denotes | Individual products generated from GalNAc-GD1a by clostridial sialidase were identified by thin layer chromatography, negative secondary ion mass spectrometry, and immunostaining with a monoclonal IgM that recognizes the GM2 epitope. |
| T10 | 1252-1338 | Sentence | denotes | Our results clearly show that GM2 activator recognizes the GM2 epitope in GalNAc-GD1a. |
| T11 | 1339-1529 | Sentence | denotes | Thus, GM2 activator may interact with the trisaccharide structure of the GM2 epitope and render the GalNAc and NeuAc residues accessible to beta-hexosaminidase A and sialidase, respectively. |
| T1 | 0-98 | Sentence | denotes | Specific recognition of N-acetylneuraminic acid in the GM2 epitope by human GM2 activator protein. |
| T2 | 99-399 | Sentence | denotes | GM2 Activator is a low molecular weight protein cofactor that stimulates the enzymatic conversion of GM2 into GM3 by human beta-hexosaminidase A and also the conversion of GM2 into GA2 by clostridial sialidase (Wu, Y.-Y., Lockyer, J.M., Sugiyama, E., Pavlova, N.V., Li, Y.-T., and Li, S.-C. (1994) J. |
| T3 | 400-405 | Sentence | denotes | Biol. |
| T4 | 406-411 | Sentence | denotes | Chem. |
| T5 | 412-430 | Sentence | denotes | 269, 16276-16283). |
| T6 | 431-592 | Sentence | denotes | Among the five known activator proteins for the enzymatic hydrolysis of glycosphingolipids, only GM2 activator is effective in stimulating the hydrolysis of GM2. |
| T7 | 593-672 | Sentence | denotes | However, the mechanism of action of GM2 activator is still not well understood. |
| T8 | 673-1017 | Sentence | denotes | Using a unique disialosylganglioside, GalNAc-GD1a, as the substrate, we were able to show that in the presence of GM2 activator, GalNAc-GD1a was specifically converted into GalNAc-GM1a by clostridial sialidase, while in the presence of saposin B, a nonspecific activator protein, GalNAc-GD1a was converted into both GalNAc-GM1a and GalNAc-GM1b. |
| T9 | 1018-1251 | Sentence | denotes | Individual products generated from GalNAc-GD1a by clostridial sialidase were identified by thin layer chromatography, negative secondary ion mass spectrometry, and immunostaining with a monoclonal IgM that recognizes the GM2 epitope. |
| T10 | 1252-1338 | Sentence | denotes | Our results clearly show that GM2 activator recognizes the GM2 epitope in GalNAc-GD1a. |
| T11 | 1339-1529 | Sentence | denotes | Thus, GM2 activator may interact with the trisaccharide structure of the GM2 epitope and render the GalNAc and NeuAc residues accessible to beta-hexosaminidase A and sialidase, respectively. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-98 | Sentence | denotes | Specific recognition of N-acetylneuraminic acid in the GM2 epitope by human GM2 activator protein. |
| T2 | 99-430 | Sentence | denotes | GM2 Activator is a low molecular weight protein cofactor that stimulates the enzymatic conversion of GM2 into GM3 by human beta-hexosaminidase A and also the conversion of GM2 into GA2 by clostridial sialidase (Wu, Y.-Y., Lockyer, J.M., Sugiyama, E., Pavlova, N.V., Li, Y.-T., and Li, S.-C. (1994) J. Biol. Chem. 269, 16276-16283). |
| T3 | 431-592 | Sentence | denotes | Among the five known activator proteins for the enzymatic hydrolysis of glycosphingolipids, only GM2 activator is effective in stimulating the hydrolysis of GM2. |
| T4 | 593-672 | Sentence | denotes | However, the mechanism of action of GM2 activator is still not well understood. |
| T5 | 673-1017 | Sentence | denotes | Using a unique disialosylganglioside, GalNAc-GD1a, as the substrate, we were able to show that in the presence of GM2 activator, GalNAc-GD1a was specifically converted into GalNAc-GM1a by clostridial sialidase, while in the presence of saposin B, a nonspecific activator protein, GalNAc-GD1a was converted into both GalNAc-GM1a and GalNAc-GM1b. |
| T6 | 1018-1251 | Sentence | denotes | Individual products generated from GalNAc-GD1a by clostridial sialidase were identified by thin layer chromatography, negative secondary ion mass spectrometry, and immunostaining with a monoclonal IgM that recognizes the GM2 epitope. |
| T7 | 1252-1338 | Sentence | denotes | Our results clearly show that GM2 activator recognizes the GM2 epitope in GalNAc-GD1a. |
| T8 | 1339-1529 | Sentence | denotes | Thus, GM2 activator may interact with the trisaccharide structure of the GM2 epitope and render the GalNAc and NeuAc residues accessible to beta-hexosaminidase A and sialidase, respectively. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 55-58 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T2 | 76-79 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T3 | 99-102 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T4 | 200-203 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T5 | 209-212 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T6 | 271-274 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T7 | 280-283 | Glycan | denotes | GA2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G90562PB |
| T8 | 528-531 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T9 | 588-591 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T10 | 629-632 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T11 | 711-722 | Glycan | denotes | GalNAc-GD1a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G92175CL |
| T12 | 787-790 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T13 | 802-813 | Glycan | denotes | GalNAc-GD1a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G92175CL |
| T14 | 846-852 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T15 | 853-857 | Glycan | denotes | GM1a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T16 | 953-964 | Glycan | denotes | GalNAc-GD1a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G92175CL |
| T17 | 989-995 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T18 | 996-1000 | Glycan | denotes | GM1a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T19 | 1005-1011 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T20 | 1012-1016 | Glycan | denotes | GM1b | https://api.glycosmos.org/wurcs2image/latest/png/binary/G03277YI |
| T21 | 1053-1064 | Glycan | denotes | GalNAc-GD1a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G92175CL |
| T22 | 1239-1242 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T23 | 1282-1285 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T24 | 1311-1314 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T25 | 1326-1337 | Glycan | denotes | GalNAc-GD1a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G92175CL |
| T26 | 1345-1348 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T27 | 1412-1415 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T28 | 1439-1445 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T29 | 1450-1455 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 711-722 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GalNAc-GD1a | http://www.glycoepitope.jp/epitopes/EP0058 |
| T2 | 802-813 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GalNAc-GD1a | http://www.glycoepitope.jp/epitopes/EP0058 |
| T3 | 953-964 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GalNAc-GD1a | http://www.glycoepitope.jp/epitopes/EP0058 |
| T4 | 1012-1016 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1b | http://www.glycoepitope.jp/epitopes/EP0048 |
| T5 | 1053-1064 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GalNAc-GD1a | http://www.glycoepitope.jp/epitopes/EP0058 |
| T6 | 1326-1337 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GalNAc-GD1a | http://www.glycoepitope.jp/epitopes/EP0058 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 70-75 | OrganismTaxon | denotes | human | 9606 |
| T2 | 216-221 | OrganismTaxon | denotes | human | 9606 |
| T3 | 350-357 | OrganismTaxon | denotes | Pavlova | 2831 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 1114-1119 | Body_part | denotes | layer | http://purl.obolibrary.org/obo/UBERON_0000119|http://purl.obolibrary.org/obo/UBERON_0022303 |