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sentences

Id Subject Object Predicate Lexical cue
T1 0-178 Sentence denotes Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system.
T2 179-487 Sentence denotes Using the yeast two-hybrid system, a genetic assay for studying protein-protein interactions, we have examined and compared the interaction of the insulin-like growth factor-I receptor (IGF-IR) and the insulin receptor (IR) with their two known substrates p52Shc and the insulin receptor substrate-1 (IRS-1).
T3 488-585 Sentence denotes We also mapped the specific domains of the IGF-IR and p52Shc participating in these interactions.
T4 586-1036 Sentence denotes Our findings can be summarized as follows: (i) the tyrosine kinase activity of the IGF-IR is essential for the interaction with p52Shc and IRS-1, (ii) p52Shc and IRS-1 bind to the IGF-IR in the NPEY-juxtamembrane motif, (iii) contrary to p52Shc, IRS-1 binds also to the major autophosphorylation sites (Tyr-1131, -1135, and -1136) of the IGF-IR, and (iv) the amino-terminal domain of p52Shc is required for its association with the IR and the IGF-IR.
T5 1037-1300 Sentence denotes We propose that (i) the IGF-IR and the IR share at least in part the same molecular mechanism underlying their interplay with their two substrates, p52Shc and IRS-1, and (ii) IRS-1 interacts with the IGF-IR in a fashion that is different from that used by p52Shc.
T6 1301-1417 Sentence denotes Finally, our data highlight the crucial role of the juxtamembrane domain in signaling by both the IR and the IGF-IR.
T1 0-178 Sentence denotes Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system.
T2 179-487 Sentence denotes Using the yeast two-hybrid system, a genetic assay for studying protein-protein interactions, we have examined and compared the interaction of the insulin-like growth factor-I receptor (IGF-IR) and the insulin receptor (IR) with their two known substrates p52Shc and the insulin receptor substrate-1 (IRS-1).
T3 488-585 Sentence denotes We also mapped the specific domains of the IGF-IR and p52Shc participating in these interactions.
T4 586-1036 Sentence denotes Our findings can be summarized as follows: (i) the tyrosine kinase activity of the IGF-IR is essential for the interaction with p52Shc and IRS-1, (ii) p52Shc and IRS-1 bind to the IGF-IR in the NPEY-juxtamembrane motif, (iii) contrary to p52Shc, IRS-1 binds also to the major autophosphorylation sites (Tyr-1131, -1135, and -1136) of the IGF-IR, and (iv) the amino-terminal domain of p52Shc is required for its association with the IR and the IGF-IR.
T5 1037-1300 Sentence denotes We propose that (i) the IGF-IR and the IR share at least in part the same molecular mechanism underlying their interplay with their two substrates, p52Shc and IRS-1, and (ii) IRS-1 interacts with the IGF-IR in a fashion that is different from that used by p52Shc.
T6 1301-1417 Sentence denotes Finally, our data highlight the crucial role of the juxtamembrane domain in signaling by both the IR and the IGF-IR.

AIMed

Id Subject Object Predicate Lexical cue
T1 43-46 protein denotes SHC
T2 55-83 protein denotes insulin receptor substrate-1
T3 85-90 protein denotes IRS-1
T4 101-146 protein denotes insulin-like growth factor-I (IGF-I) receptor
T5 326-363 protein denotes insulin-like growth factor-I receptor
T6 365-371 protein denotes IGF-IR
T7 381-397 protein denotes insulin receptor
T8 399-401 protein denotes IR
T9 435-441 protein denotes p52Shc
T10 450-478 protein denotes insulin receptor substrate-1
T11 480-485 protein denotes IRS-1
T12 531-537 protein denotes IGF-IR
T13 542-548 protein denotes p52Shc
T14 669-675 protein denotes IGF-IR
T15 714-720 protein denotes p52Shc
T16 725-730 protein denotes IRS-1
T17 737-743 protein denotes p52Shc
T18 748-753 protein denotes IRS-1
T19 766-772 protein denotes IGF-IR
T20 824-830 protein denotes p52Shc
T21 832-837 protein denotes IRS-1
T22 924-930 protein denotes IGF-IR
T23 970-976 protein denotes p52Shc
T24 1018-1020 protein denotes IR
T25 1029-1035 protein denotes IGF-IR
T26 1061-1067 protein denotes IGF-IR
T27 1076-1078 protein denotes IR
T28 1185-1191 protein denotes p52Shc
T29 1196-1201 protein denotes IRS-1
T30 1212-1217 protein denotes IRS-1
T31 1237-1243 protein denotes IGF-IR
T32 1293-1299 protein denotes p52Shc
T33 1399-1401 protein denotes IR
T34 1410-1416 protein denotes IGF-IR

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 785-798 Body_part denotes juxtamembrane http://purl.obolibrary.org/obo/GO_0005886
T2 1353-1366 Body_part denotes juxtamembrane http://purl.obolibrary.org/obo/GO_0005886