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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 169-176 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T2 293-299 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-140 Sentence denotes Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody.
T2 141-311 Sentence denotes Nuclear factor of activated T cells (NFAT) regulates transcription of a number of cytokine genes, and NFAT DNA binding activity is stimulated following T cell activation.
T3 312-426 Sentence denotes Several lines of evidence have suggested that NFAT is a substrate for calcineurin, a serine/threonine phosphatase.
T4 427-609 Sentence denotes Using a polyclonal antibody to murine NFATp, Western blot analysis of various mouse tissues demonstrated that the 110-130-kDa NFATp protein was highly expressed in thymus and spleen.
T5 610-801 Sentence denotes Treatment of immunoprecipitated NFATp from untreated HT-2 cells with calcineurin resulted in the dephosphorylation of NFATp, demonstrating that NFATp is an in vitro substrate for calcineurin.
T6 802-947 Sentence denotes NFATp immunoprecipitated from 32P-labeled HT-2 cells migrated as an approximately 120-kDa protein that was localized to the cytosol of the cells.
T7 948-1101 Sentence denotes Treatment of the cells with ionomycin resulted in a decrease in the molecular weight of NFATp and a loss of 32P, consistent with NFATp dephosphorylation.
T8 1102-1204 Sentence denotes The dephosphorylation of NFATp was accompanied by localization of the protein to the nuclear fraction.
T9 1205-1384 Sentence denotes Both of these events were blocked by preincubation of the cells with FK506, a calcineurin inhibitor, consistent with the hypothesis that NFATp is a calcineurin substrate in cells.
T1 0-140 Sentence denotes Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody.
T2 141-311 Sentence denotes Nuclear factor of activated T cells (NFAT) regulates transcription of a number of cytokine genes, and NFAT DNA binding activity is stimulated following T cell activation.
T3 312-426 Sentence denotes Several lines of evidence have suggested that NFAT is a substrate for calcineurin, a serine/threonine phosphatase.
T4 427-609 Sentence denotes Using a polyclonal antibody to murine NFATp, Western blot analysis of various mouse tissues demonstrated that the 110-130-kDa NFATp protein was highly expressed in thymus and spleen.
T5 610-801 Sentence denotes Treatment of immunoprecipitated NFATp from untreated HT-2 cells with calcineurin resulted in the dephosphorylation of NFATp, demonstrating that NFATp is an in vitro substrate for calcineurin.
T6 802-947 Sentence denotes NFATp immunoprecipitated from 32P-labeled HT-2 cells migrated as an approximately 120-kDa protein that was localized to the cytosol of the cells.
T7 948-1101 Sentence denotes Treatment of the cells with ionomycin resulted in a decrease in the molecular weight of NFATp and a loss of 32P, consistent with NFATp dephosphorylation.
T8 1102-1204 Sentence denotes The dephosphorylation of NFATp was accompanied by localization of the protein to the nuclear fraction.
T9 1205-1384 Sentence denotes Both of these events were blocked by preincubation of the cells with FK506, a calcineurin inhibitor, consistent with the hypothesis that NFATp is a calcineurin substrate in cells.

sentences

Id Subject Object Predicate Lexical cue
T1 0-140 Sentence denotes Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody.
T2 141-311 Sentence denotes Nuclear factor of activated T cells (NFAT) regulates transcription of a number of cytokine genes, and NFAT DNA binding activity is stimulated following T cell activation.
T3 312-426 Sentence denotes Several lines of evidence have suggested that NFAT is a substrate for calcineurin, a serine/threonine phosphatase.
T4 427-609 Sentence denotes Using a polyclonal antibody to murine NFATp, Western blot analysis of various mouse tissues demonstrated that the 110-130-kDa NFATp protein was highly expressed in thymus and spleen.
T5 610-801 Sentence denotes Treatment of immunoprecipitated NFATp from untreated HT-2 cells with calcineurin resulted in the dephosphorylation of NFATp, demonstrating that NFATp is an in vitro substrate for calcineurin.
T6 802-947 Sentence denotes NFATp immunoprecipitated from 32P-labeled HT-2 cells migrated as an approximately 120-kDa protein that was localized to the cytosol of the cells.
T7 948-1101 Sentence denotes Treatment of the cells with ionomycin resulted in a decrease in the molecular weight of NFATp and a loss of 32P, consistent with NFATp dephosphorylation.
T8 1102-1204 Sentence denotes The dephosphorylation of NFATp was accompanied by localization of the protein to the nuclear fraction.
T9 1205-1384 Sentence denotes Both of these events were blocked by preincubation of the cells with FK506, a calcineurin inhibitor, consistent with the hypothesis that NFATp is a calcineurin substrate in cells.
T1 0-140 Sentence denotes Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody.
T2 141-311 Sentence denotes Nuclear factor of activated T cells (NFAT) regulates transcription of a number of cytokine genes, and NFAT DNA binding activity is stimulated following T cell activation.
T3 312-426 Sentence denotes Several lines of evidence have suggested that NFAT is a substrate for calcineurin, a serine/threonine phosphatase.
T4 427-609 Sentence denotes Using a polyclonal antibody to murine NFATp, Western blot analysis of various mouse tissues demonstrated that the 110-130-kDa NFATp protein was highly expressed in thymus and spleen.
T5 610-801 Sentence denotes Treatment of immunoprecipitated NFATp from untreated HT-2 cells with calcineurin resulted in the dephosphorylation of NFATp, demonstrating that NFATp is an in vitro substrate for calcineurin.
T6 802-947 Sentence denotes NFATp immunoprecipitated from 32P-labeled HT-2 cells migrated as an approximately 120-kDa protein that was localized to the cytosol of the cells.
T7 948-1101 Sentence denotes Treatment of the cells with ionomycin resulted in a decrease in the molecular weight of NFATp and a loss of 32P, consistent with NFATp dephosphorylation.
T8 1102-1204 Sentence denotes The dephosphorylation of NFATp was accompanied by localization of the protein to the nuclear fraction.
T9 1205-1384 Sentence denotes Both of these events were blocked by preincubation of the cells with FK506, a calcineurin inhibitor, consistent with the hypothesis that NFATp is a calcineurin substrate in cells.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 591-597 http://purl.obolibrary.org/obo/MAT_0000080 denotes thymus
T2 602-608 http://purl.obolibrary.org/obo/MAT_0000085 denotes spleen

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 24-29 protein denotes NFATp
T2 76-96 cell_line denotes activated HT-2 cells
T3 114-139 protein denotes NFATp polyclonal antibody
T4 141-176 protein denotes Nuclear factor of activated T cells
T5 178-182 protein denotes NFAT
T6 223-237 protein denotes cytokine genes
T7 243-247 protein denotes NFAT
T8 358-362 protein denotes NFAT
T9 382-393 protein denotes calcineurin
T10 397-425 protein denotes serine/threonine phosphatase
T11 458-470 protein denotes murine NFATp
T12 553-566 protein denotes NFATp protein
T13 642-647 protein denotes NFATp
T14 663-673 cell_line denotes HT-2 cells
T15 679-690 protein denotes calcineurin
T16 728-733 protein denotes NFATp
T17 754-759 protein denotes NFATp
T18 789-800 protein denotes calcineurin
T19 802-807 protein denotes NFATp
T20 832-854 cell_line denotes 32P-labeled HT-2 cells
T21 1036-1041 protein denotes NFATp
T22 1077-1082 protein denotes NFATp
T23 1127-1132 protein denotes NFATp
T24 1283-1294 protein denotes calcineurin
T25 1342-1347 protein denotes NFATp
T26 1353-1364 protein denotes calcineurin

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 24-47 NP denotes NFATp dephosphorylation
C2 52-72 NP denotes nuclear localization
C3 103-139 NP denotes a specific NFATp polyclonal antibody
C4 141-183 NP denotes Nuclear factor of activated T cells (NFAT)
C5 358-362 NP denotes NFAT
C7 382-393 NP denotes calcineurin
C6 366-393 NP denotes a substrate for calcineurin
C8 395-425 NP denotes a serine/threonine phosphatase
C10 458-470 NP denotes murine NFATp
C9 433-470 NP denotes a polyclonal antibody to murine NFATp
C11 679-690 NP denotes calcineurin
C13 728-733 NP denotes NFATp
C12 703-733 NP denotes the dephosphorylation of NFATp
C14 754-759 NP denotes NFATp
C16 789-800 NP denotes calcineurin
C15 763-800 NP denotes an in vitro substrate for calcineurin
C17 832-854 NP denotes 32P-labeled HT-2 cells
C18 867-899 NP denotes an approximately 120-kDa protein
C19 900-904 NP denotes that
C20 937-946 NP denotes the cells
C21 961-970 NP denotes the cells
C22 1036-1041 NP denotes NFATp
C23 1077-1100 NP denotes NFATp dephosphorylation
C25 1127-1132 NP denotes NFATp
C24 1102-1132 NP denotes The dephosphorylation of NFATp
C27 1168-1179 NP denotes the protein
C26 1152-1203 NP denotes localization of the protein to the nuclear fraction
C28 1259-1268 NP denotes the cells
C29 1274-1279 NP denotes FK506
C30 1281-1304 NP denotes a calcineurin inhibitor
C31 1322-1336 NP denotes the hypothesis
C32 1337-1341 NP denotes that
C33 1342-1347 NP denotes NFATp
C34 1351-1374 NP denotes a calcineurin substrate
R1 C5 C4 coref-ident NFAT,Nuclear factor of activated T cells (NFAT)
R2 C8 C7 coref-appos a serine/threonine phosphatase,calcineurin
R3 C9 C3 coref-ident a polyclonal antibody to murine NFATp,a specific NFATp polyclonal antibody
R4 C11 C7 coref-ident calcineurin,calcineurin
R5 C13 C10 coref-ident NFATp,murine NFATp
R6 C12 C1 coref-ident the dephosphorylation of NFATp,NFATp dephosphorylation
R7 C14 C13 coref-ident NFATp,NFATp
R8 C16 C11 coref-ident calcineurin,calcineurin
R9 C15 C6 coref-ident an in vitro substrate for calcineurin,a substrate for calcineurin
R10 C19 C18 coref-relat that,an approximately 120-kDa protein
R11 C20 C17 coref-ident the cells,32P-labeled HT-2 cells
R12 C21 C20 coref-ident the cells,the cells
R13 C22 C14 coref-ident NFATp,NFATp
R14 C23 C12 coref-ident NFATp dephosphorylation,the dephosphorylation of NFATp
R15 C25 C22 coref-ident NFATp,NFATp
R16 C24 C23 coref-ident The dephosphorylation of NFATp,NFATp dephosphorylation
R17 C27 C25 coref-ident the protein,NFATp
R18 C26 C2 coref-ident localization of the protein to the nuclear fraction,nuclear localization
R19 C28 C21 coref-ident the cells,the cells
R20 C30 C29 coref-appos a calcineurin inhibitor,FK506
R21 C32 C31 coref-relat that,the hypothesis
R22 C33 C25 coref-ident NFATp,NFATp
R23 C34 C15 coref-ident a calcineurin substrate,an in vitro substrate for calcineurin

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-140 Sentence denotes Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody.
S2 141-311 Sentence denotes Nuclear factor of activated T cells (NFAT) regulates transcription of a number of cytokine genes, and NFAT DNA binding activity is stimulated following T cell activation.
S3 312-426 Sentence denotes Several lines of evidence have suggested that NFAT is a substrate for calcineurin, a serine/threonine phosphatase.
S4 427-609 Sentence denotes Using a polyclonal antibody to murine NFATp, Western blot analysis of various mouse tissues demonstrated that the 110-130-kDa NFATp protein was highly expressed in thymus and spleen.
S5 610-801 Sentence denotes Treatment of immunoprecipitated NFATp from untreated HT-2 cells with calcineurin resulted in the dephosphorylation of NFATp, demonstrating that NFATp is an in vitro substrate for calcineurin.
S6 802-947 Sentence denotes NFATp immunoprecipitated from 32P-labeled HT-2 cells migrated as an approximately 120-kDa protein that was localized to the cytosol of the cells.
S7 948-1101 Sentence denotes Treatment of the cells with ionomycin resulted in a decrease in the molecular weight of NFATp and a loss of 32P, consistent with NFATp dephosphorylation.
S8 1102-1204 Sentence denotes The dephosphorylation of NFATp was accompanied by localization of the protein to the nuclear fraction.
S9 1205-1384 Sentence denotes Both of these events were blocked by preincubation of the cells with FK506, a calcineurin inhibitor, consistent with the hypothesis that NFATp is a calcineurin substrate in cells.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 24-29 protein_molecule denotes NFATp
T2 52-72 other_name denotes nuclear localization
T3 76-85 cell_line denotes activated
T4 86-96 cell_line denotes HT-2 cells
T5 114-119 protein_molecule denotes NFATp
T6 141-176 protein_molecule denotes Nuclear factor of activated T cells
T7 178-182 protein_family_or_group denotes NFAT
T8 194-207 other_name denotes transcription
T9 223-237 protein_family_or_group denotes cytokine genes
T10 243-247 protein_family_or_group denotes NFAT
T11 293-310 other_name denotes T cell activation
T12 358-362 protein_family_or_group denotes NFAT
T13 382-393 protein_molecule denotes calcineurin
T14 397-425 protein_family_or_group denotes serine/threonine phosphatase
T15 458-464 protein_molecule denotes murine
T16 465-470 protein_molecule denotes NFATp
T17 472-493 other_name denotes Western blot analysis
T18 505-510 multi_cell denotes mouse
T19 553-558 protein_molecule denotes NFATp
T20 591-597 body_part denotes thymus
T21 602-608 body_part denotes spleen
T22 642-647 protein_molecule denotes NFATp
T23 663-673 cell_line denotes HT-2 cells
T24 679-690 protein_molecule denotes calcineurin
T25 728-733 protein_molecule denotes NFATp
T26 754-759 protein_molecule denotes NFATp
T27 789-800 protein_molecule denotes calcineurin
T28 802-807 protein_molecule denotes NFATp
T29 832-843 cell_line denotes 32P-labeled
T30 844-854 cell_line denotes HT-2 cells
T31 926-933 cell_component denotes cytosol
T32 976-985 other_organic_compound denotes ionomycin
T33 1016-1032 other_name denotes molecular weight
T34 1036-1041 protein_molecule denotes NFATp
T35 1056-1059 inorganic denotes 32P
T36 1077-1082 protein_molecule denotes NFATp
T37 1106-1123 other_name denotes dephosphorylation
T38 1127-1132 protein_molecule denotes NFATp
T39 1152-1164 other_name denotes localization
T40 1187-1203 cell_component denotes nuclear fraction
T41 1274-1279 other_organic_compound denotes FK506
T42 1283-1294 protein_molecule denotes calcineurin
T43 1342-1347 protein_molecule denotes NFATp
T44 1353-1364 protein_molecule denotes calcineurin

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 591-597 Body_part denotes thymus http://purl.obolibrary.org/obo/MAT_0000080
T2 602-608 Body_part denotes spleen http://purl.obolibrary.org/obo/MAT_0000085

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 505-510 OrganismTaxon denotes mouse 10088|10090
T3 591-597 OrganismTaxon denotes thymus 49990

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 293-299 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T2 591-597 Body_part denotes thymus http://purl.obolibrary.org/obo/UBERON_0002370
T3 602-608 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T4 926-933 Body_part denotes cytosol http://purl.obolibrary.org/obo/GO_0005829