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PubMed:7539799 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-60 Sentence denotes A novel form of dipeptidylpeptidase IV found in human serum.
T2 61-162 Sentence denotes Isolation, characterization, and comparison with T lymphocyte membrane dipeptidylpeptidase IV (CD26).
T3 163-416 Sentence denotes Human CD26, a Type II membrane glycoprotein with intrinsic dipeptidylpeptidase IV (DPPIV) activity and ability to bind adenosine deaminase type I (ADA-1), is expressed on epithelial cells constitutively, but on T lymphocytes its expression is regulated.
T4 417-595 Sentence denotes A soluble form of CD26/DPPIV has been described in plasma and related to immunological status, but it has been defined by the presence of DPPIV activity rather than by isolation.
T5 596-829 Sentence denotes Using nondenaturing chromatographic techniques followed by nondenaturing native preparative electrophoresis, we obtained a homogeneous preparation of soluble serum DPPIV and compared it with a recombinant soluble CD26/DPPIV (rsCD26).
T6 830-989 Sentence denotes We show that serum DPPIV is a monomer of 175 kDa in contrast to rsCD26 of 105-110 kDa, that it exists as a trimer, and that it is probably a serine proteinase.
T7 990-1155 Sentence denotes Deglycosylation removed N-linked sugar from both serum DPPIV and rsCD26; no O-linked glycosylation was observed, revealing a protein core of 130 kDa for serum DPPIV.
T8 1156-1307 Sentence denotes The large serum form expresses functional DPPIV activity with substrate and inhibitor specificities and pH activity profile similar to those of rsCD26.
T9 1308-1447 Sentence denotes Epitope analysis showed that monoclonal antibodies against five epitopes expressed by rsCD26 also bound, but more weakly, with serum DPPIV.
T10 1448-1593 Sentence denotes Analysis of peptides after limiting proteolysis and N-terminal sequences reveals no homology with rsCD26 but some identity with other peptidases.
T11 1594-1688 Sentence denotes Unlike rsCD26, the serum form does not bind ADA-1 and has no ADA-1 already associated with it.
T12 1689-1754 Sentence denotes Similarly to rsCD26, serum DPPIV is a potent T cell costimulator.
T13 1755-1854 Sentence denotes We conclude that the serum form of DPPIV is unique and is not a breakdown product of membrane CD26.
T14 1855-1981 Sentence denotes The conservation of DPPIV activity and five epitopes specific to rsCD26 suggest, however, a significant structural similarity.
T1 0-60 Sentence denotes A novel form of dipeptidylpeptidase IV found in human serum.
T2 61-162 Sentence denotes Isolation, characterization, and comparison with T lymphocyte membrane dipeptidylpeptidase IV (CD26).
T3 163-416 Sentence denotes Human CD26, a Type II membrane glycoprotein with intrinsic dipeptidylpeptidase IV (DPPIV) activity and ability to bind adenosine deaminase type I (ADA-1), is expressed on epithelial cells constitutively, but on T lymphocytes its expression is regulated.
T4 417-595 Sentence denotes A soluble form of CD26/DPPIV has been described in plasma and related to immunological status, but it has been defined by the presence of DPPIV activity rather than by isolation.
T5 596-829 Sentence denotes Using nondenaturing chromatographic techniques followed by nondenaturing native preparative electrophoresis, we obtained a homogeneous preparation of soluble serum DPPIV and compared it with a recombinant soluble CD26/DPPIV (rsCD26).
T6 830-989 Sentence denotes We show that serum DPPIV is a monomer of 175 kDa in contrast to rsCD26 of 105-110 kDa, that it exists as a trimer, and that it is probably a serine proteinase.
T7 990-1155 Sentence denotes Deglycosylation removed N-linked sugar from both serum DPPIV and rsCD26; no O-linked glycosylation was observed, revealing a protein core of 130 kDa for serum DPPIV.
T8 1156-1307 Sentence denotes The large serum form expresses functional DPPIV activity with substrate and inhibitor specificities and pH activity profile similar to those of rsCD26.
T9 1308-1447 Sentence denotes Epitope analysis showed that monoclonal antibodies against five epitopes expressed by rsCD26 also bound, but more weakly, with serum DPPIV.
T10 1448-1593 Sentence denotes Analysis of peptides after limiting proteolysis and N-terminal sequences reveals no homology with rsCD26 but some identity with other peptidases.
T11 1594-1688 Sentence denotes Unlike rsCD26, the serum form does not bind ADA-1 and has no ADA-1 already associated with it.
T12 1689-1754 Sentence denotes Similarly to rsCD26, serum DPPIV is a potent T cell costimulator.
T13 1755-1854 Sentence denotes We conclude that the serum form of DPPIV is unique and is not a breakdown product of membrane CD26.
T14 1855-1981 Sentence denotes The conservation of DPPIV activity and five epitopes specific to rsCD26 suggest, however, a significant structural similarity.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 310-313 Disease denotes ADA http://purl.obolibrary.org/obo/MONDO_0007064
T2 1638-1641 Disease denotes ADA http://purl.obolibrary.org/obo/MONDO_0007064
T3 1655-1658 Disease denotes ADA http://purl.obolibrary.org/obo/MONDO_0007064

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 48-53 OrganismTaxon denotes human 9606
T2 163-168 OrganismTaxon denotes Human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 110-122 Body_part denotes T lymphocyte http://purl.obolibrary.org/obo/CL_0000084
T2 123-131 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T5 185-193 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T8 334-350 Body_part denotes epithelial cells http://purl.obolibrary.org/obo/CL_0000066
T9 374-387 Body_part denotes T lymphocytes http://purl.obolibrary.org/obo/CL_0000084
T10 468-474 Body_part denotes plasma http://purl.obolibrary.org/obo/UBERON_0001969
T11 1734-1740 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T12 1840-1848 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 110-122 Cell denotes T lymphocyte http://purl.obolibrary.org/obo/CL:0000084
T2 112-122 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542
T3 302-308 Cell denotes type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138
T5 334-350 Cell denotes epithelial cells http://purl.obolibrary.org/obo/CL:0000066
T6 374-387 Cell denotes T lymphocytes http://purl.obolibrary.org/obo/CL:0000084
T7 1734-1740 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084