> top > docs > PubMed:7591091 > annotations

PubMed:7591091 JSONTXT

Annnotations TAB JSON ListView MergeView

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 15-31 protein denotes gamma interferon
T2 68-90 cell_type denotes mononuclear phagocytes
T3 168-181 protein denotes Janus kinases
T4 186-191 protein denotes Stat1
T5 244-260 protein denotes gamma interferon
T6 276-298 cell_type denotes mononuclear phagocytes
T7 436-452 protein denotes gamma interferon
T8 517-550 protein denotes cellular protein tyrosine kinases
T9 566-579 protein denotes Janus kinases
T10 580-584 protein denotes Jak1
T11 589-593 protein denotes Jak2
T12 638-664 protein denotes transcription factor Stat1
T13 737-753 protein denotes gamma interferon
T14 851-855 protein denotes Jak1
T15 860-864 protein denotes Jak2
T16 888-893 protein denotes Stat1
T17 911-969 cell_line denotes phorbol 12-myristate 13-acetate-differentiated U-937 cells
T18 1068-1084 protein denotes gamma interferon
T19 1235-1248 cell_type denotes control cells
T20 1312-1316 protein denotes Jak1
T21 1318-1322 protein denotes Jak2
T22 1328-1333 protein denotes Stat1
T23 1375-1399 cell_line denotes interferon-treated cells
T24 1563-1567 protein denotes Jak1
T25 1569-1573 protein denotes Jak2
T26 1579-1584 protein denotes Stat1
T27 1636-1647 cell_line denotes U-937 cells
T28 1663-1679 protein denotes gamma interferon
T29 1758-1762 protein denotes Jak1
T30 1764-1768 protein denotes Jak2
T31 1774-1779 protein denotes Stat1
T32 1951-1962 cell_line denotes U-937 cells
T33 1987-2019 cell_type denotes human peripheral blood monocytes
T34 2063-2091 cell_type denotes human mononuclear phagocytes
T35 2127-2143 protein denotes gamma interferon
T36 2211-2216 protein denotes Stat1
T37 2246-2262 protein denotes gamma interferon
T38 2344-2369 cell_type denotes leishmania-infected cells

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 105-124 NP denotes Leishmania donovani
C1 68-124 NP denotes mononuclear phagocytes infected with Leishmania donovani
C3 186-191 NP denotes Stat1
C4 244-260 NP denotes gamma interferon
C6 313-332 NP denotes Leishmania donovani
C5 276-332 NP denotes mononuclear phagocytes infected with Leishmania donovani
C7 436-452 NP denotes gamma interferon
C8 562-593 NP denotes the Janus kinases Jak1 and Jak2
C10 634-664 NP denotes the transcription factor Stat1
C9 606-664 NP denotes tyrosine phosphorylation of the transcription factor Stat1
C11 737-753 NP denotes gamma interferon
C12 851-864 NP denotes Jak1 and Jak2
C14 888-893 NP denotes Stat1
C13 869-893 NP denotes phosphorylation of Stat1
C15 1068-1084 NP denotes gamma interferon
C16 1149-1165 NP denotes several proteins
C17 1189-1203 NP denotes these proteins
C19 1256-1261 NP denotes cells
C20 1262-1266 NP denotes that
C21 1290-1301 NP denotes L. donovani
C18 1256-1310 NP denotes cells that had been infected with L. donovani for 16 h
C22 1312-1322 NP denotes Jak1, Jak2
C23 1328-1333 NP denotes Stat1
C25 1433-1447 NP denotes these proteins
C24 1405-1447 NP denotes tyrosine phosphorylation of these proteins
C26 1517-1522 NP denotes their
C28 1563-1584 NP denotes Jak1, Jak2, and Stat1
C27 1535-1584 NP denotes Tyrosine phosphorylation of Jak1, Jak2, and Stat1
C29 1663-1679 NP denotes gamma interferon
C31 1717-1728 NP denotes L. donovani
C30 1697-1728 NP denotes cells infected with L. donovani
C33 1758-1779 NP denotes Jak1, Jak2, and Stat1
C32 1730-1779 NP denotes tyrosine phosphorylation of Jak1, Jak2, and Stat1
C34 1862-1873 NP denotes L. donovani
C35 1912-1919 NP denotes Results
C36 1931-1936 NP denotes those
C37 2097-2108 NP denotes L. donovani
C38 2203-2224 NP denotes the Jak-Stat1 pathway
C39 2246-2262 NP denotes gamma interferon
C40 2281-2293 NP denotes this pathway
C41 2344-2369 NP denotes leishmania-infected cells
R1 C6 C2 coref-ident Leishmania donovani,Leishmania donovani
R2 C5 C1 coref-ident mononuclear phagocytes infected with Leishmania donovani,mononuclear phagocytes infected with Leishmania donovani
R3 C7 C4 coref-ident gamma interferon,gamma interferon
R4 C10 C3 coref-ident the transcription factor Stat1,Stat1
R5 C11 C7 coref-ident gamma interferon,gamma interferon
R6 C12 C8 coref-ident Jak1 and Jak2,the Janus kinases Jak1 and Jak2
R7 C14 C10 coref-ident Stat1,the transcription factor Stat1
R8 C13 C9 coref-ident phosphorylation of Stat1,tyrosine phosphorylation of the transcription factor Stat1
R9 C15 C11 coref-ident gamma interferon,gamma interferon
R10 C17 C16 coref-ident these proteins,several proteins
R11 C20 C19 coref-relat that,cells
R12 C21 C6 coref-ident L. donovani,Leishmania donovani
R13 C22 C12 coref-ident "Jak1, Jak2",Jak1 and Jak2
R14 C23 C14 coref-ident Stat1,Stat1
R15 C26 C25 coref-pron their,these proteins
R16 C28 C25 coref-ident "Jak1, Jak2, and Stat1",these proteins
R17 C27 C24 coref-ident "Tyrosine phosphorylation of Jak1, Jak2, and Stat1",tyrosine phosphorylation of these proteins
R18 C29 C15 coref-ident gamma interferon,gamma interferon
R19 C31 C21 coref-ident L. donovani,L. donovani
R20 C30 C18 coref-ident cells infected with L. donovani,cells that had been infected with L. donovani for 16 h
R21 C33 C28 coref-ident "Jak1, Jak2, and Stat1","Jak1, Jak2, and Stat1"
R22 C32 C27 coref-ident "tyrosine phosphorylation of Jak1, Jak2, and Stat1","Tyrosine phosphorylation of Jak1, Jak2, and Stat1"
R23 C34 C31 coref-ident L. donovani,L. donovani
R24 C36 C35 coref-pron those,Results
R25 C37 C34 coref-ident L. donovani,L. donovani
R26 C39 C29 coref-ident gamma interferon,gamma interferon
R27 C40 C38 coref-ident this pathway,the Jak-Stat1 pathway
R28 C41 C30 coref-ident leishmania-infected cells,cells infected with L. donovani

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-192 Sentence denotes Attenuation of gamma interferon-induced tyrosine phosphorylation in mononuclear phagocytes infected with Leishmania donovani: selective inhibition of signaling through Janus kinases and Stat1.
S2 193-387 Sentence denotes The induction of gene transcription in response to gamma interferon is impaired in mononuclear phagocytes infected with Leishmania donovani, and the mechanisms involved are not fully understood.
S3 388-665 Sentence denotes The changes in gene expression brought about by gamma interferon are thought to involve transient increases in the activities of cellular protein tyrosine kinases, including the Janus kinases Jak1 and Jak2, leading to tyrosine phosphorylation of the transcription factor Stat1.
S4 666-970 Sentence denotes To investigate the mechanisms accounting for the impaired responses to gamma interferon, a model system for examining overall changes in protein tyrosine phosphorylation, activation of Jak1 and Jak2 and phosphorylation of Stat1 was developed in phorbol 12-myristate 13-acetate-differentiated U-937 cells.
S5 971-1166 Sentence denotes Analysis of whole-cell lysates by antiphosphotyrosine immunoblotting showed that incubation with gamma interferon brought about specific increases in phosphotyrosine labeling of several proteins.
S6 1167-1311 Sentence denotes Increased labeling of these proteins occurred to similar extents in control cells and in cells that had been infected with L. donovani for 16 h.
S7 1312-1534 Sentence denotes Jak1, Jak2, and Stat1 were immunoprecipitated from control and interferon-treated cells, and tyrosine phosphorylation of these proteins, detected by antiphosphotyrosine immunoblotting was used to measured their activation.
S8 1535-1680 Sentence denotes Tyrosine phosphorylation of Jak1, Jak2, and Stat1 increased markedly, in a dose-dependent manner, in U-937 cells incubated with gamma interferon.
S9 1681-1802 Sentence denotes In contrast, in cells infected with L. donovani, tyrosine phosphorylation of Jak1, Jak2, and Stat1 was markedly impaired.
S10 1803-1911 Sentence denotes This effect was dependent upon the duration of exposure to L. donovani and was maximal and complete at 16 h.
S11 1912-2020 Sentence denotes Results similar to those observed with U-937 cells were also obtained with human peripheral blood monocytes.
S12 2021-2225 Sentence denotes These findings indicate that infection of human mononuclear phagocytes with L. donovani leads to impaired gamma interferon-mediated tyrosine phosphorylation and selective effects on the Jak-Stat1 pathway.
S13 2226-2370 Sentence denotes Unresponsiveness to gamma interferon for activation of this pathway may explain impaired transcriptional responses in leishmania-infected cells.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 15-31 protein_family_or_group denotes gamma interferon
T2 40-48 amino_acid_monomer denotes tyrosine
T3 68-90 cell_type denotes mononuclear phagocytes
T4 105-124 mono_cell denotes Leishmania donovani
T5 168-181 protein_family_or_group denotes Janus kinases
T6 186-191 protein_family_or_group denotes Stat1
T7 210-228 other_name denotes gene transcription
T8 244-260 protein_family_or_group denotes gamma interferon
T9 276-298 cell_type denotes mononuclear phagocytes
T10 313-332 mono_cell denotes Leishmania donovani
T11 403-418 other_name denotes gene expression
T12 436-452 protein_family_or_group denotes gamma interferon
T13 517-533 protein_family_or_group denotes cellular protein
T14 534-542 amino_acid_monomer denotes tyrosine
T15 566-579 protein_family_or_group denotes Janus kinases
T16 580-584 protein_molecule denotes Jak1
T17 589-593 protein_molecule denotes Jak2
T18 606-614 amino_acid_monomer denotes tyrosine
T19 638-658 protein_molecule denotes transcription factor
T20 659-664 protein_family_or_group denotes Stat1
T21 737-753 protein_family_or_group denotes gamma interferon
T22 811-819 amino_acid_monomer denotes tyrosine
T23 851-855 protein_molecule denotes Jak1
T24 860-864 protein_molecule denotes Jak2
T25 869-884 other_name denotes phosphorylation
T26 888-893 protein_family_or_group denotes Stat1
T27 911-942 other_organic_compound denotes phorbol 12-myristate 13-acetate
T28 1005-1024 amino_acid_monomer denotes antiphosphotyrosine
T29 1068-1084 protein_family_or_group denotes gamma interferon
T30 1121-1136 amino_acid_monomer denotes phosphotyrosine
T31 1235-1248 cell_type denotes control cells
T32 1290-1301 mono_cell denotes L. donovani
T33 1312-1316 protein_molecule denotes Jak1
T34 1318-1322 protein_molecule denotes Jak2
T35 1328-1333 protein_family_or_group denotes Stat1
T36 1375-1399 cell_line denotes interferon-treated cells
T37 1405-1413 amino_acid_monomer denotes tyrosine
T38 1461-1480 amino_acid_monomer denotes antiphosphotyrosine
T39 1535-1543 amino_acid_monomer denotes Tyrosine
T40 1563-1567 protein_molecule denotes Jak1
T41 1569-1573 protein_molecule denotes Jak2
T42 1579-1584 protein_family_or_group denotes Stat1
T43 1636-1647 cell_line denotes U-937 cells
T44 1663-1679 protein_family_or_group denotes gamma interferon
T45 1717-1728 mono_cell denotes L. donovani
T46 1730-1738 amino_acid_monomer denotes tyrosine
T47 1758-1762 protein_molecule denotes Jak1
T48 1764-1768 protein_molecule denotes Jak2
T49 1774-1779 protein_family_or_group denotes Stat1
T50 1862-1873 mono_cell denotes L. donovani
T51 1951-1962 cell_line denotes U-937 cells
T52 1987-2019 cell_type denotes human peripheral blood monocytes
T53 2063-2091 cell_type denotes human mononuclear phagocytes
T54 2097-2108 mono_cell denotes L. donovani
T55 2127-2143 protein_family_or_group denotes gamma interferon
T56 2153-2161 amino_acid_monomer denotes tyrosine
T57 2207-2211 other_name denotes Jak-
T58 2211-2216 protein_family_or_group denotes Stat1
T59 2246-2262 protein_family_or_group denotes gamma interferon
T60 2315-2340 other_name denotes transcriptional responses
T61 2344-2369 cell_type denotes leishmania-infected cells