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sentences

Id Subject Object Predicate Lexical cue
T1 0-116 Sentence denotes Tolerance to lipopolysaccharide involves mobilization of nuclear factor kappa B with predominance of p50 homodimers.
T2 117-289 Sentence denotes Stimulation of the human monocytic cell line Mono Mac 6 with lipopolysaccharide (LPS) leads to rapid and transient expression of cytokines like tumor necrosis factor (TNF).
T3 290-500 Sentence denotes When such cells are precultured for 2 days with a low dose of LPS (20 ng/ml) followed by stimulation with a high dose of LPS (1 microgram/ml), expression of the TNF gene is minimal, i.e. the cells are tolerant.
T4 501-667 Sentence denotes In nuclear run-on analysis, such tolerant cells show only a low degree of transcription, indicating that tolerance operates at or upstream of the transcription level.
T5 668-914 Sentence denotes The CD14 LPS receptor is, however, up-regulated (not down-regulated) in tolerant cells, and LPS can, in fact, still lead to activation of tolerant cells as evidenced by mobilization of the transcription factor nuclear factor kappa B (NF-kappa B).
T6 915-1142 Sentence denotes Resolution of the NF-kappa B complex in gel shift analysis shows that the binding protein, mobilized in naive Mono Mac 6 cells, consists mainly of p50-p65 heterodimers, while in tolerant cells, the p50 homodimer is predominant.
T7 1143-1269 Sentence denotes This increase in p50 homodimers coincides with an increase in p105 mRNA, suggestive of a transcriptional up-regulation of p50.
T8 1270-1575 Sentence denotes Reporter gene analysis reveals that the NF-kappa B complex mobilized in tolerant cells is functionally inactive in that NF-kappa B-dependent luciferase constructs containing the human immunodeficiency virus long terminal repeat or the TNF 5'-region show only minimal transactivation after LPS stimulation.
T9 1576-1737 Sentence denotes Similar to Mono Mac 6 cells, primary blood monocytes, when precultured with a low dose of LPS, also become tolerant and produce little TNF after LPS stimulation.
T10 1738-1857 Sentence denotes The tolerant blood monocytes also up-regulate CD14, and they mobilize NF-kappa B with a predominance of p50 homodimers.
T11 1858-2026 Sentence denotes Taken together, these results demonstrate that tolerance to LPS is determined by post-receptor mechanisms that involve an altered composition of the NF-kappa B complex.
T1 0-116 Sentence denotes Tolerance to lipopolysaccharide involves mobilization of nuclear factor kappa B with predominance of p50 homodimers.
T2 117-289 Sentence denotes Stimulation of the human monocytic cell line Mono Mac 6 with lipopolysaccharide (LPS) leads to rapid and transient expression of cytokines like tumor necrosis factor (TNF).
T3 290-500 Sentence denotes When such cells are precultured for 2 days with a low dose of LPS (20 ng/ml) followed by stimulation with a high dose of LPS (1 microgram/ml), expression of the TNF gene is minimal, i.e. the cells are tolerant.
T4 501-667 Sentence denotes In nuclear run-on analysis, such tolerant cells show only a low degree of transcription, indicating that tolerance operates at or upstream of the transcription level.
T5 668-914 Sentence denotes The CD14 LPS receptor is, however, up-regulated (not down-regulated) in tolerant cells, and LPS can, in fact, still lead to activation of tolerant cells as evidenced by mobilization of the transcription factor nuclear factor kappa B (NF-kappa B).
T6 915-1142 Sentence denotes Resolution of the NF-kappa B complex in gel shift analysis shows that the binding protein, mobilized in naive Mono Mac 6 cells, consists mainly of p50-p65 heterodimers, while in tolerant cells, the p50 homodimer is predominant.
T7 1143-1269 Sentence denotes This increase in p50 homodimers coincides with an increase in p105 mRNA, suggestive of a transcriptional up-regulation of p50.
T8 1270-1575 Sentence denotes Reporter gene analysis reveals that the NF-kappa B complex mobilized in tolerant cells is functionally inactive in that NF-kappa B-dependent luciferase constructs containing the human immunodeficiency virus long terminal repeat or the TNF 5'-region show only minimal transactivation after LPS stimulation.
T9 1576-1737 Sentence denotes Similar to Mono Mac 6 cells, primary blood monocytes, when precultured with a low dose of LPS, also become tolerant and produce little TNF after LPS stimulation.
T10 1738-1857 Sentence denotes The tolerant blood monocytes also up-regulate CD14, and they mobilize NF-kappa B with a predominance of p50 homodimers.
T11 1858-2026 Sentence denotes Taken together, these results demonstrate that tolerance to LPS is determined by post-receptor mechanisms that involve an altered composition of the NF-kappa B complex.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1613-1618 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T2 1613-1618 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T3 1751-1756 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T4 1751-1756 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 57-79 protein denotes nuclear factor kappa B
T2 101-104 protein denotes p50
T3 136-161 cell_line denotes human monocytic cell line
T4 162-172 cell_line denotes Mono Mac 6
T5 246-255 protein denotes cytokines
T6 261-282 protein denotes tumor necrosis factor
T7 284-287 protein denotes TNF
T8 451-459 DNA denotes TNF gene
T9 534-548 cell_type denotes tolerant cells
T10 672-676 protein denotes CD14
T11 740-754 cell_line denotes tolerant cells
T12 806-820 cell_line denotes tolerant cells
T13 857-877 protein denotes transcription factor
T14 878-900 protein denotes nuclear factor kappa B
T15 902-912 protein denotes NF-kappa B
T16 933-951 protein denotes NF-kappa B complex
T17 989-1004 protein denotes binding protein
T18 1019-1041 cell_line denotes naive Mono Mac 6 cells
T19 1062-1082 protein denotes p50-p65 heterodimers
T20 1093-1107 cell_line denotes tolerant cells
T21 1113-1126 protein denotes p50 homodimer
T22 1160-1174 protein denotes p50 homodimers
T23 1205-1214 RNA denotes p105 mRNA
T24 1265-1268 protein denotes p50
T25 1310-1328 protein denotes NF-kappa B complex
T26 1342-1356 cell_line denotes tolerant cells
T27 1390-1432 DNA denotes NF-kappa B-dependent luciferase constructs
T28 1448-1497 DNA denotes human immunodeficiency virus long terminal repeat
T29 1505-1518 DNA denotes TNF 5'-region
T30 1587-1603 cell_line denotes Mono Mac 6 cells
T31 1605-1628 cell_type denotes primary blood monocytes
T32 1711-1714 protein denotes TNF
T33 1742-1766 cell_type denotes tolerant blood monocytes
T34 1784-1788 protein denotes CD14
T35 1808-1818 protein denotes NF-kappa B
T36 1842-1856 protein denotes p50 homodimers
T37 2007-2025 protein denotes NF-kappa B complex

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 13-31 NP denotes lipopolysaccharide
C2 41-79 NP denotes mobilization of nuclear factor kappa B
C3 101-115 NP denotes p50 homodimers
C4 132-172 NP denotes the human monocytic cell line Mono Mac 6
C5 178-202 NP denotes lipopolysaccharide (LPS)
C6 261-288 NP denotes tumor necrosis factor (TNF)
C7 295-305 NP denotes such cells
C8 352-355 NP denotes LPS
C9 411-414 NP denotes LPS
C10 447-459 NP denotes the TNF gene
C11 477-486 NP denotes the cells
C12 529-548 NP denotes such tolerant cells
C13 740-754 NP denotes tolerant cells
C14 760-763 NP denotes LPS
C15 806-820 NP denotes tolerant cells
C17 853-913 NP denotes the transcription factor nuclear factor kappa B (NF-kappa B)
C16 837-913 NP denotes mobilization of the transcription factor nuclear factor kappa B (NF-kappa B)
C18 929-951 NP denotes the NF-kappa B complex
C19 1025-1041 NP denotes Mono Mac 6 cells
C20 1093-1107 NP denotes tolerant cells
C21 1109-1126 NP denotes the p50 homodimer
C22 1160-1174 NP denotes p50 homodimers
C23 1306-1328 NP denotes the NF-kappa B complex
C24 1342-1356 NP denotes tolerant cells
C25 1559-1574 NP denotes LPS stimulation
C26 1587-1603 NP denotes Mono Mac 6 cells
C27 1666-1669 NP denotes LPS
C28 1721-1736 NP denotes LPS stimulation
C29 1738-1766 NP denotes The tolerant blood monocytes
C30 1794-1798 NP denotes they
C31 1808-1818 NP denotes NF-kappa B
C32 1842-1856 NP denotes p50 homodimers
C33 1918-1921 NP denotes LPS
C34 1939-1963 NP denotes post-receptor mechanisms
C35 1964-1968 NP denotes that
C36 2003-2025 NP denotes the NF-kappa B complex
R1 C5 C1 coref-ident lipopolysaccharide (LPS),lipopolysaccharide
R2 C7 C4 coref-ident such cells,the human monocytic cell line Mono Mac 6
R3 C8 C5 coref-ident LPS,lipopolysaccharide (LPS)
R4 C9 C5 coref-ident LPS,lipopolysaccharide (LPS)
R5 C10 C6 coref-ident the TNF gene,tumor necrosis factor (TNF)
R6 C11 C7 coref-ident the cells,such cells
R7 C12 C11 coref-ident such tolerant cells,the cells
R8 C13 C12 coref-ident tolerant cells,such tolerant cells
R9 C14 C8 coref-ident LPS,LPS
R10 C15 C13 coref-ident tolerant cells,tolerant cells
R11 C16 C2 coref-ident mobilization of the transcription factor nuclear factor kappa B (NF-kappa B),mobilization of nuclear factor kappa B
R12 C19 C4 coref-ident Mono Mac 6 cells,the human monocytic cell line Mono Mac 6
R13 C20 C15 coref-ident tolerant cells,tolerant cells
R14 C21 C3 coref-ident the p50 homodimer,p50 homodimers
R15 C23 C18 coref-ident the NF-kappa B complex,the NF-kappa B complex
R16 C24 C20 coref-ident tolerant cells,tolerant cells
R17 C26 C19 coref-ident Mono Mac 6 cells,Mono Mac 6 cells
R18 C27 C14 coref-ident LPS,LPS
R19 C28 C25 coref-ident LPS stimulation,LPS stimulation
R20 C30 C29 coref-pron they,The tolerant blood monocytes
R21 C31 C17 coref-ident NF-kappa B,the transcription factor nuclear factor kappa B (NF-kappa B)
R22 C32 C22 coref-ident p50 homodimers,p50 homodimers
R23 C33 C27 coref-ident LPS,LPS
R24 C35 C34 coref-relat that,post-receptor mechanisms
R25 C36 C23 coref-ident the NF-kappa B complex,the NF-kappa B complex

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-116 Sentence denotes Tolerance to lipopolysaccharide involves mobilization of nuclear factor kappa B with predominance of p50 homodimers.
S2 117-289 Sentence denotes Stimulation of the human monocytic cell line Mono Mac 6 with lipopolysaccharide (LPS) leads to rapid and transient expression of cytokines like tumor necrosis factor (TNF).
S3 290-500 Sentence denotes When such cells are precultured for 2 days with a low dose of LPS (20 ng/ml) followed by stimulation with a high dose of LPS (1 microgram/ml), expression of the TNF gene is minimal, i.e. the cells are tolerant.
S4 501-667 Sentence denotes In nuclear run-on analysis, such tolerant cells show only a low degree of transcription, indicating that tolerance operates at or upstream of the transcription level.
S5 668-914 Sentence denotes The CD14 LPS receptor is, however, up-regulated (not down-regulated) in tolerant cells, and LPS can, in fact, still lead to activation of tolerant cells as evidenced by mobilization of the transcription factor nuclear factor kappa B (NF-kappa B).
S6 915-1142 Sentence denotes Resolution of the NF-kappa B complex in gel shift analysis shows that the binding protein, mobilized in naive Mono Mac 6 cells, consists mainly of p50-p65 heterodimers, while in tolerant cells, the p50 homodimer is predominant.
S7 1143-1269 Sentence denotes This increase in p50 homodimers coincides with an increase in p105 mRNA, suggestive of a transcriptional up-regulation of p50.
S8 1270-1575 Sentence denotes Reporter gene analysis reveals that the NF-kappa B complex mobilized in tolerant cells is functionally inactive in that NF-kappa B-dependent luciferase constructs containing the human immunodeficiency virus long terminal repeat or the TNF 5'-region show only minimal transactivation after LPS stimulation.
S9 1576-1737 Sentence denotes Similar to Mono Mac 6 cells, primary blood monocytes, when precultured with a low dose of LPS, also become tolerant and produce little TNF after LPS stimulation.
S10 1738-1857 Sentence denotes The tolerant blood monocytes also up-regulate CD14, and they mobilize NF-kappa B with a predominance of p50 homodimers.
S11 1858-2026 Sentence denotes Taken together, these results demonstrate that tolerance to LPS is determined by post-receptor mechanisms that involve an altered composition of the NF-kappa B complex.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 13-31 lipid denotes lipopolysaccharide
T2 57-79 protein_molecule denotes nuclear factor kappa B
T3 101-104 protein_subunit denotes p50
T4 136-161 cell_line denotes human monocytic cell line
T5 162-172 cell_line denotes Mono Mac 6
T6 178-196 lipid denotes lipopolysaccharide
T7 198-201 lipid denotes LPS
T8 246-255 protein_family_or_group denotes cytokines
T9 261-282 protein_family_or_group denotes tumor necrosis factor
T10 284-287 protein_family_or_group denotes TNF
T11 352-355 lipid denotes LPS
T12 411-414 lipid denotes LPS
T13 451-454 protein_family_or_group denotes TNF
T14 504-527 other_name denotes nuclear run-on analysis
T15 534-548 cell_type denotes tolerant cells
T16 647-666 other_name denotes transcription level
T17 672-676 protein_molecule denotes CD14
T18 677-680 lipid denotes LPS
T19 740-754 cell_line denotes tolerant cells
T20 760-763 lipid denotes LPS
T21 806-820 cell_line denotes tolerant cells
T22 857-877 protein_family_or_group denotes transcription factor
T23 878-900 protein_molecule denotes nuclear factor kappa B
T24 902-912 protein_molecule denotes NF-kappa B
T25 933-943 protein_molecule denotes NF-kappa B
T26 989-1004 protein_family_or_group denotes binding protein
T27 1019-1041 cell_line denotes naive Mono Mac 6 cells
T28 1062-1065 protein_subunit denotes p50
T29 1065-1069 protein_subunit denotes -p65
T30 1093-1107 cell_line denotes tolerant cells
T31 1113-1116 protein_subunit denotes p50
T32 1160-1163 protein_subunit denotes p50
T33 1205-1214 RNA_molecule denotes p105 mRNA
T34 1265-1268 protein_subunit denotes p50
T35 1310-1320 protein_molecule denotes NF-kappa B
T36 1342-1356 cell_line denotes tolerant cells
T37 1390-1400 protein_molecule denotes NF-kappa B
T38 1448-1497 DNA_domain_or_region denotes human immunodeficiency virus long terminal repeat
T39 1505-1508 protein_family_or_group denotes TNF
T40 1559-1562 lipid denotes LPS
T41 1587-1603 cell_line denotes Mono Mac 6 cells
T42 1605-1628 cell_type denotes primary blood monocytes
T43 1666-1669 lipid denotes LPS
T44 1711-1714 protein_family_or_group denotes TNF
T45 1721-1724 lipid denotes LPS
T46 1742-1766 cell_type denotes tolerant blood monocytes
T47 1784-1788 protein_molecule denotes CD14
T48 1808-1818 protein_molecule denotes NF-kappa B
T49 1842-1845 protein_subunit denotes p50
T50 1918-1921 lipid denotes LPS
T51 1939-1963 other_name denotes post-receptor mechanisms
T52 2007-2017 protein_molecule denotes NF-kappa B

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 261-266 Phenotype denotes tumor HP:0002664
T2 1454-1470 Phenotype denotes immunodeficiency HP:0002721

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 162-170 Disease denotes Mono Mac http://purl.obolibrary.org/obo/MONDO_0013607
T2 261-266 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T3 1025-1033 Disease denotes Mono Mac http://purl.obolibrary.org/obo/MONDO_0013607
T4 1454-1470 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T5 1587-1595 Disease denotes Mono Mac http://purl.obolibrary.org/obo/MONDO_0013607

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 136-141 OrganismTaxon denotes human 9606
T2 1448-1453 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1613-1618 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T2 1619-1628 Body_part denotes monocytes http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T4 1751-1756 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T5 1757-1766 Body_part denotes monocytes http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1613-1618 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315
T3 1751-1756 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 142-151 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T3 1619-1628 Cell denotes monocytes http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T5 1757-1766 Cell denotes monocytes http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054