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GlyCosmos6-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1661-1666 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977

sentences

Id Subject Object Predicate Lexical cue
T1 0-103 Sentence denotes The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA damaging treatments.
T2 104-469 Sentence denotes The low molecular weight GTP-binding proteins RhoA, RhoB, and RhoC are characterized as specific substrates for the ADP-ribosyltransferase C3 from Clostridium botulinum and are supposed to be involved in the organization of the microfilamental network and transformation. rhoB is known to be immediate-early inducible by growth factors and protein-tyrosine kinases.
T3 470-657 Sentence denotes Since increasing evidence indicates overlapping of growth factor- and UV-induced signal pathways, we studied the effect of UV light and other genotoxic agents on early rhoB transcription.
T4 658-753 Sentence denotes Within 30 min after UV irradiation of NIH3T3 cells, the amount of rhoB mRNA increased 3-4-fold.
T5 754-870 Sentence denotes Elevated rhoB mRNA was accompanied by an increase in RhoB protein, as detected by C3-mediated [32P]ADP-ribosylation.
T6 871-1037 Sentence denotes The transcription inhibitor actinomycin D prevented the UV-induced increase in rhoB mRNA and proved rhoB mRNA to be unstable with a half-life of approximately 20 min.
T7 1038-1118 Sentence denotes Transcriptional activation of rhoB by UV light was confirmed by run-on analysis.
T8 1119-1236 Sentence denotes The increase in rhoB mRNA after UV irradiation was prevented by inhibitors of protein kinase A (H9) and C (H7, Gö18).
T9 1237-1313 Sentence denotes The tyrosine kinase inhibitor genistein did not affect UV induction of rhoB.
T10 1314-1411 Sentence denotes In addition to UV, N-methyl-N-nitrosourea and the cytostatic drug cisplatin evoked rhoB response.
T11 1412-1581 Sentence denotes Cycloheximide was likewise effective in increasing the amount of rhoB mRNA, whereas Bt2cAMP, 12-O-tetradecanoylphorbol-13-acetate, and retinoic acid were without effect.
T12 1582-1718 Sentence denotes Prior down-regulation of signaling by 12-O-tetradecanoylphorbol-13-acetate and serum pretreatment reduced UV-stimulated rhoB expression.
T13 1719-1865 Sentence denotes The data indicate that rhoB represents a novel DNA damage-inducible function involved in early steps of signal transduction upon genotoxic stress.
T1 0-103 Sentence denotes The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA damaging treatments.
T2 104-469 Sentence denotes The low molecular weight GTP-binding proteins RhoA, RhoB, and RhoC are characterized as specific substrates for the ADP-ribosyltransferase C3 from Clostridium botulinum and are supposed to be involved in the organization of the microfilamental network and transformation. rhoB is known to be immediate-early inducible by growth factors and protein-tyrosine kinases.
T3 470-657 Sentence denotes Since increasing evidence indicates overlapping of growth factor- and UV-induced signal pathways, we studied the effect of UV light and other genotoxic agents on early rhoB transcription.
T4 658-753 Sentence denotes Within 30 min after UV irradiation of NIH3T3 cells, the amount of rhoB mRNA increased 3-4-fold.
T5 754-870 Sentence denotes Elevated rhoB mRNA was accompanied by an increase in RhoB protein, as detected by C3-mediated [32P]ADP-ribosylation.
T6 871-1037 Sentence denotes The transcription inhibitor actinomycin D prevented the UV-induced increase in rhoB mRNA and proved rhoB mRNA to be unstable with a half-life of approximately 20 min.
T7 1038-1118 Sentence denotes Transcriptional activation of rhoB by UV light was confirmed by run-on analysis.
T8 1119-1236 Sentence denotes The increase in rhoB mRNA after UV irradiation was prevented by inhibitors of protein kinase A (H9) and C (H7, Gö18).
T9 1237-1313 Sentence denotes The tyrosine kinase inhibitor genistein did not affect UV induction of rhoB.
T10 1314-1411 Sentence denotes In addition to UV, N-methyl-N-nitrosourea and the cytostatic drug cisplatin evoked rhoB response.
T11 1412-1581 Sentence denotes Cycloheximide was likewise effective in increasing the amount of rhoB mRNA, whereas Bt2cAMP, 12-O-tetradecanoylphorbol-13-acetate, and retinoic acid were without effect.
T12 1582-1718 Sentence denotes Prior down-regulation of signaling by 12-O-tetradecanoylphorbol-13-acetate and serum pretreatment reduced UV-stimulated rhoB expression.
T13 1719-1865 Sentence denotes The data indicate that rhoB represents a novel DNA damage-inducible function involved in early steps of signal transduction upon genotoxic stress.

GlyCosmos6-CLO

Id Subject Object Predicate Lexical cue
T1 696-702 http://purl.obolibrary.org/obo/CLO_0008172 denotes NIH3T3
T2 696-702 http://purl.obolibrary.org/obo/CLO_0050548 denotes NIH3T3
T3 696-702 http://purl.obolibrary.org/obo/CLO_0054324 denotes NIH3T3
T4 696-702 http://purl.obolibrary.org/obo/CLO_0054325 denotes NIH3T3
T5 703-708 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6 1054-1064 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T7 1215-1217 http://purl.obolibrary.org/obo/CLO_0003581 denotes H9

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 251-272 OrganismTaxon denotes Clostridium botulinum NCBItxid:1491

2015-BEL-Sample

Id Subject Object Predicate Lexical cue
T1 1314-1410 a(CHEBI:cisplatin) increases p(MGI:Rhob) denotes In addition to UV, N-methyl-N-nitrosourea and the cytostatic drug cisplatin evoked rhoB response

2015-BEL-Sample-2

Id Subject Object Predicate Lexical cue
BEL:20000008 1314-1410 a(CHEBI:"N-ethyl-N-nitrosourea") increases p(MGI:Rhob) denotes In addition to UV, N-methyl-N-nitrosourea and the cytostatic drug cisplatin evoked rhoB response
BEL:20000012 1314-1410 a(CHEBI:cisplatin) increases p(MGI:Rhob) denotes In addition to UV, N-methyl-N-nitrosourea and the cytostatic drug cisplatin evoked rhoB response