PubMed:7530239
Annnotations
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 13-19 | gene:3383 | denotes | ICAM-1 |
| T1 | 41-62 | disease:C0023493 | denotes | human T-cell leukemia |
| T2 | 13-19 | gene:3383 | denotes | ICAM-1 |
| T3 | 131-152 | disease:C0023492 | denotes | adult-T-cell-leukemia |
| T4 | 13-19 | gene:3383 | denotes | ICAM-1 |
| T5 | 131-152 | disease:C0023493 | denotes | adult-T-cell-leukemia |
| T6 | 24-29 | gene:965 | denotes | LFA-3 |
| T7 | 41-62 | disease:C0023493 | denotes | human T-cell leukemia |
| T8 | 33-37 | gene:6900 | denotes | Tax1 |
| T9 | 41-62 | disease:C0023493 | denotes | human T-cell leukemia |
| T10 | 112-118 | gene:3383 | denotes | ICAM-1 |
| T11 | 41-62 | disease:C0023493 | denotes | human T-cell leukemia |
| T12 | 112-118 | gene:3383 | denotes | ICAM-1 |
| T13 | 131-152 | disease:C0023492 | denotes | adult-T-cell-leukemia |
| T14 | 112-118 | gene:3383 | denotes | ICAM-1 |
| T15 | 131-152 | disease:C0023493 | denotes | adult-T-cell-leukemia |
| T16 | 122-127 | gene:3683 | denotes | LFA-1 |
| T17 | 131-152 | disease:C0023492 | denotes | adult-T-cell-leukemia |
| T18 | 122-127 | gene:3683 | denotes | LFA-1 |
| T19 | 131-152 | disease:C0023493 | denotes | adult-T-cell-leukemia |
| T20 | 122-127 | gene:3689 | denotes | LFA-1 |
| T21 | 131-152 | disease:C0023492 | denotes | adult-T-cell-leukemia |
| T22 | 122-127 | gene:3689 | denotes | LFA-1 |
| T23 | 131-152 | disease:C0023493 | denotes | adult-T-cell-leukemia |
| R1 | T0 | T1 | associated_with | ICAM-1,human T-cell leukemia |
| R2 | T2 | T3 | associated_with | ICAM-1,adult-T-cell-leukemia |
| R3 | T4 | T5 | associated_with | ICAM-1,adult-T-cell-leukemia |
| R4 | T6 | T7 | associated_with | LFA-3,human T-cell leukemia |
| R5 | T8 | T9 | associated_with | Tax1,human T-cell leukemia |
| R6 | T10 | T11 | associated_with | ICAM-1,human T-cell leukemia |
| R7 | T12 | T13 | associated_with | ICAM-1,adult-T-cell-leukemia |
| R8 | T14 | T15 | associated_with | ICAM-1,adult-T-cell-leukemia |
| R9 | T16 | T17 | associated_with | LFA-1,adult-T-cell-leukemia |
| R10 | T18 | T19 | associated_with | LFA-1,adult-T-cell-leukemia |
| R11 | T20 | T21 | associated_with | LFA-1,adult-T-cell-leukemia |
| R12 | T22 | T23 | associated_with | LFA-1,adult-T-cell-leukemia |
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 13-19 | protein | denotes | ICAM-1 |
| T2 | 24-29 | protein | denotes | LFA-3 |
| T3 | 33-37 | protein | denotes | Tax1 |
| T4 | 112-118 | protein | denotes | ICAM-1 |
| T5 | 122-127 | protein | denotes | LFA-1 |
| T6 | 131-163 | cell_line | denotes | adult-T-cell-leukemia cell lines |
| T7 | 223-234 | protein | denotes | HTLV-I TaxI |
| T8 | 259-265 | protein | denotes | ICAM-I |
| T9 | 270-275 | protein | denotes | LFA-3 |
| T10 | 279-292 | cell_type | denotes | human T cells |
| T11 | 357-363 | protein | denotes | ICAM-I |
| T12 | 368-373 | protein | denotes | LFA-I |
| T13 | 377-399 | cell_line | denotes | ATL-derived cell lines |
| T14 | 414-418 | protein | denotes | TaxI |
| T15 | 424-448 | cell_line | denotes | human T-cell line Jurkat |
| T16 | 462-471 | DNA | denotes | TaxI gene |
| T17 | 482-506 | DNA | denotes | metallothionein promoter |
| T18 | 527-531 | RNA | denotes | mRNA |
| T19 | 558-564 | protein | denotes | ICAM-I |
| T20 | 582-587 | protein | denotes | LFA-3 |
| T21 | 591-595 | protein | denotes | TaxI |
| T22 | 702-717 | DNA | denotes | ICAM-I promoter |
| T23 | 721-725 | protein | denotes | TaxI |
| T24 | 768-790 | DNA | denotes | CAT reporter construct |
| T25 | 800-815 | DNA | denotes | ICAM-I promoter |
| T26 | 822-829 | DNA | denotes | plasmid |
| T27 | 841-845 | protein | denotes | TaxI |
| T28 | 883-889 | protein | denotes | ICAM-I |
| T29 | 893-898 | protein | denotes | LFA-I |
| T30 | 902-918 | cell_line | denotes | 4 ATL cell lines |
| T31 | 938-949 | RNA | denotes | ICAM-I mRNA |
| T32 | 967-971 | cell_line | denotes | MT-I |
| T33 | 1012-1024 | DNA | denotes | CAT reporter |
| T34 | 1034-1049 | DNA | denotes | ICAM-I promoter |
| T35 | 1066-1070 | cell_line | denotes | MT-I |
| T36 | 1103-1107 | cell_line | denotes | MT-I |
| T37 | 1131-1140 | protein | denotes | IFN-gamma |
| T38 | 1166-1172 | protein | denotes | ICAM-I |
| T39 | 1192-1214 | protein | denotes | transcriptional factor |
| T40 | 1246-1257 | DNA | denotes | ICAM-I gene |
| T41 | 1278-1282 | cell_line | denotes | MT-I |
| T42 | 1320-1334 | cell_line | denotes | ATL cell lines |
| T43 | 1336-1342 | cell_line | denotes | TL-OmI |
| T44 | 1344-1348 | cell_line | denotes | H582 |
| T45 | 1350-1356 | cell_line | denotes | HuT102 |
| T46 | 1384-1388 | RNA | denotes | mRNA |
| T47 | 1397-1413 | protein | denotes | LFA-I beta chain |
| T48 | 1415-1419 | protein | denotes | CD18 |
| T49 | 1422-1426 | cell_line | denotes | H582 |
| T50 | 1431-1437 | cell_line | denotes | HuT102 |
| T51 | 1465-1495 | RNA | denotes | LFA-I alpha chain (CDIIa) mRNA |
| T52 | 1534-1551 | DNA | denotes | CAT reporter gene |
| T53 | 1561-1574 | DNA | denotes | CD18 promoter |
| T54 | 1635-1657 | protein | denotes | transcriptional factor |
| T55 | 1675-1679 | protein | denotes | CD18 |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 7530239-0#13#19#gene3383 | 13-19 | gene3383 | denotes | ICAM-1 |
| 7530239-0#33#37#gene6900 | 33-37 | gene6900 | denotes | Tax1 |
| 7530239-0#112#118#gene3383 | 112-118 | gene3383 | denotes | ICAM-1 |
| 7530239-0#41#62#diseaseC0023493 | 41-62 | diseaseC0023493 | denotes | human T-cell leukemia |
| 13#19#gene338341#62#diseaseC0023493 | 7530239-0#13#19#gene3383 | 7530239-0#41#62#diseaseC0023493 | associated_with | ICAM-1,human T-cell leukemia |
| 33#37#gene690041#62#diseaseC0023493 | 7530239-0#33#37#gene6900 | 7530239-0#41#62#diseaseC0023493 | associated_with | Tax1,human T-cell leukemia |
| 112#118#gene338341#62#diseaseC0023493 | 7530239-0#112#118#gene3383 | 7530239-0#41#62#diseaseC0023493 | associated_with | ICAM-1,human T-cell leukemia |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 13-19 | NP | denotes | ICAM-1 |
| C2 | 24-29 | NP | denotes | LFA-3 |
| C3 | 33-75 | NP | denotes | Tax1 of human T-cell leukemia virus type 1 |
| C5 | 112-118 | NP | denotes | ICAM-1 |
| C6 | 122-127 | NP | denotes | LFA-1 |
| C7 | 131-163 | NP | denotes | adult-T-cell-leukemia cell lines |
| C4 | 80-163 | NP | denotes | mechanism of down-regulation of ICAM-1 or LFA-1 in adult-T-cell-leukemia cell lines |
| C8 | 223-234 | NP | denotes | HTLV-I TaxI |
| C9 | 259-265 | NP | denotes | ICAM-I |
| C10 | 270-275 | NP | denotes | LFA-3 |
| C11 | 279-292 | NP | denotes | human T cells |
| C12 | 357-363 | NP | denotes | ICAM-I |
| C13 | 368-373 | NP | denotes | LFA-I |
| C14 | 377-399 | NP | denotes | ATL-derived cell lines |
| C16 | 414-418 | NP | denotes | TaxI |
| C17 | 422-448 | NP | denotes | a human T-cell line Jurkat |
| C15 | 401-448 | NP | denotes | Induction of TaxI in a human T-cell line Jurkat |
| C18 | 458-471 | NP | denotes | the TaxI gene |
| C19 | 558-564 | NP | denotes | ICAM-I |
| C20 | 582-587 | NP | denotes | LFA-3 |
| C21 | 591-605 | NP | denotes | TaxI induction |
| C22 | 721-725 | NP | denotes | TaxI |
| C24 | 796-815 | NP | denotes | the ICAM-I promoter |
| C23 | 766-815 | NP | denotes | a CAT reporter construct with the ICAM-I promoter |
| C25 | 841-845 | NP | denotes | TaxI |
| C27 | 883-889 | NP | denotes | ICAM-I |
| C28 | 893-898 | NP | denotes | LFA-I |
| C26 | 847-918 | NP | denotes | The mechanism of down-regulation of ICAM-I or LFA-I in 4 ATL cell lines |
| C29 | 967-971 | NP | denotes | MT-I |
| C31 | 1030-1049 | NP | denotes | the ICAM-I promoter |
| C30 | 1008-1049 | NP | denotes | The CAT reporter with the ICAM-I promoter |
| C32 | 1066-1070 | NP | denotes | MT-I |
| C33 | 1103-1107 | NP | denotes | MT-I |
| C34 | 1166-1172 | NP | denotes | ICAM-I |
| C35 | 1246-1257 | NP | denotes | ICAM-I gene |
| C36 | 1278-1282 | NP | denotes | MT-I |
| C37 | 1308-1357 | NP | denotes | Three other ATL cell lines (TL-OmI, H582, HuT102) |
| C38 | 1591-1604 | NP | denotes | the 3 of them |
| R1 | C5 | C1 | coref-ident | ICAM-1,ICAM-1 |
| R2 | C8 | C3 | coref-ident | HTLV-I TaxI,Tax1 of human T-cell leukemia virus type 1 |
| R3 | C9 | C5 | coref-ident | ICAM-I,ICAM-1 |
| R4 | C10 | C2 | coref-ident | LFA-3,LFA-3 |
| R5 | C12 | C9 | coref-ident | ICAM-I,ICAM-I |
| R6 | C13 | C6 | coref-ident | LFA-I,LFA-1 |
| R7 | C14 | C7 | coref-ident | ATL-derived cell lines,adult-T-cell-leukemia cell lines |
| R8 | C17 | C11 | coref-ident | a human T-cell line Jurkat,human T cells |
| R9 | C18 | C16 | coref-ident | the TaxI gene,TaxI |
| R10 | C19 | C12 | coref-ident | ICAM-I,ICAM-I |
| R11 | C20 | C10 | coref-ident | LFA-3,LFA-3 |
| R12 | C21 | C15 | coref-ident | TaxI induction,Induction of TaxI in a human T-cell line Jurkat |
| R13 | C22 | C16 | coref-ident | TaxI,TaxI |
| R14 | C25 | C22 | coref-ident | TaxI,TaxI |
| R15 | C27 | C19 | coref-ident | ICAM-I,ICAM-I |
| R16 | C28 | C13 | coref-ident | LFA-I,LFA-I |
| R17 | C26 | C4 | coref-ident | The mechanism of down-regulation of ICAM-I or LFA-I in 4 ATL cell lines,mechanism of down-regulation of ICAM-1 or LFA-1 in adult-T-cell-leukemia cell lines |
| R18 | C31 | C24 | coref-ident | the ICAM-I promoter,the ICAM-I promoter |
| R19 | C30 | C23 | coref-ident | The CAT reporter with the ICAM-I promoter,a CAT reporter construct with the ICAM-I promoter |
| R20 | C32 | C29 | coref-ident | MT-I,MT-I |
| R21 | C33 | C32 | coref-ident | MT-I,MT-I |
| R22 | C34 | C27 | coref-ident | ICAM-I,ICAM-I |
| R23 | C35 | C34 | coref-ident | ICAM-I gene,ICAM-I |
| R24 | C36 | C33 | coref-ident | MT-I,MT-I |
| R25 | C38 | C37 | coref-ident | the 3 of them,"Three other ATL cell lines (TL-OmI, H582, HuT102)" |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-164 | Sentence | denotes | Induction of ICAM-1 and LFA-3 by Tax1 of human T-cell leukemia virus type 1 and mechanism of down-regulation of ICAM-1 or LFA-1 in adult-T-cell-leukemia cell lines. |
| S2 | 165-400 | Sentence | denotes | The present study was undertaken to determine the role of HTLV-I TaxI in the up-regulation of ICAM-I and LFA-3 in human T cells transformed with HTLV-I and the mechanism of down-regulation of ICAM-I and LFA-I in ATL-derived cell lines. |
| S3 | 401-565 | Sentence | denotes | Induction of TaxI in a human T-cell line Jurkat carrying the TaxI gene under the metallothionein promoter led to increases in mRNA and surface expression of ICAM-I. |
| S4 | 566-678 | Sentence | denotes | The response of LFA-3 to TaxI induction was, on the other hand, relatively slow and weak, and might be indirect. |
| S5 | 679-846 | Sentence | denotes | Transactivation of the ICAM-I promoter by TaxI was further shown by co-transfection of a CAT reporter construct with the ICAM-I promoter and a plasmid expressing TaxI. |
| S6 | 847-937 | Sentence | denotes | The mechanism of down-regulation of ICAM-I or LFA-I in 4 ATL cell lines was next examined. |
| S7 | 938-1007 | Sentence | denotes | ICAM-I mRNA was quite low in MT-I, but no genomic changes were found. |
| S8 | 1008-1071 | Sentence | denotes | The CAT reporter with the ICAM-I promoter was inactive in MT-I. |
| S9 | 1072-1173 | Sentence | denotes | Finally, combined treatment of MT-I with 5-azacytidine and IFN-gamma induced re-expression of ICAM-I. |
| S10 | 1174-1307 | Sentence | denotes | Collectively, (a) transcriptional factor(s) necessary for expression of ICAM-I gene may be repressed in MT-I through DNA methylation. |
| S11 | 1308-1421 | Sentence | denotes | Three other ATL cell lines (TL-OmI, H582, HuT102) were found to have little mRNA for the LFA-I beta chain (CD18). |
| S12 | 1422-1496 | Sentence | denotes | H582 and HuT102 were also negative for the LFA-I alpha chain (CDIIa) mRNA. |
| S13 | 1497-1691 | Sentence | denotes | No genomic changes were found, and a CAT reporter gene with the CD18 promoter was inactive in the 3 of them, again suggesting lack of (a) transcriptional factor(s) necessary for CD18 expression. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 13-19 | protein_molecule | denotes | ICAM-1 |
| T2 | 24-29 | protein_molecule | denotes | LFA-3 |
| T3 | 33-37 | protein_molecule | denotes | Tax1 |
| T4 | 47-75 | virus | denotes | T-cell leukemia virus type 1 |
| T5 | 112-118 | protein_molecule | denotes | ICAM-1 |
| T6 | 122-127 | protein_molecule | denotes | LFA-1 |
| T7 | 131-163 | cell_line | denotes | adult-T-cell-leukemia cell lines |
| T8 | 223-234 | protein_molecule | denotes | HTLV-I TaxI |
| T9 | 259-265 | protein_molecule | denotes | ICAM-I |
| T10 | 270-275 | protein_molecule | denotes | LFA-3 |
| T11 | 279-292 | cell_type | denotes | human T cells |
| T12 | 310-316 | virus | denotes | HTLV-I |
| T13 | 357-363 | protein_molecule | denotes | ICAM-I |
| T14 | 368-373 | protein_molecule | denotes | LFA-I |
| T15 | 377-399 | cell_line | denotes | ATL-derived cell lines |
| T16 | 414-418 | protein_molecule | denotes | TaxI |
| T17 | 424-448 | cell_line | denotes | human T-cell line Jurkat |
| T18 | 462-466 | protein_molecule | denotes | TaxI |
| T19 | 482-506 | DNA_domain_or_region | denotes | metallothionein promoter |
| T20 | 527-531 | RNA_family_or_group | denotes | mRNA |
| T21 | 558-564 | protein_molecule | denotes | ICAM-I |
| T22 | 582-587 | protein_molecule | denotes | LFA-3 |
| T23 | 591-595 | protein_molecule | denotes | TaxI |
| T24 | 702-708 | protein_molecule | denotes | ICAM-I |
| T25 | 721-725 | protein_molecule | denotes | TaxI |
| T26 | 768-790 | DNA_domain_or_region | denotes | CAT reporter construct |
| T27 | 800-806 | protein_molecule | denotes | ICAM-I |
| T28 | 822-829 | DNA_molecule | denotes | plasmid |
| T29 | 841-845 | protein_molecule | denotes | TaxI |
| T30 | 883-889 | protein_molecule | denotes | ICAM-I |
| T31 | 893-898 | protein_molecule | denotes | LFA-I |
| T32 | 902-918 | cell_line | denotes | 4 ATL cell lines |
| T33 | 938-944 | protein_molecule | denotes | ICAM-I |
| T34 | 967-971 | cell_line | denotes | MT-I |
| T35 | 1012-1024 | DNA_molecule | denotes | CAT reporter |
| T36 | 1034-1040 | protein_molecule | denotes | ICAM-I |
| T37 | 1066-1070 | cell_line | denotes | MT-I |
| T38 | 1103-1107 | cell_line | denotes | MT-I |
| T39 | 1113-1126 | other_organic_compound | denotes | 5-azacytidine |
| T40 | 1131-1140 | protein_molecule | denotes | IFN-gamma |
| T41 | 1166-1172 | protein_molecule | denotes | ICAM-I |
| T42 | 1192-1214 | protein_family_or_group | denotes | transcriptional factor |
| T43 | 1246-1252 | protein_molecule | denotes | ICAM-I |
| T44 | 1278-1282 | cell_line | denotes | MT-I |
| T45 | 1291-1306 | other_name | denotes | DNA methylation |
| T46 | 1320-1334 | cell_line | denotes | ATL cell lines |
| T47 | 1336-1342 | cell_line | denotes | TL-OmI |
| T48 | 1344-1348 | cell_line | denotes | H582 |
| T49 | 1350-1356 | cell_line | denotes | HuT102 |
| T50 | 1384-1388 | RNA_family_or_group | denotes | mRNA |
| T51 | 1397-1413 | protein_subunit | denotes | LFA-I beta chain |
| T52 | 1415-1419 | protein_subunit | denotes | CD18 |
| T53 | 1422-1426 | cell_line | denotes | H582 |
| T54 | 1431-1437 | cell_line | denotes | HuT102 |
| T55 | 1465-1470 | protein_molecule | denotes | LFA-I |
| T56 | 1534-1551 | DNA_domain_or_region | denotes | CAT reporter gene |
| T57 | 1561-1574 | DNA_domain_or_region | denotes | CD18 promoter |
| T58 | 1635-1657 | protein_family_or_group | denotes | transcriptional factor |
| T59 | 1675-1679 | protein_molecule | denotes | CD18 |