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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 108-115 cell_type denotes T cells
T2 131-151 protein denotes thyrotropin receptor
T3 624-658 cell_type denotes peripheral blood mononuclear cells
T4 660-664 cell_type denotes PBMC
T5 670-711 cell_line denotes TSH receptor (TSHR)-specific T cell lines
T6 715-758 protein denotes recombinant human TSHR extracellular domain
T7 760-773 protein denotes thyroglobulin
T8 779-783 protein denotes TSHR
T9 912-916 protein denotes TSHR
T10 982-1002 protein denotes extracellular domain
T11 1073-1077 cell_type denotes PBMC
T12 1208-1212 protein denotes TSHR
T13 1278-1282 cell_type denotes PBMC
T14 1560-1564 protein denotes TSHR
T15 1680-1684 cell_type denotes PBMC
T16 1808-1820 cell_line denotes T cell lines
T17 1872-1876 cell_type denotes PBMC
T18 1894-1907 protein denotes TSHR antibody
T19 1912-1931 protein denotes microsomal antibody
T20 2062-2066 cell_type denotes PBMC
T21 2256-2272 protein denotes thyroid antigens
T22 2401-2408 cell_type denotes T cells
T23 2524-2528 protein denotes TSHR
T24 2679-2687 protein denotes epitopes

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 5-18 NP denotes thyroidectomy
C2 20-46 NP denotes radioactive iodine therapy
C3 98-106 NP denotes patients
C4 119-151 NP denotes epitopes of thyrotropin receptor
C6 313-333 NP denotes Graves' disease (GD)
C7 351-364 NP denotes thyroidectomy
C5 296-364 NP denotes 15 patients with Graves' disease (GD) before and after thyroidectomy
C9 383-385 NP denotes GD
C10 403-435 NP denotes radioactive iodine (RAI) therapy
C8 366-435 NP denotes 19 patients with GD before and after radioactive iodine (RAI) therapy
C12 476-499 NP denotes antithyroid drugs (ATD)
C11 441-499 NP denotes 9 patients maintained euthyroid on antithyroid drugs (ATD)
C13 594-605 NP denotes GD patients
C14 624-665 NP denotes peripheral blood mononuclear cells (PBMC)
C15 670-711 NP denotes TSH receptor (TSHR)-specific T cell lines
C16 715-758 NP denotes recombinant human TSHR extracellular domain
C17 760-773 NP denotes thyroglobulin
C18 779-792 NP denotes TSHR peptides
C19 821-828 NP denotes surgery
C20 832-843 NP denotes RAI therapy
C21 912-925 NP denotes TSHR peptides
C22 933-940 NP denotes surgery
C23 971-1002 NP denotes the entire extracellular domain
C24 1025-1047 NP denotes subtotal thyroidectomy
C26 1063-1071 NP denotes patients
C27 1092-1103 NP denotes any peptide
C25 1049-1103 NP denotes the number of patients' PBMC responding to any peptide
C29 1130-1149 NP denotes recognized peptides
C28 1108-1149 NP denotes the average number of recognized peptides
C30 1208-1221 NP denotes TSHR peptides
C31 1252-1259 NP denotes surgery
C33 1278-1282 NP denotes PBMC
C32 1261-1282 NP denotes The responses of PBMC
C34 1288-1304 NP denotes Graves' patients
C35 1312-1323 NP denotes RAI therapy
C36 1339-1344 NP denotes those
C37 1348-1369 NP denotes the presurgical group
C38 1392-1403 NP denotes RAI therapy
C40 1419-1427 NP denotes patients
C41 1442-1453 NP denotes any peptide
C39 1405-1453 NP denotes the number of patients responding to any peptide
C43 1480-1499 NP denotes recognized peptides
C42 1458-1499 NP denotes the average number of recognized peptides
C44 1535-1538 NP denotes RAI
C46 1560-1573 NP denotes TSHR peptides
C45 1540-1573 NP denotes T cell responses to TSHR peptides
C47 1589-1594 NP denotes those
C48 1611-1622 NP denotes RAI therapy
C49 1646-1656 NP denotes the values
C51 1680-1684 NP denotes PBMC
C50 1667-1684 NP denotes Responses of PBMC
C53 1704-1706 NP denotes GD
C52 1690-1706 NP denotes patients with GD
C54 1732-1735 NP denotes ATD
C55 1753-1758 NP denotes those
C56 1766-1773 NP denotes surgery
C57 1777-1788 NP denotes RAI therapy
C58 1808-1820 NP denotes T cell lines
C59 1872-1876 NP denotes PBMC
C60 1955-1962 NP denotes surgery
C61 1984-1995 NP denotes RAI therapy
C62 2074-2077 NP denotes RAI
C63 2082-2089 NP denotes surgery
C64 2139-2142 NP denotes ATD
C65 2166-2169 NP denotes RAI
C66 2212-2219 NP denotes surgery
C67 2279-2292 NP denotes thyroidectomy
C68 2446-2457 NP denotes RAI therapy
C69 2631-2633 NP denotes GD
C70 2673-2687 NP denotes these epitopes
R13 C30 C18 coref-ident TSHR peptides,TSHR peptides
R14 C31 C24 coref-ident surgery,subtotal thyroidectomy
R15 C33 C14 coref-ident PBMC,peripheral blood mononuclear cells (PBMC)
R1 C7 C1 coref-ident thyroidectomy,thyroidectomy
R2 C9 C6 coref-ident GD,Graves' disease (GD)
R3 C10 C2 coref-ident radioactive iodine (RAI) therapy,radioactive iodine therapy
R4 C13 C3 coref-ident GD patients,patients
R5 C17 C16 coref-appos thyroglobulin,recombinant human TSHR extracellular domain
R6 C19 C7 coref-ident surgery,thyroidectomy
R7 C20 C10 coref-ident RAI therapy,radioactive iodine (RAI) therapy
R8 C21 C18 coref-ident TSHR peptides,TSHR peptides
R9 C22 C19 coref-ident surgery,surgery
R10 C23 C16 coref-ident the entire extracellular domain,recombinant human TSHR extracellular domain
R11 C24 C22 coref-ident subtotal thyroidectomy,surgery
R12 C26 C5 coref-ident patients,15 patients with Graves' disease (GD) before and after thyroidectomy
R16 C34 C8 coref-ident Graves' patients,19 patients with GD before and after radioactive iodine (RAI) therapy
R17 C35 C20 coref-ident RAI therapy,RAI therapy
R18 C36 C32 coref-pron those,The responses of PBMC
R19 C37 C5 coref-ident the presurgical group,15 patients with Graves' disease (GD) before and after thyroidectomy
R20 C38 C35 coref-ident RAI therapy,RAI therapy
R21 C40 C34 coref-ident patients,Graves' patients
R22 C41 C27 coref-ident any peptide,any peptide
R23 C39 C25 coref-ident the number of patients responding to any peptide,the number of patients' PBMC responding to any peptide
R24 C43 C29 coref-ident recognized peptides,recognized peptides
R25 C42 C28 coref-ident the average number of recognized peptides,the average number of recognized peptides
R26 C44 C38 coref-ident RAI,RAI therapy
R27 C46 C30 coref-ident TSHR peptides,TSHR peptides
R28 C47 C45 coref-pron those,T cell responses to TSHR peptides
R29 C48 C44 coref-ident RAI therapy,RAI
R30 C49 C45 coref-ident the values,T cell responses to TSHR peptides
R31 C51 C33 coref-ident PBMC,PBMC
R32 C50 C32 coref-ident Responses of PBMC,The responses of PBMC
R33 C53 C9 coref-ident GD,GD
R34 C52 C11 coref-ident patients with GD,9 patients maintained euthyroid on antithyroid drugs (ATD)
R35 C54 C12 coref-ident ATD,antithyroid drugs (ATD)
R36 C55 C50 coref-pron those,Responses of PBMC
R37 C56 C31 coref-ident surgery,surgery
R38 C57 C48 coref-ident RAI therapy,RAI therapy
R39 C58 C15 coref-ident T cell lines,TSH receptor (TSHR)-specific T cell lines
R40 C59 C51 coref-ident PBMC,PBMC
R41 C60 C56 coref-ident surgery,surgery
R42 C61 C57 coref-ident RAI therapy,RAI therapy
R43 C62 C61 coref-ident RAI,RAI therapy
R44 C63 C60 coref-ident surgery,surgery
R45 C64 C54 coref-ident ATD,ATD
R46 C65 C62 coref-ident RAI,RAI
R47 C66 C63 coref-ident surgery,surgery
R48 C67 C66 coref-ident thyroidectomy,surgery
R49 C68 C65 coref-ident RAI therapy,RAI
R50 C69 C53 coref-ident GD,GD
R51 C70 C4 coref-ident these epitopes,epitopes of thyrotropin receptor

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-183 Sentence denotes Does thyroidectomy, radioactive iodine therapy, or antithyroid drug treatment alter reactivity of patients' T cells to epitopes of thyrotropin receptor in autoimmune thyroid diseases?
S2 184-500 Sentence denotes The effect of treatment on thyroid antibody production and T cell reactivity to thyroid antigens was studied in 15 patients with Graves' disease (GD) before and after thyroidectomy, 19 patients with GD before and after radioactive iodine (RAI) therapy, and 9 patients maintained euthyroid on antithyroid drugs (ATD).
S3 501-590 Sentence denotes Twenty subjects matched for age and sex without known thyroid disease served as controls.
S4 591-897 Sentence denotes In GD patients, the responses of peripheral blood mononuclear cells (PBMC) and TSH receptor (TSHR)-specific T cell lines to recombinant human TSHR extracellular domain, thyroglobulin, and TSHR peptides were examined on the day of surgery or RAI therapy (day 0) and also 6-8 weeks and 3-6 months thereafter.
S5 898-1003 Sentence denotes Reactivity to TSHR peptides before surgery was heterogeneous and spanned the entire extracellular domain.
S6 1004-1160 Sentence denotes Six to 8 weeks after subtotal thyroidectomy, the number of patients' PBMC responding to any peptide and the average number of recognized peptides decreased.
S7 1161-1260 Sentence denotes A further decrease in the T cell reactivity to TSHR peptides was observed 3-6 months after surgery.
S8 1261-1370 Sentence denotes The responses of PBMC from Graves' patients before RAI therapy were less than those in the presurgical group.
S9 1371-1510 Sentence denotes Six to 8 weeks after RAI therapy, the number of patients responding to any peptide and the average number of recognized peptides increased.
S10 1511-1666 Sentence denotes Three to 6 months after RAI, T cell responses to TSHR peptides were less than those 6-8 weeks after RAI therapy, but still higher than the values on day 0.
S11 1667-1789 Sentence denotes Responses of PBMC from patients with GD, maintained euthyroid on ATD, were lower than those before surgery or RAI therapy.
S12 1790-1893 Sentence denotes The reactivity of T cell lines in different groups reflected a pattern similar to PBMC after treatment.
S13 1894-1996 Sentence denotes TSHR antibody and microsomal antibody levels decreased after surgery, but increased after RAI therapy.
S14 1997-2220 Sentence denotes The difference in the number of recognized peptides by patients' PBMC before RAI and surgery may reflect the effect of long term therapy with ATD in the patients before RAI vs. the shorter period in patients before surgery.
S15 2221-2409 Sentence denotes The decreased T cell reactivity to thyroid antigens after thyroidectomy could be the result of removal of a major part of the thyroid gland or redistribution of suppressor-inducer T cells.
S16 2410-2538 Sentence denotes The increased T cell response after RAI therapy is probably epitope specific, rather than a response to the whole TSHR molecule.
S17 2539-2761 Sentence denotes Synchronous recognition of peptides 158-176 and 248-263 is important for the development of GD, and the loss of recognition of one of these epitopes may be an early sign of immune remission and a predictor of euthyroidism.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 5-18 other_name denotes thyroidectomy
T2 20-31 other_name denotes radioactive
T3 32-38 atom denotes iodine
T4 51-77 other_name denotes antithyroid drug treatment
T5 108-115 cell_type denotes T cells
T6 119-127 other_name denotes epitopes
T7 131-151 protein_family_or_group denotes thyrotropin receptor
T8 155-182 other_name denotes autoimmune thyroid diseases
T9 211-238 other_name denotes thyroid antibody production
T10 243-260 other_name denotes T cell reactivity
T11 264-280 other_name denotes thyroid antigens
T12 299-307 multi_cell denotes patients
T13 313-328 other_name denotes Graves' disease
T14 330-332 other_name denotes GD
T15 351-364 other_name denotes thyroidectomy
T16 369-377 multi_cell denotes patients
T17 383-385 other_name denotes GD
T18 415-421 atom denotes iodine
T19 443-451 multi_cell denotes patients
T20 476-493 other_organic_compound denotes antithyroid drugs
T21 495-498 other_organic_compound denotes ATD
T22 555-570 other_name denotes thyroid disease
T23 594-596 other_name denotes GD
T24 597-605 multi_cell denotes patients
T25 624-658 cell_type denotes peripheral blood mononuclear cells
T26 660-664 cell_type denotes PBMC
T27 670-682 protein_family_or_group denotes TSH receptor
T28 684-688 protein_family_or_group denotes TSHR
T29 715-732 protein_domain_or_region denotes recombinant human
T30 733-737 protein_family_or_group denotes TSHR
T31 760-773 protein_molecule denotes thyroglobulin
T32 779-783 protein_family_or_group denotes TSHR
T33 821-828 other_name denotes surgery
T34 832-843 other_name denotes RAI therapy
T35 912-916 protein_family_or_group denotes TSHR
T36 933-940 other_name denotes surgery
T37 982-1002 protein_domain_or_region denotes extracellular domain
T38 1034-1047 other_name denotes thyroidectomy
T39 1063-1071 multi_cell denotes patients
T40 1073-1077 cell_type denotes PBMC
T41 1096-1103 peptide denotes peptide
T42 1130-1149 peptide denotes recognized peptides
T43 1187-1204 other_name denotes T cell reactivity
T44 1208-1212 protein_family_or_group denotes TSHR
T45 1252-1259 other_name denotes surgery
T46 1278-1282 cell_type denotes PBMC
T47 1296-1304 multi_cell denotes patients
T48 1312-1323 other_name denotes RAI therapy
T49 1392-1403 other_name denotes RAI therapy
T50 1419-1427 multi_cell denotes patients
T51 1446-1453 peptide denotes peptide
T52 1535-1538 other_name denotes RAI
T53 1540-1556 other_name denotes T cell responses
T54 1560-1564 protein_family_or_group denotes TSHR
T55 1611-1622 other_name denotes RAI therapy
T56 1680-1684 cell_type denotes PBMC
T57 1690-1698 multi_cell denotes patients
T58 1704-1706 other_name denotes GD
T59 1732-1735 other_organic_compound denotes ATD
T60 1766-1773 other_name denotes surgery
T61 1777-1788 other_name denotes RAI therapy
T62 1808-1820 cell_line denotes T cell lines
T63 1872-1876 cell_type denotes PBMC
T64 1894-1898 protein_family_or_group denotes TSHR
T65 1912-1931 protein_family_or_group denotes microsomal antibody
T66 1955-1962 other_name denotes surgery
T67 1984-1995 other_name denotes RAI therapy
T68 2029-2048 peptide denotes recognized peptides
T69 2052-2060 multi_cell denotes patients
T70 2062-2066 cell_type denotes PBMC
T71 2074-2077 other_name denotes RAI
T72 2082-2089 other_name denotes surgery
T73 2139-2142 other_organic_compound denotes ATD
T74 2150-2158 multi_cell denotes patients
T75 2166-2169 other_name denotes RAI
T76 2196-2204 multi_cell denotes patients
T77 2212-2219 other_name denotes surgery
T78 2235-2252 other_name denotes T cell reactivity
T79 2256-2272 protein_family_or_group denotes thyroid antigens
T80 2279-2292 other_name denotes thyroidectomy
T81 2347-2360 body_part denotes thyroid gland
T82 2401-2408 cell_type denotes T cells
T83 2424-2439 other_name denotes T cell response
T84 2446-2449 other_name denotes RAI
T85 2470-2486 other_name denotes epitope specific
T86 2524-2528 protein_family_or_group denotes TSHR
T87 2539-2562 other_name denotes Synchronous recognition
T88 2566-2582 peptide denotes peptides 158-176
T89 2587-2594 peptide denotes 248-263
T90 2631-2633 other_name denotes GD
T91 2679-2687 protein_family_or_group denotes epitopes
T92 2712-2728 other_name denotes immune remission
T93 2748-2760 other_name denotes euthyroidism