PubMed:7525701 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	14-18	protein	denotes	CD40
T2	22-29	cell_type	denotes	B cells
T3	48-70	protein	denotes	nuclear factor-kappa B
T4	76-115	protein	denotes	B cell-associated surface molecule CD40
T5	170-174	protein	denotes	CD40
T6	178-185	cell_type	denotes	B cells
T7	223-227	protein	denotes	IL-6
T8	265-274	protein	denotes	cytokines
T9	441-445	protein	denotes	CD40
T10	523-550	protein	denotes	nuclear factor (NF)-kappa B
T11	555-592	protein	denotes	NF-kappa B-like transcription factors
T12	627-631	protein	denotes	CD40
T13	643-666	cell_type	denotes	human tonsillar B cells
T14	674-686	cell_line	denotes	B cell lines
T15	845-848	protein	denotes	p50
T16	850-853	protein	denotes	p65
T17	855-859	protein	denotes	RelA
T18	862-867	protein	denotes	c-Rel
T19	971-975	protein	denotes	CD40
T20	985-995	protein	denotes	NF-kappa B
T21	1046-1056	protein	denotes	NF-kappa B
T22	1092-1096	protein	denotes	CD40
T23	1128-1132	protein	denotes	CD40
T24	1173-1196	DNA	denotes	B cell-associated genes
T25	1202-1228	DNA	denotes	NF-kappa B consensus sites

Id	Subject	Object	Predicate	Lexical cue
C1	14-18	NP	denotes	CD40
C2	22-29	NP	denotes	B cells
C3	48-70	NP	denotes	nuclear factor-kappa B
C4	170-174	NP	denotes	CD40
C5	178-185	NP	denotes	B cells
C6	441-459	NP	denotes	CD40 cross-linking
C7	523-550	NP	denotes	nuclear factor (NF)-kappa B
C8	627-631	NP	denotes	CD40
C9	674-686	NP	denotes	B cell lines
C10	957-975	NP	denotes	cross-linking CD40
R1	C4	C1	coref-ident	CD40,CD40
R2	C5	C2	coref-ident	B cells,B cells
R3	C7	C3	coref-ident	nuclear factor (NF)-kappa B,nuclear factor-kappa B
R4	C8	C4	coref-ident	CD40,CD40
R5	C9	C5	coref-ident	B cell lines,B cells
R6	C10	C6	coref-ident	cross-linking CD40,CD40 cross-linking

Id	Subject	Object	Predicate	Lexical cue
S1	0-71	Sentence	denotes	Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B.
S2	72-155	Sentence	denotes	The B cell-associated surface molecule CD40 functions to regulate B cell responses.
S3	156-300	Sentence	denotes	Cross-linking CD40 on B cells can lead to homotypic cell adhesion, IL-6 production, and, in combination with cytokines, to Ig isotype switching.
S4	301-381	Sentence	denotes	Tyrosine kinase activity is increased shortly after engagement of this receptor.
S5	382-487	Sentence	denotes	Little is known about how the very early events induced by CD40 cross-linking link to cellular responses.
S6	488-687	Sentence	denotes	In this study, we demonstrate that nuclear factor (NF)-kappa B and NF-kappa B-like transcription factors are activated after cross-linking CD40 on resting human tonsillar B cells and on B cell lines.
S7	688-772	Sentence	denotes	The activation is rapid and is mediated through a tyrosine kinase-dependent pathway.
S8	773-902	Sentence	denotes	The complexes detected in electrophoretic mobility shift assays contain p50, p65 (RelA), c-Rel, and most likely other components.
S9	903-1022	Sentence	denotes	By using transient transfection assays, we found that cross-linking CD40 supports NF-kappa B-dependent gene expression.
S10	1023-1229	Sentence	denotes	Our results define the NF-kappa B system as an intermediate event in CD40 signaling and suggest that the CD40 pathway can influence the expression of B cell-associated genes with NF-kappa B consensus sites.

Id	Subject	Object	Predicate	Lexical cue
T1	14-18	protein_molecule	denotes	CD40
T2	22-29	cell_type	denotes	B cells
T3	48-70	protein_molecule	denotes	nuclear factor-kappa B
T4	76-110	protein_molecule	denotes	B cell-associated surface molecule
T5	111-115	protein_molecule	denotes	CD40
T6	170-174	protein_molecule	denotes	CD40
T7	178-185	cell_type	denotes	B cells
T8	223-227	protein_molecule	denotes	IL-6
T9	265-274	protein_family_or_group	denotes	cytokines
T10	279-299	other_name	denotes	Ig isotype switching
T11	301-309	amino_acid_monomer	denotes	Tyrosine
T12	441-445	protein_molecule	denotes	CD40
T13	523-550	protein_family_or_group	denotes	nuclear factor (NF)-kappa B
T14	555-570	protein_family_or_group	denotes	NF-kappa B-like
T15	571-592	protein_family_or_group	denotes	transcription factors
T16	627-631	protein_molecule	denotes	CD40
T17	643-658	cell_type	denotes	human tonsillar
T18	659-666	cell_type	denotes	B cells
T19	674-686	cell_line	denotes	B cell lines
T20	738-771	other_name	denotes	tyrosine kinase-dependent pathway
T21	799-836	other_name	denotes	electrophoretic mobility shift assays
T22	845-848	protein_subunit	denotes	p50
T23	850-853	protein_subunit	denotes	p65
T24	855-859	protein_molecule	denotes	RelA
T25	862-867	protein_subunit	denotes	c-Rel
T26	912-941	other_name	denotes	transient transfection assays
T27	971-975	protein_molecule	denotes	CD40
T28	985-995	protein_molecule	denotes	NF-kappa B
T29	1046-1056	protein_molecule	denotes	NF-kappa B
T30	1092-1096	protein_molecule	denotes	CD40
T31	1128-1132	protein_molecule	denotes	CD40
T32	1173-1196	DNA_family_or_group	denotes	B cell-associated genes
T33	1202-1212	protein_molecule	denotes	NF-kappa B