PubMed:7590249 JSONTXT

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    jnlpba-st-training

    {"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":13,"end":23},"obj":"protein"},{"id":"T2","span":{"begin":87,"end":102},"obj":"protein"},{"id":"T3","span":{"begin":119,"end":140},"obj":"protein"},{"id":"T4","span":{"begin":158,"end":175},"obj":"protein"},{"id":"T5","span":{"begin":194,"end":223},"obj":"protein"},{"id":"T6","span":{"begin":232,"end":247},"obj":"protein"},{"id":"T7","span":{"begin":252,"end":266},"obj":"protein"},{"id":"T8","span":{"begin":296,"end":311},"obj":"protein"},{"id":"T9","span":{"begin":497,"end":515},"obj":"protein"},{"id":"T10","span":{"begin":520,"end":525},"obj":"RNA"},{"id":"T11","span":{"begin":581,"end":591},"obj":"protein"},{"id":"T12","span":{"begin":593,"end":603},"obj":"protein"},{"id":"T13","span":{"begin":682,"end":697},"obj":"protein"},{"id":"T14","span":{"begin":706,"end":717},"obj":"protein"},{"id":"T15","span":{"begin":721,"end":731},"obj":"protein"},{"id":"T16","span":{"begin":799,"end":818},"obj":"cell_type"},{"id":"T17","span":{"begin":820,"end":860},"obj":"cell_line"},{"id":"T18","span":{"begin":874,"end":897},"obj":"protein"},{"id":"T19","span":{"begin":934,"end":944},"obj":"protein"},{"id":"T20","span":{"begin":981,"end":995},"obj":"protein"},{"id":"T21","span":{"begin":1059,"end":1074},"obj":"protein"},{"id":"T22","span":{"begin":1127,"end":1137},"obj":"protein"},{"id":"T23","span":{"begin":1141,"end":1152},"obj":"cell_type"},{"id":"T24","span":{"begin":1163,"end":1178},"obj":"protein"},{"id":"T25","span":{"begin":1227,"end":1237},"obj":"protein"},{"id":"T26","span":{"begin":1241,"end":1252},"obj":"cell_type"},{"id":"T27","span":{"begin":1311,"end":1320},"obj":"protein"},{"id":"T28","span":{"begin":1376,"end":1386},"obj":"protein"}],"text":"Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.\nTranscription factors belonging to the NF-kappa B family are controlled by inhibitory I kappa B proteins, mainly I kappa B alpha and I kappa B beta. Apparently normal at birth, I kappa B alpha-/- mice exhibit severe runting, skin defects, and extensive granulopoiesis postnatally, typically dying by 8 days. Hematopoietic tissues from these mice display elevated levels of both nuclear NF-kappa B and mRNAs of some, but not all, genes thought to be regulated by NF-kappa B. NF-kappa B elevation results in these phenotypic abnormalities because mice lacking both I kappa B alpha and the p50 subunit of NF-kappa B show a dramatically delayed onset of abnormalities. In contrast to hematopoietic cells, I kappa B alpha-/- embryonic fibroblasts show minimal constitutive NF-kappa B, as well as normal signal-dependent NF-kappa B activation that is concomitant with I kappa B beta degradation. Our results indicate that I kappa b beta, but not I kappa B alpha, is required for the signal-dependent activation of NF-kappa B in fibroblasts. However, I kappa B alpha is required for the postinduction repression of NF-kappa B in fibroblasts. These results define distinct roles for the two forms of I kappa B and demonstrate the necessity for stringent control of NF-kappa B."}

    GENIAcorpus

    {"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":12},"obj":"other_name"},{"id":"T2","span":{"begin":13,"end":23},"obj":"protein_molecule"},{"id":"T3","span":{"begin":36,"end":59},"obj":"other_name"},{"id":"T4","span":{"begin":65,"end":83},"obj":"other_name"},{"id":"T5","span":{"begin":87,"end":102},"obj":"protein_molecule"},{"id":"T6","span":{"begin":119,"end":140},"obj":"protein_family_or_group"},{"id":"T7","span":{"begin":158,"end":168},"obj":"protein_molecule"},{"id":"T8","span":{"begin":194,"end":223},"obj":"protein_family_or_group"},{"id":"T9","span":{"begin":232,"end":247},"obj":"protein_molecule"},{"id":"T10","span":{"begin":252,"end":266},"obj":"protein_molecule"},{"id":"T11","span":{"begin":296,"end":311},"obj":"protein_molecule"},{"id":"T12","span":{"begin":344,"end":356},"obj":"other_name"},{"id":"T13","span":{"begin":372,"end":386},"obj":"other_name"},{"id":"T14","span":{"begin":427,"end":448},"obj":"tissue"},{"id":"T15","span":{"begin":460,"end":464},"obj":"multi_cell"},{"id":"T16","span":{"begin":497,"end":504},"obj":"protein_molecule"},{"id":"T17","span":{"begin":505,"end":515},"obj":"protein_molecule"},{"id":"T18","span":{"begin":520,"end":525},"obj":"RNA_family_or_group"},{"id":"T19","span":{"begin":581,"end":591},"obj":"protein_molecule"},{"id":"T20","span":{"begin":593,"end":603},"obj":"protein_molecule"},{"id":"T21","span":{"begin":631,"end":655},"obj":"other_name"},{"id":"T22","span":{"begin":664,"end":668},"obj":"multi_cell"},{"id":"T23","span":{"begin":682,"end":697},"obj":"protein_molecule"},{"id":"T24","span":{"begin":706,"end":717},"obj":"protein_subunit"},{"id":"T25","span":{"begin":721,"end":731},"obj":"protein_molecule"},{"id":"T26","span":{"begin":769,"end":782},"obj":"other_name"},{"id":"T27","span":{"begin":799,"end":818},"obj":"cell_type"},{"id":"T28","span":{"begin":820,"end":835},"obj":"protein_molecule"},{"id":"T29","span":{"begin":874,"end":886},"obj":"protein_molecule"},{"id":"T30","span":{"begin":887,"end":897},"obj":"protein_molecule"},{"id":"T31","span":{"begin":917,"end":933},"obj":"other_name"},{"id":"T32","span":{"begin":934,"end":944},"obj":"protein_molecule"},{"id":"T33","span":{"begin":981,"end":995},"obj":"protein_molecule"},{"id":"T34","span":{"begin":1059,"end":1074},"obj":"protein_molecule"},{"id":"T35","span":{"begin":1096,"end":1123},"obj":"other_name"},{"id":"T36","span":{"begin":1127,"end":1137},"obj":"protein_molecule"},{"id":"T37","span":{"begin":1141,"end":1152},"obj":"cell_type"},{"id":"T38","span":{"begin":1163,"end":1178},"obj":"protein_molecule"},{"id":"T39","span":{"begin":1199,"end":1223},"obj":"other_name"},{"id":"T40","span":{"begin":1227,"end":1237},"obj":"protein_molecule"},{"id":"T41","span":{"begin":1241,"end":1252},"obj":"cell_type"},{"id":"T42","span":{"begin":1311,"end":1320},"obj":"protein_molecule"},{"id":"T43","span":{"begin":1376,"end":1386},"obj":"protein_molecule"}],"text":"Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.\nTranscription factors belonging to the NF-kappa B family are controlled by inhibitory I kappa B proteins, mainly I kappa B alpha and I kappa B beta. Apparently normal at birth, I kappa B alpha-/- mice exhibit severe runting, skin defects, and extensive granulopoiesis postnatally, typically dying by 8 days. Hematopoietic tissues from these mice display elevated levels of both nuclear NF-kappa B and mRNAs of some, but not all, genes thought to be regulated by NF-kappa B. NF-kappa B elevation results in these phenotypic abnormalities because mice lacking both I kappa B alpha and the p50 subunit of NF-kappa B show a dramatically delayed onset of abnormalities. In contrast to hematopoietic cells, I kappa B alpha-/- embryonic fibroblasts show minimal constitutive NF-kappa B, as well as normal signal-dependent NF-kappa B activation that is concomitant with I kappa B beta degradation. Our results indicate that I kappa b beta, but not I kappa B alpha, is required for the signal-dependent activation of NF-kappa B in fibroblasts. However, I kappa B alpha is required for the postinduction repression of NF-kappa B in fibroblasts. These results define distinct roles for the two forms of I kappa B and demonstrate the necessity for stringent control of NF-kappa B."}

    genia-medco-coref

    {"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":87,"end":117},"obj":"NP"},{"id":"C2","span":{"begin":194,"end":223},"obj":"NP"},{"id":"C3","span":{"begin":232,"end":247},"obj":"NP"},{"id":"C4","span":{"begin":252,"end":266},"obj":"NP"},{"id":"C5","span":{"begin":296,"end":319},"obj":"NP"},{"id":"C6","span":{"begin":328,"end":398},"obj":"NP"},{"id":"C7","span":{"begin":454,"end":464},"obj":"NP"},{"id":"C8","span":{"begin":581,"end":591},"obj":"NP"},{"id":"C9","span":{"begin":625,"end":655},"obj":"NP"},{"id":"C10","span":{"begin":682,"end":697},"obj":"NP"},{"id":"C11","span":{"begin":721,"end":731},"obj":"NP"},{"id":"C12","span":{"begin":820,"end":860},"obj":"NP"},{"id":"C13","span":{"begin":910,"end":955},"obj":"NP"},{"id":"C14","span":{"begin":956,"end":960},"obj":"NP"},{"id":"C15","span":{"begin":1035,"end":1049},"obj":"NP"},{"id":"C16","span":{"begin":1059,"end":1074},"obj":"NP"},{"id":"C17","span":{"begin":1127,"end":1137},"obj":"NP"},{"id":"C18","span":{"begin":1141,"end":1152},"obj":"NP"},{"id":"C19","span":{"begin":1163,"end":1178},"obj":"NP"},{"id":"C20","span":{"begin":1227,"end":1237},"obj":"NP"},{"id":"C21","span":{"begin":1241,"end":1252},"obj":"NP"},{"id":"C22","span":{"begin":1311,"end":1320},"obj":"NP"},{"id":"C23","span":{"begin":1376,"end":1386},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C5","obj":"C1"},{"id":"R2","pred":"coref-ident","subj":"C7","obj":"C5"},{"id":"R3","pred":"coref-ident","subj":"C9","obj":"C6"},{"id":"R4","pred":"coref-ident","subj":"C10","obj":"C3"},{"id":"R5","pred":"coref-ident","subj":"C11","obj":"C8"},{"id":"R6","pred":"coref-relat","subj":"C14","obj":"C13"},{"id":"R7","pred":"coref-ident","subj":"C15","obj":"C4"},{"id":"R8","pred":"coref-ident","subj":"C16","obj":"C10"},{"id":"R9","pred":"coref-ident","subj":"C17","obj":"C11"},{"id":"R10","pred":"coref-ident","subj":"C18","obj":"C12"},{"id":"R11","pred":"coref-ident","subj":"C19","obj":"C16"},{"id":"R12","pred":"coref-ident","subj":"C20","obj":"C17"},{"id":"R13","pred":"coref-ident","subj":"C21","obj":"C18"},{"id":"R14","pred":"coref-ident","subj":"C22","obj":"C2"},{"id":"R15","pred":"coref-ident","subj":"C23","obj":"C20"}],"text":"Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.\nTranscription factors belonging to the NF-kappa B family are controlled by inhibitory I kappa B proteins, mainly I kappa B alpha and I kappa B beta. Apparently normal at birth, I kappa B alpha-/- mice exhibit severe runting, skin defects, and extensive granulopoiesis postnatally, typically dying by 8 days. Hematopoietic tissues from these mice display elevated levels of both nuclear NF-kappa B and mRNAs of some, but not all, genes thought to be regulated by NF-kappa B. NF-kappa B elevation results in these phenotypic abnormalities because mice lacking both I kappa B alpha and the p50 subunit of NF-kappa B show a dramatically delayed onset of abnormalities. In contrast to hematopoietic cells, I kappa B alpha-/- embryonic fibroblasts show minimal constitutive NF-kappa B, as well as normal signal-dependent NF-kappa B activation that is concomitant with I kappa B beta degradation. Our results indicate that I kappa b beta, but not I kappa B alpha, is required for the signal-dependent activation of NF-kappa B in fibroblasts. However, I kappa B alpha is required for the postinduction repression of NF-kappa B in fibroblasts. These results define distinct roles for the two forms of I kappa B and demonstrate the necessity for stringent control of NF-kappa B."}

    pubmed-sentences-benchmark

    {"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":118},"obj":"Sentence"},{"id":"S2","span":{"begin":119,"end":267},"obj":"Sentence"},{"id":"S3","span":{"begin":268,"end":426},"obj":"Sentence"},{"id":"S4","span":{"begin":427,"end":592},"obj":"Sentence"},{"id":"S5","span":{"begin":593,"end":783},"obj":"Sentence"},{"id":"S6","span":{"begin":784,"end":1008},"obj":"Sentence"},{"id":"S7","span":{"begin":1009,"end":1153},"obj":"Sentence"},{"id":"S8","span":{"begin":1154,"end":1253},"obj":"Sentence"},{"id":"S9","span":{"begin":1254,"end":1387},"obj":"Sentence"}],"text":"Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.\nTranscription factors belonging to the NF-kappa B family are controlled by inhibitory I kappa B proteins, mainly I kappa B alpha and I kappa B beta. Apparently normal at birth, I kappa B alpha-/- mice exhibit severe runting, skin defects, and extensive granulopoiesis postnatally, typically dying by 8 days. Hematopoietic tissues from these mice display elevated levels of both nuclear NF-kappa B and mRNAs of some, but not all, genes thought to be regulated by NF-kappa B. NF-kappa B elevation results in these phenotypic abnormalities because mice lacking both I kappa B alpha and the p50 subunit of NF-kappa B show a dramatically delayed onset of abnormalities. In contrast to hematopoietic cells, I kappa B alpha-/- embryonic fibroblasts show minimal constitutive NF-kappa B, as well as normal signal-dependent NF-kappa B activation that is concomitant with I kappa B beta degradation. Our results indicate that I kappa b beta, but not I kappa B alpha, is required for the signal-dependent activation of NF-kappa B in fibroblasts. However, I kappa B alpha is required for the postinduction repression of NF-kappa B in fibroblasts. These results define distinct roles for the two forms of I kappa B and demonstrate the necessity for stringent control of NF-kappa B."}