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sentences

Id Subject Object Predicate Lexical cue
T1 0-118 Sentence denotes Mutually exclusive interaction of a novel matrix attachment region binding protein and the NF-muNR enhancer repressor.
T2 119-188 Sentence denotes Implications for regulation of immunoglobulin heavy chain expression.
T3 189-337 Sentence denotes The immunoglobulin heavy chain (IgH) intronic enhancer stimulates transcription from functional promoters in B lymphocytes but not other cell types.
T4 338-663 Sentence denotes The observation that binding sites for the nuclear factor-mu negative regulator (NF-muNR) enhancer repressor overlap nuclear matrix attachment regions (MARs) in this enhancer has lead to the hypothesis that the cell type specificity of the enhancer might be controlled by regulating nuclear matrix attachment (Scheuermann, R.
T5 664-700 Sentence denotes H., and Chen, U. (1989) Genes & Dev.
T6 701-715 Sentence denotes 3, 1255-1266).
T7 716-947 Sentence denotes To understand the role of MARs in IgH enhancer regulation, we have identified a novel MAR-binding protein, MAR-BP1, from soluble nuclear matrix preparations based on its ability to bind to the MARs associated with the IgH enhancer.
T8 948-1102 Sentence denotes Purified MAR-BP1 migrates as a 33-kDa protein, and it can be found in nuclear matrix preparations from a number of different types of lymphoid cell lines.
T9 1103-1282 Sentence denotes Although specific binding sites have been difficult to localize by chemical or enzymatic footprinting procedures, NF-muNR binding sites are critical for efficient MAR-BP1 binding.
T10 1283-1419 Sentence denotes Indeed, binding of the IgH enhancer to either intact nuclear matrix preparations or to MAR-BP1 is mutually exclusive to NF-muNR binding.
T11 1420-1665 Sentence denotes These results are consistent with a model for cell-type specific regulation in which binding of the NF-muNR repressor to the IgH enhancer prevents nuclear matrix attachment in inappropriate cells by interfering with MAR-BP1/enhancer interaction.
T1 0-118 Sentence denotes Mutually exclusive interaction of a novel matrix attachment region binding protein and the NF-muNR enhancer repressor.
T2 119-188 Sentence denotes Implications for regulation of immunoglobulin heavy chain expression.
T3 189-337 Sentence denotes The immunoglobulin heavy chain (IgH) intronic enhancer stimulates transcription from functional promoters in B lymphocytes but not other cell types.
T4 338-663 Sentence denotes The observation that binding sites for the nuclear factor-mu negative regulator (NF-muNR) enhancer repressor overlap nuclear matrix attachment regions (MARs) in this enhancer has lead to the hypothesis that the cell type specificity of the enhancer might be controlled by regulating nuclear matrix attachment (Scheuermann, R.
T5 664-700 Sentence denotes H., and Chen, U. (1989) Genes & Dev.
T6 701-715 Sentence denotes 3, 1255-1266).
T7 716-947 Sentence denotes To understand the role of MARs in IgH enhancer regulation, we have identified a novel MAR-binding protein, MAR-BP1, from soluble nuclear matrix preparations based on its ability to bind to the MARs associated with the IgH enhancer.
T8 948-1102 Sentence denotes Purified MAR-BP1 migrates as a 33-kDa protein, and it can be found in nuclear matrix preparations from a number of different types of lymphoid cell lines.
T9 1103-1282 Sentence denotes Although specific binding sites have been difficult to localize by chemical or enzymatic footprinting procedures, NF-muNR binding sites are critical for efficient MAR-BP1 binding.
T10 1283-1419 Sentence denotes Indeed, binding of the IgH enhancer to either intact nuclear matrix preparations or to MAR-BP1 is mutually exclusive to NF-muNR binding.
T11 1420-1665 Sentence denotes These results are consistent with a model for cell-type specific regulation in which binding of the NF-muNR repressor to the IgH enhancer prevents nuclear matrix attachment in inappropriate cells by interfering with MAR-BP1/enhancer interaction.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 42-82 protein denotes matrix attachment region binding protein
T2 91-117 protein denotes NF-muNR enhancer repressor
T3 150-176 protein denotes immunoglobulin heavy chain
T4 193-219 protein denotes immunoglobulin heavy chain
T5 221-224 protein denotes IgH
T6 381-488 protein denotes nuclear factor-mu negative regulator (NF-muNR) enhancer repressor overlap nuclear matrix attachment regions
T7 490-494 protein denotes MARs
T8 504-512 DNA denotes enhancer
T9 578-586 DNA denotes enhancer
T10 742-746 protein denotes MARs
T11 750-762 DNA denotes IgH enhancer
T12 802-821 protein denotes MAR-binding protein
T13 823-830 protein denotes MAR-BP1
T14 909-913 protein denotes MARs
T15 934-946 DNA denotes IgH enhancer
T16 957-964 protein denotes MAR-BP1
T17 979-993 protein denotes 33-kDa protein
T18 1082-1101 cell_line denotes lymphoid cell lines
T19 1217-1224 protein denotes NF-muNR
T20 1266-1273 protein denotes MAR-BP1
T21 1306-1318 DNA denotes IgH enhancer
T22 1370-1377 protein denotes MAR-BP1
T23 1403-1410 protein denotes NF-muNR
T24 1520-1537 protein denotes NF-muNR repressor
T25 1545-1557 DNA denotes IgH enhancer
T26 1636-1643 protein denotes MAR-BP1
T27 1643-1652 DNA denotes /enhancer

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-118 Sentence denotes Mutually exclusive interaction of a novel matrix attachment region binding protein and the NF-muNR enhancer repressor.
S2 119-188 Sentence denotes Implications for regulation of immunoglobulin heavy chain expression.
S3 189-337 Sentence denotes The immunoglobulin heavy chain (IgH) intronic enhancer stimulates transcription from functional promoters in B lymphocytes but not other cell types.
S4 338-715 Sentence denotes The observation that binding sites for the nuclear factor-mu negative regulator (NF-muNR) enhancer repressor overlap nuclear matrix attachment regions (MARs) in this enhancer has lead to the hypothesis that the cell type specificity of the enhancer might be controlled by regulating nuclear matrix attachment (Scheuermann, R. H., and Chen, U. (1989) Genes & Dev. 3, 1255-1266).
S5 716-947 Sentence denotes To understand the role of MARs in IgH enhancer regulation, we have identified a novel MAR-binding protein, MAR-BP1, from soluble nuclear matrix preparations based on its ability to bind to the MARs associated with the IgH enhancer.
S6 948-1102 Sentence denotes Purified MAR-BP1 migrates as a 33-kDa protein, and it can be found in nuclear matrix preparations from a number of different types of lymphoid cell lines.
S7 1103-1282 Sentence denotes Although specific binding sites have been difficult to localize by chemical or enzymatic footprinting procedures, NF-muNR binding sites are critical for efficient MAR-BP1 binding.
S8 1283-1419 Sentence denotes Indeed, binding of the IgH enhancer to either intact nuclear matrix preparations or to MAR-BP1 is mutually exclusive to NF-muNR binding.
S9 1420-1665 Sentence denotes These results are consistent with a model for cell-type specific regulation in which binding of the NF-muNR repressor to the IgH enhancer prevents nuclear matrix attachment in inappropriate cells by interfering with MAR-BP1/enhancer interaction.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 34-82 NP denotes a novel matrix attachment region binding protein
C2 87-117 NP denotes the NF-muNR enhancer repressor
C3 189-243 NP denotes The immunoglobulin heavy chain (IgH) intronic enhancer
C4 338-353 NP denotes The observation
C5 354-358 NP denotes that
C7 377-446 NP denotes the nuclear factor-mu negative regulator (NF-muNR) enhancer repressor
C6 359-446 NP denotes binding sites for the nuclear factor-mu negative regulator (NF-muNR) enhancer repressor
C8 455-495 NP denotes nuclear matrix attachment regions (MARs)
C9 499-512 NP denotes this enhancer
C10 525-539 NP denotes the hypothesis
C11 540-544 NP denotes that
C12 574-586 NP denotes the enhancer
C13 621-646 NP denotes nuclear matrix attachment
C14 742-746 NP denotes MARs
C15 794-821 NP denotes a novel MAR-binding protein
C16 823-830 NP denotes MAR-BP1
C17 882-885 NP denotes its
C18 930-946 NP denotes the IgH enhancer
C19 948-964 NP denotes Purified MAR-BP1
C20 999-1001 NP denotes it
C21 1217-1238 NP denotes NF-muNR binding sites
C22 1302-1318 NP denotes the IgH enhancer
C23 1370-1377 NP denotes MAR-BP1
C24 1454-1495 NP denotes a model for cell-type specific regulation
C25 1499-1504 NP denotes which
C26 1516-1537 NP denotes the NF-muNR repressor
C27 1541-1557 NP denotes the IgH enhancer
C28 1567-1592 NP denotes nuclear matrix attachment
R1 C5 C4 coref-relat that,The observation
R2 C7 C2 coref-ident the nuclear factor-mu negative regulator (NF-muNR) enhancer repressor,the NF-muNR enhancer repressor
R3 C9 C3 coref-ident this enhancer,The immunoglobulin heavy chain (IgH) intronic enhancer
R4 C11 C10 coref-relat that,the hypothesis
R5 C12 C9 coref-ident the enhancer,this enhancer
R6 C14 C8 coref-ident MARs,nuclear matrix attachment regions (MARs)
R7 C15 C1 coref-ident a novel MAR-binding protein,a novel matrix attachment region binding protein
R8 C16 C15 coref-appos MAR-BP1,a novel MAR-binding protein
R9 C17 C15 coref-pron its,a novel MAR-binding protein
R10 C18 C12 coref-ident the IgH enhancer,the enhancer
R11 C20 C19 coref-pron it,Purified MAR-BP1
R12 C21 C6 coref-ident NF-muNR binding sites,binding sites for the nuclear factor-mu negative regulator (NF-muNR) enhancer repressor
R13 C22 C18 coref-ident the IgH enhancer,the IgH enhancer
R14 C23 C15 coref-ident MAR-BP1,a novel MAR-binding protein
R15 C25 C24 coref-relat which,a model for cell-type specific regulation
R16 C26 C7 coref-ident the NF-muNR repressor,the nuclear factor-mu negative regulator (NF-muNR) enhancer repressor
R17 C27 C22 coref-ident the IgH enhancer,the IgH enhancer
R18 C28 C13 coref-ident nuclear matrix attachment,nuclear matrix attachment

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 42-82 protein_family_or_group denotes matrix attachment region binding protein
T2 91-117 protein_molecule denotes NF-muNR enhancer repressor
T3 150-176 protein_subunit denotes immunoglobulin heavy chain
T4 193-219 protein_subunit denotes immunoglobulin heavy chain
T5 221-224 protein_subunit denotes IgH
T6 298-311 cell_component denotes B lymphocytes
T7 381-417 protein_molecule denotes nuclear factor-mu negative regulator
T8 419-426 protein_molecule denotes NF-muNR
T9 455-488 protein_domain_or_region denotes nuclear matrix attachment regions
T10 490-494 protein_domain_or_region denotes MARs
T11 504-512 DNA_domain_or_region denotes enhancer
T12 578-586 DNA_domain_or_region denotes enhancer
T13 621-646 other_name denotes nuclear matrix attachment
T14 742-746 protein_domain_or_region denotes MARs
T15 750-753 protein_subunit denotes IgH
T16 802-821 protein_molecule denotes MAR-binding protein
T17 823-830 protein_molecule denotes MAR-BP1
T18 845-872 other_name denotes nuclear matrix preparations
T19 909-913 protein_domain_or_region denotes MARs
T20 934-937 protein_subunit denotes IgH
T21 957-964 protein_molecule denotes MAR-BP1
T22 979-993 protein_molecule denotes 33-kDa protein
T23 1082-1101 cell_line denotes lymphoid cell lines
T24 1182-1215 other_name denotes enzymatic footprinting procedures
T25 1217-1224 protein_molecule denotes NF-muNR
T26 1266-1273 protein_molecule denotes MAR-BP1
T27 1306-1309 protein_subunit denotes IgH
T28 1336-1363 cell_component denotes nuclear matrix preparations
T29 1370-1377 protein_molecule denotes MAR-BP1
T30 1403-1410 protein_molecule denotes NF-muNR
T31 1520-1527 protein_molecule denotes NF-muNR
T32 1545-1548 protein_subunit denotes IgH
T33 1567-1581 cell_component denotes nuclear matrix
T34 1636-1643 protein_molecule denotes MAR-BP1
T35 1643-1652 DNA_domain_or_region denotes /enhancer

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 136-176 Disease denotes regulation of immunoglobulin heavy chain http://purl.obolibrary.org/obo/MONDO_0007755
T2 802-805 Disease denotes MAR http://purl.obolibrary.org/obo/MONDO_0007925
T3 823-826 Disease denotes MAR http://purl.obolibrary.org/obo/MONDO_0007925
T4 957-960 Disease denotes MAR http://purl.obolibrary.org/obo/MONDO_0007925
T5 1266-1269 Disease denotes MAR http://purl.obolibrary.org/obo/MONDO_0007925
T6 1370-1373 Disease denotes MAR http://purl.obolibrary.org/obo/MONDO_0007925
T7 1636-1639 Disease denotes MAR http://purl.obolibrary.org/obo/MONDO_0007925

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 298-311 Body_part denotes B lymphocytes http://purl.obolibrary.org/obo/CL_0000236

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 298-311 Cell denotes B lymphocytes http://purl.obolibrary.org/obo/CL:0000236