PubMed:7585505
Annnotations
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 1023-1026 | gene:3565 | denotes | IL4 |
| T1 | 1114-1128 | disease:C0149678 | denotes | infection, EBV |
| R1 | T0 | T1 | associated_with | IL4,"infection, EBV" |
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 78-101 | cell_type | denotes | quiescent B lymphocytes |
| T2 | 125-138 | cell_type | denotes | B lymphocytes |
| T3 | 372-391 | cell_line | denotes | immortal cell lines |
| T4 | 450-474 | cell_type | denotes | peripheral B lymphocytes |
| T5 | 532-559 | DNA | denotes | cell cycle-associated genes |
| T6 | 563-593 | cell_type | denotes | quiescent and stimulated cells |
| T7 | 631-641 | DNA | denotes | cell genes |
| T8 | 643-648 | DNA | denotes | cdc-2 |
| T9 | 650-658 | DNA | denotes | cyclin E |
| T10 | 660-664 | DNA | denotes | CD23 |
| T11 | 670-679 | DNA | denotes | cyclin D2 |
| T12 | 948-971 | cell_type | denotes | quiescent B lymphocytes |
| T13 | 998-1007 | protein | denotes | anti-CD40 |
| T14 | 1009-1017 | protein | denotes | anti-IgM |
| T15 | 1023-1026 | protein | denotes | IL4 |
| T16 | 1160-1172 | cell_type | denotes | B-lymphocyte |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 7585505-6#100#103#gene3565 | 1023-1026 | gene3565 | denotes | IL4 |
| 7585505-6#191#205#diseaseC0149678 | 1114-1128 | diseaseC0149678 | denotes | infection, EBV |
| 100#103#gene3565191#205#diseaseC0149678 | 7585505-6#100#103#gene3565 | 7585505-6#191#205#diseaseC0149678 | associated_with | IL4,"infection, EBV" |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 0-40 | NP | denotes | The normal cell cycle activation program |
| C3 | 78-101 | NP | denotes | quiescent B lymphocytes |
| C4 | 105-123 | NP | denotes | Epstein-Barr virus |
| C2 | 61-123 | NP | denotes | the infection of quiescent B lymphocytes by Epstein-Barr virus |
| C5 | 125-168 | NP | denotes | B lymphocytes in the peripheral circulation |
| C7 | 291-315 | NP | denotes | Epstein-Barr virus (EBV) |
| C6 | 276-315 | NP | denotes | infection with Epstein-Barr virus (EBV) |
| C8 | 446-474 | NP | denotes | the peripheral B lymphocytes |
| C9 | 626-641 | NP | denotes | four cell genes |
| C10 | 643-679 | NP | denotes | cdc-2, cyclin E, CD23, and cyclin D2 |
| C11 | 774-785 | NP | denotes | these genes |
| C12 | 846-868 | NP | denotes | this regulatory switch |
| C13 | 948-971 | NP | denotes | quiescent B lymphocytes |
| C14 | 1031-1034 | NP | denotes | EBV |
| C15 | 1070-1089 | NP | denotes | the same four genes |
| C16 | 1114-1123 | NP | denotes | infection |
| C17 | 1125-1128 | NP | denotes | EBV |
| C18 | 1138-1194 | NP | denotes | the normal program of B-lymphocyte cell cycle activation |
| R1 | C7 | C4 | coref-ident | Epstein-Barr virus (EBV),Epstein-Barr virus |
| R2 | C6 | C2 | coref-ident | infection with Epstein-Barr virus (EBV),the infection of quiescent B lymphocytes by Epstein-Barr virus |
| R3 | C8 | C5 | coref-ident | the peripheral B lymphocytes,B lymphocytes in the peripheral circulation |
| R4 | C10 | C9 | coref-appos | "cdc-2, cyclin E, CD23, and cyclin D2",four cell genes |
| R5 | C11 | C9 | coref-ident | these genes,four cell genes |
| R6 | C12 | C6 | coref-ident | this regulatory switch,infection with Epstein-Barr virus (EBV) |
| R7 | C13 | C3 | coref-ident | quiescent B lymphocytes,quiescent B lymphocytes |
| R8 | C14 | C7 | coref-ident | EBV,Epstein-Barr virus (EBV) |
| R9 | C15 | C11 | coref-ident | the same four genes,these genes |
| R10 | C16 | C6 | coref-ident | infection,infection with Epstein-Barr virus (EBV) |
| R11 | C17 | C14 | coref-ident | EBV,EBV |
| R12 | C18 | C1 | coref-ident | the normal program of B-lymphocyte cell cycle activation,The normal cell cycle activation program |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-124 | Sentence | denotes | The normal cell cycle activation program is exploited during the infection of quiescent B lymphocytes by Epstein-Barr virus. |
| S2 | 125-213 | Sentence | denotes | B lymphocytes in the peripheral circulation are maintained in a non-proliferative state. |
| S3 | 214-392 | Sentence | denotes | Antigen recognition stimulates limited proliferation, whereas infection with Epstein-Barr virus (EBV) results in continual proliferation and the outgrowth of immortal cell lines. |
| S4 | 393-594 | Sentence | denotes | Because it is not clear at which point in cell cycle the peripheral B lymphocytes are arrested, we characterized the expression of several cell cycle-associated genes in quiescent and stimulated cells. |
| S5 | 595-765 | Sentence | denotes | We show that the expression of four cell genes, cdc-2, cyclin E, CD23, and cyclin D2, are up-regulated approximately 100-fold as a result of EBV-mediated immortalization. |
| S6 | 766-922 | Sentence | denotes | Because these genes play a positive role in cell proliferation, we suggest that this regulatory switch contributes to controlling entry into the cell cycle. |
| S7 | 923-1195 | Sentence | denotes | Transient stimulation of quiescent B lymphocytes with either a cocktail of anti-CD40, anti-IgM, and IL4, or EBV results in the rapid expression of the same four genes, suggesting that, after infection, EBV exploits the normal program of B-lymphocyte cell cycle activation. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 11-40 | other_name | denotes | cell cycle activation program |
| T2 | 78-101 | cell_type | denotes | quiescent B lymphocytes |
| T3 | 105-123 | virus | denotes | Epstein-Barr virus |
| T4 | 125-138 | cell_type | denotes | B lymphocytes |
| T5 | 146-168 | other_name | denotes | peripheral circulation |
| T6 | 189-212 | other_name | denotes | non-proliferative state |
| T7 | 291-309 | virus | denotes | Epstein-Barr virus |
| T8 | 311-314 | virus | denotes | EBV |
| T9 | 372-391 | cell_line | denotes | immortal cell lines |
| T10 | 450-460 | cell_type | denotes | peripheral |
| T11 | 461-474 | cell_type | denotes | B lymphocytes |
| T12 | 532-559 | DNA_family_or_group | denotes | cell cycle-associated genes |
| T13 | 631-641 | DNA_family_or_group | denotes | cell genes |
| T14 | 643-648 | DNA_domain_or_region | denotes | cdc-2 |
| T15 | 650-658 | DNA_domain_or_region | denotes | cyclin E |
| T16 | 660-664 | DNA_domain_or_region | denotes | CD23 |
| T17 | 670-679 | DNA_domain_or_region | denotes | cyclin D2 |
| T18 | 736-739 | virus | denotes | EBV |
| T19 | 851-868 | other_name | denotes | regulatory switch |
| T20 | 911-921 | other_name | denotes | cell cycle |
| T21 | 923-944 | other_name | denotes | Transient stimulation |
| T22 | 948-957 | cell_type | denotes | quiescent |
| T23 | 958-971 | cell_type | denotes | B lymphocytes |
| T24 | 998-1007 | protein_family_or_group | denotes | anti-CD40 |
| T25 | 1009-1017 | protein_family_or_group | denotes | anti-IgM |
| T26 | 1023-1026 | protein_molecule | denotes | IL4 |
| T27 | 1031-1034 | virus | denotes | EBV |
| T28 | 1050-1066 | other_name | denotes | rapid expression |
| T29 | 1125-1128 | virus | denotes | EBV |
| T30 | 1160-1172 | cell_type | denotes | B-lymphocyte |