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PubMed:7538131 JSONTXT

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ngly1-sample4

Id Subject Object Predicate Lexical cue
T1 1153-1159 chem:24139 denotes GlcNAc
T2 1086-1092 chem:24139 denotes GlcNAc

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 604-618 Glycan_Motif denotes sialyl Lewis x https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T2 611-618 Glycan_Motif denotes Lewis x https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00051MO
T4 979-988 Glycan_Motif denotes T-antigen https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO
T5 1048-1054 Glycan_Motif denotes core-2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO
T6 1212-1218 Glycan_Motif denotes core-2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO

sentences

Id Subject Object Predicate Lexical cue
T1 0-85 Sentence denotes Structure of the O-glycans in GlyCAM-1, an endothelial-derived ligand for L-selectin.
T2 86-245 Sentence denotes L-selectin, the leukocyte selectin, mediates the carbohydrate-dependent attachment of circulating leukocytes to endothelium, preceding emigration into tissues.
T3 246-337 Sentence denotes It functions in inflammatory leukocyte trafficking and in lymphocyte homing to lymph nodes.
T4 338-526 Sentence denotes From previous work, the binding of L-selectin to endothelial-associated glycoprotein ligands, GlyCAM-1 and CD34, requires oligosaccharide sialylation, sulfation, and probably fucosylation.
T5 527-692 Sentence denotes We have recently identified a major capping group in GlyCAM-1 as 6' sulfated sialyl Lewis x, a novel structure which potentially satisfies all of these requirements.
T6 693-924 Sentence denotes In the present study, we define the complete structure of beta-eliminated chains of GlyCAM-1 using metabolic radiolabeling, plant lectin binding, and glycosidase digestions in conjunction with high pH anion-exchange chromatography.
T7 925-1169 Sentence denotes The majority of the O-glycans in GlyCAM-1 contain the T-antigen, i.e. Gal beta 1-->3GalNAc, which is incorporated into the core-2 structure, i.e. Gal beta 1-->3[GlcNAc beta 1-->6]GalNAc or larger core structures with additional GlcNAc residues.
T8 1170-1368 Sentence denotes The structures of two O-glycans, based on core-2, were determined to be: [sequence: see text] The implications of these structures and more complex O-glycans for binding by L-selectin are discussed.
T1 0-85 Sentence denotes Structure of the O-glycans in GlyCAM-1, an endothelial-derived ligand for L-selectin.
T2 86-245 Sentence denotes L-selectin, the leukocyte selectin, mediates the carbohydrate-dependent attachment of circulating leukocytes to endothelium, preceding emigration into tissues.
T3 246-337 Sentence denotes It functions in inflammatory leukocyte trafficking and in lymphocyte homing to lymph nodes.
T4 338-526 Sentence denotes From previous work, the binding of L-selectin to endothelial-associated glycoprotein ligands, GlyCAM-1 and CD34, requires oligosaccharide sialylation, sulfation, and probably fucosylation.
T5 527-692 Sentence denotes We have recently identified a major capping group in GlyCAM-1 as 6' sulfated sialyl Lewis x, a novel structure which potentially satisfies all of these requirements.
T6 693-924 Sentence denotes In the present study, we define the complete structure of beta-eliminated chains of GlyCAM-1 using metabolic radiolabeling, plant lectin binding, and glycosidase digestions in conjunction with high pH anion-exchange chromatography.
T7 925-1169 Sentence denotes The majority of the O-glycans in GlyCAM-1 contain the T-antigen, i.e. Gal beta 1-->3GalNAc, which is incorporated into the core-2 structure, i.e. Gal beta 1-->3[GlcNAc beta 1-->6]GalNAc or larger core structures with additional GlcNAc residues.
T8 1170-1368 Sentence denotes The structures of two O-glycans, based on core-2, were determined to be: [sequence: see text] The implications of these structures and more complex O-glycans for binding by L-selectin are discussed.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 325-336 http://purl.obolibrary.org/obo/MAT_0000197 denotes lymph nodes
T2 325-336 http://purl.obolibrary.org/obo/MAT_0000442 denotes lymph nodes
T3 325-330 http://purl.obolibrary.org/obo/MAT_0000055 denotes lymph

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 604-618 https://glytoucan.org/Structures/Glycans/G00054MO denotes sialyl Lewis x
T2 611-618 https://glytoucan.org/Structures/Glycans/G00051MO denotes Lewis x
T3 611-618 https://glytoucan.org/Structures/Glycans/G01187XC denotes Lewis x
T4 979-988 https://glytoucan.org/Structures/Glycans/G00031MO denotes T-antigen

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 604-618 http://www.glycoepitope.jp/epitopes/EP0012 denotes sialyl Lewis x
T2 611-618 http://www.glycoepitope.jp/epitopes/EP0011 denotes Lewis x
T3 979-988 http://www.glycoepitope.jp/epitopes/EP0020 denotes T-antigen

NGLY1-deficiency

Id Subject Object Predicate Lexical cue
PD-NGLY1-deficiency-B_T1 1086-1092 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T2 1153-1159 chem:24139 denotes GlcNAc

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 325-336 Body_part denotes lymph nodes http://purl.obolibrary.org/obo/MAT_0000197|http://purl.obolibrary.org/obo/MAT_0000442

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 611-618 Glycan denotes Lewis x https://api.glycosmos.org/wurcs2image/latest/png/binary/G00051MO

Glycosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 604-618 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sialyl Lewis x http://www.glycoepitope.jp/epitopes/EP0012
T2 979-988 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T-antigen http://www.glycoepitope.jp/epitopes/EP0020

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 102-111 Body_part denotes leukocyte http://purl.obolibrary.org/obo/CL_0000738
T2 184-194 Body_part denotes leukocytes http://purl.obolibrary.org/obo/CL_0000738
T3 198-209 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T4 275-284 Body_part denotes leukocyte http://purl.obolibrary.org/obo/CL_0000738
T5 304-314 Body_part denotes lymphocyte http://purl.obolibrary.org/obo/CL_0000542
T6 325-336 Body_part denotes lymph nodes http://purl.obolibrary.org/obo/UBERON_0000029

Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 102-111 Cell denotes leukocyte http://purl.obolibrary.org/obo/CL:0000738
T2 184-194 Cell denotes leukocytes http://purl.obolibrary.org/obo/CL:0000738
T3 275-284 Cell denotes leukocyte http://purl.obolibrary.org/obo/CL:0000738
T4 304-314 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542