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PubMed:7584520 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 195-218 gene:2908 denotes glucocorticoid receptor
T1 286-312 disease:C0023434 denotes chronic lymphatic leukemia
T2 195-218 gene:2908 denotes glucocorticoid receptor
T3 314-317 disease:C0023434 denotes CLL
R1 T0 T1 associated_with glucocorticoid receptor,chronic lymphatic leukemia
R2 T2 T3 associated_with glucocorticoid receptor,CLL

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 12-35 protein denotes steroid binding domains
T2 43-66 protein denotes glucocorticoid receptor
T3 86-103 cell_type denotes mononuclear cells
T4 195-218 protein denotes glucocorticoid receptor
T5 498-511 protein denotes receptor-cDNA
T6 722-757 protein denotes DNA- and the steroid-binding region
T7 831-854 protein denotes glucocorticoid receptor
T8 1265-1295 cell_line denotes mouse and human lymphoma cells

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 12-19 lipid denotes steroid
T2 43-66 protein_family_or_group denotes glucocorticoid receptor
T3 86-103 cell_type denotes mononuclear cells
T4 107-118 multi_cell denotes treated CLL
T5 119-127 multi_cell denotes patients
T6 195-218 protein_family_or_group denotes glucocorticoid receptor
T7 272-280 multi_cell denotes patients
T8 286-312 other_name denotes chronic lymphatic leukemia
T9 314-317 other_name denotes CLL
T10 322-346 other_name denotes combination chemotherapy
T11 397-404 lipid denotes steroid
T12 450-489 other_name denotes denaturing gradient gel electrophoresis
T13 498-511 protein_complex denotes receptor-cDNA
T14 517-539 other_name denotes receptor concentration
T15 569-576 lipid denotes steroid
T16 690-714 other_name denotes mutation screening assay
T17 735-742 lipid denotes steroid
T18 779-787 multi_cell denotes patients
T19 831-854 protein_family_or_group denotes glucocorticoid receptor
T20 862-865 other_name denotes CLL
T21 866-874 multi_cell denotes patients
T22 976-991 other_name denotes silent mutation
T23 1009-1024 other_name denotes receptor allele
T24 1166-1178 other_name denotes chemotherapy
T25 1241-1261 other_name denotes corticoid resistance

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 39-66 NP denotes the glucocorticoid receptor
C1 0-66 NP denotes The DNA and steroid binding domains of the glucocorticoid receptor
C3 107-127 NP denotes treated CLL patients
C4 191-218 NP denotes the glucocorticoid receptor
C5 272-318 NP denotes patients with chronic lymphatic leukemia (CLL)
C6 322-346 NP denotes combination chemotherapy
C7 348-360 NP denotes The receptor
C8 767-787 NP denotes the treated patients
C9 827-854 NP denotes the glucocorticoid receptor
C10 858-874 NP denotes the CLL patients
C11 900-913 NP denotes these domains
C12 918-932 NP denotes one individual
C13 933-936 NP denotes who
C14 1106-1118 NP denotes the receptor
C15 1166-1178 NP denotes chemotherapy
R1 C4 C2 coref-ident the glucocorticoid receptor,the glucocorticoid receptor
R2 C7 C4 coref-ident The receptor,the glucocorticoid receptor
R3 C8 C3 coref-ident the treated patients,treated CLL patients
R4 C9 C7 coref-ident the glucocorticoid receptor,The receptor
R5 C10 C5 coref-ident the CLL patients,patients with chronic lymphatic leukemia (CLL)
R6 C11 C1 coref-ident these domains,The DNA and steroid binding domains of the glucocorticoid receptor
R7 C13 C12 coref-relat who,one individual
R8 C14 C7 coref-ident the receptor,The receptor
R9 C15 C6 coref-ident chemotherapy,combination chemotherapy

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-128 Sentence denotes The DNA and steroid binding domains of the glucocorticoid receptor are not altered in mononuclear cells of treated CLL patients.
S2 129-347 Sentence denotes The aim of this study was to investigate whether mutations in the glucocorticoid receptor could account for the increasing unresponsiveness of patients with chronic lymphatic leukemia (CLL) to combination chemotherapy.
S3 348-512 Sentence denotes The receptor was tested immunocytochemically, in steroid binding assays, and by a mutation screening (denaturing gradient gel electrophoresis) of the receptor-cDNA.
S4 513-664 Sentence denotes The receptor concentration, as measured by staining and steroid binding test, varied considerably but showed no clear correlation to clinical response.
S5 665-914 Sentence denotes Using a highly sensitive mutation screening assay of the DNA- and the steroid-binding region, none of the treated patients revealed any mutation, suggesting that the glucocorticoid receptor in the CLL patients tested is not altered in these domains.
S6 915-1025 Sentence denotes In one individual who had not been treated before analysis a silent mutation was found in one receptor allele.
S7 1026-1179 Sentence denotes The results suggest that mechanisms other than altered ligand or DNA binding of the receptor may be responsible for the lack of response to chemotherapy.
S8 1180-1307 Sentence denotes This conclusion is discussed in relation to the mechanism of corticoid resistance in mouse and human lymphoma cells in culture.