> top > docs > PubMed:7526398 > annotations

PubMed:7526398 JSONTXT

Annnotations TAB JSON ListView MergeView

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 65-75 protein denotes NF-kappa B
T2 146-156 protein denotes NF-kappa B
T3 250-259 protein denotes cytokines
T4 261-288 protein denotes tumor necrosis factor alpha
T5 537-547 protein denotes NF-kappa B
T6 651-661 protein denotes NF-kappa B
T7 692-710 cell_line denotes human T-cell lines
T8 712-720 cell_line denotes Wurzburg
T9 729-735 cell_line denotes Jurkat
T10 746-773 protein denotes tumor necrosis factor alpha
T11 1105-1115 protein denotes NF-kappa B
T12 1130-1142 cell_line denotes Jurkat cells
T13 1177-1187 protein denotes NF-kappa B
T14 1340-1350 protein denotes NF-kappa B
T15 1489-1497 protein denotes cytokine
T16 1523-1533 protein denotes NF-kappa B
T17 1689-1699 protein denotes NF-kappa B
T18 1789-1799 protein denotes NF-kappa B

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 61-103 NP denotes the NF-kappa B signal transduction pathway
C2 189-235 NP denotes a parallel series of stimuli-specific pathways
C3 244-249 NP denotes which
C4 250-388 NP denotes cytokines (tumor necrosis factor alpha), oxidants (hydrogen peroxide and mitomycin C), and phorbol ester (phorbol 12-myristate 13-acetate)
C5 422-444 NP denotes These initial pathways
C6 458-474 NP denotes a common pathway
C7 483-488 NP denotes which
C8 489-518 NP denotes all of the stimulating agents
C9 537-558 NP denotes NF-kappa B activation
C10 575-604 NP denotes the stimuli-specific pathways
C11 651-672 NP denotes NF-kappa B activation
C12 688-710 NP denotes two human T-cell lines
C13 831-841 NP denotes both lines
C14 854-872 NP denotes the common pathway
C15 1022-1041 NP denotes this common pathway
C16 1105-1126 NP denotes NF-kappa B activation
C17 1130-1142 NP denotes Jurkat cells
C18 1147-1152 NP denotes which
C19 1177-1187 NP denotes NF-kappa B
C20 1225-1243 NP denotes the common pathway
C21 1340-1361 NP denotes NF-kappa B activation
C22 1365-1376 NP denotes all stimuli
C23 1387-1402 NP denotes both cell lines
C24 1523-1533 NP denotes NF-kappa B
C25 1689-1710 NP denotes NF-kappa B activation
C26 1785-1827 NP denotes the NF-kappa B signal transduction pathway
R1 C3 C2 coref-relat which,a parallel series of stimuli-specific pathways
R2 C5 C2 coref-ident These initial pathways,a parallel series of stimuli-specific pathways
R3 C7 C6 coref-relat which,a common pathway
R4 C8 C4 coref-ident all of the stimulating agents,"cytokines (tumor necrosis factor alpha), oxidants (hydrogen peroxide and mitomycin C), and phorbol ester (phorbol 12-myristate 13-acetate)"
R5 C10 C5 coref-ident the stimuli-specific pathways,These initial pathways
R6 C11 C9 coref-ident NF-kappa B activation,NF-kappa B activation
R7 C13 C12 coref-ident both lines,two human T-cell lines
R8 C14 C6 coref-ident the common pathway,a common pathway
R9 C15 C14 coref-ident this common pathway,the common pathway
R10 C16 C11 coref-ident NF-kappa B activation,NF-kappa B activation
R11 C17 C12 coref-ident Jurkat cells,two human T-cell lines
R12 C18 C17 coref-relat which,Jurkat cells
R13 C20 C15 coref-ident the common pathway,this common pathway
R14 C21 C16 coref-ident NF-kappa B activation,NF-kappa B activation
R15 C22 C8 coref-ident all stimuli,all of the stimulating agents
R16 C23 C13 coref-ident both cell lines,both lines
R17 C24 C19 coref-ident NF-kappa B,NF-kappa B
R18 C25 C21 coref-ident NF-kappa B activation,NF-kappa B activation
R19 C26 C1 coref-ident the NF-kappa B signal transduction pathway,the NF-kappa B signal transduction pathway

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-104 Sentence denotes Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.
S2 105-421 Sentence denotes Studies presented here show that overall NF-kappa B signal transduction begins with a parallel series of stimuli-specific pathways through which cytokines (tumor necrosis factor alpha), oxidants (hydrogen peroxide and mitomycin C), and phorbol ester (phorbol 12-myristate 13-acetate) individually initiate signaling.
S3 422-559 Sentence denotes These initial pathways culminate in a common pathway through which all of the stimulating agents ultimately signal NF-kappa B activation.
S4 560-842 Sentence denotes We distinguish the stimuli-specific pathways by showing that the oxidative stimuli trigger NF-kappa B activation in only one of two human T-cell lines (Wurzburg but not Jurkat), whereas tumor necrosis factor alpha and phorbol 12-myristate 13-acetate readily stimulate in both lines.
S5 843-975 Sentence denotes We propose the common pathway as the simplest way of accounting for the common requirements and properties of the signaling pathway.
S6 976-1403 Sentence denotes We include a redox-regulatory mechanism(s) in this common pathway to account for the previously demonstrated redox regulation of NF-kappa B activation in Jurkat cells (in which oxidants don't activate NF-kappa B); we put tyrosine phosphorylation in the common pathway by showing that kinase activity (inhibitable by herbimycin A and tyrphostin 47) is required for NF-kappa B activation by all stimuli tested in both cell lines.
S7 1404-1828 Sentence denotes Since internal sites of oxidant production have been shown to play a key role in the cytokine-stimulated activation of NF-kappa B, and since tyrosine kinase and phosphatase activities are known to be altered by oxidants, these findings suggest that intracellular redox status controls NF-kappa B activation by regulating tyrosine phosphorylation event(s) within the common step of the NF-kappa B signal transduction pathway.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 65-75 protein_molecule denotes NF-kappa B
T2 146-156 protein_molecule denotes NF-kappa B
T3 210-235 other_name denotes stimuli-specific pathways
T4 250-259 protein_family_or_group denotes cytokines
T5 261-288 protein_molecule denotes tumor necrosis factor alpha
T6 291-299 other_name denotes oxidants
T7 301-318 other_organic_compound denotes hydrogen peroxide
T8 323-334 other_organic_compound denotes mitomycin C
T9 341-354 other_organic_compound denotes phorbol ester
T10 356-387 other_organic_compound denotes phorbol 12-myristate 13-acetate
T11 537-547 protein_molecule denotes NF-kappa B
T12 651-661 protein_molecule denotes NF-kappa B
T13 692-710 cell_line denotes human T-cell lines
T14 712-720 cell_line denotes Wurzburg
T15 729-735 cell_line denotes Jurkat
T16 746-773 protein_molecule denotes tumor necrosis factor alpha
T17 778-809 other_organic_compound denotes phorbol 12-myristate 13-acetate
T18 989-1015 other_name denotes redox-regulatory mechanism
T19 1085-1101 other_name denotes redox regulation
T20 1105-1115 protein_molecule denotes NF-kappa B
T21 1130-1142 cell_line denotes Jurkat cells
T22 1177-1187 protein_molecule denotes NF-kappa B
T23 1197-1205 amino_acid_monomer denotes tyrosine
T24 1260-1275 other_name denotes kinase activity
T25 1292-1304 other_organic_compound denotes herbimycin A
T26 1309-1322 other_organic_compound denotes tyrphostin 47
T27 1340-1350 protein_molecule denotes NF-kappa B
T28 1489-1497 protein_family_or_group denotes cytokine
T29 1523-1533 protein_molecule denotes NF-kappa B
T30 1545-1553 amino_acid_monomer denotes tyrosine
T31 1653-1679 other_name denotes intracellular redox status
T32 1689-1699 protein_molecule denotes NF-kappa B
T33 1725-1733 amino_acid_monomer denotes tyrosine
T34 1789-1799 protein_molecule denotes NF-kappa B