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PubMed:7517211 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 1239-1254 gene:4353 denotes myeloperoxidase
T1 1321-1354 disease:C0023487 denotes acute promyelocytic leukemia (APL
T2 1239-1254 gene:4353 denotes myeloperoxidase
T3 1401-1404 disease:C0023467 denotes AML
T4 1397-1400 gene:2187 denotes FAB
T5 1321-1354 disease:C0023487 denotes acute promyelocytic leukemia (APL
T6 1397-1400 gene:2187 denotes FAB
T7 1401-1404 disease:C0023467 denotes AML
R1 T0 T1 associated_with myeloperoxidase,acute promyelocytic leukemia (APL
R2 T2 T3 associated_with myeloperoxidase,AML
R3 T4 T5 associated_with FAB,acute promyelocytic leukemia (APL
R4 T6 T7 associated_with FAB,AML

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 316-353 cell_type denotes myeloid and natural killer (NK) cells
T2 547-553 protein denotes HLA-DR
T3 556-560 protein denotes CD16
T4 627-692 protein denotes myeloid (CD33, CD13, CD15) and NK cell-associated (CD56) antigens
T5 805-809 protein denotes CD56
T6 811-840 protein denotes neural cell adhesion molecule
T7 845-860 cell_type denotes leukemic blasts
T8 891-894 protein denotes CD4
T9 914-917 protein denotes CD2
T10 919-922 protein denotes CD3
T11 927-930 protein denotes CD8
T12 993-1008 protein denotes T-cell receptor
T13 1010-1032 protein denotes TCR beta, gamma, delta
T14 1239-1254 protein denotes myeloperoxidase
T15 1374-1395 protein denotes microgranular variant
T16 1397-1408 protein denotes FAB AML-M3v
T17 1484-1556 RNA denotes promyelocytic/retinoic acid receptor alpha (RAR alpha) fusion transcript
T18 1652-1666 DNA denotes chromosome 17q
T19 1675-1687 DNA denotes del(17)(q25)
T20 1707-1724 DNA denotes t(11;17)(q23;q21)
T21 1733-1795 RNA denotes promyelocytic leukemia zinc finger/RAR alpha fusion transcript
T22 1846-1854 DNA denotes t(11;17)
T23 2172-2176 protein denotes CD16
T24 2198-2236 cell_type denotes normal CD56+, CD16- NK precursor cells
T25 2329-2372 cell_type denotes normal CD56+, CD33+, CD16- counterpart cell
T26 2570-2598 cell_type denotes myeloid and NK cell lineages

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
7517211-2#145#149#gene945 500-504 gene945 denotes CD33
7517211-2#152#156#gene4684 507-511 gene4684 denotes CD56
7517211-2#159#164#gene3683 514-519 gene3683 denotes CD11a
7517211-2#183#187#gene947 538-542 gene947 denotes CD34
7517211-2#56#78#diseaseC0023467 411-433 diseaseC0023467 denotes acute myeloid leukemia
7517211-5#204#219#gene4353 1239-1254 gene4353 denotes myeloperoxidase
7517211-5#362#365#gene2187 1397-1400 gene2187 denotes FAB
7517211-5#286#314#diseaseC0023487 1321-1349 diseaseC0023487 denotes acute promyelocytic leukemia
7517211-5#316#319#diseaseC0023487 1351-1354 diseaseC0023487 denotes APL
7517211-5#366#369#diseaseC0023467 1401-1404 diseaseC0023467 denotes AML
7517211-5#286#314#diseaseC0023487 1321-1349 diseaseC0023487 denotes acute promyelocytic leukemia
7517211-5#316#319#diseaseC0023487 1351-1354 diseaseC0023487 denotes APL
7517211-5#366#369#diseaseC0023467 1401-1404 diseaseC0023467 denotes AML
145#149#gene94556#78#diseaseC0023467 7517211-2#145#149#gene945 7517211-2#56#78#diseaseC0023467 associated_with CD33,acute myeloid leukemia
152#156#gene468456#78#diseaseC0023467 7517211-2#152#156#gene4684 7517211-2#56#78#diseaseC0023467 associated_with CD56,acute myeloid leukemia
159#164#gene368356#78#diseaseC0023467 7517211-2#159#164#gene3683 7517211-2#56#78#diseaseC0023467 associated_with CD11a,acute myeloid leukemia
183#187#gene94756#78#diseaseC0023467 7517211-2#183#187#gene947 7517211-2#56#78#diseaseC0023467 associated_with CD34,acute myeloid leukemia
204#219#gene4353286#314#diseaseC0023487 7517211-5#204#219#gene4353 7517211-5#286#314#diseaseC0023487 associated_with myeloperoxidase,acute promyelocytic leukemia
204#219#gene4353316#319#diseaseC0023487 7517211-5#204#219#gene4353 7517211-5#316#319#diseaseC0023487 associated_with myeloperoxidase,APL
204#219#gene4353366#369#diseaseC0023467 7517211-5#204#219#gene4353 7517211-5#366#369#diseaseC0023467 associated_with myeloperoxidase,AML
204#219#gene4353286#314#diseaseC0023487 7517211-5#204#219#gene4353 7517211-5#286#314#diseaseC0023487 associated_with myeloperoxidase,acute promyelocytic leukemia
204#219#gene4353316#319#diseaseC0023487 7517211-5#204#219#gene4353 7517211-5#316#319#diseaseC0023487 associated_with myeloperoxidase,APL
204#219#gene4353366#369#diseaseC0023467 7517211-5#204#219#gene4353 7517211-5#366#369#diseaseC0023467 associated_with myeloperoxidase,AML
362#365#gene2187286#314#diseaseC0023487 7517211-5#362#365#gene2187 7517211-5#286#314#diseaseC0023487 associated_with FAB,acute promyelocytic leukemia
362#365#gene2187316#319#diseaseC0023487 7517211-5#362#365#gene2187 7517211-5#316#319#diseaseC0023487 associated_with FAB,APL
362#365#gene2187366#369#diseaseC0023467 7517211-5#362#365#gene2187 7517211-5#366#369#diseaseC0023467 associated_with FAB,AML
362#365#gene2187286#314#diseaseC0023487 7517211-5#362#365#gene2187 7517211-5#286#314#diseaseC0023487 associated_with FAB,acute promyelocytic leukemia
362#365#gene2187316#319#diseaseC0023487 7517211-5#362#365#gene2187 7517211-5#316#319#diseaseC0023487 associated_with FAB,APL
362#365#gene2187366#369#diseaseC0023467 7517211-5#362#365#gene2187 7517211-5#366#369#diseaseC0023467 associated_with FAB,AML

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 238-286 NP denotes a previously unrecognized form of acute leukemia
C2 287-291 NP denotes that
C3 311-353 NP denotes both myeloid and natural killer (NK) cells
C4 384-439 NP denotes 350 cases of adult de novo acute myeloid leukemia (AML)
C5 455-498 NP denotes 20 cases (6%) with a unique immunophenotype
C6 715-778 NP denotes reverse transcription polymerase chain reaction (RT-PCR) assays
C7 1083-1279 NP denotes unique morphologic features (deeply invaginated nuclear membranes, scant cytoplasm with fine azurophilic granularity, and finely granular Sudan black B and myeloperoxidase cytochemical reactivity)
C8 1280-1284 NP denotes that
C9 1312-1317 NP denotes those
C10 1420-1432 NP denotes all 20 cases
C11 1480-1556 NP denotes the promyelocytic/retinoic acid receptor alpha (RAR alpha) fusion transcript
C12 1560-1573 NP denotes RT-PCR assays
C13 1729-1795 NP denotes the promyelocytic leukemia zinc finger/RAR alpha fusion transcript
C14 1797-1806 NP denotes All cases
C15 1904-1934 NP denotes all-trans retinoic acid (ATRA)
C16 1952-1963 NP denotes these cases
C17 1980-1989 NP denotes some APLs
C18 1990-1994 NP denotes that
C19 2033-2037 NP denotes ATRA
C20 2327-2372 NP denotes a normal CD56+, CD33+, CD16- counterpart cell
C21 2473-2500 NP denotes this form of acute leukemia
C22 2561-2598 NP denotes both the myeloid and NK cell lineages
C23 2616-2657 NP denotes the designation myeloid/NK acute leukemia
C24 2674-2698 NP denotes this new leukemic entity
R1 C2 C1 coref-relat that,a previously unrecognized form of acute leukemia
R2 C8 C7 coref-relat that,"unique morphologic features (deeply invaginated nuclear membranes, scant cytoplasm with fine azurophilic granularity, and finely granular Sudan black B and myeloperoxidase cytochemical reactivity)"
R3 C9 C7 coref-pron those,"unique morphologic features (deeply invaginated nuclear membranes, scant cytoplasm with fine azurophilic granularity, and finely granular Sudan black B and myeloperoxidase cytochemical reactivity)"
R4 C10 C5 coref-ident all 20 cases,20 cases (6%) with a unique immunophenotype
R5 C12 C6 coref-ident RT-PCR assays,reverse transcription polymerase chain reaction (RT-PCR) assays
R6 C13 C11 coref-ident the promyelocytic leukemia zinc finger/RAR alpha fusion transcript,the promyelocytic/retinoic acid receptor alpha (RAR alpha) fusion transcript
R7 C14 C4 coref-ident All cases,350 cases of adult de novo acute myeloid leukemia (AML)
R8 C16 C14 coref-ident these cases,All cases
R9 C18 C17 coref-relat that,some APLs
R10 C19 C15 coref-ident ATRA,all-trans retinoic acid (ATRA)
R11 C21 C20 coref-ident this form of acute leukemia,"a normal CD56+, CD33+, CD16- counterpart cell"
R12 C22 C3 coref-ident both the myeloid and NK cell lineages,both myeloid and natural killer (NK) cells
R13 C24 C23 coref-ident this new leukemic entity,the designation myeloid/NK acute leukemia

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-200 Sentence denotes HLA-DR-, CD33+, CD56+, CD16- myeloid/natural killer cell acute leukemia: a previously unrecognized form of acute leukemia potentially misdiagnosed as French-American-British acute myeloid leukemia-M3.
S2 201-354 Sentence denotes We have identified and characterized a previously unrecognized form of acute leukemia that shares features of both myeloid and natural killer (NK) cells.
S3 355-562 Sentence denotes From a consecutive series of 350 cases of adult de novo acute myeloid leukemia (AML), we identified 20 cases (6%) with a unique immunophenotype: CD33+, CD56+, CD11a+, CD13lo, CD15lo, CD34+/-, HLA-DR-, CD16-.
S4 563-861 Sentence denotes Multicolor flow cytometric assays confirmed the coexpression of myeloid (CD33, CD13, CD15) and NK cell-associated (CD56) antigens in each case, whereas reverse transcription polymerase chain reaction (RT-PCR) assays confirmed the identity of CD56 (neural cell adhesion molecule) in leukemic blasts.
S5 862-1034 Sentence denotes Although two cases expressed CD4, no case expressed CD2, CD3, or CD8 and no case showed clonal rearrangement of genes encoding the T-cell receptor (TCR beta, gamma, delta).
S6 1035-1410 Sentence denotes Leukemic blasts in the majority of cases shared unique morphologic features (deeply invaginated nuclear membranes, scant cytoplasm with fine azurophilic granularity, and finely granular Sudan black B and myeloperoxidase cytochemical reactivity) that were remarkably similar to those of acute promyelocytic leukemia (APL); particularly the microgranular variant (FAB AML-M3v).
S7 1411-1796 Sentence denotes However, all 20 cases lacked the t(15;17) and 17 cases tested lacked the promyelocytic/retinoic acid receptor alpha (RAR alpha) fusion transcript in RT-PCR assays; 12 cases had 46,XX or 46,XY karyotypes, whereas 2 cases had abnormalities of chromosome 17q: 1 with del(17)(q25) and the other with t(11;17)(q23;q21) and the promyelocytic leukemia zinc finger/RAR alpha fusion transcript.
S8 1797-2038 Sentence denotes All cases tested (6/20), including the case with t(11;17), failed to differentiate in vitro in response to all-trans retinoic acid (ATRA), suggesting that these cases may account for some APLs that have not shown a clinical response to ATRA.
S9 2039-2237 Sentence denotes Four of 6 cases tested showed functional NK cell-mediated cytotoxicity, suggesting a relationship between these unique CD33+, CD56+, CD16- acute leukemias and normal CD56+, CD16- NK precursor cells.
S10 2238-2447 Sentence denotes Using a combination of panning and multiparameter flow cytometric sorting, we identified a normal CD56+, CD33+, CD16- counterpart cell at a frequency of 1% to 2% in the peripheral blood of healthy individuals.
S11 2448-2658 Sentence denotes Our studies suggest that this form of acute leukemia may arise from transformation of a precursor cell common to both the myeloid and NK cell lineages; thus we propose the designation myeloid/NK acute leukemia.
S12 2659-2796 Sentence denotes Recognition of this new leukemic entity will be important in distinguishing these ATRA-nonresponsive cases from ATRA-responsive true APL.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 107-121 other_name denotes acute leukemia
T2 150-199 other_name denotes French-American-British acute myeloid leukemia-M3
T3 272-286 other_name denotes acute leukemia
T4 397-416 other_name denotes adult de novo acute
T5 417-433 other_name denotes myeloid leukemia
T6 435-438 other_name denotes AML
T7 500-546 other_name denotes CD33+, CD56+, CD11a+, CD13lo, CD15lo, CD34+/-,
T8 547-553 protein_molecule denotes HLA-DR
T9 556-560 protein_molecule denotes CD16
T10 715-778 other_name denotes reverse transcription polymerase chain reaction (RT-PCR) assays
T11 805-809 protein_molecule denotes CD56
T12 811-840 protein_family_or_group denotes neural cell adhesion molecule
T13 845-860 cell_type denotes leukemic blasts
T14 891-894 protein_molecule denotes CD4
T15 914-917 protein_molecule denotes CD2
T16 919-922 protein_molecule denotes CD3
T17 927-930 protein_molecule denotes CD8
T18 993-1008 protein_family_or_group denotes T-cell receptor
T19 1090-1110 other_name denotes morphologic features
T20 1112-1148 cell_component denotes deeply invaginated nuclear membranes
T21 1150-1165 cell_component denotes scant cytoplasm
T22 1171-1199 other_name denotes fine azurophilic granularity
T23 1205-1238 other_name denotes finely granular Sudan black B and
T24 1239-1254 protein_molecule denotes myeloperoxidase
T25 1321-1349 other_name denotes acute promyelocytic leukemia
T26 1351-1354 other_name denotes APL
T27 1374-1395 protein_family_or_group denotes microgranular variant
T28 1397-1400 protein_molecule denotes FAB
T29 1401-1404 other_name denotes AML
T30 1484-1526 protein_molecule denotes promyelocytic/retinoic acid receptor alpha
T31 1528-1537 protein_molecule denotes RAR alpha
T32 1560-1573 other_name denotes RT-PCR assays
T33 1652-1666 DNA_molecule denotes chromosome 17q
T34 1675-1687 DNA_domain_or_region denotes del(17)(q25)
T35 1707-1724 DNA_domain_or_region denotes t(11;17)(q23;q21)
T36 1733-1768 RNA_molecule denotes promyelocytic leukemia zinc finger/
T37 1768-1777 protein_molecule denotes RAR alpha
T38 1846-1854 DNA_domain_or_region denotes t(11;17)
T39 1904-1927 other_organic_compound denotes all-trans retinoic acid
T40 1929-1933 other_organic_compound denotes ATRA
T41 2033-2037 other_organic_compound denotes ATRA
T42 2080-2109 other_name denotes NK cell-mediated cytotoxicity
T43 2158-2171 other_name denotes CD33+, CD56+,
T44 2172-2176 protein_molecule denotes CD16
T45 2198-2236 cell_type denotes normal CD56+, CD16- NK precursor cells
T46 2329-2372 cell_type denotes normal CD56+, CD33+, CD16- counterpart cell
T47 2407-2423 tissue denotes peripheral blood
T48 2427-2446 multi_cell denotes healthy individuals
T49 2486-2500 other_name denotes acute leukemia
T50 2632-2642 other_name denotes myeloid/NK
T51 2643-2657 other_name denotes acute leukemia
T52 2679-2698 other_name denotes new leukemic entity
T53 2741-2745 other_organic_compound denotes ATRA
T54 2771-2775 other_organic_compound denotes ATRA
T55 2792-2795 other_name denotes APL