> top > docs > PubMed:7554315 > annotations

PubMed:7554315 JSONTXT

Annnotations TAB JSON ListView MergeView

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-149 Sentence denotes Temperature-induced down-regulation of the glucocorticoid receptor in peripheral blood mononuclear leucocyte in patients with sepsis or septic shock.
T2 150-160 Sentence denotes OBJECTIVE:
T3 161-262 Sentence denotes Activation of the hypothalamic-pituitary-adrenal axis is of vital importance during critical illness.
T4 263-432 Sentence denotes We have studied the adaptive mechanisms which occur at the level of the glucocorticoid receptor in glucocorticoid target tissues in patients with sepsis or septic shock.
T5 433-440 Sentence denotes DESIGN:
T6 441-730 Sentence denotes The effects of hypercortisolaemia, hyperthermia and cellular composition on number of glucocorticoid receptors per cell and their affinity were evaluated, both in vitro and in vivo, in peripheral blood mononuclear leucocytes of control subjects and in patients with sepsis or septic shock.
T7 731-740 Sentence denotes SUBJECTS:
T8 741-855 Sentence denotes Fifteen patients (age 25-79) with sepsis or septic shock who were admitted to an intensive care unit were studied.
T9 856-919 Sentence denotes The control group consisted of 24 healthy laboratory employees.
T10 920-933 Sentence denotes MEASUREMENTS:
T11 934-1083 Sentence denotes The binding capacity and affinity of the glucocorticoid receptors were measured and compared to clinical data and the plasma cortisol concentrations.
T12 1084-1092 Sentence denotes RESULTS:
T13 1093-1220 Sentence denotes Hypercortisolaemia, in vitro, resulted in a decreased affinity and a decreased binding capacity of the glucocorticoid receptor.
T14 1221-1340 Sentence denotes In vitro, hyperthermia as well as variations in the cellular composition did not influence the glucocorticoid receptor.
T15 1341-1478 Sentence denotes In vivo, there was no change in the number of receptors per cell in patients with sepsis or septic shock as compared to healthy controls.
T16 1479-1553 Sentence denotes However, a decreased affinity of the glucocorticoid receptor was observed.
T17 1554-1697 Sentence denotes There was a weak but significant negative correlation between body temperature and the number of glucocorticoid receptors in the patient group.
T18 1698-1812 Sentence denotes There was no relation between circulating cortisol concentrations and glucocorticoid receptor affinity and number.
T19 1813-1825 Sentence denotes CONCLUSIONS:
T20 1826-1941 Sentence denotes There is no obvious regulation of the number of glucocorticoid receptors by plasma cortisol concentrations in vivo.
T21 1942-2310 Sentence denotes The decreased affinity of the glucocorticoid receptor together with the negative correlation between hyperthermia and the number of glucocorticoid receptors in patients with sepsis or septic shock suggest that hypothalamic-pituitary-adrenal axis activation during critical illness is accompanied by peripheral adaptation in glucocorticoid receptor number and affinity.
T1 0-149 Sentence denotes Temperature-induced down-regulation of the glucocorticoid receptor in peripheral blood mononuclear leucocyte in patients with sepsis or septic shock.
T2 150-160 Sentence denotes OBJECTIVE:
T3 161-262 Sentence denotes Activation of the hypothalamic-pituitary-adrenal axis is of vital importance during critical illness.
T4 263-432 Sentence denotes We have studied the adaptive mechanisms which occur at the level of the glucocorticoid receptor in glucocorticoid target tissues in patients with sepsis or septic shock.
T5 433-440 Sentence denotes DESIGN:
T6 441-730 Sentence denotes The effects of hypercortisolaemia, hyperthermia and cellular composition on number of glucocorticoid receptors per cell and their affinity were evaluated, both in vitro and in vivo, in peripheral blood mononuclear leucocytes of control subjects and in patients with sepsis or septic shock.
T7 731-740 Sentence denotes SUBJECTS:
T8 741-855 Sentence denotes Fifteen patients (age 25-79) with sepsis or septic shock who were admitted to an intensive care unit were studied.
T9 856-919 Sentence denotes The control group consisted of 24 healthy laboratory employees.
T10 920-933 Sentence denotes MEASUREMENTS:
T11 934-1083 Sentence denotes The binding capacity and affinity of the glucocorticoid receptors were measured and compared to clinical data and the plasma cortisol concentrations.
T12 1084-1092 Sentence denotes RESULTS:
T13 1093-1220 Sentence denotes Hypercortisolaemia, in vitro, resulted in a decreased affinity and a decreased binding capacity of the glucocorticoid receptor.
T14 1221-1340 Sentence denotes In vitro, hyperthermia as well as variations in the cellular composition did not influence the glucocorticoid receptor.
T15 1341-1478 Sentence denotes In vivo, there was no change in the number of receptors per cell in patients with sepsis or septic shock as compared to healthy controls.
T16 1479-1553 Sentence denotes However, a decreased affinity of the glucocorticoid receptor was observed.
T17 1554-1697 Sentence denotes There was a weak but significant negative correlation between body temperature and the number of glucocorticoid receptors in the patient group.
T18 1698-1812 Sentence denotes There was no relation between circulating cortisol concentrations and glucocorticoid receptor affinity and number.
T19 1813-1825 Sentence denotes CONCLUSIONS:
T20 1826-1941 Sentence denotes There is no obvious regulation of the number of glucocorticoid receptors by plasma cortisol concentrations in vivo.
T21 1942-2310 Sentence denotes The decreased affinity of the glucocorticoid receptor together with the negative correlation between hyperthermia and the number of glucocorticoid receptors in patients with sepsis or septic shock suggest that hypothalamic-pituitary-adrenal axis activation during critical illness is accompanied by peripheral adaptation in glucocorticoid receptor number and affinity.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 43-66 protein denotes glucocorticoid receptor
T2 70-108 cell_type denotes peripheral blood mononuclear leucocyte
T3 335-358 protein denotes glucocorticoid receptor
T4 527-551 protein denotes glucocorticoid receptors
T5 626-665 cell_type denotes peripheral blood mononuclear leucocytes
T6 975-999 protein denotes glucocorticoid receptors
T7 1196-1219 protein denotes glucocorticoid receptor
T8 1516-1539 protein denotes glucocorticoid receptor
T9 1651-1675 protein denotes glucocorticoid receptors
T10 1768-1791 protein denotes glucocorticoid receptor
T11 1874-1898 protein denotes glucocorticoid receptors
T12 1972-1995 protein denotes glucocorticoid receptor
T13 2074-2098 protein denotes glucocorticoid receptors
T14 2266-2289 protein denotes glucocorticoid receptor

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 39-66 NP denotes the glucocorticoid receptor
C2 112-148 NP denotes patients with sepsis or septic shock
C3 161-214 NP denotes Activation of the hypothalamic-pituitary-adrenal axis
C4 279-302 NP denotes the adaptive mechanisms
C5 303-308 NP denotes which
C6 331-358 NP denotes the glucocorticoid receptor
C7 395-431 NP denotes patients with sepsis or septic shock
C8 456-474 NP denotes hypercortisolaemia
C9 476-488 NP denotes hyperthermia
C10 493-513 NP denotes cellular composition
C12 527-551 NP denotes glucocorticoid receptors
C11 517-560 NP denotes number of glucocorticoid receptors per cell
C13 565-570 NP denotes their
C14 669-685 NP denotes control subjects
C15 693-729 NP denotes patients with sepsis or septic shock
C17 741-797 NP denotes Fifteen patients (age 25-79) with sepsis or septic shock
C18 798-801 NP denotes who
C16 741-841 NP denotes Fifteen patients (age 25-79) with sepsis or septic shock who were admitted to an intensive care unit
C19 856-873 NP denotes The control group
C20 971-999 NP denotes the glucocorticoid receptors
C21 1093-1111 NP denotes Hypercortisolaemia
C22 1192-1219 NP denotes the glucocorticoid receptor
C23 1231-1243 NP denotes hyperthermia
C24 1269-1293 NP denotes the cellular composition
C25 1312-1339 NP denotes the glucocorticoid receptor
C27 1387-1396 NP denotes receptors
C26 1373-1405 NP denotes the number of receptors per cell
C28 1409-1445 NP denotes patients with sepsis or septic shock
C29 1461-1477 NP denotes healthy controls
C31 1512-1539 NP denotes the glucocorticoid receptor
C30 1488-1539 NP denotes a decreased affinity of the glucocorticoid receptor
C33 1651-1675 NP denotes glucocorticoid receptors
C32 1637-1675 NP denotes the number of glucocorticoid receptors
C34 1679-1696 NP denotes the patient group
C35 1768-1811 NP denotes glucocorticoid receptor affinity and number
C37 1874-1898 NP denotes glucocorticoid receptors
C36 1860-1898 NP denotes the number of glucocorticoid receptors
C39 1968-1995 NP denotes the glucocorticoid receptor
C38 1942-1995 NP denotes The decreased affinity of the glucocorticoid receptor
C40 2043-2055 NP denotes hyperthermia
C41 2060-2098 NP denotes the number of glucocorticoid receptors
C42 2102-2138 NP denotes patients with sepsis or septic shock
C43 2152-2198 NP denotes hypothalamic-pituitary-adrenal axis activation
C44 2266-2309 NP denotes glucocorticoid receptor number and affinity
R1 C5 C4 coref-relat which,the adaptive mechanisms
R2 C6 C1 coref-ident the glucocorticoid receptor,the glucocorticoid receptor
R3 C7 C2 coref-ident patients with sepsis or septic shock,patients with sepsis or septic shock
R4 C12 C6 coref-ident glucocorticoid receptors,the glucocorticoid receptor
R5 C13 C12 coref-pron their,glucocorticoid receptors
R6 C15 C7 coref-ident patients with sepsis or septic shock,patients with sepsis or septic shock
R7 C18 C17 coref-relat who,Fifteen patients (age 25-79) with sepsis or septic shock
R8 C19 C14 coref-ident The control group,control subjects
R9 C20 C12 coref-ident the glucocorticoid receptors,glucocorticoid receptors
R10 C21 C8 coref-ident Hypercortisolaemia,hypercortisolaemia
R11 C22 C20 coref-ident the glucocorticoid receptor,the glucocorticoid receptors
R12 C23 C9 coref-ident hyperthermia,hyperthermia
R13 C24 C10 coref-ident the cellular composition,cellular composition
R14 C25 C22 coref-ident the glucocorticoid receptor,the glucocorticoid receptor
R15 C27 C25 coref-ident receptors,the glucocorticoid receptor
R16 C26 C11 coref-ident the number of receptors per cell,number of glucocorticoid receptors per cell
R17 C28 C16 coref-ident patients with sepsis or septic shock,Fifteen patients (age 25-79) with sepsis or septic shock who were admitted to an intensive care unit
R18 C29 C19 coref-ident healthy controls,The control group
R19 C31 C25 coref-ident the glucocorticoid receptor,the glucocorticoid receptor
R20 C33 C31 coref-ident glucocorticoid receptors,the glucocorticoid receptor
R21 C32 C26 coref-ident the number of glucocorticoid receptors,the number of receptors per cell
R22 C34 C28 coref-ident the patient group,patients with sepsis or septic shock
R23 C37 C33 coref-ident glucocorticoid receptors,glucocorticoid receptors
R24 C36 C32 coref-ident the number of glucocorticoid receptors,the number of glucocorticoid receptors
R25 C39 C37 coref-ident the glucocorticoid receptor,glucocorticoid receptors
R26 C38 C30 coref-ident The decreased affinity of the glucocorticoid receptor,a decreased affinity of the glucocorticoid receptor
R27 C40 C23 coref-ident hyperthermia,hyperthermia
R28 C41 C36 coref-ident the number of glucocorticoid receptors,the number of glucocorticoid receptors
R29 C42 C34 coref-ident patients with sepsis or septic shock,the patient group
R30 C43 C3 coref-ident hypothalamic-pituitary-adrenal axis activation,Activation of the hypothalamic-pituitary-adrenal axis
R31 C44 C35 coref-ident glucocorticoid receptor number and affinity,glucocorticoid receptor affinity and number

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-149 Sentence denotes Temperature-induced down-regulation of the glucocorticoid receptor in peripheral blood mononuclear leucocyte in patients with sepsis or septic shock.
S2 150-262 Sentence denotes OBJECTIVE: Activation of the hypothalamic-pituitary-adrenal axis is of vital importance during critical illness.
S3 263-432 Sentence denotes We have studied the adaptive mechanisms which occur at the level of the glucocorticoid receptor in glucocorticoid target tissues in patients with sepsis or septic shock.
S4 433-730 Sentence denotes DESIGN: The effects of hypercortisolaemia, hyperthermia and cellular composition on number of glucocorticoid receptors per cell and their affinity were evaluated, both in vitro and in vivo, in peripheral blood mononuclear leucocytes of control subjects and in patients with sepsis or septic shock.
S5 731-855 Sentence denotes SUBJECTS: Fifteen patients (age 25-79) with sepsis or septic shock who were admitted to an intensive care unit were studied.
S6 856-919 Sentence denotes The control group consisted of 24 healthy laboratory employees.
S7 920-1083 Sentence denotes MEASUREMENTS: The binding capacity and affinity of the glucocorticoid receptors were measured and compared to clinical data and the plasma cortisol concentrations.
S8 1084-1220 Sentence denotes RESULTS: Hypercortisolaemia, in vitro, resulted in a decreased affinity and a decreased binding capacity of the glucocorticoid receptor.
S9 1221-1340 Sentence denotes In vitro, hyperthermia as well as variations in the cellular composition did not influence the glucocorticoid receptor.
S10 1341-1478 Sentence denotes In vivo, there was no change in the number of receptors per cell in patients with sepsis or septic shock as compared to healthy controls.
S11 1479-1553 Sentence denotes However, a decreased affinity of the glucocorticoid receptor was observed.
S12 1554-1697 Sentence denotes There was a weak but significant negative correlation between body temperature and the number of glucocorticoid receptors in the patient group.
S13 1698-1812 Sentence denotes There was no relation between circulating cortisol concentrations and glucocorticoid receptor affinity and number.
S14 1813-1941 Sentence denotes CONCLUSIONS: There is no obvious regulation of the number of glucocorticoid receptors by plasma cortisol concentrations in vivo.
S15 1942-2310 Sentence denotes The decreased affinity of the glucocorticoid receptor together with the negative correlation between hyperthermia and the number of glucocorticoid receptors in patients with sepsis or septic shock suggest that hypothalamic-pituitary-adrenal axis activation during critical illness is accompanied by peripheral adaptation in glucocorticoid receptor number and affinity.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 43-66 protein_family_or_group denotes glucocorticoid receptor
T2 70-108 cell_type denotes peripheral blood mononuclear leucocyte
T3 112-120 multi_cell denotes patients
T4 126-132 other_name denotes sepsis
T5 136-148 other_name denotes septic shock
T6 179-214 body_part denotes hypothalamic-pituitary-adrenal axis
T7 335-358 protein_family_or_group denotes glucocorticoid receptor
T8 362-391 tissue denotes glucocorticoid target tissues
T9 395-403 multi_cell denotes patients
T10 409-415 other_name denotes sepsis
T11 419-431 other_name denotes septic shock
T12 456-474 other_name denotes hypercortisolaemia
T13 476-488 other_name denotes hyperthermia
T14 493-513 other_name denotes cellular composition
T15 527-551 protein_family_or_group denotes glucocorticoid receptors
T16 626-665 cell_type denotes peripheral blood mononuclear leucocytes
T17 693-701 multi_cell denotes patients
T18 707-713 other_name denotes sepsis
T19 717-729 other_name denotes septic shock
T20 749-757 multi_cell denotes patients
T21 775-781 other_name denotes sepsis
T22 785-797 other_name denotes septic shock
T23 975-999 protein_family_or_group denotes glucocorticoid receptors
T24 1196-1219 protein_family_or_group denotes glucocorticoid receptor
T25 1409-1417 multi_cell denotes patients
T26 1423-1429 other_name denotes sepsis
T27 1433-1445 other_name denotes septic shock
T28 1461-1477 multi_cell denotes healthy controls
T29 1516-1539 protein_family_or_group denotes glucocorticoid receptor
T30 1616-1632 other_name denotes body temperature
T31 1651-1675 protein_family_or_group denotes glucocorticoid receptors
T32 1728-1739 other_name denotes circulating
T33 1740-1748 lipid denotes cortisol
T34 1768-1791 protein_family_or_group denotes glucocorticoid receptor
T35 1874-1898 protein_family_or_group denotes glucocorticoid receptors
T36 1902-1908 other_name denotes plasma
T37 1909-1917 lipid denotes cortisol
T38 1972-1995 protein_family_or_group denotes glucocorticoid receptor
T39 2043-2055 other_name denotes hyperthermia
T40 2074-2098 protein_family_or_group denotes glucocorticoid receptors
T41 2102-2110 multi_cell denotes patients
T42 2116-2122 other_name denotes sepsis
T43 2126-2138 other_name denotes septic shock
T44 2152-2187 body_part denotes hypothalamic-pituitary-adrenal axis
T45 2241-2262 other_name denotes peripheral adaptation
T46 2266-2289 protein_family_or_group denotes glucocorticoid receptor