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PubMed:7565683 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-27 protein denotes N- and C-terminal sequences
T2 51-71 protein denotes MAD3/I kappa B alpha
T3 99-109 protein denotes NF-kappa B
T4 155-173 protein denotes inhibitory protein
T5 174-194 protein denotes MAD3/I kappa B alpha
T6 284-304 protein denotes transcription factor
T7 305-315 protein denotes NF-kappa B
T8 347-376 protein denotes human I kappa B alpha protein
T9 404-421 cell_line denotes mouse 70Z/3 cells
T10 482-497 protein denotes I kappa B alpha
T11 537-547 protein denotes NF-kappa B
T12 663-673 protein denotes proteasome
T13 836-865 protein denotes human I kappa B alpha protein
T14 923-932 cell_line denotes cell line
T15 1058-1073 protein denotes I kappa B alpha
T16 1113-1123 protein denotes C terminus
T17 1131-1146 protein denotes I kappa B alpha
T18 1162-1176 protein denotes amino acid 279
T19 1347-1362 protein denotes I kappa B alpha
T20 1390-1400 protein denotes N terminus

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-119 Sentence denotes N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity.
S2 120-316 Sentence denotes The proteolytic degradation of the inhibitory protein MAD3/I kappa B alpha in response to extracellular stimulation is a prerequisite step in the activation of the transcription factor NF-kappa B.
S3 317-614 Sentence denotes Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity, such as phorbol myristate acetate or lipopolysaccharide.
S4 615-866 Sentence denotes In addition, pretreatment of the cells with the proteasome inhibitor N-Ac-Leu-Leu-norleucinal inhibits this ligand-induced degradation and, in agreement with previous studies, stabilizes a hyperphosphorylated form of the human I kappa B alpha protein.
S5 867-1074 Sentence denotes By expressing mutant forms of the human protein in this cell line, we have been able to delineate the sequences responsible for both the ligand-induced phosphorylation and the degradation of I kappa B alpha.
S6 1075-1283 Sentence denotes Our results show that deletion of the C terminus of the I kappa B alpha molecule up to amino acid 279 abolishes constitutive but not ligand-inducible phosphorylation and inhibits ligand-inducible degradation.
S7 1284-1620 Sentence denotes Further analysis reveals that the inducible phosphorylation of I kappa B alpha maps to two serines in the N terminus of the protein (residues 32 and 36) and that the mutation of either residue is sufficient to abolish ligand-induced degradation, whereas both residues must be mutated to abolish inducible phosphorylation of the protein.
S8 1621-2003 Sentence denotes We propose that treatment of 70Z/3 cells with either phorbol myristate acetate or lipopolysaccharide induces a kinase activity which phosphorylates serines 32 and that these phosphorylations target the protein for rapid proteolytic degradation, possibly by the ubiquitin-26S proteasome pathway, thus allowing NF-kappa B to translocate to the nucleus and to activate gene expression.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-27 NP denotes N- and C-terminal sequences
C3 51-71 NP denotes MAD3/I kappa B alpha
C2 36-71 NP denotes degradation of MAD3/I kappa B alpha
C4 87-118 NP denotes inducers of NF-kappa B activity
C6 151-194 NP denotes the inhibitory protein MAD3/I kappa B alpha
C5 120-194 NP denotes The proteolytic degradation of the inhibitory protein MAD3/I kappa B alpha
C7 347-376 NP denotes human I kappa B alpha protein
C8 404-421 NP denotes mouse 70Z/3 cells
C9 525-556 NP denotes inducers of NF-kappa B activity
C10 644-653 NP denotes the cells
C11 718-749 NP denotes this ligand-induced degradation
C12 832-865 NP denotes the human I kappa B alpha protein
C13 897-914 NP denotes the human protein
C14 918-932 NP denotes this cell line
C16 1058-1073 NP denotes I kappa B alpha
C15 965-1073 NP denotes the sequences responsible for both the ligand-induced phosphorylation and the degradation of I kappa B alpha
C17 1254-1282 NP denotes ligand-inducible degradation
C19 1347-1362 NP denotes I kappa B alpha
C18 1314-1362 NP denotes the inducible phosphorylation of I kappa B alpha
C21 1404-1415 NP denotes the protein
C20 1371-1436 NP denotes two serines in the N terminus of the protein (residues 32 and 36)
C22 1502-1528 NP denotes ligand-induced degradation
C23 1538-1551 NP denotes both residues
C25 1608-1619 NP denotes the protein
C24 1579-1619 NP denotes inducible phosphorylation of the protein
R1 C6 C3 coref-ident the inhibitory protein MAD3/I kappa B alpha,MAD3/I kappa B alpha
R2 C5 C2 coref-ident The proteolytic degradation of the inhibitory protein MAD3/I kappa B alpha,degradation of MAD3/I kappa B alpha
R3 C9 C4 coref-ident inducers of NF-kappa B activity,inducers of NF-kappa B activity
R4 C10 C8 coref-ident the cells,mouse 70Z/3 cells
R5 C11 C5 coref-ident this ligand-induced degradation,The proteolytic degradation of the inhibitory protein MAD3/I kappa B alpha
R6 C12 C7 coref-ident the human I kappa B alpha protein,human I kappa B alpha protein
R7 C13 C12 coref-ident the human protein,the human I kappa B alpha protein
R8 C14 C8 coref-ident this cell line,mouse 70Z/3 cells
R9 C16 C12 coref-ident I kappa B alpha,the human I kappa B alpha protein
R10 C15 C1 coref-ident the sequences responsible for both the ligand-induced phosphorylation and the degradation of I kappa B alpha,N- and C-terminal sequences
R11 C17 C11 coref-ident ligand-inducible degradation,this ligand-induced degradation
R12 C19 C16 coref-ident I kappa B alpha,I kappa B alpha
R13 C21 C19 coref-ident the protein,I kappa B alpha
R14 C22 C17 coref-ident ligand-induced degradation,ligand-inducible degradation
R15 C23 C20 coref-ident both residues,two serines in the N terminus of the protein (residues 32 and 36)
R16 C25 C21 coref-ident the protein,the protein
R17 C24 C18 coref-ident inducible phosphorylation of the protein,the inducible phosphorylation of I kappa B alpha

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-27 protein_domain_or_region denotes N- and C-terminal sequences
T2 51-56 protein_molecule denotes MAD3/
T3 56-71 protein_molecule denotes I kappa B alpha
T4 99-109 protein_molecule denotes NF-kappa B
T5 155-173 protein_family_or_group denotes inhibitory protein
T6 174-179 protein_molecule denotes MAD3/
T7 179-194 protein_molecule denotes I kappa B alpha
T8 210-235 other_name denotes extracellular stimulation
T9 284-304 protein_family_or_group denotes transcription factor
T10 305-315 protein_molecule denotes NF-kappa B
T11 347-352 protein_molecule denotes human
T12 353-368 protein_molecule denotes I kappa B alpha
T13 404-421 cell_line denotes mouse 70Z/3 cells
T14 482-497 protein_molecule denotes I kappa B alpha
T15 537-547 protein_molecule denotes NF-kappa B
T16 566-591 other_organic_compound denotes phorbol myristate acetate
T17 595-613 lipid denotes lipopolysaccharide
T18 663-673 protein_complex denotes proteasome
T19 684-708 other_organic_compound denotes N-Ac-Leu-Leu-norleucinal
T20 836-841 protein_molecule denotes human
T21 842-857 protein_molecule denotes I kappa B alpha
T22 923-932 cell_line denotes cell line
T23 1004-1034 other_name denotes ligand-induced phosphorylation
T24 1043-1054 other_name denotes degradation
T25 1058-1073 protein_molecule denotes I kappa B alpha
T26 1113-1123 protein_domain_or_region denotes C terminus
T27 1131-1146 protein_molecule denotes I kappa B alpha
T28 1162-1176 protein_domain_or_region denotes amino acid 279
T29 1208-1240 other_name denotes ligand-inducible phosphorylation
T30 1254-1282 other_name denotes ligand-inducible degradation
T31 1318-1343 other_name denotes inducible phosphorylation
T32 1347-1362 protein_molecule denotes I kappa B alpha
T33 1375-1382 amino_acid_monomer denotes serines
T34 1390-1400 protein_domain_or_region denotes N terminus
T35 1450-1458 other_name denotes mutation
T36 1543-1551 amino_acid_monomer denotes residues
T37 1579-1604 other_name denotes inducible phosphorylation