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PubMed:7520914 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-126 Sentence denotes CD14-mediated translocation of nuclear factor-kappa B induced by lipopolysaccharide does not require tyrosine kinase activity.
T2 127-374 Sentence denotes During the course of serious bacterial infections, lipopolysaccharide (LPS) is believed to interact with macrophage receptors, resulting in the generation of inflammatory mediators and systemic symptoms including hemodynamic instability and shock.
T3 375-467 Sentence denotes CD14, a glycosylphosphatidylinositol-linked antigen, functions as an LPS signaling receptor.
T4 468-602 Sentence denotes A critical issue concerns the mechanism by which CD14, which has no transmembrane domain, transduces its signal following LPS binding.
T5 603-798 Sentence denotes Recently, investigators have hypothesized that CD14-mediated signaling is effected through a receptor-associated tyrosine kinase (TK), suggesting a multicomponent receptor model of LPS signaling.
T6 799-950 Sentence denotes Wild-type Chinese hamster ovary (CHO)-K1 cells can be activated by endotoxin to release arachidonate following transfection with human CD14 (CHO/CD14).
T7 951-1052 Sentence denotes Nuclear translocation of cytosolic NF-kappa B is correlated with a number of LPS-inducible responses.
T8 1053-1210 Sentence denotes We sought to determine if this pathway were present in CHO/CD14 cells and to elucidate the relationship of NF-kappa B activation to the CD14 receptor system.
T9 1211-1350 Sentence denotes LPS-stimulated translocation of NF-kappa B in CHO/CD14 cells resembled the same response in the murine macrophage-like cell line RAW 264.7.
T10 1351-1624 Sentence denotes Protein synthesis inhibitors and corticosteroids, which suppress arachidonate release and the synthesis of proinflammatory cytokines, had no effect on translocation of NF-kappa B in CHO/CD14 or RAW 264.7 cells, demonstrating that NF-kappa B translocation is an early event.
T11 1625-1824 Sentence denotes Although TK activity was consistently observed by immunoblotting extracts from activated RAW 264.7 cells, LPS-induced phosphotyrosine residues were not observed from similarly treated CHO/CD14 cells.
T12 1825-2044 Sentence denotes Furthermore, the TK inhibitors herbimycin A and genistein failed to inhibit translocation of NF-kappa B in CHO/CD14 or RAW 264.7 cells, although both of these agents inhibited LPS-induced TK activity in RAW 264.7 cells.
T13 2045-2166 Sentence denotes These results imply that TK activity is not obligatory for CD14-mediated signal transduction to occur in response to LPS.
T1 0-126 Sentence denotes CD14-mediated translocation of nuclear factor-kappa B induced by lipopolysaccharide does not require tyrosine kinase activity.
T2 127-374 Sentence denotes During the course of serious bacterial infections, lipopolysaccharide (LPS) is believed to interact with macrophage receptors, resulting in the generation of inflammatory mediators and systemic symptoms including hemodynamic instability and shock.
T3 375-467 Sentence denotes CD14, a glycosylphosphatidylinositol-linked antigen, functions as an LPS signaling receptor.
T4 468-602 Sentence denotes A critical issue concerns the mechanism by which CD14, which has no transmembrane domain, transduces its signal following LPS binding.
T5 603-798 Sentence denotes Recently, investigators have hypothesized that CD14-mediated signaling is effected through a receptor-associated tyrosine kinase (TK), suggesting a multicomponent receptor model of LPS signaling.
T6 799-950 Sentence denotes Wild-type Chinese hamster ovary (CHO)-K1 cells can be activated by endotoxin to release arachidonate following transfection with human CD14 (CHO/CD14).
T7 951-1052 Sentence denotes Nuclear translocation of cytosolic NF-kappa B is correlated with a number of LPS-inducible responses.
T8 1053-1210 Sentence denotes We sought to determine if this pathway were present in CHO/CD14 cells and to elucidate the relationship of NF-kappa B activation to the CD14 receptor system.
T9 1211-1350 Sentence denotes LPS-stimulated translocation of NF-kappa B in CHO/CD14 cells resembled the same response in the murine macrophage-like cell line RAW 264.7.
T10 1351-1624 Sentence denotes Protein synthesis inhibitors and corticosteroids, which suppress arachidonate release and the synthesis of proinflammatory cytokines, had no effect on translocation of NF-kappa B in CHO/CD14 or RAW 264.7 cells, demonstrating that NF-kappa B translocation is an early event.
T11 1625-1824 Sentence denotes Although TK activity was consistently observed by immunoblotting extracts from activated RAW 264.7 cells, LPS-induced phosphotyrosine residues were not observed from similarly treated CHO/CD14 cells.
T12 1825-2044 Sentence denotes Furthermore, the TK inhibitors herbimycin A and genistein failed to inhibit translocation of NF-kappa B in CHO/CD14 or RAW 264.7 cells, although both of these agents inhibited LPS-induced TK activity in RAW 264.7 cells.
T13 2045-2166 Sentence denotes These results imply that TK activity is not obligatory for CD14-mediated signal transduction to occur in response to LPS.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-4 protein denotes CD14
T2 31-53 protein denotes nuclear factor-kappa B
T3 101-116 protein denotes tyrosine kinase
T4 232-252 protein denotes macrophage receptors
T5 375-379 protein denotes CD14
T6 383-426 protein denotes glycosylphosphatidylinositol-linked antigen
T7 444-466 protein denotes LPS signaling receptor
T8 517-521 protein denotes CD14
T9 536-556 protein denotes transmembrane domain
T10 650-654 protein denotes CD14
T11 716-731 protein denotes tyrosine kinase
T12 809-845 cell_line denotes Chinese hamster ovary (CHO)-K1 cells
T13 934-938 protein denotes CD14
T14 940-948 protein denotes CHO/CD14
T15 1108-1122 cell_line denotes CHO/CD14 cells
T16 1160-1170 protein denotes NF-kappa B
T17 1189-1193 protein denotes CD14
T18 1243-1253 protein denotes NF-kappa B
T19 1257-1271 cell_line denotes CHO/CD14 cells
T20 1307-1339 cell_line denotes murine macrophage-like cell line
T21 1340-1349 cell_line denotes RAW 264.7
T22 1458-1483 protein denotes proinflammatory cytokines
T23 1519-1529 protein denotes NF-kappa B
T24 1537-1541 protein denotes CD14
T25 1545-1560 cell_line denotes RAW 264.7 cells
T26 1581-1591 protein denotes NF-kappa B
T27 1714-1729 cell_line denotes RAW 264.7 cells
T28 1809-1823 cell_line denotes CHO/CD14 cells
T29 1918-1928 protein denotes NF-kappa B
T30 1932-1940 cell_line denotes CHO/CD14
T31 1944-1959 cell_line denotes RAW 264.7 cells
T32 2028-2043 cell_line denotes RAW 264.7 cells
T33 2104-2108 protein denotes CD14

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 65-83 NP denotes lipopolysaccharide
C2 101-125 NP denotes tyrosine kinase activity
C3 178-202 NP denotes lipopolysaccharide (LPS)
C4 375-379 NP denotes CD14
C5 381-426 NP denotes a glycosylphosphatidylinositol-linked antigen
C6 494-507 NP denotes the mechanism
C7 511-516 NP denotes which
C8 517-521 NP denotes CD14
C9 523-528 NP denotes which
C10 569-572 NP denotes its
C11 928-949 NP denotes human CD14 (CHO/CD14)
C12 1108-1122 NP denotes CHO/CD14 cells
C13 1257-1271 NP denotes CHO/CD14 cells
C14 1303-1349 NP denotes the murine macrophage-like cell line RAW 264.7
C15 1351-1399 NP denotes Protein synthesis inhibitors and corticosteroids
C16 1401-1406 NP denotes which
C18 1533-1541 NP denotes CHO/CD14
C19 1545-1560 NP denotes RAW 264.7 cells
C17 1502-1560 NP denotes translocation of NF-kappa B in CHO/CD14 or RAW 264.7 cells
C20 1634-1645 NP denotes TK activity
C22 1932-1940 NP denotes CHO/CD14
C23 1944-1959 NP denotes RAW 264.7 cells
C21 1901-1959 NP denotes translocation of NF-kappa B in CHO/CD14 or RAW 264.7 cells
C24 1970-1990 NP denotes both of these agents
C25 2028-2043 NP denotes RAW 264.7 cells
C26 2070-2081 NP denotes TK activity
C27 2162-2165 NP denotes LPS
R1 C3 C1 coref-ident lipopolysaccharide (LPS),lipopolysaccharide
R2 C5 C4 coref-appos a glycosylphosphatidylinositol-linked antigen,CD14
R3 C7 C6 coref-relat which,the mechanism
R4 C9 C8 coref-relat which,CD14
R5 C10 C8 coref-pron its,CD14
R6 C12 C11 coref-ident CHO/CD14 cells,human CD14 (CHO/CD14)
R7 C13 C12 coref-ident CHO/CD14 cells,CHO/CD14 cells
R8 C16 C15 coref-relat which,Protein synthesis inhibitors and corticosteroids
R9 C18 C13 coref-ident CHO/CD14,CHO/CD14 cells
R10 C19 C14 coref-ident RAW 264.7 cells,the murine macrophage-like cell line RAW 264.7
R11 C20 C2 coref-ident TK activity,tyrosine kinase activity
R12 C22 C18 coref-ident CHO/CD14,CHO/CD14
R13 C23 C19 coref-ident RAW 264.7 cells,RAW 264.7 cells
R14 C21 C17 coref-ident translocation of NF-kappa B in CHO/CD14 or RAW 264.7 cells,translocation of NF-kappa B in CHO/CD14 or RAW 264.7 cells
R15 C24 C22 coref-ident both of these agents,CHO/CD14
R16 C24 C23 coref-ident both of these agents,RAW 264.7 cells
R17 C25 C23 coref-ident RAW 264.7 cells,RAW 264.7 cells
R18 C26 C20 coref-ident TK activity,TK activity
R19 C27 C3 coref-ident LPS,lipopolysaccharide (LPS)

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-126 Sentence denotes CD14-mediated translocation of nuclear factor-kappa B induced by lipopolysaccharide does not require tyrosine kinase activity.
S2 127-374 Sentence denotes During the course of serious bacterial infections, lipopolysaccharide (LPS) is believed to interact with macrophage receptors, resulting in the generation of inflammatory mediators and systemic symptoms including hemodynamic instability and shock.
S3 375-467 Sentence denotes CD14, a glycosylphosphatidylinositol-linked antigen, functions as an LPS signaling receptor.
S4 468-602 Sentence denotes A critical issue concerns the mechanism by which CD14, which has no transmembrane domain, transduces its signal following LPS binding.
S5 603-798 Sentence denotes Recently, investigators have hypothesized that CD14-mediated signaling is effected through a receptor-associated tyrosine kinase (TK), suggesting a multicomponent receptor model of LPS signaling.
S6 799-950 Sentence denotes Wild-type Chinese hamster ovary (CHO)-K1 cells can be activated by endotoxin to release arachidonate following transfection with human CD14 (CHO/CD14).
S7 951-1052 Sentence denotes Nuclear translocation of cytosolic NF-kappa B is correlated with a number of LPS-inducible responses.
S8 1053-1210 Sentence denotes We sought to determine if this pathway were present in CHO/CD14 cells and to elucidate the relationship of NF-kappa B activation to the CD14 receptor system.
S9 1211-1350 Sentence denotes LPS-stimulated translocation of NF-kappa B in CHO/CD14 cells resembled the same response in the murine macrophage-like cell line RAW 264.7.
S10 1351-1624 Sentence denotes Protein synthesis inhibitors and corticosteroids, which suppress arachidonate release and the synthesis of proinflammatory cytokines, had no effect on translocation of NF-kappa B in CHO/CD14 or RAW 264.7 cells, demonstrating that NF-kappa B translocation is an early event.
S11 1625-1824 Sentence denotes Although TK activity was consistently observed by immunoblotting extracts from activated RAW 264.7 cells, LPS-induced phosphotyrosine residues were not observed from similarly treated CHO/CD14 cells.
S12 1825-2044 Sentence denotes Furthermore, the TK inhibitors herbimycin A and genistein failed to inhibit translocation of NF-kappa B in CHO/CD14 or RAW 264.7 cells, although both of these agents inhibited LPS-induced TK activity in RAW 264.7 cells.
S13 2045-2166 Sentence denotes These results imply that TK activity is not obligatory for CD14-mediated signal transduction to occur in response to LPS.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-4 protein_molecule denotes CD14
T2 31-53 protein_molecule denotes nuclear factor-kappa B
T3 65-83 lipid denotes lipopolysaccharide
T4 101-109 amino_acid_monomer denotes tyrosine
T5 148-176 other_name denotes serious bacterial infections
T6 178-196 lipid denotes lipopolysaccharide
T7 198-201 lipid denotes LPS
T8 232-252 protein_family_or_group denotes macrophage receptors
T9 285-307 other_name denotes inflammatory mediators
T10 340-363 other_name denotes hemodynamic instability
T11 368-373 other_name denotes shock
T12 375-379 protein_molecule denotes CD14
T13 383-426 protein_family_or_group denotes glycosylphosphatidylinositol-linked antigen
T14 444-447 lipid denotes LPS
T15 517-521 protein_molecule denotes CD14
T16 536-556 protein_domain_or_region denotes transmembrane domain
T17 590-593 lipid denotes LPS
T18 650-654 protein_molecule denotes CD14
T19 716-724 amino_acid_monomer denotes tyrosine
T20 784-787 lipid denotes LPS
T21 809-845 cell_line denotes Chinese hamster ovary (CHO)-K1 cells
T22 887-899 other_organic_compound denotes arachidonate
T23 934-938 protein_molecule denotes CD14
T24 940-944 protein_molecule denotes CHO/
T25 944-948 protein_molecule denotes CD14
T26 1028-1031 lipid denotes LPS
T27 1108-1112 cell_line denotes CHO/
T28 1112-1116 protein_molecule denotes CD14
T29 1160-1170 protein_molecule denotes NF-kappa B
T30 1189-1193 protein_molecule denotes CD14
T31 1211-1214 lipid denotes LPS
T32 1243-1253 protein_molecule denotes NF-kappa B
T33 1257-1261 cell_line denotes CHO/
T34 1261-1265 protein_molecule denotes CD14
T35 1307-1339 cell_line denotes murine macrophage-like cell line
T36 1340-1349 cell_line denotes RAW 264.7
T37 1384-1399 lipid denotes corticosteroids
T38 1416-1428 other_organic_compound denotes arachidonate
T39 1458-1483 protein_family_or_group denotes proinflammatory cytokines
T40 1519-1529 protein_molecule denotes NF-kappa B
T41 1537-1541 protein_molecule denotes CD14
T42 1545-1560 cell_line denotes RAW 264.7 cells
T43 1581-1591 protein_molecule denotes NF-kappa B
T44 1634-1645 other_name denotes TK activity
T45 1675-1698 other_name denotes immunoblotting extracts
T46 1714-1729 cell_line denotes RAW 264.7 cells
T47 1731-1767 amino_acid_monomer denotes LPS-induced phosphotyrosine residues
T48 1809-1823 cell_line denotes CHO/CD14 cells
T49 1842-1855 other_name denotes TK inhibitors
T50 1856-1868 other_organic_compound denotes herbimycin A
T51 1873-1882 other_organic_compound denotes genistein
T52 1918-1928 protein_molecule denotes NF-kappa B
T53 1932-1940 cell_line denotes CHO/CD14
T54 1944-1959 cell_line denotes RAW 264.7 cells
T55 2001-2004 lipid denotes LPS
T56 2013-2024 other_name denotes TK activity
T57 2028-2043 cell_line denotes RAW 264.7 cells
T58 2070-2081 other_name denotes TK activity
T59 2104-2108 protein_molecule denotes CD14
T60 2162-2165 lipid denotes LPS

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 368-373 Phenotype denotes shock HP:0031273

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 156-176 Disease denotes bacterial infections http://purl.obolibrary.org/obo/MONDO_0005113

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 809-824 OrganismTaxon denotes Chinese hamster 10029
T2 928-933 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 232-242 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T2 536-549 Body_part denotes transmembrane http://purl.obolibrary.org/obo/GO_0016020
T3 825-830 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T4 1314-1324 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 232-242 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T3 1314-1324 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394