PubMed:7523507 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	97-131	protein	denotes	phosphotyrosine-containing protein
T2	137-157	DNA	denotes	proto-oncogene c-fos
T3	164-184	DNA	denotes	immediate-early gene
T4	431-453	DNA	denotes	serum response element
T5	455-458	DNA	denotes	SRE
T6	467-490	DNA	denotes	c-fos regulatory region
T7	545-559	protein	denotes	growth factors
T8	652-667	protein	denotes	protein complex
T9	669-675	protein	denotes	Band A
T10	686-693	DNA	denotes	SRE DNA
T11	739-750	cell_line	denotes	human PBL-T
T12	789-795	protein	denotes	Band A
T13	809-830	protein	denotes	serum response factor
T14	916-929	cell_line	denotes	resting PBL-T
T15	967-973	protein	denotes	Band A
T16	981-990	DNA	denotes	SRE motif
T17	1073-1079	protein	denotes	Band A

Id	Subject	Object	Predicate	Lexical cue
C1	21-53	NP	denotes	the c-fos serum response element
C2	95-131	NP	denotes	a phosphotyrosine-containing protein
C3	133-157	NP	denotes	The proto-oncogene c-fos
C4	190-212	NP	denotes	one of the first genes
C5	427-490	NP	denotes	The serum response element (SRE) in the c-fos regulatory region
C6	639-676	NP	denotes	an inducible protein complex (Band A)
C7	789-795	NP	denotes	Band A
C9	858-867	NP	denotes	A protein
C10	868-872	NP	denotes	that
C8	858-912	NP	denotes	A protein that is phosphorylated on a tyrosine residue
C11	967-973	NP	denotes	Band A
C12	1023-1035	NP	denotes	this protein
C13	1073-1079	NP	denotes	Band A
R1	C4	C3	coref-ident	one of the first genes,The proto-oncogene c-fos
R2	C5	C1	coref-ident	The serum response element (SRE) in the c-fos regulatory region,the c-fos serum response element
R3	C7	C6	coref-ident	Band A,an inducible protein complex (Band A)
R4	C10	C9	coref-relat	that,A protein
R5	C8	C2	coref-ident	A protein that is phosphorylated on a tyrosine residue,a phosphotyrosine-containing protein
R6	C11	C7	coref-ident	Band A,Band A
R7	C12	C9	coref-ident	this protein,A protein
R8	C13	C11	coref-ident	Band A,Band A

Id	Subject	Object	Predicate	Lexical cue
S1	0-132	Sentence	denotes	Inducible binding to the c-fos serum response element during T cell activation is regulated by a phosphotyrosine-containing protein.
S2	133-283	Sentence	denotes	The proto-oncogene c-fos is an immediate-early gene, and one of the first genes transcribed after stimulation of most cells with a variety of ligands.
S3	284-426	Sentence	denotes	Fos expression may be a pivotal event in converting ligand-receptor interactions at the membrane into functional modulation of cell phenotype.
S4	427-625	Sentence	denotes	The serum response element (SRE) in the c-fos regulatory region participates in induction of transcription by various growth factors and by phorbol esters and subsequent squelching of transcription.
S5	626-788	Sentence	denotes	We show that an inducible protein complex (Band A) binds to SRE DNA within 10 min after mitogenic stimulation of human PBL-T, and becomes nondetectable by 60 min.
S6	789-857	Sentence	denotes	Band A contains the serum response factor plus additional factor(s).
S7	858-991	Sentence	denotes	A protein that is phosphorylated on a tyrosine residue in resting PBL-T suppresses binding of a component of Band A to the SRE motif.
S8	992-1134	Sentence	denotes	Upon stimulation of the cells, this protein no longer prevents binding of DNA by Band A, and suppression of binding is restored within 30 min.
S9	1135-1227	Sentence	denotes	The phosphorylated tyrosine residue itself is important for the protein-protein interaction.

Id	Subject	Object	Predicate	Lexical cue
T1	61-78	other_name	denotes	T cell activation
T2	97-131	protein_family_or_group	denotes	phosphotyrosine-containing protein
T3	137-157	DNA_domain_or_region	denotes	proto-oncogene c-fos
T4	164-184	DNA_family_or_group	denotes	immediate-early gene
T5	336-364	other_name	denotes	ligand-receptor interactions
T6	372-380	cell_component	denotes	membrane
T7	411-425	other_name	denotes	cell phenotype
T8	431-453	DNA_domain_or_region	denotes	serum response element
T9	455-458	DNA_domain_or_region	denotes	SRE
T10	467-490	DNA_domain_or_region	denotes	c-fos regulatory region
T11	545-559	protein_family_or_group	denotes	growth factors
T12	567-581	other_organic_compound	denotes	phorbol esters
T13	652-667	protein_complex	denotes	protein complex
T14	669-675	protein_molecule	denotes	Band A
T15	686-689	DNA_domain_or_region	denotes	SRE
T16	714-735	other_name	denotes	mitogenic stimulation
T17	739-750	cell_line	denotes	human PBL-T
T18	789-795	protein_molecule	denotes	Band A
T19	809-830	protein_family_or_group	denotes	serum response factor
T20	896-912	amino_acid_monomer	denotes	tyrosine residue
T21	916-929	cell_line	denotes	resting PBL-T
T22	967-973	protein_molecule	denotes	Band A
T23	981-984	DNA_domain_or_region	denotes	SRE
T24	1073-1079	protein_molecule	denotes	Band A
T25	1139-1170	amino_acid_monomer	denotes	phosphorylated tyrosine residue
T26	1199-1226	other_name	denotes	protein-protein interaction