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PubMed:7539796 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-176 Sentence denotes Localization of functional receptor epitopes on the structure of ciliary neurotrophic factor indicates a conserved, function-related epitope topography among helical cytokines.
T2 177-486 Sentence denotes By rational mutagenesis, receptor-specific functional analysis, and visualization of complex formation in solution, we identified individual amino acid side chains involved specifically in the interaction of ciliary neurotrophic factor (CNTF) with CNTFR alpha and not with the beta-components, gp130 and LIFR.
T3 487-709 Sentence denotes In the crystal structure, the side chains of these residues, which are located in helix A, the AB loop, helix B, and helix D, are surface accessible and are clustered in space, thus constituting an epitope for CNTFR alpha.
T4 710-845 Sentence denotes By the same analysis, a partial epitope for gp130 was also identified on the surface of helix A that faces away from the alpha-epitope.
T5 846-1057 Sentence denotes Superposition of the CNTF and growth hormone structures showed that the location of these epitopes on CNTF is analogous to the location of the first and second receptor epitopes on the surface of growth hormone.
T6 1058-1257 Sentence denotes Further comparison with proposed binding sites for alpha- and beta-receptors on interleukin-6 and leukemia inhibitory factor indicated that this epitope topology is conserved among helical cytokines.
T7 1258-1396 Sentence denotes In each case, epitope I is utilized by the specificity-conferring component, whereas epitopes II and III are used by accessory components.
T8 1397-1521 Sentence denotes Thus, in addition to a common fold, helical cytokines share a conserved order of receptor epitopes that is function related.
T1 0-176 Sentence denotes Localization of functional receptor epitopes on the structure of ciliary neurotrophic factor indicates a conserved, function-related epitope topography among helical cytokines.
T2 177-486 Sentence denotes By rational mutagenesis, receptor-specific functional analysis, and visualization of complex formation in solution, we identified individual amino acid side chains involved specifically in the interaction of ciliary neurotrophic factor (CNTF) with CNTFR alpha and not with the beta-components, gp130 and LIFR.
T3 487-709 Sentence denotes In the crystal structure, the side chains of these residues, which are located in helix A, the AB loop, helix B, and helix D, are surface accessible and are clustered in space, thus constituting an epitope for CNTFR alpha.
T4 710-845 Sentence denotes By the same analysis, a partial epitope for gp130 was also identified on the surface of helix A that faces away from the alpha-epitope.
T5 846-1057 Sentence denotes Superposition of the CNTF and growth hormone structures showed that the location of these epitopes on CNTF is analogous to the location of the first and second receptor epitopes on the surface of growth hormone.
T6 1058-1257 Sentence denotes Further comparison with proposed binding sites for alpha- and beta-receptors on interleukin-6 and leukemia inhibitory factor indicated that this epitope topology is conserved among helical cytokines.
T7 1258-1396 Sentence denotes In each case, epitope I is utilized by the specificity-conferring component, whereas epitopes II and III are used by accessory components.
T8 1397-1521 Sentence denotes Thus, in addition to a common fold, helical cytokines share a conserved order of receptor epitopes that is function related.

AIMed

Id Subject Object Predicate Lexical cue
T1 385-412 protein denotes ciliary neurotrophic factor
T2 414-418 protein denotes CNTF
T3 425-436 protein denotes CNTFR alpha
T4 471-476 protein denotes gp130
T5 481-485 protein denotes LIFR
T6 697-708 protein denotes CNTFR alpha
T7 754-759 protein denotes gp130
T8 867-871 protein denotes CNTF
T9 948-952 protein denotes CNTF
T10 1138-1151 protein denotes interleukin-6

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1156-1164 Phenotype denotes leukemia HP:0001909

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1156-1164 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 569-574 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T2 591-596 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T3 604-609 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T4 657-662 Body_part denotes space http://purl.obolibrary.org/obo/UBERON_0000464
T5 798-803 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488