PubMed:7569976 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	52-62	protein	denotes	NF-kappa B
T2	93-102	protein	denotes	I kappa B
T3	247-256	protein	denotes	cytokines
T4	272-294	protein	denotes	cell surface molecules
T5	449-471	protein	denotes	nuclear factor kappa B
T6	473-483	protein	denotes	NF-kappa B
T7	508-522	cell_line	denotes	cultured cells
T8	572-581	protein	denotes	I kappa B
T9	630-640	protein	denotes	NF-kappa B
T10	644-674	protein	denotes	inactive cytoplasmic complexes
T11	684-694	protein	denotes	NF-kappa B
T12	710-732	DNA	denotes	immunoregulatory genes

Id	Subject	Object	Predicate	Lexical cue
C2	21-36	NP	denotes	glucocorticoids
C1	0-36	NP	denotes	Immunosuppression by glucocorticoids
C3	38-71	NP	denotes	inhibition of NF-kappa B activity
C4	114-129	NP	denotes	Glucocorticoids
C5	204-208	NP	denotes	They
C6	354-367	NP	denotes	this activity
C7	408-423	NP	denotes	glucocorticoids
C8	524-539	NP	denotes	This inhibition
C9	568-606	NP	denotes	the I kappa B alpha inhibitory protein
C10	608-613	NP	denotes	which
C11	684-694	NP	denotes	NF-kappa B
C13	792-795	NP	denotes	its
C12	774-804	NP	denotes	the inhibition of its activity
C14	867-882	NP	denotes	glucocorticoids
R1	C4	C2	coref-ident	Glucocorticoids,glucocorticoids
R2	C5	C4	coref-pron	They,Glucocorticoids
R3	C6	C1	coref-ident	this activity,Immunosuppression by glucocorticoids
R4	C7	C4	coref-ident	glucocorticoids,Glucocorticoids
R5	C8	C3	coref-ident	This inhibition,inhibition of NF-kappa B activity
R6	C10	C9	coref-relat	which,the I kappa B alpha inhibitory protein
R7	C13	C11	coref-pron	its,NF-kappa B
R8	C12	C3	coref-ident	the inhibition of its activity,inhibition of NF-kappa B activity
R9	C14	C7	coref-ident	glucocorticoids,glucocorticoids

Id	Subject	Object	Predicate	Lexical cue
S1	0-113	Sentence	denotes	Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis.
S2	114-203	Sentence	denotes	Glucocorticoids are among the most potent anti-inflammatory and immunosuppressive agents.
S3	204-385	Sentence	denotes	They inhibit synthesis of almost all known cytokines and of several cell surface molecules required for immune function, but the mechanism underlying this activity has been unclear.
S4	386-523	Sentence	denotes	Here it is shown that glucocorticoids are potent inhibitors of nuclear factor kappa B (NF-kappa B) activation in mice and cultured cells.
S5	524-675	Sentence	denotes	This inhibition is mediated by induction of the I kappa B alpha inhibitory protein, which traps activated NF-kappa B in inactive cytoplasmic complexes.
S6	676-883	Sentence	denotes	Because NF-kappa B activates many immunoregulatory genes in response to pro-inflammatory stimuli, the inhibition of its activity can be a major component of the anti-inflammatory activity of glucocorticoids.

Id	Subject	Object	Predicate	Lexical cue
T1	0-17	other_name	denotes	Immunosuppression
T2	21-36	lipid	denotes	glucocorticoids
T3	52-62	protein_molecule	denotes	NF-kappa B
T4	93-102	protein_molecule	denotes	I kappa B
T5	114-129	lipid	denotes	Glucocorticoids
T6	247-256	protein_family_or_group	denotes	cytokines
T7	272-294	protein_family_or_group	denotes	cell surface molecules
T8	308-323	other_name	denotes	immune function
T9	408-423	lipid	denotes	glucocorticoids
T10	435-445	other_name	denotes	inhibitors
T11	449-471	protein_molecule	denotes	nuclear factor kappa B
T12	473-483	protein_molecule	denotes	NF-kappa B
T13	499-503	multi_cell	denotes	mice
T14	508-522	cell_line	denotes	cultured cells
T15	572-581	protein_molecule	denotes	I kappa B
T16	630-640	protein_molecule	denotes	NF-kappa B
T17	644-674	protein_complex	denotes	inactive cytoplasmic complexes
T18	684-694	protein_molecule	denotes	NF-kappa B
T19	710-732	DNA_domain_or_region	denotes	immunoregulatory genes
T20	837-863	other_name	denotes	anti-inflammatory activity
T21	867-882	lipid	denotes	glucocorticoids