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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-93 Sentence denotes Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells.
T2 94-148 Sentence denotes A possible signaling role for the Syk tyrosine kinase.
T3 149-260 Sentence denotes Activation of cytoplasmic tyrosine kinases is an important aspect of signal transduction mediated by integrins.
T4 261-511 Sentence denotes In the human monocytic cell line THP-1, either integrin-dependent cell adhesion to fibronectin or ligation of beta 1 integrins with antibodies causes a rapid and intense tyrosine phosphorylation of two sets of proteins of about 65-75 and 120-125 kDa.
T5 512-832 Sentence denotes In addition, integrin ligation leads to nuclear translocation of the p50 and p65 subunits of the NF-kappa B transcription factor, to activation of a reporter gene driven by a promoter containing NF-kappa B sites, and to increased levels of mRNAs for immediate-early genes, including the cytokine interleukin (IL)-1 beta.
T6 833-1044 Sentence denotes The tyrosine kinase inhibitors genistein and herbimycin A block both integrin-mediated tyrosine phosphorylation and increases in IL-1 beta message levels, indicating a causal relationship between the two events.
T7 1045-1190 Sentence denotes The components tyrosine phosphorylated subsequent to cell adhesion include paxillin, pp125FAK, and the SH2 domain containing tyrosine kinase Syk.
T8 1191-1305 Sentence denotes In contrast, integrin ligation with antibodies induces tyrosine phosphorylation of Syk but not of FAK or paxillin.
T9 1306-1479 Sentence denotes In adhering cells, pre-treatment with cytochalasin D suppresses tyrosine phosphorylation of FAK and paxillin but not of Syk, while IL-1 beta message induction is unaffected.
T10 1480-1701 Sentence denotes These observations indicate that the Syk tyrosine kinase may be an important component of an integrin signaling pathway in monocytic cells, leading to activation of NF-kappa B and to increased levels of cytokine messages.
T1 0-93 Sentence denotes Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells.
T2 94-148 Sentence denotes A possible signaling role for the Syk tyrosine kinase.
T3 149-260 Sentence denotes Activation of cytoplasmic tyrosine kinases is an important aspect of signal transduction mediated by integrins.
T4 261-511 Sentence denotes In the human monocytic cell line THP-1, either integrin-dependent cell adhesion to fibronectin or ligation of beta 1 integrins with antibodies causes a rapid and intense tyrosine phosphorylation of two sets of proteins of about 65-75 and 120-125 kDa.
T5 512-832 Sentence denotes In addition, integrin ligation leads to nuclear translocation of the p50 and p65 subunits of the NF-kappa B transcription factor, to activation of a reporter gene driven by a promoter containing NF-kappa B sites, and to increased levels of mRNAs for immediate-early genes, including the cytokine interleukin (IL)-1 beta.
T6 833-1044 Sentence denotes The tyrosine kinase inhibitors genistein and herbimycin A block both integrin-mediated tyrosine phosphorylation and increases in IL-1 beta message levels, indicating a causal relationship between the two events.
T7 1045-1190 Sentence denotes The components tyrosine phosphorylated subsequent to cell adhesion include paxillin, pp125FAK, and the SH2 domain containing tyrosine kinase Syk.
T8 1191-1305 Sentence denotes In contrast, integrin ligation with antibodies induces tyrosine phosphorylation of Syk but not of FAK or paxillin.
T9 1306-1479 Sentence denotes In adhering cells, pre-treatment with cytochalasin D suppresses tyrosine phosphorylation of FAK and paxillin but not of Syk, while IL-1 beta message induction is unaffected.
T10 1480-1701 Sentence denotes These observations indicate that the Syk tyrosine kinase may be an important component of an integrin signaling pathway in monocytic cells, leading to activation of NF-kappa B and to increased levels of cytokine messages.

sentences

Id Subject Object Predicate Lexical cue
T4 261-511 Sentence denotes In the human monocytic cell line THP-1, either integrin-dependent cell adhesion to fibronectin or ligation of beta 1 integrins with antibodies causes a rapid and intense tyrosine phosphorylation of two sets of proteins of about 65-75 and 120-125 kDa.
T5 512-832 Sentence denotes In addition, integrin ligation leads to nuclear translocation of the p50 and p65 subunits of the NF-kappa B transcription factor, to activation of a reporter gene driven by a promoter containing NF-kappa B sites, and to increased levels of mRNAs for immediate-early genes, including the cytokine interleukin (IL)-1 beta.
T6 833-1044 Sentence denotes The tyrosine kinase inhibitors genistein and herbimycin A block both integrin-mediated tyrosine phosphorylation and increases in IL-1 beta message levels, indicating a causal relationship between the two events.
T7 1045-1190 Sentence denotes The components tyrosine phosphorylated subsequent to cell adhesion include paxillin, pp125FAK, and the SH2 domain containing tyrosine kinase Syk.
T8 1191-1305 Sentence denotes In contrast, integrin ligation with antibodies induces tyrosine phosphorylation of Syk but not of FAK or paxillin.
T9 1306-1479 Sentence denotes In adhering cells, pre-treatment with cytochalasin D suppresses tyrosine phosphorylation of FAK and paxillin but not of Syk, while IL-1 beta message induction is unaffected.
T10 1480-1701 Sentence denotes These observations indicate that the Syk tyrosine kinase may be an important component of an integrin signaling pathway in monocytic cells, leading to activation of NF-kappa B and to increased levels of cytokine messages.
T1 0-93 Sentence denotes Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells.
T2 94-148 Sentence denotes A possible signaling role for the Syk tyrosine kinase.
T3 149-260 Sentence denotes Activation of cytoplasmic tyrosine kinases is an important aspect of signal transduction mediated by integrins.
T1 0-93 Sentence denotes Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells.
T2 94-148 Sentence denotes A possible signaling role for the Syk tyrosine kinase.
T3 149-260 Sentence denotes Activation of cytoplasmic tyrosine kinases is an important aspect of signal transduction mediated by integrins.
T4 261-511 Sentence denotes In the human monocytic cell line THP-1, either integrin-dependent cell adhesion to fibronectin or ligation of beta 1 integrins with antibodies causes a rapid and intense tyrosine phosphorylation of two sets of proteins of about 65-75 and 120-125 kDa.
T5 512-832 Sentence denotes In addition, integrin ligation leads to nuclear translocation of the p50 and p65 subunits of the NF-kappa B transcription factor, to activation of a reporter gene driven by a promoter containing NF-kappa B sites, and to increased levels of mRNAs for immediate-early genes, including the cytokine interleukin (IL)-1 beta.
T6 833-1044 Sentence denotes The tyrosine kinase inhibitors genistein and herbimycin A block both integrin-mediated tyrosine phosphorylation and increases in IL-1 beta message levels, indicating a causal relationship between the two events.
T7 1045-1190 Sentence denotes The components tyrosine phosphorylated subsequent to cell adhesion include paxillin, pp125FAK, and the SH2 domain containing tyrosine kinase Syk.
T8 1191-1305 Sentence denotes In contrast, integrin ligation with antibodies induces tyrosine phosphorylation of Syk but not of FAK or paxillin.
T9 1306-1479 Sentence denotes In adhering cells, pre-treatment with cytochalasin D suppresses tyrosine phosphorylation of FAK and paxillin but not of Syk, while IL-1 beta message induction is unaffected.
T10 1480-1701 Sentence denotes These observations indicate that the Syk tyrosine kinase may be an important component of an integrin signaling pathway in monocytic cells, leading to activation of NF-kappa B and to increased levels of cytokine messages.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 47-55 protein denotes cytokine
T2 77-92 cell_type denotes monocytic cells
T3 128-147 protein denotes Syk tyrosine kinase
T4 163-191 protein denotes cytoplasmic tyrosine kinases
T5 250-259 protein denotes integrins
T6 268-299 cell_line denotes human monocytic cell line THP-1
T7 308-316 protein denotes integrin
T8 344-355 protein denotes fibronectin
T9 393-403 protein denotes antibodies
T10 489-510 protein denotes 65-75 and 120-125 kDa
T11 525-533 protein denotes integrin
T12 581-584 protein denotes p50
T13 589-601 protein denotes p65 subunits
T14 609-640 protein denotes NF-kappa B transcription factor
T15 661-674 DNA denotes reporter gene
T16 687-695 DNA denotes promoter
T17 707-723 DNA denotes NF-kappa B sites
T18 752-757 RNA denotes mRNAs
T19 762-783 DNA denotes immediate-early genes
T20 799-831 protein denotes cytokine interleukin (IL)-1 beta
T21 902-910 protein denotes integrin
T22 962-971 protein denotes IL-1 beta
T23 1120-1128 protein denotes paxillin
T24 1130-1138 protein denotes pp125FAK
T25 1148-1189 protein denotes SH2 domain containing tyrosine kinase Syk
T26 1204-1212 protein denotes integrin
T27 1227-1237 protein denotes antibodies
T28 1274-1277 protein denotes Syk
T29 1289-1292 protein denotes FAK
T30 1296-1304 protein denotes paxillin
T31 1309-1323 cell_type denotes adhering cells
T32 1398-1401 protein denotes FAK
T33 1406-1414 protein denotes paxillin
T34 1426-1429 protein denotes Syk
T35 1437-1446 protein denotes IL-1 beta
T36 1517-1520 protein denotes Syk
T37 1573-1581 protein denotes integrin
T38 1603-1618 cell_type denotes monocytic cells
T39 1645-1655 protein denotes NF-kappa B
T40 1683-1691 protein denotes cytokine

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-42 NP denotes Integrin-mediated tyrosine phosphorylation
C2 77-92 NP denotes monocytic cells
C3 124-147 NP denotes the Syk tyrosine kinase
C4 525-542 NP denotes integrin ligation
C5 605-640 NP denotes the NF-kappa B transcription factor
C6 902-944 NP denotes integrin-mediated tyrosine phosphorylation
C7 1120-1128 NP denotes paxillin
C8 1170-1189 NP denotes tyrosine kinase Syk
C9 1204-1221 NP denotes integrin ligation
C10 1274-1277 NP denotes Syk
C11 1289-1292 NP denotes FAK
C12 1296-1304 NP denotes paxillin
C13 1398-1401 NP denotes FAK
C14 1406-1414 NP denotes paxillin
C15 1426-1429 NP denotes Syk
C16 1513-1536 NP denotes the Syk tyrosine kinase
C17 1603-1618 NP denotes monocytic cells
C18 1645-1655 NP denotes NF-kappa B
R1 C6 C1 coref-ident integrin-mediated tyrosine phosphorylation,Integrin-mediated tyrosine phosphorylation
R2 C8 C3 coref-ident tyrosine kinase Syk,the Syk tyrosine kinase
R3 C9 C4 coref-ident integrin ligation,integrin ligation
R4 C10 C8 coref-ident Syk,tyrosine kinase Syk
R5 C12 C7 coref-ident paxillin,paxillin
R6 C13 C11 coref-ident FAK,FAK
R7 C14 C12 coref-ident paxillin,paxillin
R8 C15 C10 coref-ident Syk,Syk
R9 C16 C15 coref-ident the Syk tyrosine kinase,Syk
R10 C17 C2 coref-ident monocytic cells,monocytic cells
R11 C18 C5 coref-ident NF-kappa B,the NF-kappa B transcription factor

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-93 Sentence denotes Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells.
S2 94-148 Sentence denotes A possible signaling role for the Syk tyrosine kinase.
S3 149-260 Sentence denotes Activation of cytoplasmic tyrosine kinases is an important aspect of signal transduction mediated by integrins.
S4 261-511 Sentence denotes In the human monocytic cell line THP-1, either integrin-dependent cell adhesion to fibronectin or ligation of beta 1 integrins with antibodies causes a rapid and intense tyrosine phosphorylation of two sets of proteins of about 65-75 and 120-125 kDa.
S5 512-832 Sentence denotes In addition, integrin ligation leads to nuclear translocation of the p50 and p65 subunits of the NF-kappa B transcription factor, to activation of a reporter gene driven by a promoter containing NF-kappa B sites, and to increased levels of mRNAs for immediate-early genes, including the cytokine interleukin (IL)-1 beta.
S6 833-1044 Sentence denotes The tyrosine kinase inhibitors genistein and herbimycin A block both integrin-mediated tyrosine phosphorylation and increases in IL-1 beta message levels, indicating a causal relationship between the two events.
S7 1045-1190 Sentence denotes The components tyrosine phosphorylated subsequent to cell adhesion include paxillin, pp125FAK, and the SH2 domain containing tyrosine kinase Syk.
S8 1191-1305 Sentence denotes In contrast, integrin ligation with antibodies induces tyrosine phosphorylation of Syk but not of FAK or paxillin.
S9 1306-1479 Sentence denotes In adhering cells, pre-treatment with cytochalasin D suppresses tyrosine phosphorylation of FAK and paxillin but not of Syk, while IL-1 beta message induction is unaffected.
S10 1480-1701 Sentence denotes These observations indicate that the Syk tyrosine kinase may be an important component of an integrin signaling pathway in monocytic cells, leading to activation of NF-kappa B and to increased levels of cytokine messages.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 18-26 amino_acid_monomer denotes tyrosine
T2 47-55 protein_family_or_group denotes cytokine
T3 77-92 cell_type denotes monocytic cells
T4 128-131 protein_family_or_group denotes Syk
T5 132-140 amino_acid_monomer denotes tyrosine
T6 163-174 protein_family_or_group denotes cytoplasmic
T7 175-183 amino_acid_monomer denotes tyrosine
T8 218-237 other_name denotes signal transduction
T9 250-259 protein_family_or_group denotes integrins
T10 268-299 cell_line denotes human monocytic cell line THP-1
T11 308-316 protein_family_or_group denotes integrin
T12 344-355 protein_family_or_group denotes fibronectin
T13 393-403 protein_family_or_group denotes antibodies
T14 431-439 amino_acid_monomer denotes tyrosine
T15 525-533 protein_family_or_group denotes integrin
T16 552-573 other_name denotes nuclear translocation
T17 581-584 protein_subunit denotes p50
T18 589-601 protein_subunit denotes p65 subunits
T19 609-640 protein_complex denotes NF-kappa B transcription factor
T20 661-674 DNA_family_or_group denotes reporter gene
T21 687-695 DNA_domain_or_region denotes promoter
T22 707-723 DNA_domain_or_region denotes NF-kappa B sites
T23 752-757 RNA_family_or_group denotes mRNAs
T24 762-783 DNA_family_or_group denotes immediate-early genes
T25 799-831 protein_molecule denotes cytokine interleukin (IL)-1 beta
T26 837-845 amino_acid_monomer denotes tyrosine
T27 864-873 other_organic_compound denotes genistein
T28 878-890 other_organic_compound denotes herbimycin A
T29 902-910 protein_family_or_group denotes integrin
T30 920-928 amino_acid_monomer denotes tyrosine
T31 962-971 protein_molecule denotes IL-1 beta
T32 1060-1068 amino_acid_monomer denotes tyrosine
T33 1098-1111 other_name denotes cell adhesion
T34 1120-1128 protein_molecule denotes paxillin
T35 1130-1138 protein_molecule denotes pp125FAK
T36 1148-1158 protein_domain_or_region denotes SH2 domain
T37 1170-1178 amino_acid_monomer denotes tyrosine
T38 1204-1212 protein_family_or_group denotes integrin
T39 1227-1237 protein_family_or_group denotes antibodies
T40 1246-1254 amino_acid_monomer denotes tyrosine
T41 1274-1277 protein_molecule denotes Syk
T42 1289-1292 protein_molecule denotes FAK
T43 1296-1304 protein_molecule denotes paxillin
T44 1309-1323 cell_type denotes adhering cells
T45 1344-1358 other_organic_compound denotes cytochalasin D
T46 1370-1378 amino_acid_monomer denotes tyrosine
T47 1398-1401 protein_molecule denotes FAK
T48 1406-1414 protein_molecule denotes paxillin
T49 1426-1429 protein_molecule denotes Syk
T50 1437-1446 protein_molecule denotes IL-1 beta
T51 1517-1520 protein_molecule denotes Syk
T52 1521-1529 amino_acid_monomer denotes tyrosine
T53 1573-1581 protein_family_or_group denotes integrin
T54 1603-1618 cell_type denotes monocytic cells
T55 1645-1655 protein_molecule denotes NF-kappa B
T56 1683-1691 protein_family_or_group denotes cytokine

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 268-273 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 163-174 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 77-86 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T3 274-283 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T5 1603-1612 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054